Article
Psychology, Clinical
Scott A. Wilke, Crystal L. Johnson, Juliana Corlier, Katharine G. Marder, Andrew C. Wilson, Christopher M. Pleman, Andrew F. Leuchter
Summary: MDD patients taking psychostimulant medication show greater clinical improvement during rTMS treatment, particularly in sleep and mood/cognition. There are no significant differences among different drug categories, and the clinical efficacy of some medications may be dose-dependent.
DEPRESSION AND ANXIETY
(2022)
Article
Multidisciplinary Sciences
Julian Gerson, Murat Kaan Erdal, Matthew H. McDonough, Kyle L. Ploense, Philippe Dauphin-Ducharme, Kevin M. Honeywell, Kaylyn K. Leung, Netzahualcoyotl Arroyo-Curras, Jenny M. Gibson, Nicole A. Emmons, Wendy Meiring, Joao P. Hespanha, Kevin W. Plaxco, Tod E. Kippin
Summary: In this study, electrochemical aptamer-based sensors were used to achieve real-time measurement of drug concentrations in the brains of freely moving rats. The results showed that the sensors can provide high-resolution, seconds-resolved neuropharmacokinetics and concentration-response relations of individual subjects. Additionally, a closed-loop feedback-controlled drug delivery system was employed to maintain stable intracranial drug levels.
Article
Multidisciplinary Sciences
Guangfu Wu, Ian Heck, Nannan Zhang, Glenn Phaup, Xincheng Zhang, Yixin Wu, David E. Stalla, Zhengyan Weng, He Sun, Huijie Li, Zhe Zhang, Shinghua Ding, De-Pei Li, Yi Zhang
Summary: This study introduces a wireless, programmable push-pull microsystem for membrane-free neurochemical sampling with cellular spatial resolution in freely moving animals. It shows high efficiency in sampling various neurochemicals and captures the release of neuropeptides in freely moving mice. This system provides opportunities for understanding the modulation of diverse behavioral outputs of the brain by neuropeptide release.
Article
Multidisciplinary Sciences
Bingqian Zhou, Kuikui Fan, Jingjing Guo, Jiesi Feng, Changxi Yang, Yulong Li, Songhai Shi, Lingjie Kong
Summary: In vivo detection of neurochemicals is crucial for understanding brain mechanisms and diagnosing brain diseases. However, current sensors lack high specificity for real-time monitoring. In this study, fiber-optic probes based on engineered cells (FOPECs) were developed for plug-and-play, real-time detection of neurochemicals in freely moving animals. FOPECs demonstrated unprecedented chemical specificity and could be widely used in vertebrates without viral infection. They also showed potential for monitoring drug metabolisms in vivo.
Article
Neurosciences
Hiroki Kawashima, Yuri Aono, Yuriko Watanabe, John L. Waddington, Tadashi Saigusa
Summary: This study demonstrates that accumbal OX2 receptors, not OX1 receptors, inhibit basal dopamine efflux, while blocking OX2 receptors increases dopamine efflux. OX1 receptors have no effect on dopamine efflux.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2022)
Review
Endocrinology & Metabolism
Julian B. Wilson, Ma'ayan Epstein, Briana Lopez, Amira K. Brown, Kabirullah Lutfy, Theodore C. Friedman
Summary: Type 2 diabetes mellitus (T2DM) and depression are significant public health and socioeconomic issues, with high co-occurrence rates. This review explores how T2DM and depression interact through shared molecular pathways, affecting brain structure, function, and reward. Treating the symptoms of T2DM without addressing these underlying pathways may not be effective, and targeting immune system, stress circuit, melatonin, and other alterations could offer more promising approaches.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Agriculture, Dairy & Animal Science
Marcos Antonio Lopez-Patino, Arleta Krystyna Skrzynska, Fatemeh Naderi, Juan Miguel Mancera, Jesus Manuel Miguez, Juan Antonio Martos-Sitcha
Summary: Chronic stress exposure, such as high stocking density and food deprivation, enhanced the stress response parameters in gilthead sea bream juveniles. The monoaminergic activities in different brain regions helped to reorganize the physiological response to the challenges applied, suggesting a role of brain monoaminergic activity in orchestrating the endocrine response to chronic stress in fish.
