Article
Clinical Neurology
Hui Wang, Liang Liang, Can Yang, Ling Xiao, Huiling Wang, Gaohua Wang, Zhixian Zhu
Summary: This study found that low-density lipoprotein receptor-related protein 1 (LRP1) in the hippocampus of rats is positively correlated with depressive-like behaviors. Administration of LRP1 improved depressive-like behaviors, while LRP1 knockdown alleviated the inhibition of synaptic plasticity induced by chronic unpredicted mild stress (CUMS). Furthermore, LRP1 knockdown increased synaptic plasticity through microtubule dynamics and activation of the Akt/GSK-3 beta signaling pathway. These findings suggest that LRP1 may serve as a potential therapeutic target for depression.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Biochemistry & Molecular Biology
Marta Andres-Mach, Aleksandra Szewczyk, Miroslaw Zagaja, Joanna Szala-Rycaj, Marta Kinga Lemieszek, Maciej Maj, Michal Abram, Krzysztof Kaminski
Summary: The study discovered that the new compound C11 has a protective effect on astrocytes in vitro and beneficial effects on neurogenesis and cognitive functions in vivo, indicating the need for further research on its neuroprotective mechanisms.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Pharmacology & Pharmacy
Samuel S. Newton, Monica Sathyanesan
Summary: Cognitive deficits are common in psychiatric disorders, such as major depression and schizophrenia, and play a significant role in functional impairment. Targeted treatments for cognitive deficits are limited, with a need for more efficacious treatments. Erythropoietin (Epo) shows promising procognitive effects in psychiatric disorders, supporting a neurotrophic drug development approach.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Genevieve A. Secker, Natasha L. Harvey
Summary: The importance of lymphatic vessels in human diseases, the initiation of lymphatic vascular development during embryogenesis, and the role of VEGF/VEGFR signaling in driving the construction of lymphatic vessels were discussed in this review.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Clinical Neurology
Jiale Gao, Mingjiang Yao, Dennis Chang, Jianxun Liu
Summary: Ischemic stroke is a leading cause of morbidity and disability globally. The body's limited repair capacity makes the sequelae of serious neurological damage irreversible. However, endogenous neurogenesis induced by cerebral ischemia plays a critical role in the repair and regeneration of impaired neural cells after ischemic brain injury.
Article
Chemistry, Medicinal
Yu Li, Mei-Ling Wang, Bo Zhang, Xiao-Xu Fan, Qin Tang, Xue Yu, Li-Na Li, Ang-Ran Fan, Hong-Sheng Chang, Lan-Zhen Zhang
Summary: The study aimed to investigate the antidepressant-like effect and underlying mechanisms of ginsenoside Rd (GRd). The results showed that GRd significantly reversed depression-like behavior and promoted the expression of HIF-1 alpha signaling pathway and synaptic plasticity-related regulators. Molecular docking results also indicated significant binding affinity between GRd and HIF-1 alpha, VEGF, and VEGFR-2.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2022)
Article
Neurosciences
Domenico Ribatti, Diego Guidolin
Summary: Vascular and neuronal networks are formed through branching morphogenesis, and there is molecular crosstalk and common cues between nerves and blood vessels. Vascular endothelial growth factor (VEGF) affects the nervous system, while nerve growth factor (NGF) exhibits angiogenic properties. This study focuses on the morphogenesis and remodeling processes of vascular and neuronal networks.
BRAIN RESEARCH BULLETIN
(2022)
Review
Neurosciences
Xiansu Chi, Liuding Wang, Hongxi Liu, Yunling Zhang, Wei Shen
Summary: Post-stroke cognitive impairment is a major complication of stroke, characterized by cognitive dysfunction that directly affects quality of life. This review examines the pathological damage of stroke on synaptic plasticity, analyzes changes in synaptic plasticity in post-stroke cognitive impairment, and summarizes commonly used Chinese herbal drugs that can regulate synaptic plasticity. The review aims to establish the relationship between post-stroke cognitive impairment and synaptic plasticity, provide new insights for future exploration of its mechanism, compile evidence for the use of Chinese herbal drugs in treating post-stroke cognitive impairment, and lay the foundation for the development of novel formulas.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Hualing Peng, Jie Jia, Yisheng Lu, Hua Zheng
Summary: Isoflurane may treat schizophrenia by increasing the number of PV-positive GABAergic interneurons in the DG and repairing the abnormal NRG1-ErbB4 signaling, independent of PVI GABA release.
