Article
Biochemistry & Molecular Biology
Daniel B. Dorman, Kim T. Blackwell
Summary: Synaptic plasticity, the experience-induced change in connections between neurons, plays a crucial role in learning and memory. This study investigates how spatiotemporal synaptic input patterns produce plasticity under in vivo-like conditions. The findings reveal the robustness of plasticity to trial-to-trial variability of spike timing and derive general rules describing the control of plasticity by spatiotemporal patterns of synaptic inputs.
Article
Neurosciences
Madeleine Kyrke-Smith, Lenora J. Volk, Samuel F. Cooke, Mark F. Bear, Richard L. Huganir, Jason D. Shepherd
Summary: Research shows that mice lacking the Arc gene do not exhibit deficits in hippocampal long-term potentiation (LTP), indicating that Arc is not necessary for LTP in the hippocampus.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Neurosciences
Karl Peter Giese
Summary: Autophosphorylation of calcium/calmodulin-dependent kinase II (CaMKII) plays a critical role in synaptic potentiation by allowing kinase signaling to outlast NMDA receptor-dependent calcium influx. However, the role of CaMKII is conditional, depending on the developmental stage and location of the synapse.
Article
Cell Biology
Jonas Cornelius, Stefan Haak, Martin Rothkegel, Martin Korte, Kristin Michaelsen-Preusse
Summary: The study reveals that phosphorylated profilin2a in glutamate uncaging agents regulates actin dynamics and structural plasticity in neurons.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Neurosciences
Margarita Anisimova, Bas van Bommel, Rui Wang, Marina Mikhaylova, Joern Simon Wiegert, Thomas G. Oertner, Christine E. Gee
Summary: The study uses optogenetic stimulation to induce STDP and observes timing-dependent depression and potentiation. This study does not require electrodes and results suggest that synaptic depression after anticausal activation is a transient phenomenon.
Article
Neurosciences
Natalia Babushkina, Denise Manahan-Vaughan
Summary: Patterned stimulation of the locus coeruleus can induce long-term depression (LTD) of synaptic plasticity in the hippocampus, and the effect is frequency-dependent. The locus coeruleus can trigger the release of noradrenaline and dopamine in the hippocampus to induce LTD. The regulation of hippocampal LTD may involve the DA D1/D5 receptors and beta-adrenergic receptors.
Article
Multidisciplinary Sciences
Malika Sammari, Yanis Inglebert, Norbert Ankri, Michael Russier, Salvatore Incontro, Dominique Debanne
Summary: This study reveals that brain oscillations at specific frequencies can induce both synaptic and intrinsic potentiation in O-LM interneurons, contrary to the typical response seen in glutamatergic neurons.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Review
Pharmacology & Pharmacy
Hang Wang, Xianghuan Dong, Maher Un Nisa Awan, Jie Bai
Summary: This review briefly summarizes the studies on epigenetics involved in METH addiction, elucidating the molecular mechanism of METH addiction and the effects of METH on neurotransmitter release and brain area activation.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Cell Biology
Jennifer L. Sanderson, Ronald K. Freund, Jessica A. Gorski, Mark L. Dell'Acqua
Summary: Regulated insertion and removal of postsynaptic AMPA glutamate receptors mediate synaptic plasticity underlying learning and memory, with disrupted signaling balance and CP-AMPARs playing a crucial role in normal and aberrant plasticity, particularly in Alzheimer's disease where A beta oligomers impact AMPAR trafficking and LTP/LTD balance.
