期刊
NEUROPEPTIDES
卷 43, 期 5, 页码 397-400出版社
CHURCHILL LIVINGSTONE
DOI: 10.1016/j.npep.2009.08.005
关键词
GHRH; Neuroendocrine tumors; VEGF; Chromogranin A; Angiogenesis
资金
- European Cooperation [CM0602]
- Polish Ministry of Science and Higher Education
Growth hormone-releasing hormone (GHRH) and its receptors have been implicated in a variety of cellular processes like cell survival, proliferation, apoptosis, angiogenesis and neoplastic transformation of various non-pituitary tissues. Here, we investigated for the first time the in vitro effect of GHRH(1-29)NH2 on the proliferation and the secretion of vascular endothelial growth factor (VEGF) and chromogranin A by the human bronchial neuroendocrine tumor cells NCI-H727. GHRH(1-29)NH2 at the concentrations of 10(-8)-10(-6) M increased the proliferation of these cells and this effect was associated with a statistically significant increase in VEGF and chromogranin A secretion into the supernatants of the tested cells. Our findings indicate that GHRH functions as a trophic hormone for bronchial neuroendocrine (NET) tumors. (C) 2009 Elsevier Ltd. All rights reserved.
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