Article
Pharmacology & Pharmacy
Momoko Kawabe, Takumi Nishida, Chihoko Horita, Asami Ikeda, Ryuji Takahashi, Akio Inui, Kazuhiro Shiozaki
Summary: Sociability is crucial for human and other vertebrates' communication. This study investigated the effect of Ninjinyoeito (NYT), a traditional Japanese herbal medicine, on low sociability in NPY-KO zebrafish. The results showed that NPY-KO zebrafish fed with NYT exhibited increased social interaction, decreased phosphorylation of ERK, and suppression of certain neuronal genes. Additionally, two specific herbs, Cinnamon Bark and Polygala Root, were identified to have similar effects as NYT.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Biology
Daniel Assan, Umar Farouk Mustapha, Huapu Chen, Zhiyuan Li, Yuhao Peng, Guangli Li
Summary: The Neuropeptide Y family, including Npy and Pyy, has been extensively studied in fish to understand mechanisms related to feeding, heart activity, and emotional regulation. These studies aid in determining feeding regimes and growth in aquaculture settings.
Article
Multidisciplinary Sciences
Nao Horio, Stephen D. Liberles
Summary: This study reveals a neuronal mechanism by which hunger selectively enhances attraction to food odors over other olfactory cues. Specifically, activation of hypothalamic AGRP neurons promotes food odor preference, which is mediated by neuropeptide Y release in the thalamus.
Review
Veterinary Sciences
Elizabeth S. Greene, Nedra Abdelli, Jalila S. Dridi, Sami Dridi
Summary: This review provides an overview of the expression and regulatory effects of neuropeptide Y (NPY) in both the central and peripheral nervous systems, with a special emphasis on the distribution and function of peripherally expressed NPY. While there have been extensive studies on centrally expressed NPY, more research is needed to fully understand the functions of peripherally expressed NPY, especially in non-mammalian species.
VETERINARY SCIENCES
(2022)
Article
Nutrition & Dietetics
Yermek Rakhat, Kentaro Kaneko, Lei Wang, Wanxin Han, Yutaka Seino, Daisuke Yabe, Toshihiko Yada
Summary: d-allulose can suppress hunger-associated feeding and inhibit hunger-promoting neurons in the hypothalamic arcuate nucleus.
Article
Nutrition & Dietetics
Isabel van Ackern, Angela Kuhla, Bjoern Kuhla
Summary: The endocannabinoid system is crucial in regulating food intake, with pharmacological activation increasing intake in energy-deficient stages, particularly in intermittent feeders. Injection of 2-AG and AEA can boost food intake in the short term, with varying responses to food deprivation, 2-AG showing higher sensitivity than AEA.
Article
Endocrinology & Metabolism
Franco Barrile, Daniela Cassano, Gimena Fernandez, Pablo N. De Francesco, Mirta Reynaldo, Sonia Cantel, Jean-Alain Fehrentz, Jose Donato Jr, Helgi B. Schioth, Jeffrey M. Zigman, Mario Perello
Summary: This study found that ghrelin receptor (GHSR) is widely distributed in the mouse lateral hypothalamic area (LHA), mediating the effects of ghrelin on food intake. Local injections of ghrelin in LHA increase food intake and locomotor activity through the indirect recruitment of orexin neurons in LHA and activation of neurons in the arcuate nucleus (ARH). These findings provide a neuroanatomical and functional characterization of LHA GHSR neurons and their important role in regulating food intake.
PSYCHONEUROENDOCRINOLOGY
(2023)
Article
Entomology
Bin Liu, Danyang Fu, Hang Ning, Ming Tang, Hui Chen
Summary: The Chinese white pine beetle, Dendroctonus armandi, is a destructive pest of coniferous forests in the middle Qinling Mountains of China. Research has shown that its food intake is regulated by the sNPF signaling pathway, and RNA interference knockdown of sNPF and sNPFR significantly increased mortality, reduced food intake, and body weight.
Article
Physiology
Bin Liu, Danyang Fu, Haiming Gao, Hang Ning, Yaya Sun, Hui Chen, Ming Tang
Summary: The study cloned NPF precursor and receptor genes in Chinese white pine beetle, finding that the NPF signaling pathway plays a significant positive role in regulating food intake, providing a potential target for sustainable management of this pest.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Behavioral Sciences
E. -M. Kim, J. G. Quinn, R. E. Reid, E. O'Hare
Summary: This study examined the interaction between melanocortin in the nucleus of the solitary tract (NTS) and neuropeptide Y (NPY) in the paraventricular nucleus of the hypothalamus (PVN), showing an antagonistic effect of melanocortin on NPY-induced feeding.
