Article
Health Care Sciences & Services
Keren Nitzan, Roni Toledano, Shiran Shapira, Nadir Arber, Ravid Doron
Summary: The study found that CD24 knockout mice exhibited better cognitive performance and less anxiety-like behavior compared to wild-type mice, with no effect on depression-like behavior. This phenotype remained constant from childhood to adulthood.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Danielle M. Diniz, Francesca Calabrese, Paola Brivio, Marco A. Riva, Joanes Grandjean, Judith R. Homberg
Summary: BDNF plays a crucial role in neuroplasticity, vulnerability and resilience to stress-related disorders. Modulation of BDNF levels in the ventral hippocampus of SERT-/- rats led to positive behavioral outcomes, suggesting BDNF upregulation as a potential target for new therapeutic approaches in improving depressive symptoms.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Psychiatry
Chao Ciu-Gwok Guo, Tao He, Joanes Grandjean, Judith Homberg
Summary: In the study, it was discovered that 5-HTT KO rats processed visual information faster than WT rats during outcome generalization, while showing less ability to update changes in information during stimulus generalization. This suggests that KO 5-HTT modulates information processing when the environment changes.
TRANSLATIONAL PSYCHIATRY
(2021)
Article
Cell Biology
Jose Erik Alvarez-Contino, Estela Diaz-Sanchez, Marina Mirchandani-Duque, Jose Andres Sanchez-Perez, Miguel A. Barbancho, Alexander Lopez-Salas, Natalia Garcia-Casares, Kjell Fuxe, Dasiel O. Borroto-Escuela, Manuel Narvaez
Summary: This study found that intranasal infusion of GALR2 and Y1R agonists promotes neuroblast proliferation and induces the expression of the neurotrophic factor BDNF in the ventral hippocampus, resulting in antidepressant effects. These effects may be mediated by increased formation of Y1R-GALR2 heteroreceptor complexes. These findings may provide a new approach for the development of novel therapies for major depressive disorder.
JOURNAL OF CELLULAR PHYSIOLOGY
(2023)
Article
Multidisciplinary Sciences
Mahsa Rezazadegan, Farnaz Shahdadian, Maryam Soheilipour, Mohammad Javad Tarrahi, Reza Amani
Summary: This study found that IBS-D patients had lower serum zinc levels compared to the control group, and patients scored higher in depression, anxiety, and stress, with lower overall quality of life, physical and psychological health than controls. Dietary zinc intake was positively correlated with psychological health in controls.
SCIENTIFIC REPORTS
(2022)
Article
Public, Environmental & Occupational Health
Francisco-Javier Ruiz, Pilar A. Saiz, Maria Paz Garcia-Portilla, Leticia Gonzalez-Blanco, Leticia Garcia-Alvarez, Paula Zurron Madera, Maria Teresa Bobes-Bascaran, Luis Jimenez Trevino, Mercedes Valtuena Garcia, Clara Martinez Cao, Ainoa Garcia Fernandez, Julia Rodriguez Revuelta, Carlota Moya Lacasa, Francesco Dal Santo, Gonzalo Paniagua Calzon, Maria Suarez Alvarez, Maria Teresa Bascaran Fernandez, Elisa Seijo Zazo, Celso Iglesias Garcia, Eduardo Fonseca Pedrero, Rosa Molina Ruiz, Julio Bobes
Summary: A study found that during the COVID-19 pandemic, the prevalence of anxiety and stress gradually increased, while depression remained relatively stable. Women and young people had a higher probability of experiencing depression, anxiety, or stress. However, in the last survey, depression and stress decreased among young people while anxiety and stress significantly increased among older adults.
JOURNAL OF GLOBAL HEALTH
(2022)
Article
Clinical Neurology
Janine V. Olthuis, Kara Thompson, Margo C. Watt, Sherry H. Stewart
Summary: High anxiety sensitivity (AS) is associated with functional impairment through a chained indirect pathway involving anxiety symptoms and depression symptoms, but not through unhealthy coping behaviours. This cross-sectional study highlights the importance of reducing AS and addressing depressive symptoms for improving clients' functioning.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Multidisciplinary Sciences
Qinglan Ding, Mark Daniel Ward, Nancy Edwards, Emily Anna Wu, Susan Kersey, Marjorie Funk
Summary: This study investigated the prevalence and risk factors of mental and general health symptoms among university students attending in-person and online classes during COVID-19. It found that university students attending classes during the pandemic are experiencing negative mental health impacts, and many found it challenging to comply with COVID-19 policies.