Review
Pharmacology & Pharmacy
Atrin Yousefizadeh, Gaia Piccioni, Amira Saidi, Viviana Triaca, Dalila Mango, Robert Nistico
Summary: This review discusses the pathophysiological roles of microglia in Alzheimer's disease and explores potential pharmacological intervention targets. It also provides evidence for microglia-targeted strategies in preclinical research and early clinical trials.
PHARMACOLOGICAL RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Chelcie F. Heaney, Sanjeev V. Namjoshi, Ayse Uneri, Eva C. Bach, Jeffrey L. Weiner, Kimberly F. Raab-Graham
Summary: Rapid antidepressants work by regulating FMRP expression in dendrites and modulating the mTORC1 pathway. The behavioral effects of Ro-25-6981 are dependent on FMRP expression and its differential mRNA binding controlled by mTORC1. In animal models with FXS, GABA(B)R activity can hinder the effects of Ro-25-6981, indicating a need for combined therapy targeting GABA(B)Rs and NMDARs in individuals with comorbid FXS and MDD.
MOLECULAR PSYCHIATRY
(2021)
Article
Biochemistry & Molecular Biology
Douglas A. Formolo, Thomas H. Lee, Jiasui Yu, Kangguang Lin, Gang Chen, Georg S. Kranz, Suk-Yu Yau
Summary: Sub-chronic treatment with AdipoRon has antidepressant- and anxiolytic-like effects in mice, independent of changes in hippocampal neurogenesis and synaptic plasticity.
Article
Neurosciences
Tonghui Su, Yi Lu, Chaoying Fu, Yang Geng, Yelin Chen
Summary: This study demonstrates that the loss of GluN2A in adult mouse brains can elicit strong antidepressant-like responses without causing psychomimetic effects similar to Ketamine. The antidepressant effects of Ketamine and MK-801 are mainly mediated by the suppression of GluN2A rather than GluN2B.
NATURE NEUROSCIENCE
(2023)
Article
Neurosciences
Tonghui Su, Yi Lu, Chaoying Fu, Yang Geng, Yelin Chen
Summary: The study found that the loss of GluN2A in adult mice elicits antidepressant-like responses without causing psychomimetic effects similar to ketamine. The antidepressant effects of ketamine and MK-801 are mediated by the suppression of GluN2A, not GluN2B. Additionally, these drugs increase the excitability of hippocampal neurons through GluN2A.
NATURE NEUROSCIENCE
(2023)
Article
Pharmacology & Pharmacy
Jiale Gao, Jianxun Liu, Mingjiang Yao, Wei Zhang, Bin Yang, Guangrui Wang
Summary: This study found that Notoginseng Saponins (PNS) can promote hippocampal neurogenesis by stimulating cell proliferation, migration, and differentiation activity, as well as modulating synaptic plasticity. Furthermore, it protects against cerebral ischemia injury through the upregulation of brain-derived neurotrophic factor (BDNF) expression and activation of the Akt/mTOR/p70S6K signaling pathway.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Ewa Obuchowicz, Anna Bielecka-Wajdman, Michel Zielinski, Grzegorz Machnik, Milosz Golyszny, Tomasz Ludyga
FRONTIERS IN PHARMACOLOGY
(2020)
Article
Neurosciences
Arkadiusz Liskiewicz, Marta Przybyla, Anna Wojakowska, Lukasz Marczak, Katarzyna Bogus, Marta Nowacka-Chmielewska, Daniela Liskiewicz, Andrzej Malecki, Jaroslaw Barski, Joanna Lewin-Kowalik, Michal Toborek
Article
Neurosciences
Marta Nowacka-Chmielewska, Daniela Liskiewicz, Arkadiusz Liskiewicz, Lukasz Marczak, Anna Wojakowska, Jaroslaw Jerzy Barski, Andrzej Malecki
Summary: The combination of the western diet and chronic stress exposure may lead to impairments of neuronal function and signaling, resulting in obesity and metabolic diseases.