Article
Neurosciences
Ye Sun, Michael Smirnov, Naomi Kamasawa, Ryohei Yasuda
Summary: The structural plasticity of dendritic spines plays a crucial role in synaptic plasticity, learning, and memory. Rapid ultrastructural changes in the PSD and surrounding membrane during sLTP induction may contribute to rapid electrophysiological plasticity. PSD area transiently increases while nsASI area shows lasting expansion after sLTP induction.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Environmental Sciences
Li-Xia Liang, Jingjing Liang, Qing-Qing Li, Mohammed Zeeshan, Zheqing Zhang, Nanxiang Jin, Li-Zi Lin, Lu-Yin Wu, Ming-Kun Sun, Wei-Hong Tan, Yang Zhou, Chu Chu, Li-Wen Hu, Ru-Qing Liu, Xiao-Wen Zeng, Yunjiang Yu, Guang-Hui Dong
Summary: This study found that early exposure to F-53B may have adverse effects on neurobehavior in developing children and weaning mice, which may be modulated by dopamine-dependent synaptic plasticity.
ENVIRONMENT INTERNATIONAL
(2023)
Article
Neurosciences
G. France, R. Volianskis, R. Ingram, N. Bannister, R. Rotharmel, M. W. Irvine, G. Fang, E. S. Burnell, K. Sapkota, B. M. Costa, D. A. Chopra, S. M. Dravid, A. T. Michael-Titus, D. T. Monaghan, J. Georgiou, Z. A. Bortolotto, D. E. Jane, G. L. Collingridge, A. Volianskis
Summary: This passage discusses how different types of memory rely on different types of synaptic plasticity and the potential use of positive allosteric modulators (PAMs) of NMDA receptors as cognitive enhancers. It also presents experimental findings that show PAMs can differently regulate distinct forms of NMDAR-dependent synaptic plasticity based on their subtype selectivity.
Article
Multidisciplinary Sciences
Sarah G. Cook, Olivia R. Buonarati, Steven J. Coultrap, K. Ulrich Bayer
Summary: The decision between long-term potentiation (LTP) and depression (LTD) in higher brain functions is determined by the complex cross-regulation of T286 and T305/306 autophosphorylation within the 12meric CaMKII holoenzyme. T305/306 phosphorylation selectively promotes LTD while T286 phosphorylation is required for both LTP and LTD. The differential T305/306 phosphorylation directs CaMKII movement to either excitatory or inhibitory synapses, coordinating plasticity at both synapse types.
Article
Endocrinology & Metabolism
J. Fernandez-Felipe, B. Merino, A. B. Sanz-Martos, A. Plaza, A. Contreras, V Naranjo, L. Morales, J. A. Chowen, V Cano, M. Ruiz-Gayo, N. Del Olmo
Summary: Chronic consumption of both SOLF and UOLF impairs spatial short-term memory, modulates hippocampal synaptic plasticity mechanisms and gene expression of NMDA receptor subunits. PPAR gamma gene expression is specifically down-regulated in adolescent SOLF individuals and up-regulated in adult UOLF mice.
PSYCHONEUROENDOCRINOLOGY
(2021)
Review
Cell Biology
Luisa Speranza, Umberto di Porzio, Davide Viggiano, Antonio de Donato, Floriana Volpicelli
Summary: Dopamine is a key neurotransmitter involved in various physiological functions such as motor control, emotional regulation, reward mechanisms, and cognitive functions. Dysfunction in dopamine transmission is linked to devastating neurological and psychiatric disorders like Parkinson's disease and schizophrenia. Additionally, dopamine plays a crucial role in regulating synaptic dynamics, synaptic plasticity, and dendritic spines.
Article
Behavioral Sciences
Antoine Hoffmann, Thomas Bourgeois, Alicia Munoz, Sylvia Anton, Jeremy Gevar, Matthieu Dacher, Michel Renou
JOURNAL OF COMPARATIVE PHYSIOLOGY A-NEUROETHOLOGY SENSORY NEURAL AND BEHAVIORAL PHYSIOLOGY
(2020)
Article
Neurosciences
Ryan D. Shepard, Ludovic D. Langlois, Michael E. Authement, Fereshteh S. Nugent
JOURNAL OF NEUROSCIENCE RESEARCH
(2020)
Article
Biochemistry & Molecular Biology
Ludovic D. Langlois, Rina Y. Berman, Ryan D. Shepard, Sarah C. Simmons, Mumeko C. Tsuda, Shawn Gouty, Kwang H. Choi, Fereshteh S. Nugent
Summary: Early life stress induces dysfunction in the ventral tegmental area and its negative controller, the lateral habenula, through potentiation of glutamatergic synaptic transmission onto LHb neurons, resulting in increased neuronal activity and intrinsic excitability. This stress-induced changes persist into adulthood and may contribute to anhedonia and dysphoric states associated with opioids.