Article
Multidisciplinary Sciences
Daria A. Pawlak, Arash Sahraie
Summary: The accurate placement of events on a timeline is often a challenge, particularly for distant past events. In a study conducted with 277 participants in May 2022, it was found that participants made more errors in recalling the timeline of distant events compared to more recent ones. Surprisingly, there was also a significant error in estimating the timing of events that occurred in 2021, similar to events that happened 3 to 4 years earlier. This error in perception of event timeline was associated with levels of depression, anxiety, resilience, and the demands of the COVID pandemic.
Article
Psychology, Multidisciplinary
Khalaf Kridin, Jennifer E. Hundt, Ralf J. Ludwig, Yochai Schonmann, Arnon D. Cohen
Summary: A history of anxiety, depression, and anxiety-depression comorbidity predisposes individuals to bullous pemphigoid (BP), while patients with BP are at an increased risk of depression. Female BP patients are more likely to develop depression and anxiety.
CURRENT PSYCHOLOGY
(2022)
Article
Sport Sciences
Manzur Kader, Bjorn Pasternak, Carl-Emil Lim, Martin Neovius, Magnus Forssblad, Henrik Svanstroem, Jonas F. Ludvigsson, Peter Ueda
Summary: According to a nationwide cohort study in Sweden, male elite football players have a lower risk of depression, anxiety-related disorders, and suicide compared to the general population.
BRITISH JOURNAL OF SPORTS MEDICINE
(2023)
Article
Obstetrics & Gynecology
Brian G. Danaher, John R. Seeley, Richard K. Silver, Milagra S. Tyler, J. Jo Kim, Laura M. La Porte, Emily Cleveland, David R. Smith, Jeannette Milgrom, Jeff M. Gau
Summary: Depression is a common complication of childbirth, but most affected women go untreated. This study evaluated the effectiveness of an eHealth program, MomMoodBooster2, combined with universal depression screening and referral, as a treatment option for perinatal women with depression. Results showed that the eHealth program was effective in reducing depression severity and stress among perinatal women, and it was well-accepted by program users.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2023)
Article
Public, Environmental & Occupational Health
Joseph Maffly-Kipp, Nikolett Eisenbeck, David F. Carreno, Joshua Hicks
Summary: This study found that mental health disparities are greater in countries with more severe COVID-19 outbreaks, with subjective SES, gender, and age as contributing factors. These findings are crucial for understanding the global impact of the ongoing pandemic and its implications for collective trauma.
SOCIAL SCIENCE & MEDICINE
(2021)
Article
Clinical Neurology
Afagh Garjani, Rodden M. Middleton, Richard Nicholas, Nikos Evangelou
Summary: This study aims to understand the recovery process from COVID-19 among patients with MS and identify predictors, including patients' pre-COVID-19 physical and mental health status. The findings suggest that patients with preexisting severe neurologic impairment or mental health problems are less likely to recover from COVID-19.
NEUROLOGY-NEUROIMMUNOLOGY & NEUROINFLAMMATION
(2022)
Article
Neurosciences
Hirotaka Shoji, Kazutaka Ikeda, Tsuyoshi Miyakawa
Summary: This study investigated the effects of 5-HTT deficiency on behavior, gut microbiota, and brain c-Fos expression. The findings revealed abnormal behaviors including decreased locomotor activity, reduced pain sensitivity, increased anxiety and depression-related behavior, and altered gut microbiota composition in 5-HTT-/- mice. The expression of c-Fos in certain brain regions was also different from normal. These results indicate that 5-HTT-/- mice serve as a valid animal model to study anxiety and depression.
