Article
Neurosciences
Yang Wang, Jingran Lin, Jiarui Li, Lu Yan, Wenwen Li, Xingzhi He, Huan Ma
Summary: Activity-dependent changes in protein expression are crucial for neuronal plasticity. Homeostatic synaptic up-scaling, induced primarily by neuronal inactivity, involves autophagy and the regulation of key synaptic proteins. The turnover mechanism of synaptic proteins in this process remains unclear.
JOURNAL OF NEUROSCIENCE
(2023)
Article
Biology
Samuel J. Barnes, Georg B. Keller, Tara Keck
Summary: This study used two-photon imaging to observe changes in neuronal synaptic calcium signals in awake mice, revealing that spines correlated with intrinsic network activity undergo TNF-α-dependent homeostatic enhancement, while spines responsive to sensory stimulation do not. Following sensory deprivation, global sensory-evoked responses increased, despite identified sensory inputs not strengthening.
Article
Biochemistry & Molecular Biology
David Colameo, Marek Rajman, Michael Soutschek, Silvia Bicker, Lukas von Ziegler, Johannes Bohacek, Jochen Winterer, Pierre-Luc Germain, Christoph Dieterich, Gerhard Schratt
Summary: This study revealed different regulations between the somatic and process compartments of neurons during synaptic scaling. While crucial regulators of neuronal excitability were primarily downregulated in the somatic compartment, structural components of excitatory postsynapses were mainly downregulated in processes. This suggests that compartmentalized gene expression changes coexist with neuron-wide mechanisms during synaptic scaling to allow synaptic computation and homeostasis.
Article
Biology
Shruti Thapliyal, Kristin L. Arendt, Anthony G. Lau, Lu Chen, Dion K. Dickman
Summary: Homeostatic synaptic plasticity is a mechanism that adjusts synaptic strength to maintain network stability. This study reveals that synaptic signaling through retinoic acid and its receptor, RAR alpha, regulates presynaptic neurotransmitter release to achieve homeostatic adjustment.
Article
Mathematics, Interdisciplinary Applications
Gustavo Menesse, Boris Marin, Mauricio Girardi-Schappo, Osame Kinouchi
Summary: In self-organized criticality models, criticality is usually only observed for vanishing external fields h -> 0, which is not common in natural systems. In dissipative systems, a phenomenon called dirty criticality or self-organized quasi-criticality (SOqC) exists instead of true critical behavior characterized by clean power laws obeying finite-size scaling. This study proposes simple homeostatic mechanisms for neuronal networks to achieve near criticality even in the presence of significant external input.
CHAOS SOLITONS & FRACTALS
(2022)
Editorial Material
Biochemistry & Molecular Biology
David Colameo, Gerhard Schratt
Summary: This article investigates the plasticity mechanisms of neurons in the face of network activity disruptions. The study reveals that individual synapses are tagged for future strengthening during periods of chronic inactivity. These findings support the role of local mechanisms in homeostatic synaptic plasticity.
Article
Neurosciences
Israt Jahan, Ryota Adachi, Ryo Egawa, Haruka Nomura, Hiroshi Kuba
Summary: This study reveals that microtubule reorganization via activation of CDK5 plays a role in the plasticity of the axon initial segment (AIS). Treatment with a high-K+ medium shortened the AIS, specifically in neurons tuned to high-frequency sound. CDK5/p35-mediated AIS shortening is achieved by promoting disassembly of microtubules at distal AIS.
JOURNAL OF NEUROSCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Sandra Dubes, Anais Soula, Sebastien Benquet, Beatrice Tessier, Christel Poujol, Alexandre Favereaux, Olivier Thoumine, Mathieu Letellier
Summary: This study reveals the molecular mechanism of synapse-specific homeostatic plasticity. The synaptic tagging mechanism, driven by synaptopodin, regulates the enhancement of synaptic strength in a synapse-specific manner. This finding shifts the understanding of homeostatic plasticity towards the idea that the ability for changes depends on the functional and biochemical state of individual synapses.