Article
Environmental Sciences
Laetitia Frat, Thomas Chertemps, Elise Pesce, Francoise Bozzolan, Matthieu Dacher, Rosario Planello, Oscar Herrero, Lola Llorente, Didier Moers, David Siaussat
Summary: Heavy metals like cadmium and mercury are naturally present in the environment but have increased in concentration due to human activities. Studies on fruit flies show that these metals cause developmental delays and mortality, affecting genes related to hormonal control, stress, and oxidative stress. Synergistic interactions between cadmium and mercury were also observed.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Neurosciences
Ryan D. Shepard, Fereshteh S. Nugent
Summary: Adverse events and childhood trauma can increase the risk of developing psychiatric disorders in adulthood, with the endocannabinoid system potentially serving as an intervention therapy to prevent maladaptive processes.
FRONTIERS IN SYNAPTIC NEUROSCIENCE
(2021)
Article
Neurosciences
Sarah Simmons, Ludovic D. Langlois, Mario G. Oyola, Shawn Gouty, T. John Wu, Fereshteh S. Nugent
Summary: Blast-induced mild traumatic brain injury may dysregulate hypothalamic corticotropin-releasing factor (CRF) neurons and GABAergic synaptic function, contributing to stress psychopathology associated with blast injury.
FRONTIERS IN SYNAPTIC NEUROSCIENCE
(2022)
Article
Neurosciences
Phillip M. Baker, Victor Mathis, Lucas Lecourtier, Sarah C. Simmons, Fereshteh S. Nugent, Sierra Hill, Sheri J. Y. Mizumori
Summary: This Perspective review focuses on the less explored aspects of lateral habenula (LHb) function in contextual memory, sleep, and behavioral flexibility. It provides evidence that LHb plays a critical role in integrating different internal states and multimodal sensory information, essential for survival and decision making. The review also discusses the impact of early life stress on LHb function and its association with stress-induced psychopathology.
FRONTIERS IN SYSTEMS NEUROSCIENCE
(2022)
Article
Neurosciences
Ludovic D. Langlois, Prabhuanand Selvaraj, Sarah C. Simmons, Shawn Gouty, Yumin Zhang, Fereshteh S. Nugent
Summary: mTBI can induce alterations in postsynaptic function and excitation/inhibition imbalance in hippocampal CA1 pyramidal neurons, which may have long-term effects on memory and learning.
IBRO NEUROSCIENCE REPORTS
(2022)
Article
Critical Care Medicine
William. J. J. Flerlage, Ludovic. D. D. Langlois, Milan Rusnak, Sarah. C. C. Simmons, Shawn Gouty, Regina. C. C. Armstrong, Brian. M. M. Cox, Aviva. J. J. Symes, Mumeko. C. C. Tsuda, Fereshteh. S. S. Nugent
Summary: In this study, we used a repetitive closed-head injury model to investigate the long-term alterations in LHb activity and motivated behavior following mTBI. We found that mTBI increased the number of spontaneously active LHb neurons and decreased bursting activity. Additionally, mTBI disrupted synaptic activity onto LHb neurons, leading to an imbalance towards excitation. Behaviorally, mTBI resulted in delayed grooming behavior, which could be reversed by inhibiting LHb activity. Overall, our study provides evidence for persistent LHb dysfunction as a neural correlate of dysregulated motivation after mTBI.
