Article
Biology
Alexander Kaplan, Aviv D. Mizrahi-Kliger, Pnina Rappel, Liliya Iskhakova, Gennadiy Fonar, Zvi Israel, Hagai Bergman
Summary: Integrated analysis of non-human primate data reveals that pauses in GPe firing are associated with pupil dilation, suggesting that GPe pauses may influence basal ganglia downstream structures and play a role in exploratory behavior.
COMMUNICATIONS BIOLOGY
(2022)
Article
Geriatrics & Gerontology
Jinyoung Youn, Mansu Kim, Suyeon Park, Ji Sun Kim, Hyunjin Park, Jin Whan Cho
Summary: This study investigates the structural changes in the basal ganglia related to levodopa-induced dyskinesia (LID) in Parkinson's disease (PD). The results demonstrate distinct shape alterations, especially in the globus pallidus interna (GPi), in the LID group compared to the non-LID group. These findings suggest the crucial role of the basal ganglia pathway in the development of LID.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Neurosciences
Varoth Lilascharoen, Eric Hou-Jen Wang, Nam Do, Stefan Carl Pate, Amanda Ngoc Tran, Christopher Dabin Yoon, Jun-Hyeok Choi, Xiao-Yun Wang, Horia Pribiag, Young-Gyun Park, Kwanghun Chung, Byung Kook Lim
Summary: The study investigates the functional roles of distinct GPe-PV neuronal populations in controlling behaviors such as locomotion and reversal learning, and reveals their different contributions to various PD-related behaviors.
NATURE NEUROSCIENCE
(2021)
Editorial Material
Clinical Neurology
Cassiana Trandafir, Dimitri Renard, Federico Cagnazzo, Ioana Maria Ion
Summary: This case report describes a 43-year-old woman who presented with symptoms of behavior change, hypersomnia, and abulia after whiplash injury. MRI revealed symmetrical globus pallidus infarction and bilateral carotid artery dissection. This is the first reported case of isolated symmetrical globus pallidus infarction related to bilateral carotid dissection.
NEUROLOGICAL SCIENCES
(2022)
Article
Neurosciences
James A. Jones, Matthew H. Higgs, Erick Olivares, Jacob Pella, Charles J. Wilson
Summary: Autonomously firing GABAergic neurons in the external globus pallidus (GPe) form a local synaptic network. Silencing the firing of PV+ GPe neurons increases the firing rate and regularity of PV- neurons, while silencing Npas1+ GPe neurons has no significant effect on Npas1- neuron firing. Spontaneous GABAergic synaptic input blockade reproduces the effects of silencing PV+ neuron firing. Furthermore, as few as 5 unitary inputs can cause large increases in firing irregularity in GPe neurons.
JOURNAL OF NEUROSCIENCE
(2023)
Article
Clinical Neurology
Indiko Z. Dzhalagoniya, Svetlana Usova, Anna A. Gamaleya, Alexey A. Tomskiy, Aasef G. Shaikh, Alexey S. Sedov
Summary: The objective of this study is to investigate the physiological differences in pallidal neurons between DYT1 and non-DYT1 dystonia. Microelectrode recording was performed during deep brain stimulation implantation, revealing reduced firing rate, reduced burst rate, and increased pause index in both pallidal segments of DYT1 patients. It was concluded that DYT1 has a common pathological focus in the striatum, leading to similarity in neuronal activity.
