Article
Neurosciences
Xuaner Xiang, Yuzhang Chen, Ke-Xin Li, Jianqiao Fang, Philip E. Bickler, Zhonghui Guan, Wei Zhou
Summary: Hypothalamic orexin neurons play a crucial role in arousal control and their involvement in anesthesia and analgesia is still not well understood. This study systematically mapped the projections of orexin neurons using advanced imaging techniques and found novel features related to arousal and pain regulation. Optogenetic activation of orexin neurons in the lateral hypothalamus significantly affected anesthesia-related behaviors, suggesting the importance of orexin in anesthesia and analgesia.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Article
Endocrinology & Metabolism
Bin Li, Leilei Chang, Xiaochun Peng
Summary: Orexin, mainly synthesized in the lateral hypothalamus/perifornical area, is implicated in feeding, sleep-wake cycles, and reward. Activation of OX2R in the NAc shell has been found to play a role in regulating acute stress-induced anxiety, suggesting OX2R antagonist as a potential treatment for anxiety disorders.
PSYCHONEUROENDOCRINOLOGY
(2021)
Article
Neurosciences
Jazmine D. W. Yaeger, Kevin T. Krupp, Benjamin M. Jacobs, Benard O. Onserio, Brandon L. Meyerink, Jacob T. Cain, Patrick J. Ronan, Kenneth J. Renner, Ralph J. DiLeone, Cliff H. Summers
Summary: This study investigates the role of Orx1 receptors in stress-induced phenotypes in mice and finds that antagonism of Orx1 receptors can modulate behavioral responses and lead to reorganization of gene expression, providing evidence for a receptor-driven mechanism that balances stress and anti-stress responses.
BIOLOGICAL PSYCHIATRY
(2022)
Article
Neurosciences
Xiaoyue Wei, Kezhu Wang, Jinfeng Gao, Shijian Chen, Siying Zeng, Yuhong Zhao
Summary: By using FG7142 combined with restraint stress, an anxiety animal model was established, which induced anxiety-like behavior in behavior tests and showed increased c-fos expression in the hippocampus and amygdala, as well as decreased expression of GABA receptor and serotonin receptors in the hippocampus.
Article
Neurosciences
Catherine S. Thomas, Aida Mohammadkhani, Madiha Rana, Min Qiao, Corey Baimel, Stephanie L. Borgland
Summary: Reward and reinforcement processes are critical for survival and propagation of genes, with mesolimbic dopamine playing a central role. Optogenetic stimulation of orexin/dynorphin inputs in the VTA potentiates dopamine release in the NAc core, resulting in real time and conditioned place preference as well as increased food cue-directed orientation. While dynorphin contributes to aversive conditioning, the rewarding effects of LH orexin/dynorphin stimulation in the VTA are primarily driven by orexin rather than dynorphin.
NEUROPSYCHOPHARMACOLOGY
(2022)
Article
Cell Biology
Alessandra Franceschini, Giacomo Mazzamuto, Curzio Checcucci, Lorenzo Chicchi, Duccio Fanelli, Irene Costantini, Maria Beatrice Passani, Bianca Ambrogina Silva, Francesco Saverio Pavone, Ludovico Silvestri
Summary: Fear responses are adaptive behaviors strengthened as memories. Understanding the neural circuitry modulating fear memory is crucial for comprehension of this emotion and its pathological states. The brain-wide neuron quantification toolkit (BRANT) allows for mapping whole-brain neuronal activation at micron-scale resolution, providing a comprehensive characterization of the evolution of fear memory.
Article
Multidisciplinary Sciences
Ivan Vlasov, Elena Filatova, Petr Slominsky, Maria Shadrina
Summary: This study investigates the changes in the transcriptome of the rat hippocampus after exposure to the forced swim test (FST) and identifies differentially expressed genes associated with the pathogenesis of depression. The findings provide important insights for the research and treatment of depression.
SCIENTIFIC REPORTS
(2023)
Article
Neurosciences
Hye Ji J. Kim, Ayat Zagzoog, Costanza Ceni, Rebecca Ferrisi, Nicola Janz, Robert B. Laprairie
Summary: The endocannabinoid and orexin systems have similar biological functions and their downregulation due to chronic stress can lead to anhedonia. In this study, a 24 h restraint stress test reduced sucrose preference in mice, but administration of the cannabinoid receptor antagonist SR141716A, orexin receptor agonist YNT-185, or the combination of these drugs reduced anhedonia. The results suggest that the stress test decreased orexin signaling, which was restored by YNT-185, and the combination of these drugs increased receptor colocalization.
