Article
Neurosciences
Judith Schweimer, Julia T. Brouard, Yan Li, Connie Sanchez, Trevor Sharp
Summary: The study found that vortioxetine inhibits 5-HT3R-INs and excites pyramidal neurons, thereby changing the balance between excitatory and inhibitory activity in the cortex.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2022)
Article
Neurosciences
Rika Moriya, Mitsuko Kanamaru, Naoki Okuma, Akira Yoshikawa, Kenji F. Tanaka, Satoshi Hokari, Yasuyoshi Ohshima, Akihiro Yamanaka, Motoyasu Honma, Hiroshi Onimaru, Toshiaki Kikuchi, Masahiko Izumizaki
Summary: Studies have shown that 5-HT neurons in the DRN play a crucial role in regulating different waking states, with optogenetic activation of these neurons causing rapid transition from non-REM sleep to active wakefulness. Activation of medullary 5-HT neurons, on the other hand, does not seem to affect sleep/wake states or locomotor activity. Further research into the cortical functional connectivity involved in sleep/wake state regulation is encouraged based on these findings.
BRAIN RESEARCH BULLETIN
(2021)
Article
Chemistry, Analytical
Yun Wang, Mixia Wang, Yuchuan Dai, Yilin Song, Yiding Wang, Botao Lu, Yinghui Li, Xinxia Cai
Summary: Research on the intracerebral mechanism of insomnia induced by serotonin deficiency is essential. Using a microelectrode array, the study explored the impact of 5-HT deficiency-induced insomnia on brain regions involved in memory, and found that the deficiency leads to hyperactivity of neurons in the hippocampus and DRN. The firing rate of DRN and the neuronal amplitude of hippocampus are more effective indicators of insomnia in rats.
Review
Biochemistry & Molecular Biology
Kristine Conde, Shuzheng Fang, Yong Xu
Summary: The prevalence of obesity is increasing rapidly worldwide, but effective obesity therapies are lacking. Despite the identification of new therapeutic targets and improvements in drug efficacy, adverse side effects and increased health risks remain challenges for the weight-loss industry. The neurotransmitter serotonin, specifically its involvement in appetite reduction and weight loss, has been extensively studied. This review focuses on the history, current research, previous therapies, and future prospects of serotonin as a therapeutic target for individuals with obesity.
CELL AND BIOSCIENCE
(2023)
Article
Neurosciences
Yong Liu, Min Wu, Zongyue Sun, Qiongyu Li, Rong Jiang, Fantao Meng, Jing Liu, Wentao Wang, Juanjuan Dai, Chen Li, Shujun Jiang
Summary: This study reveals the important role of PPM1F in the regulation of METH addiction. By modulating key components of the 5-HT neurotransmitter system, PPM1F affects METH-induced conditioned place preference behaviors and influences 5-HT levels in the dorsal raphe nucleus.
BRAIN RESEARCH BULLETIN
(2022)
Article
Neurosciences
Sheikh Mizanur Rahaman, Srikanta Chowdhury, Yasutaka Mukai, Daisuke Ono, Hiroshi Yamaguchi, Akihiro Yamanaka
Summary: GABAergic neurons in the ventral tegmental area (VTA) are responsive to different neurotransmitters and play a role in regulating sleep/wakefulness. These neurons have projections in brain areas related to sleep/wakefulness and are activated by cholinergic agonists, but inhibited by serotonin, dopamine, and histamine. VTA(Gad67+) neurons inhibit neurons in the dorsal raphe nucleus (DRN), but not in the central amygdala (CeA) and locus coeruleus (LC). They also monosynaptically inhibit serotonergic neurons in the DRN (DRN5-HT).
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Multidisciplinary Sciences
Amina Benhadda, Celia Delhaye, Imane Moutkine, Xavier Marques, Marion Russeau, Corentin Le Magueresse, Anne Roumier, Sabine Levi, Luc Maroteaux
Summary: Many psychiatric diseases are associated with dysfunction of serotonin (5-HT) neurons. This study shows that 5-HT1A and 5-HT2B receptors can form heterodimers and co-cluster at the plasma membrane of dendrites. Stimulation of these receptors prevents 5-HT1A receptor internalization and increases 5-HT2B receptor membrane clustering, regulating the excitability of serotonergic neurons.
Article
Neurosciences
Burak Yaman, Ramazan Bal
Summary: This study suggests that pindolol may enhance the antidepressant effect of venlafaxine by inhibiting the response of DRN neurons to 5-HT, leading to reduced immobility time in mice. Therefore, pindolol has the potential to prevent the inhibition of serotonergic neurons after antidepressant use, making it a promising addition to mood disorder treatment.