PARKINSONISM & RELATED DISORDERS
(2023)
Article
Neurosciences
Yannick Mullie, Trevor Drew
Summary: The pallidum plays a crucial role in the control of posture and movement. Different cells in the pallidum show distinct activity patterns during different phases of reaching tasks and with different limbs, indicating contextual-dependent control of movement and posture.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Neurosciences
Joshua W. Callahan, David L. Wokosin, Mark D. Bevan
Summary: This study used optogenetics and electrophysiology to reveal some characteristics of early Huntington's disease, including abnormal activity of the indirect pathway neurons and changes in inhibitory mechanisms.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Neurosciences
Elena Borra, Dalila Biancheri, Marianna Rizzo, Fabio Leonardi, Giuseppe Luppino
Summary: This study analyzed and compared the crossed corticostriatal (CSt) projections in the striatum of nonhuman primates. These projections are robust and mainly originate from motor, prefrontal, and cingulate areas. The findings provide the anatomical basis for the bilateral distribution of motor, motivational, and cognitive signals.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Aaron W. Beger, Beatrix Dudzik, Randall L. Woltjer, Paul L. Wood
Summary: Sphingolipids play important roles in neural tissue and are associated with neurological diseases such as Parkinson's disease and Lewy body disease. Mass spectrometry analysis revealed significant alterations in sphingolipid levels, particularly in the putamen, providing evidence for their involvement in neuronal cell death in these diseases.
Article
Neurosciences
Adriana Galvan, Thomas Wichmann
Summary: This study examines the occurrence of repeating sequences of interspike intervals in the firing activity of basal ganglia neurons in Parkinson's disease. The results show that neurons in certain structures fire in recognizable sequences, and the incidence of these sequences is influenced by the induction of Parkinson's disease.
JOURNAL OF NEUROPHYSIOLOGY
(2023)
Article
Neurosciences
Kelsey Barcomb, Christopher P. Ford
Summary: This review summarizes the previous work on the changes in neurotransmitter co-release and circuit dysfunction associated with the degeneration of midbrain dopamine neurons in Parkinson's disease.
EXPERIMENTAL NEUROLOGY
(2023)
Article
Neurosciences
Woranan Wongmassang, Taku Hasegawa, Satomi Chiken, Atsushi Nambu
Summary: The basal ganglia control voluntary movements through firing rate changes in the external and internal segments of the globus pallidus, with correlated activity playing a minor role in motor control in the healthy state.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2021)
Article
Neurosciences
Jie Dong, Sarah Hawes, Junbing Wu, Weidong Le, Huaibin Cai
Summary: The globus pallidus externa (GPe) serves as a central hub in the basal ganglia system for processing motor and non-motor information, forming complex connections with other nuclei and brain regions. Recent advances in genetic tools have led to a better understanding of the molecular, anatomical, electrophysiological, and functional properties of GPe neurons and non-neuronal cells. Impairments in dopamine transmission in the basal ganglia, which contribute to Parkinson's disease (PD), are associated with altered GPe neuron activity and synaptic connections, as observed in both PD patients and pre-clinical models.
FRONTIERS IN NEURAL CIRCUITS
(2021)
Article
Clinical Neurology
Khaled Moussawi, Min Jae Kim, Sydney Baybayan, Myles Wood, Kelly A. Mills
Summary: The study investigated the behavioral responses of Parkinson's disease patients under globus pallidus internus DBS settings, revealing a negative correlation between the volume of tissue activation connected to the right prefrontal cortex and impulsivity, while greater overlap with the non-prefrontally-connected globus pallidus internus was associated with increased impulsivity.