Article
Multidisciplinary Sciences
Philippe A. Melas, Malin Wirf, Helder Andre, Nitya Jayaram-Lindstrom, Aleksander A. Mathe, Pia Steensland
Summary: This study investigated the effects of a drug (OSU) on anxiety-like behaviors following long-term drinking in a genetic rat model, and found that OSU not only attenuated alcohol-mediated behaviors but also significantly reduced anxiety-like behaviors, suggesting further clinical evaluation is warranted.
SCIENTIFIC REPORTS
(2021)
Article
Neurosciences
Devika S. Bodas, Aditi Maduskar, Tarun Kaniganti, Debia Wakhloo, Akilandeswari Balasubramanian, Nishikant Subhedar, Aurnab Ghose
Summary: The internal energy stores adaptively regulate feeding-associated behaviors and integrate opposing hunger and satiety signals at the level of neural circuits. The activities of the neuropeptides CART and NPY converge on a population of neurons in the Dm to generate nutritional state-dependent circuit plasticity. CART facilitates glutamatergic neurotransmission, while NPY dampens the response to glutamate. The opposing actions of satiety and hunger signals induce a behavioral switch correlated with the convergent integration of CART and NPY inputs by the Dm neurons.
JOURNAL OF NEUROSCIENCE
(2023)
Article
Endocrinology & Metabolism
Momoko Kawabe, Akito Hayashi, Masaharu Komatsu, Akio Inui, Kazuhiro Shiozaki
Summary: Excessive mental or physical stress-induced anxiety is closely linked to the development of psychiatric diseases. Kampo medicines, particularly Ninjinyoeito (NYT), have shown promise as antidepressants due to their synergistic effects. NYT was found to significantly reduce anxiety behaviors in neuropeptide Y-knockout zebrafish, potentially attributed to the compound schizandrin.
Article
Cell Biology
Ke Lu, Xiaodan Jia, Jiaqi Wu, Qiuling Wang, Xu-Fang Liang
Summary: In this study, a npy2r-deficient medaka model was established using the CRISPR/Cas9 system. The deletion of npy2r resulted in an all-male medaka population and increased food intake. It also led to significant changes in the expression levels of appetite stimulating and anorexia factors. Moreover, npy2r deletion improved sociability and reduced anxiety-like behavior in medaka, accompanied by decreased expression levels of anxiety-related genes.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Joyce Dos Reis Lima, Maria Kueirislene Amancio Ferreira, Ketelly Vanessa Barros Sales, Antonio Wlisses da Silva, Emanuelle Machado Marinho, Francisco Ernani Alves Magalhaes, Emmanuel Silva Marinho, Marcia Machado Marinho, Matheus Nunes da Rocha, Paulo Nogueira Bandeira, Alexandre Magno Rodrigues Teixeira, Jane Eire Silva Alencar de Menezes, Helcio Silva dos Santos
Summary: This study evaluated the anxiolytic potential of the clerodine-type diterpene CBWS isolated from Croton blanchetianus in adult zebrafish. The results indicated that CBWS has anxiolytic effects mediated by serotonergic and anti-acetylcholinesterase actions. The study also suggested the involvement of 5-HTR1 and 5-HTR2A/2C receptors in the low anticonvulsant effect of CBWS.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2022)
Article
Endocrinology & Metabolism
Andreia Biolchi Mayer, Henrique de Oliveira Amaral, Danilo Gustavo R. de Oliveira, Gabriel Avohay Alves Campos, Priscilla Galante Ribeiro, Solange Cristina Rego Fernandes, Adolfo Carlos Barros de Souza, Raffael Hinio Araijo de Castro, Anamelia Lorenzetti Bocca, Marcia Renata Mortari
Summary: This study synthesized three bioinspired peptides based on fraternine and tested their effects in a Parkinson's disease model. The peptides fra-10 and fra-14 improved motor coordination, but most of the peptides were toxic at the applied doses. All three peptides reduced the intensity of lesion-induced rotations. The peptide fra-24 increased the number of TH+ neurons in the substantia nigra and reduced the concentration of the cytokine TNF-alpha, suggesting it has neuroprotective effects in Parkinson's disease.
