Article
Endocrinology & Metabolism
Hiroshi Arima, Timothy Cheetham, Mirjam Christ-Crain, Deborah Cooper, Juliana Drummond, Mark Gurnell, Miles Levy, Ann McCormack, John Newell-Price, Joseph G. Verbalis, John Wass, John Wass
Summary: Recent data suggests that patients with diabetes insipidus (DI) are being harmed. The authors propose renaming central and nephrogenic DI as arginine vasopressin deficiency and resistance, respectively.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Multidisciplinary Sciences
Arjen J. Boender, Marina Boon, Samantha R. Eck, Brandon A. Fricker, Aubrey M. Kelly, Joseph E. LeDoux, Simone C. Motta, Prerana Shrestha, Jack H. Taylor, Brian C. Trainor, Rodrigo Triana-Del Rio, Larry J. Young, H. Elliott Albers
Summary: A major issue in neuroscience is the poor translatability of research results from preclinical studies in animals to clinical outcomes. Comparative neuroscience aims to overcome this issue by studying multiple species to differentiate between species-specific and general mechanisms of neural circuit functioning. This study developed a viral-mediated CRISPR/Cas9 strategy that can target the oxytocin receptor (Oxtr) gene in over 80 rodent species, demonstrating the potential of comparative gene editing approaches to improve the translatability of neuroscientific research.
Article
Neurosciences
Bo Zhou, Xiaoli Zheng, Yunhua Chen, Xuehui Yan, Jinggang Peng, Yibu Liu, Yi Zhang, Lei Tang, Min Wen
Summary: AVP can significantly improve the social interaction disorder of VPA-induced autism model by modulating the vasopressin pathways. Transcriptome sequencing results showed significant impairments in the nervous system developmental processes in the VPA-induced autism model group compared to the normal group. Pathway enrichment analysis showed dysregulation in the PI3K/AKT and Wnt pathways in the VPA-induced autism model group. AVP treatment improved deficits in oligodendrocyte development and function and enriched pathways related to NOTCH, mitogen-activated protein kinase, and focal adhesion signaling pathways.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Peripheral Vascular Disease
Yexiu Sun, Ying Guo, He Xu, Ji Zhao, Di Wu, Jianwei Hu, Dandan Wang, Lei Wu, Hao Peng, Hongmei Li
Summary: This study aimed to investigate the relationship between AVP gene polymorphism and plasma copeptin concentration with the occurrence of hypertension in pregnancy. The results showed that higher plasma copeptin and AVP gene variants are associated with the occurrence of gestational hypertension and preeclampsia with chronic hypertension. The detection of copeptin and AVP gene in the early second trimester improves the predictive ability of traditional factors for gestational hypertension and preeclampsia with chronic hypertension.
JOURNAL OF HYPERTENSION
(2023)
Article
Multidisciplinary Sciences
Matthew T. Rich, Samantha J. Worobey, Sharvari Mankame, Zhiping P. Pang, Sarah E. Swinford-Jackson, R. Christopher Pierce
Summary: Cocaine exposure in male rats affects fear-associated behaviors in their offspring, with enhanced freezing behavior in female progeny and enhanced expression of cue-conditioned fear during extinction in male progeny. The absence of long-term potentiation (LTP) in the basolateral amygdala (BLA) suggests synaptic plasticity deficits in male offspring of cocaine-exposed sires.
Article
Medicine, Research & Experimental
Hayder M. Al-kuraishy, Ali Al-Gareeb, Safaa Qusti, Eida M. Alshammari, Francis O. Atanu, Gaber El-Saber Batiha
Summary: The release of AVP in Covid-19 is influenced by various factors and may trigger inflammatory disorders, leading to complications. Antagonizing AVP could be a potential therapeutic approach for treating Covid-19.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Multidisciplinary Sciences
Takashi Maejima, Yusuke Tsuno, Shota Miyazaki, Yousuke Tsuneoka, Emi Hasegawa, Md Tarikul Islam, Ryosuke Enoki, Takahiro J. Nakamura, Michihiro Mieda
Summary: The study found that specific deletion of vesicular GABA transporter in AVP neurons led to significant impairment of circadian rhythm and disruption of GABA-mediated synaptic transmission in SCN neurons. While molecular circadian oscillations among SCN neurons did not significantly change, there were significant alterations in the phase relationships between molecular clocks and circadian behavioral activities.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Andrology
Sapna Ramdin, Thajasvarie Naicker, Virushka Pillay, Sanil D. Singh, Sooraj Baijnath, Blessing N. Mkhwanazi, Nalini Govender
Summary: The study found that the AVP-induced rat model of PE is reliable in mimicking the pathological changes associated with PE development in humans, providing important insights into the pathophysiology of PE.