Article
Neurosciences
Evan R. Harrell, Diogo Pimentel, Gero Miesenbock
Summary: The study showed that by altering the postsynaptic excitability, gene expression in presynaptic neurons at the first synaptic relay of the Drosophila olfactory system was affected. The changes in gene expression were related to synaptic vesicle release, synaptic remodeling, and eventually tilting towards protein synthesis, folding and degradation, energy metabolism, and cellular stress defenses, indicating the system had been pushed to its homeostatic limits.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Cell Biology
Yifu Han, Pragya Goel, Jiawen Chen, Sarah Perry, Nancy Tran, Samantha Nishimura, Manisha Sanjani, Chun Chien, Dion Dickman
Summary: This study investigates the impact of synaptic glutamate levels on GluRA and GluRB receptors at the Drosophila neuromuscular junction. It demonstrates that proper receptor abundance and composition can be regulated in the absence of synaptic glutamate release, but excess glutamate can adaptively adjust receptor abundance. Furthermore, GluRB becomes insensitive to glutamate modulation when competition with GluRA is eliminated, whereas GluRA is homeostatically regulated to maintain stable miniature activity through excess glutamate and Ca2+ signaling.
Article
Multidisciplinary Sciences
Paola Muttathukunnel, Patrick Frei, Sarah Perry, Dion Dickman, Martin Mueller
Summary: Robust neural information transfer relies on the delicate molecular nano-architecture of chemical synapses. This study reveals the alignment of presynaptic nanorings with postsynaptic glutamate receptor rings and the formation of nanocolumn rings by presynaptic proteins and glutamate receptors. The impairment of glutamate receptors triggers the formation of transsynaptic nanocolumns on a minute timescale during homeostatic plasticity. This research uncovers the regulatory mechanism of synaptic nano-architecture and highlights its importance in stabilizing synaptic transmission.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Neurosciences
Wei Wen, Gina G. Turrigiano
Summary: Homeostatic plasticity in neural circuits can be modulated differently at various developmental stages, with excitatory synaptic scaling and intrinsic homeostatic plasticity being induced during critical periods but only excitatory synaptic scaling persisting into adulthood. This suggests that distinct sets of homeostatic plasticity mechanisms are recruited based on the needs of the developing neural circuit.
JOURNAL OF NEUROSCIENCE
(2021)
Review
Clinical Neurology
Andrew G. Koesters, Mark M. Rich, Kathrin L. Engisch
Summary: The idea that the nervous system maintains a set point of network activity and homeostatically returns to that set point is rapidly gaining acceptance. The study of homeostatic synaptic plasticity has shown that the scaling factor for miniature excitatory synaptic currents is not uniform, but increases as the amplitudes increase, a phenomenon known as divergent scaling. This finding has important implications for understanding the molecular mechanisms underlying synaptic scaling.
Article
Biochemistry & Molecular Biology
Eric de Hoog, Gaynor E. Spencer
Summary: The metabolite of vitamin A, retinoic acid (RA), influences neuronal firing by inducing spike broadening and complex spiking, and modulates Ca2+ influx through CaV2 channels by enhancing inactivation of delayed rectifier voltage-gated K+ channels.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2022)
Review
Neurosciences
Henry B. C. Taylor, Alexander F. Jeans
Summary: Homeostatic synaptic plasticity is crucial in regulating synaptic strength to ensure stability and efficient information transfer in neural networks. Deficits in HSP have been linked to various neurological diseases, including migraine, epilepsy, and neurodegenerative diseases, highlighting the importance of understanding its role for potential novel therapeutic approaches.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Article