JOURNAL OF NEUROTRAUMA
(2023)
Article
Neurosciences
Sarah C. Simmons, Greg G. Grecco, Brady K. Atwood, Fereshteh S. Nugent
Summary: This review focuses on the effects of prenatal opioid exposure (POE) on the mental health outcomes of children and explores the interactions between developmental age and sex on synaptic plasticity and associated behaviors. The review provides an overview of research on hippocampal behaviors and plasticity in POE, discusses recent findings on reward circuit dysregulation following POE, and highlights the influence of early life stress on synaptic and behavioral outcomes. The review aims to draw similarities between POE and early life stress in terms of opioid-induced plasticity and altered behaviors in reward circuits.
Editorial Material
Neurosciences
Fereshteh S. Nugent, Alfredo Kirkwood, Carl R. Lupica, P. Jesper Sjostrom
FRONTIERS IN SYNAPTIC NEUROSCIENCE
(2022)
Article
Environmental Sciences
Laetitia Frat, Thomas Chertemps, Elise Pesce, Francoise Bozzolan, Matthieu Dacher, Rosario Planello, Oscar Herrero, Lola Llorente, Didier Moers, David Siaussat
Summary: Many priority pollutants are concentrated in the environment due to human activity. The effects of single and binary exposure have been widely explored, but the simultaneous presence of several pollutants in the environment needs to be considered. Using the model organism Drosophila melanogaster, we investigated the impact of multiple pollutants on post-embryonic development and gene expression patterns. Molecular biology analyses enhance pollution monitoring and should be incorporated in toxicological studies.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Plant Sciences
Yao Zheng, Cecile Cabassa-Hourton, Severine Planchais, Emilie Crilat, Gilles Clement, Matthieu Dacher, Nina Durand, Marianne Bordenave-Jacquemin, Anne Guivarc'h, Corentin Dourmap, Pierre Carol, Sandrine Lebreton, Arnould Savoure
Summary: During leaf senescence, nitrogen is remobilized and carbon backbones are replenished through amino acid catabolism in mitochondria. Metabolic changes were studied in Arabidopsis thaliana leaves of different mutants, and it was found that the levels of P5C and proline were higher in p5cdh mutant than in prodh1prodh2 mutant. Furthermore, the down-regulation of ProDH1 activity and protein amount in the p5cdh mutant played a critical role in determining the flow through amino acid remobilization pathways.
PLANT CELL AND ENVIRONMENT
(2023)
Article
Neurosciences
Sarah C. Simmons, Ryan D. Shepard, Shawn Gouty, Ludovic D. Langlois, William J. Flerlage, Brian M. Cox, Fereshteh S. Nugent
NEUROBIOLOGY OF STRESS
(2020)
Review
Cell Biology
Ryan D. Shepard, Fereshteh S. Nugent
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2020)
Correction
Neurosciences
Lucia Privitera, Ellen L. Hogg, Matthias Gaestel, Mark J. Wall, Sonia A. L. Correa
Article
Neurosciences
Li-Ya Jiang, Guan-Hao Wang, Jing-Jiao Xu, Xiao-Li Li, Xiao-Yan Lin, Xiang Fang, Hong-Xu Zhang, Mei Feng, Chun-Ming Jiang
Summary: This study reveals the importance of LINC00473 in regulating temozolomide (TMZ) resistance in glioblastoma (GB) and its potential mechanism. By regulating the expression of CEBP alpha and MGMT, LINC00473 promotes the formation of chemoresistance. Furthermore, LINC00473 can transfer chemoresistance to adjacent sensitive cells through exosomes.
Article
Neurosciences
Olga Kopach, Tetyana Pivneva, Nataliya Fedirko, Nana Voitenko
Summary: This study found that diabetic animals exhibit severe xerostomia characterized by reduced saliva flow rate, diminished total protein content, and decreased amylase activity. The impaired saliva production in diabetes is associated with reduced and delayed intracellular Ca2+ signals in submandibular acinar cells, caused by malfunctioning mitochondria. Targeting malfunctioning mitochondria may be a potential strategy for the treatment of diabetic xerostomia.