SYSTEMS BIOLOGY IN REPRODUCTIVE MEDICINE
(2022)
Article
Neurosciences
Kelle E. Nett, Alexa R. Zimbelman, Matthew S. McGregor, Vanessa Alizo Vera, Molly R. Harris, Ryan T. LaLumiere
Summary: Previous evidence suggests that the infralimbic cortex (IL) plays a role in inhibiting cocaine seeking behavior in rats. In this study, the researchers investigated whether IL activity and its outputs to the nucleus accumbens shell (NAshell) and amygdala are involved in encoding extinction contingencies following cocaine self-administration. They used optogenetic techniques to silence IL-NAshell or IL-amygdala activity after an unreinforced lever press during extinction training and found that inhibition of IL-NAshell or IL-amygdala activity impaired extinction retention.
JOURNAL OF NEUROSCIENCE
(2023)
Article
Cell Biology
Bo Zhou, Xuehui Yan, Liu Yang, Xiaoli Zheng, Yunhua Chen, Yibu Liu, Yibing Ren, Jingang Peng, Yi Zhang, Jiayu Huang, Lei Tang, Min Wen
Summary: This study demonstrates that AVP can improve synaptic and axon dysplasia in the prefrontal cortex of VPA-induced autism models by regulating multiple signaling pathways, and promote oligodendrocyte development.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2022)
Article
Multidisciplinary Sciences
Julong Wei, Tova Y. Lambert, Aditi Valada, Nikhil Patel, Kellie Walker, Jayna Lenders, Carl J. Schmidt, Marina Iskhakova, Adnan Alazizi, Henriette Mair-Meijers, Deborah C. Mash, Francesca Luca, Roger Pique-Regi, Michael J. Bannon, Schahram Akbarian
Summary: This study found that chronic exposure to opioids results in broad transcriptional changes in glial cells, including upregulation of genes associated with immune response and downregulation of synaptic signaling and plasticity genes. It also identified certain genes that are linked to risk of substance use in the population.
NATURE COMMUNICATIONS
(2023)
Review
Pharmacology & Pharmacy
Lucia Caffino, Francesca Mottarlini, Gianmaria Zita, Dawid Gawlinski, Kinga Gawlinska, Karolina Wydra, Edmund Przegalinski, Fabio Fumagalli
Summary: Drug addiction is a devastating disorder that poses a huge economic and social burden on modern society, with adolescents being particularly vulnerable. Research has shown that exposure to cocaine during adolescence confers a vulnerable endophenotype primarily by inducing changes in neuroplasticity.
BRITISH JOURNAL OF PHARMACOLOGY
(2022)
Article
Endocrinology & Metabolism
Dong Hee Kim, Kwang Kon Kim, Tae Hwan Lee, Hyejin Eom, Jin Woo Kim, Jeong Woo Park, Jin Kwon Jeong, Byung Ju Lee
Summary: The study found a positive correlation between hypothalamic TonEBP and AVP production under dehydration conditions. TonEBP can directly bind to the upstream promoter regions of the AVP gene, regulating AVP gene transcription. Additionally, dehydration-induced reductions in body weight were rescued in TonEBP haploinsufficiency mice.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Review
Endocrinology & Metabolism
Nareshni Moodley
Summary: Copeptin, as an alternative to arginine vasopressin measurement, has advantages of high stability, simple analysis, and ease of automation. Research has shown its suitability for differentiating arginine vasopressin resistance and deficiency as well as primary polydipsia in adults, but further studies are needed in Syndrome of Inappropriate Antidiuretic Hormone (SIADH) and the pediatric population.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Biochemical Research Methods
Kyle D. Ketchesin, Darius D. Becker-Krail, Xiangning Xue, Rashaun S. Wilson, TuKiet T. Lam, Kenneth R. Williams, Angus C. Nairn, George C. Tseng, Ryan W. Logan
Summary: Substance use disorders disrupt sleep and circadian rhythms, increasing the risk of relapse. This study investigates the effects of cocaine and morphine on the diurnal rhythms of proteome in the nucleus accumbens (NAc), a key brain region for reward and motivation. The results show that cocaine and morphine differentially alter proteome diurnal rhythms in the NAc, with distinct proteins expressed at different times of the day. Cocaine altered proteins related to glucocorticoid signaling and metabolism, while morphine was associated with neuroinflammation. These findings provide insights into the regulation of NAc proteome and the differential effects of cocaine and morphine.
JOURNAL OF PROTEOME RESEARCH
(2023)
Correction
Neurosciences
Lucia Privitera, Ellen L. Hogg, Matthias Gaestel, Mark J. Wall, Sonia A. L. Correa
Article
Neurosciences
Li-Ya Jiang, Guan-Hao Wang, Jing-Jiao Xu, Xiao-Li Li, Xiao-Yan Lin, Xiang Fang, Hong-Xu Zhang, Mei Feng, Chun-Ming Jiang
Summary: This study reveals the importance of LINC00473 in regulating temozolomide (TMZ) resistance in glioblastoma (GB) and its potential mechanism. By regulating the expression of CEBP alpha and MGMT, LINC00473 promotes the formation of chemoresistance. Furthermore, LINC00473 can transfer chemoresistance to adjacent sensitive cells through exosomes.
