期刊
NEUROPHARMACOLOGY
卷 67, 期 -, 页码 32-36出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.neuropharm.2012.10.018
关键词
Cortical spreading depression; Dexmedetomidine; Isoflurane; Neuronal injury; Pentobarbital; Propofol
资金
- JSPS KAKENHI [21791992]
- Grants-in-Aid for Scientific Research [21791992] Funding Source: KAKEN
Cortical spreading depression (CSD) is a transient neuronal and glial depolarization and disruption of membrane ionic gradients that propagates slowly across the cerebral cortex. Recent clinical and experimental evidence has implicated CSD in the pathophysiology of migraines and neuronal injury states. In the current study, we examined the influence of four different anesthetics (propofol, dexmedetomidine, isoflurane, pentobarbital) on CSD susceptibility in a KCl application animal model. We found that isoflurane and dexmedetomidine suppressed CSD frequency, and tended to reduce the CSD propagation speed. Our data suggest that these anesthetics may be therapeutically beneficial in preventing CSD in diverse neuronal injury states. (c) 2012 Elsevier Ltd. All rights reserved.
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