INTERNATIONAL JOURNAL OF NEUROSCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Xiao-ju Liu, Hai-juan Wang, Xiao-yu Wang, Yin-xia Ning, Jie Gao
Summary: The study aimed to clarify the role of GABABR1 in regulating aggressive behavior in rats. Rat models of highly and less aggressive behavior were established through social isolation plus resident intruder. Results indicated that the regulatory relationship between GABA and serotonin in different brain regions plays a role in rodent aggressive behavior.
NEUROCHEMISTRY INTERNATIONAL
(2021)
Article
Behavioral Sciences
Liuchang Zhou, Dan Liu, Zedan Xie, Di Deng, Guoqi Shi, Jinlan Zhao, Shasha Bai, Lei Yang, Rong Zhang, Yafei Shi
Summary: The dorsal raphe nucleus (DRN) is a crucial source of serotonin in the central nervous system and is closely associated with depression-like behaviors. This study reveals that gamma oscillation is linked to despair-like behaviors, while burst fraction is important for survival-like behaviors. Through optogenetics, it was found that serotonin transporter-positive neurons are mostly survival units, and approximately 50% of survival units belong to parvalbumin-positive neurons. These findings provide new insights into the study of anti-depression targets and highlight the role of GABAergic interneurons in the coding and regulation of local neural networks.
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2022)
Article
Behavioral Sciences
Houari Boukersi, Nemcha Lebaili, Anne Nosjean, Nathalie Samson, Alexis Faure, Sylvie Granon
Summary: The study showed that temporary mild dehydration significantly increases the time spent by mice in social contact and social dominance, as well as expanding the density of 5-HT neurons in the dorsal and median raphe nuclei. Additionally, the behavioral and neuronal plasticity caused by temporary dehydration were positively correlated.
BEHAVIOURAL BRAIN RESEARCH
(2021)
Article
Multidisciplinary Sciences
Sen Li, Ikuo Otsuka, Takaki Tanifuji, Satoshi Okazaki, Tadasu Horai, Motonori Takahashi, Takeshi Kondo, Yasuhiro Ueno, Akitoyo Hishimoto
Summary: Previous evidence has shown increased ribosomal DNA (rDNA) content in the blood of patients with schizophrenia (SCZ) among European populations. This study investigated rDNA copy number (rDNAcn) of SCZ in East Asian populations, as well as in blood and brain tissues. The results showed that patients with SCZ had significantly increased rDNAcn in both blood and brain tissues compared to controls. These findings replicate previous observations in Europeans and provide new insights into the molecular mechanisms underlying SCZ pathophysiology.
Article
Neurosciences
Bailey N. Keller, Patrick A. Randall, Amy C. Arnold, Kirsteen N. Browning, Yuval Silberman
Summary: Alcohol use disorder is a growing concern in the United States, leading to an increase in alcohol-related end-organ damage. This study found that alcohol intake can affect the function of pancreatic neurons, potentially leading to changes in pancreatic secretions. Serotonin plays a critical role in mediating the effects of alcohol on these neurons.
BRAIN RESEARCH BULLETIN
(2022)
Article
Pharmacology & Pharmacy
Aitziber Mendiguren, Erik Aostri, Irati Rodilla, Iker Pujana, Ekaterina Noskova, Joseba Pineda
Summary: The pharmacological profile of cannabigerol (CBG), particularly its effect on alpha(2)-adrenoceptor and 5-HT1A receptor, is poorly understood. In this study, male Sprague-Dawley rat brain slices were used to investigate the impact of CBG on firing rate of LC NA cells and DRN 5-HT cells, as well as its interaction with alpha(2)-adrenergic and 5-HT1A autoreceptors. CBG was also evaluated for its anxiolytic-like effects using behavior tests. The findings indicate that CBG inhibits the suppressive effects of alpha(2)-adrenoceptor and 5-HT1A receptor agonists on NA-LC and 5-HT-DRN neurons, and produces anxiolytic-like effects through the 5-HT1A receptor.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Behavioral Sciences
Ross A. McDevitt, Rosa Anna M. Marino, Hugo A. Tejeda, Antonello Bonci
Summary: Serotonin plays a crucial role in cue-reward learning in mice, as serotonin reuptake inhibitors can reduce lever pressing behavior, and alterations in serotonin levels in different brain regions can impact behavioral responses.
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
(2021)
Correction
Neurosciences
Lucia Privitera, Ellen L. Hogg, Matthias Gaestel, Mark J. Wall, Sonia A. L. Correa
Article
Neurosciences
Li-Ya Jiang, Guan-Hao Wang, Jing-Jiao Xu, Xiao-Li Li, Xiao-Yan Lin, Xiang Fang, Hong-Xu Zhang, Mei Feng, Chun-Ming Jiang
Summary: This study reveals the importance of LINC00473 in regulating temozolomide (TMZ) resistance in glioblastoma (GB) and its potential mechanism. By regulating the expression of CEBP alpha and MGMT, LINC00473 promotes the formation of chemoresistance. Furthermore, LINC00473 can transfer chemoresistance to adjacent sensitive cells through exosomes.