Article
Neurosciences
Daniela R. C. Foscolo, Paulo M. A. Lima, Gisele Rodovalho, Candido C. Coimbra
Summary: This study examined the impact of early maternal separation (MS) on activating stress-responsive areas in the brain of adult rats. The results showed that the MS group had a greater increase in c-Fos immunoreactive (c-Fos-ir) neurons in multiple brain regions in response to physical or psychological stressors. This suggests that early life adversity can induce reprogramming in the brain response to stress in adulthood.
NEUROSCIENCE LETTERS
(2022)
Article
Behavioral Sciences
Alejandro Borja Grau-Perales, Fernando Gamiz, Milagros Gallo
Summary: Research has shown that the hippocampal administration of 6-OHDA disrupts context-dependent taste recognition memory, indicating that auditory background can modulate safe taste memory acquisition through catecholaminergic activity in the hippocampus.
BEHAVIOURAL BRAIN RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Daria Peleg-Raibstein, Denis Burdakov
Summary: Hypothalamic neurons producing orexins/hypocretins have broad axonal projections throughout the brain, and are activated not only by nutrient depletion but also by diverse sensory stimuli signaling stress. This unified theory suggests that HON activity may represent a cumulative response to stress, leading to various stress-counteracting behaviors.
Article
Psychology, Biological
Nadine Faesel, Michael Koch, Markus Fendt
Summary: Binge eating disorder is a debilitating disease associated with excessive food consumption and psychiatric comorbidities. This study investigates the role of the orexin neuropeptide system in binge-like eating, finding a sexual dimorphism in its effects on weight, hypophagia, stress levels, and anxiety.
PHYSIOLOGY & BEHAVIOR
(2023)
Article
Behavioral Sciences
Takahiro Okuda, Yoji Osako, Chiharu Hidaka, Makoto Nishihara, Larry J. Young, Shinichi Mitsui, Kazunari Yuri
Summary: The research found that in a social stress-induced hyperalgesia animal model, males who were separated from their partners showed lower neuronal activation in the medial prefrontal cortex and nucleus accumbens shell following inflammatory pain. This suggests that pain exacerbation by social stress may emerge through alteration of signaling in social brain circuitry.
BEHAVIOURAL BRAIN RESEARCH
(2022)
Article
Clinical Neurology
Kobra Askari, Shahrbanoo Oryan, Akram Eidi, Jalal Zaringhalam, Abbas Haghparast
Summary: Exposure to stressful stimuli induces physiological and behavioral responses, affects pain perception, and alters gene expression. This study investigated the modulatory role of the ventral tegmental area (VTA) orexinergic system and ERK signaling in stress-induced analgesia.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2023)
Article
Neurosciences
Hibiki Okamura, Shinnosuke Yasugaki, Haruka Suzuki-Abe, Yoshifumi Arai, Katsuyasu Sakurai, Masashi Yanagisawa, Hotaka Takizawa, Yu Hayashi
Summary: Understanding the long-term effects of stress on brain function is crucial for understanding the mechanisms of depression. This study investigated the effects of repeated social defeat stress (SDS) on behavior and brain activity in BALB/c mice over subsequent weeks. The results revealed the long-term effects of social stress on behavior and brain activity, providing insight into the underlying mechanisms of related diseases.
Article
Biochemistry & Molecular Biology
Jianyu Lu, Angelo Aguilar, Bende Zou, Weier Bao, Serkan Koldas, Aibin Shi, John Desper, Philine Wangemann, Xinmin Simon Xie, Duy H. Hua
BIOORGANIC & MEDICINAL CHEMISTRY
(2015)
Article
Pharmacology & Pharmacy