Article
Biochemistry & Molecular Biology
Laoise Casserly, Daniel R. Garton, Ana Montano-Rodriguez, Jaan-Olle Andressoo
Summary: The increase in presynaptic striatal dopamine is the main abnormality observed in schizophrenia. The treatment of schizophrenia mainly focuses on modulating the activity of dopamine and serotonin receptors. Glial cell line-derived neurotrophic factor (GDNF) is a strong dopaminergic factor that has been found to be correlated with schizophrenia. The researchers analyzed the effects of methamphetamine on Gdnf and its receptors in the mouse brain, and found that acute methamphetamine increases Gdnf expression while chronic methamphetamine decreases the expression of GDNF receptors. Methamphetamine treatment also upregulates the expression of genes related to dopamine and serotonin metabolism. These findings provide insights into the mechanism by which methamphetamine increases the risk of psychosis, and may guide future development of precision medicine for methamphetamine-induced psychosis using GDNF/GFRa1/RET antagonists.
Review
Immunology
Tiziana Carandini, Mara Cercignani, Daniela Galimberti, Elio Scarpini, Marco Bozzali
Summary: Dopamine, noradrenaline, and serotonin play crucial roles in the interaction between the nervous and immune systems by binding to cell-receptors and regulating their function. Dysregulation of monoamines may contribute to fatigue and depression in Multiple Sclerosis, with potential for targeted drug treatments.
BRAIN BEHAVIOR AND IMMUNITY
(2021)
Article
Multidisciplinary Sciences
Jokubas Ausra, Mingzheng Wu, Xin Zhang, Abraham Vazquez-Guardado, Patrick Skelton, Roberto Peralta, Raudel Avila, Thomas Murickan, Chad R. Haney, Yonggang Huang, John A. Rogers, Yevgenia Kozorovitskiy, Philipp Gutruf
Summary: Wireless, battery-free, and fully subdermally implantable optogenetic tools have the potential to revolutionize neurobiological research in freely moving animals, but current devices still have issues with invasive stimulus delivery causing damage during implantation, as well as power delivery constraints limiting the size of operational arenas.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Medicine, Research & Experimental
Getulio Nicola Bressan, Paola Magro Cardoso, Juliane Reckziegel, Roselei Fachinetto
Summary: This study investigated the role of monoamines (dopamine and serotonin) in the response to thermal nociceptive stimuli in Drosophila melanogaster. The results showed that monoamines play an important role in the thermal tolerance and avoidance of noxious heat in flies. Inhibitors of dopamine and serotonin receptors decreased heat tolerance and avoidance behavior in Drosophila melanogaster. These findings suggest that monoamines, particularly serotonin, are associated with the impaired avoidance of noxious heat and reduction of heat tolerance in flies.
Article
Medicine, General & Internal
Seong Hoon Bae, Seo Jin Moon, Jeong Gum Lee, Yun Kyung Yim, Hee So Oh, Dong Hee Han, In Seok Moon
Summary: The study compared the effects of rTMS and tDCS treatments for chronic tinnitus, showing comparable results in reducing tinnitus symptoms, with tDCS possibly being more cost-effective.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Chemistry, Medicinal
Cesar Emmanuel Santana-Gomez, Daniel Perez-Perez, Daniel Fonseca-Barriendos, Oscar Arias-Carrion, Walter Besio, Luisa Rocha
Summary: Transcranial focal stimulation (TFS) is a non-invasive neuromodulation strategy with neuroprotective effects, and it has been shown to prevent biogenic amines' changes induced by 6-OHDA in different brain areas. However, TFS did not avoid changes in dopamine tissue content in the striatum. Interestingly, TFS alone did not induce significant changes in the different brain areas evaluated.
Article
Biochemistry & Molecular Biology
Gleice Kelli Silva-Cardoso, Manoel Jorge Nobre
Summary: Ketamine is a drug that can be abused for its reinforcing properties and can induce tolerance through Pavlovian conditioning in specific environmental contexts. Research shows that ketamine can induce short-term and pharmacological conditioned tolerance, affecting dopamine and serotonin release, with potential implications in specific environments.