Article
Neurosciences
Stefanie L. Ritter-Makinson, Maryse Paquet, James W. Bogenpohl, Rachel E. Rodin, C. Chris Yun, Edward J. Weinman, Yoland Smith, Randy A. Hall
Article
Clinical Neurology
Gunasingh J. Masilamoni, James W. Bogenpohl, David Alagille, Kristen Delevich, Gilles Tamagnan, John R. Votaw, Thomas Wichmann, Yoland Smith
Article
Neurosciences
James W. Bogenpohl, Stefanie L. Ritter, Randy A. Hall, Yoland Smith
JOURNAL OF COMPARATIVE NEUROLOGY
(2012)
Article
Chemistry, Medicinal
Carrie K. Jones, Darren W. Engers, Analisa D. Thompson, Julie R. Field, Anna L. Blobaum, Stacey R. Lindsley, Ya Zhou, Rocco D. Gogliotti, Satyawan Jadhav, Rocio Zamorano, Jim Bogenpohl, Yoland Smith, Ryan Morrison, J. Scott Daniels, C. David Weaver, P. Jeffrey Conn, Craig W. Lindsley, Colleen M. Niswender, Corey R. Hopkins
JOURNAL OF MEDICINAL CHEMISTRY
(2011)
Article
Behavioral Sciences
Heather A. Mitchell, James W. Bogenpohl, L. Cameron Liles, Michael R. Epstein, Donna Bozyczko-Coyne, Michael Williams, David Weinshenker
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
(2008)
Article
Neurosciences
James W. Bogenpoh, Maren L. Smith, Sean P. Farris, Catherine Dumur, Marcelo F. Lopez, Howard C. Becker, Kathleen A. Grant, Michael F. Miles
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2019)
Article
Substance Abuse
James W. Bogenpohl, Rory M. Weston, Taylor N. Foreman, Kaitlyn E. Kitchen, Michael F. Miles
Summary: Through immunohistochemical and stereological techniques, we found that CLIC4 protein is robustly expressed by oligodendrocytes (most abundant), microglia, and astrocytes, with minimal expression in neurons. Following acute EtOH exposure, we observed a rapid increase in Clic4 mRNA expression in female but not male mice, and an overall increase in the number of oligodendrocytes and astrocytes expressing the CLIC4 protein. These findings suggest that Clic4 functions as an early response gene for acute EtOH in brain, which likely underlies its ability to modulate EtOH behavior.
ALCOHOL-CLINICAL AND EXPERIMENTAL RESEARCH
(2022)
Article
Genetics & Heredity
Serguei V. Kozlov, James W. Bogenpohl, Maureen P. Howell, Rachel Wevrick, Satchin Panda, John B. Hogenesch, Louis J. Muglia, Russell N. Van Gelder, Erik D. Herzog, Colin L. Stewart
Article
Biotechnology & Applied Microbiology
EE Slawson, CD Shaffer, CD Malone, W Leung, E Kellmann, RB Shevchek, CA Craig, SM Bloom, J Bogenpohl, J Dee, ETA Morimoto, J Myoung, AS Nett, F Ozsolak, ME Tittiger, A Zeug, ML Pardue, J Buhler, ER Mardis, SCR Elgin
Correction
Neurosciences
Lucia Privitera, Ellen L. Hogg, Matthias Gaestel, Mark J. Wall, Sonia A. L. Correa
Article
Neurosciences
Li-Ya Jiang, Guan-Hao Wang, Jing-Jiao Xu, Xiao-Li Li, Xiao-Yan Lin, Xiang Fang, Hong-Xu Zhang, Mei Feng, Chun-Ming Jiang
Summary: This study reveals the importance of LINC00473 in regulating temozolomide (TMZ) resistance in glioblastoma (GB) and its potential mechanism. By regulating the expression of CEBP alpha and MGMT, LINC00473 promotes the formation of chemoresistance. Furthermore, LINC00473 can transfer chemoresistance to adjacent sensitive cells through exosomes.
Article
Neurosciences
Olga Kopach, Tetyana Pivneva, Nataliya Fedirko, Nana Voitenko
Summary: This study found that diabetic animals exhibit severe xerostomia characterized by reduced saliva flow rate, diminished total protein content, and decreased amylase activity. The impaired saliva production in diabetes is associated with reduced and delayed intracellular Ca2+ signals in submandibular acinar cells, caused by malfunctioning mitochondria. Targeting malfunctioning mitochondria may be a potential strategy for the treatment of diabetic xerostomia.