Andrea Cippitelli, Jinhua Wu, Kelly A. Gaiolini, Daniela Mercatelli, Jennifer Schoch, Michelle Gorman, Alejandra Ramirez, Roberto Ciccocioppo, Taline V. Khroyan, Dennis Yasuda, Nurulain T. Zaveri, Conrado Pascual, Xinmin (Simon) Xie, Lawrence Toll
BRITISH JOURNAL OF PHARMACOLOGY
(2015)
Article
Neurosciences
Mario A. Saporta, Vu Dang, Dmitri Volfson, Bende Zou, Xinmin (Simon) Xie, Adijat Adebola, Ronald K. Liem, Michael Shy, John T. Dimos
EXPERIMENTAL NEUROLOGY
(2015)
Article
Neurosciences
Akihiko Ozawa, Gloria Brunori, Daniela Mercatelli, Jinhua Wu, Andrea Cippitelli, Bende Zou, Xinmin (Simon) Xie, Melissa Williams, Nurulain T. Zaveri, Sarah Low, Gregory Scherrer, Brigitte L. Kieffer, Lawrence Toll
JOURNAL OF NEUROSCIENCE
(2015)
Article
Chemistry, Multidisciplinary
Xi Xie, Conrado Pascual, Christopher Lieu, Seajin Oh, Ji Wang, Bende Zou, Julian Xie, Zhaohui Li, James Xie, David C. Yeomans, Mei X. Wu, Xinmin Simon Xie
Article
Neurosciences
Izumi Maezawa, Bende Zou, Jacopo Di Lucente, William S. Cao, Conrado Pascual, Sahani Weerasekara, Man Zhang, Xinmin Simon Xie, Duy H. Hua, Lee-Way Jin
JOURNAL OF ALZHEIMERS DISEASE
(2017)
Article
Multidisciplinary Sciences
Joseph M. Castellano, Kira I. Mosher, Rachelle J. Abbey, Alisha A. McBride, Michelle L. James, Daniela Berdnik, Jadon C. Shen, Bende Zou, Xinmin S. Xie, Martha Tingle, Izumi V. Hinkson, Martin S. Angst, Tony Wyss-Coray
Article
Multidisciplinary Sciences
Cong Shi, Xuedong Yuan, Karen Chang, Kin-Sang Cho, Xinmin Simon Xie, Dong Feng Chen, Gang Luo
SCIENTIFIC REPORTS
(2018)
Article
Biochemistry & Molecular Biology
Kristian Kaufmann, Ian Romaine, Emily Days, Conrado Pascual, Adam Malik, Liya Yang, Bende Zou, Yu Du, Greg Sliwoski, Ryan D. Morrison, Jerod Denton, Colleen M. Niswender, J. Scott Daniels, Gary A. Sulikowski, Xinmin (Simon) Xie, Craig W. Lindsley, C. David Weaver
ACS CHEMICAL NEUROSCIENCE
(2013)
Article
Neurosciences
Liya Yang, Bende Zou, Xiaoxing Xiong, Conrado Pascual, James Xie, Adam Malik, Julian Xie, Takeshi Sakurai, Xinmin (Simon) Xie
JOURNAL OF NEUROSCIENCE
(2013)
Article
Neurosciences
Sarah Srodulski, Savita Sharma, Adam B. Bachstetter, Jennifer M. Brelsfoard, Conrado Pascual, Xinmin Simon Xie, Kathryn E. Saatman, Linda J. Van Eldik, Florin Despa
MOLECULAR NEURODEGENERATION
(2014)
Article
Biochemistry & Molecular Biology
Maral Tajerian, Victor Hung, Huy Nguyen, Gail Lee, Lydia-Marie Joubert, Andrey Victorovich Malkovskiy, Bende Zou, Simon Xie, Ting-Ting Huang, J. David Clark
MOLECULAR PSYCHIATRY
(2018)
Article
Biochemistry & Molecular Biology
Saul A. Villeda, Kristopher E. Plambeck, Jinte Middeldorp, Joseph M. Castellano, Kira I. Mosher, Jian Luo, Lucas K. Smith, Gregor Bieri, Karin Lin, Daniela Berdnik, Rafael Wabl, Joe Udeochu, Elizabeth G. Wheatley, Bende Zou, Danielle A. Simmons, Xinmin S. Xie, Frank M. Longo, Tony Wyss-Coray
Article
Clinical Neurology
Xiaoxing Xiong, Robin E. White, Lijun Xu, Liya Yang, Xiaoyun Sun, Bende Zou, Conrado Pascual, Takeshi Sakurai, Rona G. Giffard, Xinmin (Simon) Xie
Article
Cell & Tissue Engineering
Yanxia Liu, Chen Yu, Timothy Patrick Daley, Fangyuan Wang, William S. Cao, Salil Bhate, Xueqiu Lin, Chris Still, Honglei Liu, Dehua Zhao, Haifeng Wang, Xinmin S. Xie, Sheng Ding, Wing Hung Wong, Marius Wernig, Lei S. Qi
Correction
Neurosciences
Lucia Privitera, Ellen L. Hogg, Matthias Gaestel, Mark J. Wall, Sonia A. L. Correa
Article
Neurosciences
Li-Ya Jiang, Guan-Hao Wang, Jing-Jiao Xu, Xiao-Li Li, Xiao-Yan Lin, Xiang Fang, Hong-Xu Zhang, Mei Feng, Chun-Ming Jiang
Summary: This study reveals the importance of LINC00473 in regulating temozolomide (TMZ) resistance in glioblastoma (GB) and its potential mechanism. By regulating the expression of CEBP alpha and MGMT, LINC00473 promotes the formation of chemoresistance. Furthermore, LINC00473 can transfer chemoresistance to adjacent sensitive cells through exosomes.