NEUROCHEMICAL RESEARCH
(2021)
Review
Immunology
Yi-Wen Bai, Qi-Hao Yang, Pei-Jie Chen, Xue-Qiang Wang
Summary: Neuropathic pain is a common condition caused by damage or disease to the nervous system, and is associated with excessive inflammation. Repetitive transcranial magnetic stimulation (rTMS) is an adjunctive treatment for neuropathic pain, which can regulate the neuroinflammation system to produce analgesic effects.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Materials Science, Biomaterials
Susanne Loffler, Ben Libberton, Agneta Richter-Dahlfors
JOURNAL OF MATERIALS CHEMISTRY B
(2015)
Article
Materials Science, Biomaterials
S. Loffler, A. Richter-Dahlfors
JOURNAL OF MATERIALS CHEMISTRY B
(2015)
Review
Computer Science, Information Systems
Susanne Loffler, Ben Libberton, Agneta Richter-Dahlfors
Article
Chemistry, Multidisciplinary
Susanne Loffler, Silke Seyock, Rolf Nybom, Gunilla B. Jacobson, Agneta Richter-Dahlfors
JOURNAL OF CONTROLLED RELEASE
(2016)
Article
Medicine, General & Internal
S. Loffler, K. Melican, K. P. R. Nilsson, A. Richter-Dahlfors
JOURNAL OF INTERNAL MEDICINE
(2017)
Article
Chemistry, Multidisciplinary
Kristin M. Persson, Roger Karlsson, Karl Svennersten, Susanne Loffler, Edwin W. H. Jager, Agneta Richter-Dahlfors, Peter Konradsson, Magnus Berggren
ADVANCED MATERIALS
(2011)
Article
Engineering, Biomedical
S. Loeffler, Y. Xie, P. Detemple, A. Moser, U. G. Hofmann
BIOMEDICAL ENGINEERING-BIOMEDIZINISCHE TECHNIK
(2012)
Article
Engineering, Biomedical
S. Loeffler, Y. Xie, P. Klimach, A. Richter, P. Detemple, T. Stieglitz, A. Moser, U. G. Hofmann
BIOMEDICAL ENGINEERING-BIOMEDIZINISCHE TECHNIK
(2012)
Article
Engineering, Biomedical
Yijing Xie, Tim Bonin, Susanne Loeffler, Gereon Huettmann, Volker Tronnier, Ulrich G. Hofmann
PHYSICS IN MEDICINE AND BIOLOGY
(2013)
Article
Biochemical Research Methods
A. Hiller, S. Loeffler, C. Haupt, M. Litza, U. Hofmann, A. Moser
JOURNAL OF NEUROSCIENCE METHODS
(2007)
Correction
Neurosciences
Lucia Privitera, Ellen L. Hogg, Matthias Gaestel, Mark J. Wall, Sonia A. L. Correa
Article
Neurosciences
Li-Ya Jiang, Guan-Hao Wang, Jing-Jiao Xu, Xiao-Li Li, Xiao-Yan Lin, Xiang Fang, Hong-Xu Zhang, Mei Feng, Chun-Ming Jiang
Summary: This study reveals the importance of LINC00473 in regulating temozolomide (TMZ) resistance in glioblastoma (GB) and its potential mechanism. By regulating the expression of CEBP alpha and MGMT, LINC00473 promotes the formation of chemoresistance. Furthermore, LINC00473 can transfer chemoresistance to adjacent sensitive cells through exosomes.
Article
Neurosciences
Olga Kopach, Tetyana Pivneva, Nataliya Fedirko, Nana Voitenko
Summary: This study found that diabetic animals exhibit severe xerostomia characterized by reduced saliva flow rate, diminished total protein content, and decreased amylase activity. The impaired saliva production in diabetes is associated with reduced and delayed intracellular Ca2+ signals in submandibular acinar cells, caused by malfunctioning mitochondria. Targeting malfunctioning mitochondria may be a potential strategy for the treatment of diabetic xerostomia.