Article
Neurosciences
Nicholas M. Timme, Cherish E. Ardinger, Seth D. C. Weir, Rachel Zelaya-Escobar, Rachel Kruger, Christopher C. Lapish
Summary: This study aimed to assess aversion-resistant drinking behavior in head-fixed mice and explore the relationship between non-consummatory behaviors and aversion-resistant drinking. The results showed that head-fixed mice exhibited heterogenous levels of aversion-resistant drinking and non-consummatory behaviors were related to the intensity of this behavior.
Article
Neurosciences
David R. Maguire, Charles P. France
Summary: Methocinnamox (MCAM) is a novel, long-acting opioid receptor antagonist that effectively decreases fentanyl self-administration and prevents opioid overdose in monkeys. The study demonstrates the potential therapeutic utility of MCAM in the treatment of opioid use disorder.
Article
Neurosciences
Xiang Li, Dan Feng, Shenglu Ma, Mingxing Li, Shulei Zhao, Man Tang
Summary: This study investigated the effects of fluoxetine on neurochemical, neurobiological, and neurobehavioral changes in different subregions of the hippocampus. The results showed that fluoxetine increased dialysate 5-HT, decreased membrane 5-HTT protein, and increased cytoplasmic fraction. Additionally, fluoxetine reduced immobility times in behavioral tests, with greater effects observed in the ventral subregion compared to the dorsal subregion.
Article
Neurosciences
Alexander V. Zholos, Mariia I. Melnyk, Dariia O. Dryn
Summary: Acetylcholine is an important neurotransmitter in visceral smooth muscles, activating M2 and M3 muscarinic receptors to cause smooth muscle excitation and contraction. This review focuses on the cellular and molecular mechanisms underlying acetylcholine-induced depolarisation and smooth muscle contraction, as well as the effects of anticholinergic drugs on gastrointestinal motility. The knowledge gained from recent studies has greatly expanded our understanding of these processes.
Article
Neurosciences
Zhenlong Li, Hsien-Yu Peng, Chau-Shoun Lee, Tzer-Bin Lin, Ming-Chun Hsieh, Cheng-Yuan Lai, Han-Fang Wu, Lih-Chyang Chen, Mei-Ci Chen, Dylan Chou
Summary: Methylone shows significant efficacy in treating depression and social deficits, making it an ideal candidate for anti-depressant medication.
Article
Neurosciences
Aline Freyssin, Allison Carles, Sarra Guehairia, Gilles Rubinstenn, Tangui Maurice
Summary: This study explores the potential of combining FENM and S1R agonists in the treatment of Alzheimer's disease. The results showed that most FENM-based combinations can protect against learning deficits caused by A beta 25-35, with better efficacy in short-term memory.
Article
Neurosciences
J. D. Lorente, J. Cuitavi, L. Rullo, S. Candeletti, P. Romualdi, L. Hipolito
Summary: This study analyzed the effects of pain on negative affect in different sexes and time courses, as well as the involvement of the dynorphinergic and corticotropin releasing factor systems in these pain-related behaviors. The results showed sex and time-dependent anxiety- and anhedonia-like behaviors induced by pain in female rats. The recruitment of KOR/DYN in the NAc was identified as a key neurological substrate mediating pain-induced behavioral alterations.
Article
Neurosciences
Rongjun Liu, Daofan Sun, Xiuzhong Xing, Qingge Chen, Bo Lu, Bo Meng, Hui Yuan, Lan Mo, Liufang Sheng, Jinwei Zheng, Qiusheng Wang, Junping Chen, Xiaowei Chen
Summary: The coexistence of pain and depression is frequently observed in patients with chronic pain and depression. Oxytocin, a neuropeptide, has been reported to relieve chronic pain and depressive symptoms. This study investigated the effect of intranasal oxytocin on neuropathic pain and comorbid depressive symptoms, and found that oxytocin attenuated depression-like behavior but did not alleviate mechanical hyperalgesia. The results suggest that intranasal oxytocin may have the potential to treat depressive symptoms in neuropathic pain patients.