Article
Neurosciences
Olga Kopach, Tetyana Pivneva, Nataliya Fedirko, Nana Voitenko
Summary: This study found that diabetic animals exhibit severe xerostomia characterized by reduced saliva flow rate, diminished total protein content, and decreased amylase activity. The impaired saliva production in diabetes is associated with reduced and delayed intracellular Ca2+ signals in submandibular acinar cells, caused by malfunctioning mitochondria. Targeting malfunctioning mitochondria may be a potential strategy for the treatment of diabetic xerostomia.
Article
Neurosciences
Nicholas M. Timme, Cherish E. Ardinger, Seth D. C. Weir, Rachel Zelaya-Escobar, Rachel Kruger, Christopher C. Lapish
Summary: This study aimed to assess aversion-resistant drinking behavior in head-fixed mice and explore the relationship between non-consummatory behaviors and aversion-resistant drinking. The results showed that head-fixed mice exhibited heterogenous levels of aversion-resistant drinking and non-consummatory behaviors were related to the intensity of this behavior.
Article
Neurosciences
David R. Maguire, Charles P. France
Summary: Methocinnamox (MCAM) is a novel, long-acting opioid receptor antagonist that effectively decreases fentanyl self-administration and prevents opioid overdose in monkeys. The study demonstrates the potential therapeutic utility of MCAM in the treatment of opioid use disorder.
Article
Neurosciences
Xiang Li, Dan Feng, Shenglu Ma, Mingxing Li, Shulei Zhao, Man Tang
Summary: This study investigated the effects of fluoxetine on neurochemical, neurobiological, and neurobehavioral changes in different subregions of the hippocampus. The results showed that fluoxetine increased dialysate 5-HT, decreased membrane 5-HTT protein, and increased cytoplasmic fraction. Additionally, fluoxetine reduced immobility times in behavioral tests, with greater effects observed in the ventral subregion compared to the dorsal subregion.
Article
Neurosciences
Alexander V. Zholos, Mariia I. Melnyk, Dariia O. Dryn
Summary: Acetylcholine is an important neurotransmitter in visceral smooth muscles, activating M2 and M3 muscarinic receptors to cause smooth muscle excitation and contraction. This review focuses on the cellular and molecular mechanisms underlying acetylcholine-induced depolarisation and smooth muscle contraction, as well as the effects of anticholinergic drugs on gastrointestinal motility. The knowledge gained from recent studies has greatly expanded our understanding of these processes.
Article
Neurosciences
Zhenlong Li, Hsien-Yu Peng, Chau-Shoun Lee, Tzer-Bin Lin, Ming-Chun Hsieh, Cheng-Yuan Lai, Han-Fang Wu, Lih-Chyang Chen, Mei-Ci Chen, Dylan Chou
Summary: Methylone shows significant efficacy in treating depression and social deficits, making it an ideal candidate for anti-depressant medication.
Article
Neurosciences
Aline Freyssin, Allison Carles, Sarra Guehairia, Gilles Rubinstenn, Tangui Maurice
Summary: This study explores the potential of combining FENM and S1R agonists in the treatment of Alzheimer's disease. The results showed that most FENM-based combinations can protect against learning deficits caused by A beta 25-35, with better efficacy in short-term memory.
Article
Neurosciences
J. D. Lorente, J. Cuitavi, L. Rullo, S. Candeletti, P. Romualdi, L. Hipolito
Summary: This study analyzed the effects of pain on negative affect in different sexes and time courses, as well as the involvement of the dynorphinergic and corticotropin releasing factor systems in these pain-related behaviors. The results showed sex and time-dependent anxiety- and anhedonia-like behaviors induced by pain in female rats. The recruitment of KOR/DYN in the NAc was identified as a key neurological substrate mediating pain-induced behavioral alterations.
Article
Neurosciences
Rongjun Liu, Daofan Sun, Xiuzhong Xing, Qingge Chen, Bo Lu, Bo Meng, Hui Yuan, Lan Mo, Liufang Sheng, Jinwei Zheng, Qiusheng Wang, Junping Chen, Xiaowei Chen
Summary: The coexistence of pain and depression is frequently observed in patients with chronic pain and depression. Oxytocin, a neuropeptide, has been reported to relieve chronic pain and depressive symptoms. This study investigated the effect of intranasal oxytocin on neuropathic pain and comorbid depressive symptoms, and found that oxytocin attenuated depression-like behavior but did not alleviate mechanical hyperalgesia. The results suggest that intranasal oxytocin may have the potential to treat depressive symptoms in neuropathic pain patients.