Article
Neurosciences
Nicholas M. Timme, Cherish E. Ardinger, Seth D. C. Weir, Rachel Zelaya-Escobar, Rachel Kruger, Christopher C. Lapish
Summary: This study aimed to assess aversion-resistant drinking behavior in head-fixed mice and explore the relationship between non-consummatory behaviors and aversion-resistant drinking. The results showed that head-fixed mice exhibited heterogenous levels of aversion-resistant drinking and non-consummatory behaviors were related to the intensity of this behavior.
Article
Neurosciences
David R. Maguire, Charles P. France
Summary: Methocinnamox (MCAM) is a novel, long-acting opioid receptor antagonist that effectively decreases fentanyl self-administration and prevents opioid overdose in monkeys. The study demonstrates the potential therapeutic utility of MCAM in the treatment of opioid use disorder.
Article
Neurosciences
Xiang Li, Dan Feng, Shenglu Ma, Mingxing Li, Shulei Zhao, Man Tang
Summary: This study investigated the effects of fluoxetine on neurochemical, neurobiological, and neurobehavioral changes in different subregions of the hippocampus. The results showed that fluoxetine increased dialysate 5-HT, decreased membrane 5-HTT protein, and increased cytoplasmic fraction. Additionally, fluoxetine reduced immobility times in behavioral tests, with greater effects observed in the ventral subregion compared to the dorsal subregion.
Article
Neurosciences
Alexander V. Zholos, Mariia I. Melnyk, Dariia O. Dryn
Summary: Acetylcholine is an important neurotransmitter in visceral smooth muscles, activating M2 and M3 muscarinic receptors to cause smooth muscle excitation and contraction. This review focuses on the cellular and molecular mechanisms underlying acetylcholine-induced depolarisation and smooth muscle contraction, as well as the effects of anticholinergic drugs on gastrointestinal motility. The knowledge gained from recent studies has greatly expanded our understanding of these processes.
Article
Neurosciences
Zhenlong Li, Hsien-Yu Peng, Chau-Shoun Lee, Tzer-Bin Lin, Ming-Chun Hsieh, Cheng-Yuan Lai, Han-Fang Wu, Lih-Chyang Chen, Mei-Ci Chen, Dylan Chou
Summary: Methylone shows significant efficacy in treating depression and social deficits, making it an ideal candidate for anti-depressant medication.
Article
Neurosciences
Aline Freyssin, Allison Carles, Sarra Guehairia, Gilles Rubinstenn, Tangui Maurice
Summary: This study explores the potential of combining FENM and S1R agonists in the treatment of Alzheimer's disease. The results showed that most FENM-based combinations can protect against learning deficits caused by A beta 25-35, with better efficacy in short-term memory.
Article
Neurosciences
J. D. Lorente, J. Cuitavi, L. Rullo, S. Candeletti, P. Romualdi, L. Hipolito
Summary: This study analyzed the effects of pain on negative affect in different sexes and time courses, as well as the involvement of the dynorphinergic and corticotropin releasing factor systems in these pain-related behaviors. The results showed sex and time-dependent anxiety- and anhedonia-like behaviors induced by pain in female rats. The recruitment of KOR/DYN in the NAc was identified as a key neurological substrate mediating pain-induced behavioral alterations.
Article
Neurosciences
Rongjun Liu, Daofan Sun, Xiuzhong Xing, Qingge Chen, Bo Lu, Bo Meng, Hui Yuan, Lan Mo, Liufang Sheng, Jinwei Zheng, Qiusheng Wang, Junping Chen, Xiaowei Chen
Summary: The coexistence of pain and depression is frequently observed in patients with chronic pain and depression. Oxytocin, a neuropeptide, has been reported to relieve chronic pain and depressive symptoms. This study investigated the effect of intranasal oxytocin on neuropathic pain and comorbid depressive symptoms, and found that oxytocin attenuated depression-like behavior but did not alleviate mechanical hyperalgesia. The results suggest that intranasal oxytocin may have the potential to treat depressive symptoms in neuropathic pain patients.