Article
Neurosciences
Olga Kopach, Tetyana Pivneva, Nataliya Fedirko, Nana Voitenko
Summary: This study found that diabetic animals exhibit severe xerostomia characterized by reduced saliva flow rate, diminished total protein content, and decreased amylase activity. The impaired saliva production in diabetes is associated with reduced and delayed intracellular Ca2+ signals in submandibular acinar cells, caused by malfunctioning mitochondria. Targeting malfunctioning mitochondria may be a potential strategy for the treatment of diabetic xerostomia.
Article
Neurosciences
Nicholas M. Timme, Cherish E. Ardinger, Seth D. C. Weir, Rachel Zelaya-Escobar, Rachel Kruger, Christopher C. Lapish
Summary: This study aimed to assess aversion-resistant drinking behavior in head-fixed mice and explore the relationship between non-consummatory behaviors and aversion-resistant drinking. The results showed that head-fixed mice exhibited heterogenous levels of aversion-resistant drinking and non-consummatory behaviors were related to the intensity of this behavior.
Article
Neurosciences
David R. Maguire, Charles P. France
Summary: Methocinnamox (MCAM) is a novel, long-acting opioid receptor antagonist that effectively decreases fentanyl self-administration and prevents opioid overdose in monkeys. The study demonstrates the potential therapeutic utility of MCAM in the treatment of opioid use disorder.
Article
Neurosciences
Xiang Li, Dan Feng, Shenglu Ma, Mingxing Li, Shulei Zhao, Man Tang
Summary: This study investigated the effects of fluoxetine on neurochemical, neurobiological, and neurobehavioral changes in different subregions of the hippocampus. The results showed that fluoxetine increased dialysate 5-HT, decreased membrane 5-HTT protein, and increased cytoplasmic fraction. Additionally, fluoxetine reduced immobility times in behavioral tests, with greater effects observed in the ventral subregion compared to the dorsal subregion.
Article
Neurosciences
Alexander V. Zholos, Mariia I. Melnyk, Dariia O. Dryn
Summary: Acetylcholine is an important neurotransmitter in visceral smooth muscles, activating M2 and M3 muscarinic receptors to cause smooth muscle excitation and contraction. This review focuses on the cellular and molecular mechanisms underlying acetylcholine-induced depolarisation and smooth muscle contraction, as well as the effects of anticholinergic drugs on gastrointestinal motility. The knowledge gained from recent studies has greatly expanded our understanding of these processes.
Article
Neurosciences
Zhenlong Li, Hsien-Yu Peng, Chau-Shoun Lee, Tzer-Bin Lin, Ming-Chun Hsieh, Cheng-Yuan Lai, Han-Fang Wu, Lih-Chyang Chen, Mei-Ci Chen, Dylan Chou
Summary: Methylone shows significant efficacy in treating depression and social deficits, making it an ideal candidate for anti-depressant medication.
Article
Neurosciences
Aline Freyssin, Allison Carles, Sarra Guehairia, Gilles Rubinstenn, Tangui Maurice
Summary: This study explores the potential of combining FENM and S1R agonists in the treatment of Alzheimer's disease. The results showed that most FENM-based combinations can protect against learning deficits caused by A beta 25-35, with better efficacy in short-term memory.
Article
Neurosciences
J. D. Lorente, J. Cuitavi, L. Rullo, S. Candeletti, P. Romualdi, L. Hipolito
Summary: This study analyzed the effects of pain on negative affect in different sexes and time courses, as well as the involvement of the dynorphinergic and corticotropin releasing factor systems in these pain-related behaviors. The results showed sex and time-dependent anxiety- and anhedonia-like behaviors induced by pain in female rats. The recruitment of KOR/DYN in the NAc was identified as a key neurological substrate mediating pain-induced behavioral alterations.
Article
Neurosciences
Rongjun Liu, Daofan Sun, Xiuzhong Xing, Qingge Chen, Bo Lu, Bo Meng, Hui Yuan, Lan Mo, Liufang Sheng, Jinwei Zheng, Qiusheng Wang, Junping Chen, Xiaowei Chen
Summary: The coexistence of pain and depression is frequently observed in patients with chronic pain and depression. Oxytocin, a neuropeptide, has been reported to relieve chronic pain and depressive symptoms. This study investigated the effect of intranasal oxytocin on neuropathic pain and comorbid depressive symptoms, and found that oxytocin attenuated depression-like behavior but did not alleviate mechanical hyperalgesia. The results suggest that intranasal oxytocin may have the potential to treat depressive symptoms in neuropathic pain patients.