Neurosciences
Shu-Xin Zhang, Li-Hui Duan, Hong Qian, Xiang Yu
NEUROSCIENCE BULLETIN
(2016)
Article
Neurosciences
Min-Yin Li, Wan-Ying Miao, Qiu-Zi Wu, Shun-Ji He, Guoquan Yan, Yanrui Yang, Jia-Jia Liu, M. Mark Taketo, Xiang Yu
Article
Neurosciences
Miao Wang, Huiping Li, Toru Takumi, Zilong Qiu, Xiu Xu, Xiang Yu, Wen-Jie Bian
NEUROSCIENCE BULLETIN
(2017)
Editorial Material
Neurosciences
Xiang Yu, Zilong Qiu, Dai Zhang
NEUROSCIENCE BULLETIN
(2017)
Article
Behavioral Sciences
Chun-Chun Hu, Xiu Xu, Guo-Liang Xiong, Qiong Xu, Bing-Rui Zhou, Chun-Yang Li, Qi Qin, Chun-Xue Liu, Hui-Ping Li, Yun-Jun Sun, Xiang Yu
Article
Neurosciences
Lihui Duan, Xiao-Di Zhang, Wan-Ying Miao, Yun-Jun Sun, Guoliang Xiong, Qiuzi Wu, Guangying Li, Ping Yang, Hang Yu, Humingzhu Li, Yue Wang, Min Zhang, Li-Yuan Hu, Xiaoping Tong, Wen-Hao Zhou, Xiang Yu
Article
Multidisciplinary Sciences
Huimin Liu, Shaoming Sang, Yuan Lu, Zhongfeng Wang, Xiang Yu, Chunjiu Zhong
SCIENTIFIC REPORTS
(2017)
Article
Neurosciences
Miao Wang, Zixian Yu, Guangying Li, Xiang Yu
Article
Cell Biology
Huateng Cao, Min-Yin Li, Guangying Li, Shu-Jing Li, Bincheng Wen, Yuan Lu, Xiang Yu
Article
Neurosciences
Hang Yu, Wanying Miao, En Ji, Shajin Huang, Sen Jin, Xutao Zhu, Ming-Zhe Liu, Yan-Gang Sun, Fuqiang Xu, Xiang Yu
Summary: Affective and pleasant touch can enhance the firing of oxytocin neurons in mouse paraventricular hypothalamus, promoting social interactions and positive affective valence. Tachykinin 1 neurons in the lateral and ventrolateral periaqueductal gray send excitatory projections to oxytocin neurons in the paraventricular hypothalamus, and their activation promotes social interactions and preference for social touch context.
Editorial Material
Neurosciences
Xiang Yu, Xiu Xu
NEUROSCIENCE BULLETIN
(2023)
Editorial Material
Neurosciences
Xiang Yu
NATURE REVIEWS NEUROSCIENCE
(2023)
Article
Neurosciences
Miao Wang, Xiang Yu
Summary: Sensory experience plays a crucial role in shaping the structure and function of neuronal circuits in both development and adulthood. This review examines how experience affects the plasticity of pyramidal neurons in sensory cortices, discussing the advantages and limitations of labeling techniques and identifying the most plastic structural parameters. The review also highlights recent advances in sparse labeling and imaging techniques that could provide insights into unanswered questions in the field of structural plasticity.
CURRENT OPINION IN NEUROBIOLOGY
(2023)
Article
Cell Biology
Lingbo Wang, Min-Yin Li, Chao Qu, Wan-Ying Miao, Qi Yin, Jiaoyang Liao, Hua-Teng Cao, Min Huang, Kai Wang, Erwei Zuo, Guangdun Peng, Shu-Xin Zhang, Guodong Chen, Qing Li, Ke Tang, Qian Yu, Zhoujie Li, Catherine C. L. Wong, Guoliang Xu, Naihe Jing, Xiang Yu, Jinsong Li
Article
Cell Biology
Shu-Xin Zhang, Li-Hui Duan, Shun-Ji He, Gui-Feng Zhuang, Xiang Yu
Correction
Neurosciences
Lucia Privitera, Ellen L. Hogg, Matthias Gaestel, Mark J. Wall, Sonia A. L. Correa
Article
Neurosciences
Li-Ya Jiang, Guan-Hao Wang, Jing-Jiao Xu, Xiao-Li Li, Xiao-Yan Lin, Xiang Fang, Hong-Xu Zhang, Mei Feng, Chun-Ming Jiang
Summary: This study reveals the importance of LINC00473 in regulating temozolomide (TMZ) resistance in glioblastoma (GB) and its potential mechanism. By regulating the expression of CEBP alpha and MGMT, LINC00473 promotes the formation of chemoresistance. Furthermore, LINC00473 can transfer chemoresistance to adjacent sensitive cells through exosomes.
Article
Neurosciences
Olga Kopach, Tetyana Pivneva, Nataliya Fedirko, Nana Voitenko
Summary: This study found that diabetic animals exhibit severe xerostomia characterized by reduced saliva flow rate, diminished total protein content, and decreased amylase activity. The impaired saliva production in diabetes is associated with reduced and delayed intracellular Ca2+ signals in submandibular acinar cells, caused by malfunctioning mitochondria. Targeting malfunctioning mitochondria may be a potential strategy for the treatment of diabetic xerostomia.