Article
Neurosciences
Nicholas M. Timme, Cherish E. Ardinger, Seth D. C. Weir, Rachel Zelaya-Escobar, Rachel Kruger, Christopher C. Lapish
Summary: This study aimed to assess aversion-resistant drinking behavior in head-fixed mice and explore the relationship between non-consummatory behaviors and aversion-resistant drinking. The results showed that head-fixed mice exhibited heterogenous levels of aversion-resistant drinking and non-consummatory behaviors were related to the intensity of this behavior.
Article
Neurosciences
David R. Maguire, Charles P. France
Summary: Methocinnamox (MCAM) is a novel, long-acting opioid receptor antagonist that effectively decreases fentanyl self-administration and prevents opioid overdose in monkeys. The study demonstrates the potential therapeutic utility of MCAM in the treatment of opioid use disorder.
Article
Neurosciences
Xiang Li, Dan Feng, Shenglu Ma, Mingxing Li, Shulei Zhao, Man Tang
Summary: This study investigated the effects of fluoxetine on neurochemical, neurobiological, and neurobehavioral changes in different subregions of the hippocampus. The results showed that fluoxetine increased dialysate 5-HT, decreased membrane 5-HTT protein, and increased cytoplasmic fraction. Additionally, fluoxetine reduced immobility times in behavioral tests, with greater effects observed in the ventral subregion compared to the dorsal subregion.
Article
Neurosciences
Alexander V. Zholos, Mariia I. Melnyk, Dariia O. Dryn
Summary: Acetylcholine is an important neurotransmitter in visceral smooth muscles, activating M2 and M3 muscarinic receptors to cause smooth muscle excitation and contraction. This review focuses on the cellular and molecular mechanisms underlying acetylcholine-induced depolarisation and smooth muscle contraction, as well as the effects of anticholinergic drugs on gastrointestinal motility. The knowledge gained from recent studies has greatly expanded our understanding of these processes.
Article
Neurosciences
Zhenlong Li, Hsien-Yu Peng, Chau-Shoun Lee, Tzer-Bin Lin, Ming-Chun Hsieh, Cheng-Yuan Lai, Han-Fang Wu, Lih-Chyang Chen, Mei-Ci Chen, Dylan Chou
Summary: Methylone shows significant efficacy in treating depression and social deficits, making it an ideal candidate for anti-depressant medication.
Article
Neurosciences
Aline Freyssin, Allison Carles, Sarra Guehairia, Gilles Rubinstenn, Tangui Maurice
Summary: This study explores the potential of combining FENM and S1R agonists in the treatment of Alzheimer's disease. The results showed that most FENM-based combinations can protect against learning deficits caused by A beta 25-35, with better efficacy in short-term memory.
Article
Neurosciences
J. D. Lorente, J. Cuitavi, L. Rullo, S. Candeletti, P. Romualdi, L. Hipolito
Summary: This study analyzed the effects of pain on negative affect in different sexes and time courses, as well as the involvement of the dynorphinergic and corticotropin releasing factor systems in these pain-related behaviors. The results showed sex and time-dependent anxiety- and anhedonia-like behaviors induced by pain in female rats. The recruitment of KOR/DYN in the NAc was identified as a key neurological substrate mediating pain-induced behavioral alterations.
Article
Neurosciences
Rongjun Liu, Daofan Sun, Xiuzhong Xing, Qingge Chen, Bo Lu, Bo Meng, Hui Yuan, Lan Mo, Liufang Sheng, Jinwei Zheng, Qiusheng Wang, Junping Chen, Xiaowei Chen
Summary: The coexistence of pain and depression is frequently observed in patients with chronic pain and depression. Oxytocin, a neuropeptide, has been reported to relieve chronic pain and depressive symptoms. This study investigated the effect of intranasal oxytocin on neuropathic pain and comorbid depressive symptoms, and found that oxytocin attenuated depression-like behavior but did not alleviate mechanical hyperalgesia. The results suggest that intranasal oxytocin may have the potential to treat depressive symptoms in neuropathic pain patients.