NUTRITIONAL NEUROSCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Daniela Liskiewicz, Arkadiusz Liskiewicz, Mateusz Grabowski, Marta Maria Nowacka-Chmielewska, Konstancja Jablonska, Anna Wojakowska, Lukasz Marczak, Jaroslaw J. Barski, Andrzej Malecki
Summary: The study evaluated the influence of the ketogenic diet on hepatic autophagy, showing an upregulation of autophagy in animals fed with the diet. The magnitude of this effect appeared to vary depending on the diet composition. Additionally, markers of regulatory pathways linking the ketogenic diet to autophagy were measured, revealing treatment-specific effects such as an upregulation of SIRT1 and downregulation of FOXO3 and p53.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2021)
Article
Neurosciences
Daniela Liskiewicz, Arkadiusz Liskiewicz, Marta M. Nowacka-Chmielewska, Mateusz Grabowski, Natalia Pondel, Konstancja Grabowska, Sebastian Student, Jaroslaw J. Barski, Andrzej Malecki
Summary: Experimental and clinical data support the neuroprotective properties of the ketogenic diet and ketone bodies, with autophagy being a key mechanism for maintaining cell homeostasis. Recent studies suggest possible interconnections between ketone body metabolism and autophagy, indicating that the stimulation of autophagy may contribute to the neuroprotection provided by the ketogenic diet.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Review
Endocrinology & Metabolism
Milosz Golyszny, Ewa Obuchowicz, Michal Zielinski
Summary: This article reviews the direct or indirect effects of neuropeptides on the hypothalamus-pituitary-gonadal (HPG) axis and discusses their role in stress-induced infertility. The reviewed literature suggests that neuropeptides may contribute to new pathophysiological mechanisms leading to fertility disturbances induced by stress.
Article
Nutrition & Dietetics
Marta Maria Nowacka-Chmielewska, Daniela Liskiewicz, Konstancja Grabowska, Arkadiusz Liskiewicz, Lukasz Marczak, Anna Wojakowska, Natalia Pondel, Mateusz Grabowski, Jaroslaw Jerzy Barski, Andrzej Malecki
Summary: The study highlighted the impact of simultaneous exposure to a Western diet and wheel-running on the cerebrocortical protein expression and brain metabolism-related proteins in female rats. Wheel-running was found to reverse the decline in protein levels, indicating its potential benefits in mitigating the effects of unhealthy dietary habits on brain function.
Article
Neurosciences
Milosz Golyszny, Michal Zielinski, Monika Paul-Samojedny, Lukasz Filipczyk, Artur Palasz, Ewa Obuchowicz
Summary: Maternal separation leads to anxiety and depressive behavior, endocrine stress response, and up-regulation of the hypothalamic orexinergic system in adult rats. Escitalopram increases the activity of the hypothalamic orexin system in control rats, but has no effect on the MS group. The disturbed signaling of the orexin pathway may contribute to the harmful long-term consequences of early-life stress.
NEUROSCIENCE RESEARCH
(2022)
Article
Nutrition & Dietetics
Maria Marta Nowacka-Chmielewska, Daniela Liskiewicz, Arkadiusz Liskiewicz, Marta Przybyla, Lukasz Marczak, Anna Wojakowska, Konstancja Grabowska, Mateusz Grabowski, Jaroslaw Jerzy Barski, Andrzej Malecki
Summary: This study used a global brain proteome approach to investigate protein alterations after exposure to a Western diet and/or stress. The results showed that consuming a Western diet led to obesity and changes in serum metabolic parameters. Chronic stress had a significant impact on protein alterations, with 86.3% of detected proteins being down-regulated. However, feeding with a specific diet modified the effects of stress on the brain proteome.