Article
Neurosciences
Nicholas M. Timme, Cherish E. Ardinger, Seth D. C. Weir, Rachel Zelaya-Escobar, Rachel Kruger, Christopher C. Lapish
Summary: This study aimed to assess aversion-resistant drinking behavior in head-fixed mice and explore the relationship between non-consummatory behaviors and aversion-resistant drinking. The results showed that head-fixed mice exhibited heterogenous levels of aversion-resistant drinking and non-consummatory behaviors were related to the intensity of this behavior.
Article
Neurosciences
David R. Maguire, Charles P. France
Summary: Methocinnamox (MCAM) is a novel, long-acting opioid receptor antagonist that effectively decreases fentanyl self-administration and prevents opioid overdose in monkeys. The study demonstrates the potential therapeutic utility of MCAM in the treatment of opioid use disorder.
Article
Neurosciences
Xiang Li, Dan Feng, Shenglu Ma, Mingxing Li, Shulei Zhao, Man Tang
Summary: This study investigated the effects of fluoxetine on neurochemical, neurobiological, and neurobehavioral changes in different subregions of the hippocampus. The results showed that fluoxetine increased dialysate 5-HT, decreased membrane 5-HTT protein, and increased cytoplasmic fraction. Additionally, fluoxetine reduced immobility times in behavioral tests, with greater effects observed in the ventral subregion compared to the dorsal subregion.
Article
Neurosciences
Alexander V. Zholos, Mariia I. Melnyk, Dariia O. Dryn
Summary: Acetylcholine is an important neurotransmitter in visceral smooth muscles, activating M2 and M3 muscarinic receptors to cause smooth muscle excitation and contraction. This review focuses on the cellular and molecular mechanisms underlying acetylcholine-induced depolarisation and smooth muscle contraction, as well as the effects of anticholinergic drugs on gastrointestinal motility. The knowledge gained from recent studies has greatly expanded our understanding of these processes.
Article
Neurosciences
Zhenlong Li, Hsien-Yu Peng, Chau-Shoun Lee, Tzer-Bin Lin, Ming-Chun Hsieh, Cheng-Yuan Lai, Han-Fang Wu, Lih-Chyang Chen, Mei-Ci Chen, Dylan Chou
Summary: Methylone shows significant efficacy in treating depression and social deficits, making it an ideal candidate for anti-depressant medication.
Article
Neurosciences
Aline Freyssin, Allison Carles, Sarra Guehairia, Gilles Rubinstenn, Tangui Maurice
Summary: This study explores the potential of combining FENM and S1R agonists in the treatment of Alzheimer's disease. The results showed that most FENM-based combinations can protect against learning deficits caused by A beta 25-35, with better efficacy in short-term memory.
Article
Neurosciences
J. D. Lorente, J. Cuitavi, L. Rullo, S. Candeletti, P. Romualdi, L. Hipolito
Summary: This study analyzed the effects of pain on negative affect in different sexes and time courses, as well as the involvement of the dynorphinergic and corticotropin releasing factor systems in these pain-related behaviors. The results showed sex and time-dependent anxiety- and anhedonia-like behaviors induced by pain in female rats. The recruitment of KOR/DYN in the NAc was identified as a key neurological substrate mediating pain-induced behavioral alterations.
Article
Neurosciences
Rongjun Liu, Daofan Sun, Xiuzhong Xing, Qingge Chen, Bo Lu, Bo Meng, Hui Yuan, Lan Mo, Liufang Sheng, Jinwei Zheng, Qiusheng Wang, Junping Chen, Xiaowei Chen
Summary: The coexistence of pain and depression is frequently observed in patients with chronic pain and depression. Oxytocin, a neuropeptide, has been reported to relieve chronic pain and depressive symptoms. This study investigated the effect of intranasal oxytocin on neuropathic pain and comorbid depressive symptoms, and found that oxytocin attenuated depression-like behavior but did not alleviate mechanical hyperalgesia. The results suggest that intranasal oxytocin may have the potential to treat depressive symptoms in neuropathic pain patients.