Article
Neurosciences
Olga Kopach, Tetyana Pivneva, Nataliya Fedirko, Nana Voitenko
Summary: This study found that diabetic animals exhibit severe xerostomia characterized by reduced saliva flow rate, diminished total protein content, and decreased amylase activity. The impaired saliva production in diabetes is associated with reduced and delayed intracellular Ca2+ signals in submandibular acinar cells, caused by malfunctioning mitochondria. Targeting malfunctioning mitochondria may be a potential strategy for the treatment of diabetic xerostomia.
Article
Neurosciences
Nicholas M. Timme, Cherish E. Ardinger, Seth D. C. Weir, Rachel Zelaya-Escobar, Rachel Kruger, Christopher C. Lapish
Summary: This study aimed to assess aversion-resistant drinking behavior in head-fixed mice and explore the relationship between non-consummatory behaviors and aversion-resistant drinking. The results showed that head-fixed mice exhibited heterogenous levels of aversion-resistant drinking and non-consummatory behaviors were related to the intensity of this behavior.
Article
Neurosciences
David R. Maguire, Charles P. France
Summary: Methocinnamox (MCAM) is a novel, long-acting opioid receptor antagonist that effectively decreases fentanyl self-administration and prevents opioid overdose in monkeys. The study demonstrates the potential therapeutic utility of MCAM in the treatment of opioid use disorder.
Article
Neurosciences
Xiang Li, Dan Feng, Shenglu Ma, Mingxing Li, Shulei Zhao, Man Tang
Summary: This study investigated the effects of fluoxetine on neurochemical, neurobiological, and neurobehavioral changes in different subregions of the hippocampus. The results showed that fluoxetine increased dialysate 5-HT, decreased membrane 5-HTT protein, and increased cytoplasmic fraction. Additionally, fluoxetine reduced immobility times in behavioral tests, with greater effects observed in the ventral subregion compared to the dorsal subregion.
Article
Neurosciences
Alexander V. Zholos, Mariia I. Melnyk, Dariia O. Dryn
Summary: Acetylcholine is an important neurotransmitter in visceral smooth muscles, activating M2 and M3 muscarinic receptors to cause smooth muscle excitation and contraction. This review focuses on the cellular and molecular mechanisms underlying acetylcholine-induced depolarisation and smooth muscle contraction, as well as the effects of anticholinergic drugs on gastrointestinal motility. The knowledge gained from recent studies has greatly expanded our understanding of these processes.
Article
Neurosciences
Zhenlong Li, Hsien-Yu Peng, Chau-Shoun Lee, Tzer-Bin Lin, Ming-Chun Hsieh, Cheng-Yuan Lai, Han-Fang Wu, Lih-Chyang Chen, Mei-Ci Chen, Dylan Chou
Summary: Methylone shows significant efficacy in treating depression and social deficits, making it an ideal candidate for anti-depressant medication.
Article
Neurosciences
Aline Freyssin, Allison Carles, Sarra Guehairia, Gilles Rubinstenn, Tangui Maurice
Summary: This study explores the potential of combining FENM and S1R agonists in the treatment of Alzheimer's disease. The results showed that most FENM-based combinations can protect against learning deficits caused by A beta 25-35, with better efficacy in short-term memory.
Article
Neurosciences
J. D. Lorente, J. Cuitavi, L. Rullo, S. Candeletti, P. Romualdi, L. Hipolito
Summary: This study analyzed the effects of pain on negative affect in different sexes and time courses, as well as the involvement of the dynorphinergic and corticotropin releasing factor systems in these pain-related behaviors. The results showed sex and time-dependent anxiety- and anhedonia-like behaviors induced by pain in female rats. The recruitment of KOR/DYN in the NAc was identified as a key neurological substrate mediating pain-induced behavioral alterations.
Article
Neurosciences
Rongjun Liu, Daofan Sun, Xiuzhong Xing, Qingge Chen, Bo Lu, Bo Meng, Hui Yuan, Lan Mo, Liufang Sheng, Jinwei Zheng, Qiusheng Wang, Junping Chen, Xiaowei Chen
Summary: The coexistence of pain and depression is frequently observed in patients with chronic pain and depression. Oxytocin, a neuropeptide, has been reported to relieve chronic pain and depressive symptoms. This study investigated the effect of intranasal oxytocin on neuropathic pain and comorbid depressive symptoms, and found that oxytocin attenuated depression-like behavior but did not alleviate mechanical hyperalgesia. The results suggest that intranasal oxytocin may have the potential to treat depressive symptoms in neuropathic pain patients.