Review
Biochemistry & Molecular Biology
Marta Nowacka-Chmielewska, Konstancja Grabowska, Mateusz Grabowski, Patrick Meybohm, Malgorzata Burek, Andrzej Malecki
Summary: Regular physical activity has positive effects on the central nervous system, increasing stress resilience, improving mood and cognitive abilities, reducing inflammation, and showing potential in preventing and treating neurologic diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Environmental Sciences
Agnieszka Nawrat-Szoltysik, Marta Sieradzka, Marta Nowacka-Chmielewska, Laura Piejko, Julia Duda, Anna Brachman, Anna Polak
Summary: This study found that Whole Body Vibration Training (WBVT) has an impact on selected fall risk factors in women aged 60+ at fall risk, improving gait, balance, exercise tolerance, and functional strength.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Medicine, General & Internal
Danuta Loboda, Beata Sarecka-Hujar, Jacek Wilczek, Michal Gibinski, Wioleta Zielinska-Danch, Izabela Szoltysek-Boldys, Elzbieta Paradowska-Nowakowska, Marta Nowacka-Chmielewska, Mateusz Grabowski, Mateusz Lejawa, Andrzej Malecki, Krzysztof S. Golba
Summary: This study investigated the cardiac status of convalescents after COVID-19 and assessed the 10-year risk of ASCVD events using the SCORE2 and SCORE2-OP algorithms. The results showed that 20.7% of men and 17.7% of women had cardiac complications during acute COVID-19, and after 4 months, 16.7% of men and 9.7% of women had echocardiographic abnormalities. Additionally, the prevalence of ASCVD was higher in men compared to women.
POLISH ARCHIVES OF INTERNAL MEDICINE-POLSKIE ARCHIWUM MEDYCYNY WEWNETRZNEJ
(2023)
Article
Neurosciences
Milosz Golyszny, Michal Zielinski, Monika Paul-Samojedny, Artur Palasz, Ewa Obuchowicz
Summary: This study investigated the effects of long-term treatment with escitalopram or venlafaxine on the Neuropeptide S (NPS) system under stress conditions. The results showed that these antidepressants affect the NPS system differently, suggesting that the NPS system may partially mediate the pharmacological effects of these drugs.
Article
Oncology
Anna M. Bielecka-Wajdman, Tomasz Ludyga, Daria Smyk, Wojciech Smyk, Magdalena Mularska, Patrycja Swiderek, Wojciech Majewski, Christina Susanne Mullins, Michael Linnebacher, Ewa Obuchowicz
Summary: The weakness of glucose metabolism is found to be related to the invasiveness and growth of GBM. DXM may support GBM energy metabolism and contribute to its recurrence. Under low oxygen and high glucose conditions, the study shows that DXM attenuates the cytotoxic effect of TMZ and intensifies malignancy features in GBM cell lines. A preliminary retrospective analysis indicates a correlation between serum glucose levels and Ki-67 expression in GBM patients.
Meeting Abstract
Nutrition & Dietetics
Arkadiusz Liskiewicz, Lukasz Marczak, Marta Przybyla, Anna Slugocka, Daniela Liskiewicz, Marta Nowacka-Chmielewska, Sebastian Student, Katarzyna Bogus, Andrzej Malecki, Joanna Lewin-Kowalik
PROCEEDINGS OF THE NUTRITION SOCIETY
(2020)
Article
Endocrinology & Metabolism
Andreia Biolchi Mayer, Henrique de Oliveira Amaral, Danilo Gustavo R. de Oliveira, Gabriel Avohay Alves Campos, Priscilla Galante Ribeiro, Solange Cristina Rego Fernandes, Adolfo Carlos Barros de Souza, Raffael Hinio Araijo de Castro, Anamelia Lorenzetti Bocca, Marcia Renata Mortari
Summary: This study synthesized three bioinspired peptides based on fraternine and tested their effects in a Parkinson's disease model. The peptides fra-10 and fra-14 improved motor coordination, but most of the peptides were toxic at the applied doses. All three peptides reduced the intensity of lesion-induced rotations. The peptide fra-24 increased the number of TH+ neurons in the substantia nigra and reduced the concentration of the cytokine TNF-alpha, suggesting it has neuroprotective effects in Parkinson's disease.