Article
Multidisciplinary Sciences
Manuel Sanchez-Alavez, William Nguyen, Simone Mori, Gianluca Moroncini, Andreu Viader, Daniel K. Nomura, Benjamin F. Cravatt, Bruno Conti
Article
Multidisciplinary Sciences
Daisuke Ogasawara, Hui Deng, Andreu Viader, Marc P. Baggelaar, Arjen Breman, Hans den Dulk, Adriann M. C. H. van den Nieuwendijk, Marjolein Soethoudt, Tom van der Wel, Juan Zhou, Herman S. Overkleeft, Manuel Sanchez-Alavez, Simone Mo, William Nguyen, Bruno Conti, Xiaojie Liu, Yao Chen, Qing-song Liu, Benjamin F. Cravatt, Mario van der Stelt
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2016)
Article
Biochemistry & Molecular Biology
Jennifer M. Spaethling, Manuel Sanchez-Alavez, JaeHee Lee, Feng C. Xia, Hannah Dueck, Wenshan Wang, Stephen A. Fisher, Jai-Yoon Sul, Patrick Seale, Junhyong Kim, Tamas Bartfai, James Eberwine
Article
Psychology, Biological
Manuel Sanchez-Alavez, Cindy L. Ehlers
INTERNATIONAL JOURNAL OF PSYCHOPHYSIOLOGY
(2016)
Article
Neurosciences
Walter Francesconi, Manuel Sanchez-Alavez, Fulvia Berton, Silvia Alboni, Cristina Benatti, Simone Mori, William Nguyen, Eric Zorrilla, Gianluca Moroncini, Fabio Tascedda, Bruno Conti
JOURNAL OF NEUROSCIENCE
(2016)
Correction
Multidisciplinary Sciences
Daisuke Ogasawara, Hui Deng, Andreu Viader, Marc P. Baggelaar, Arjen Breman, Hans den Dulk, Adrianus M. C. H. van den Nieuwendijk, Marjolein Soethoudt, Tom van der Wel, Juan Zhou, Herman S. Overkleeft, Manuel Sanchez-Alavez, Simone Mori, William Nguyen, Bruno Conti, Xiaojie Liu, Yao Chen, Qing-song Liu, Benjamin F. Cravatt, Mario van der Stelt
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2016)
Article
Biology
Andreu Viader, Daisuke Ogasawara, Christopher M. Joslyn, Manuel Sanchez-Alavez, Simone Mori, William Nguyen, Bruno Conti, Benjamin F. Cravatt
Article
Immunology
Simone Mori, Shuei Sugama, William Nguyen, Tatiana Michel, M. Germana Sanna, Manuel Sanchez-Alavez, Rigo Cintron-Colon, Gianluca Moroncini, Yoshihiko Kakinuma, Pamela Maher, Bruno Conti
JOURNAL OF NEUROINFLAMMATION
(2017)
Article
Multidisciplinary Sciences
Rigo Cintron-Colon, Manuel Sanchez-Alavez, William Nguyen, Simone Mori, Ruben Gonzalez-Rivera, Tiffany Lien, Tamas Bartfai, Saba Aid, Jean-Christophe Francois, Martin Holzenberger, Bruno Conti
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2017)
Article
Substance Abuse
Manuel Sanchez-Alavez, Derek N. Wills, Leslie Amodeo, Cindy L. Ehlers
ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH
(2018)
Article
Clinical Neurology
Manuel Sanchez-Alavez, Jessica Benedict, Derek N. Wills, Cindy L. Ehlers
Article
Substance Abuse
Manuel Sanchez-Alavez, William Nguyen, Simone Mori, Derek N. Wills, Dennis Otero, Carlos A. Aguirre, Mona Singh, Cindy L. Ehlers, Bruno Conti
ALCOHOL-CLINICAL AND EXPERIMENTAL RESEARCH
(2019)
Article
Substance Abuse
Leslie R. Amodeo, Derek N. Wills, Manuel Sanchez-Alavez, Cindy L. Ehlers
ALCOHOL-CLINICAL AND EXPERIMENTAL RESEARCH
(2020)
Article
Biochemistry & Molecular Biology
Carlos Guijas, J. Rafael Montenegro-Burke, Rigo Cintron-Colon, Xavier Domingo-Almenara, Manuel Sanchez-Alavez, Carlos A. Aguirre, Kokila Shankar, Erica L-W Majumder, Elizabeth Billings, Bruno Conti, Gary Siuzdak
Article
Clinical Neurology
Cristian O. Mancilla-Corona, Manuel Sanchez-Alavez, Gisela Pineda-Garcia, Julieta Y. Islas-Limon, Oscar E. Zazueta, Jonathan Lopez-Baena, Jesus I. Rodriguez-Vasquez, Idanya R. Serafin-Higuera
Summary: Fatigue has been identified as a persistent condition following COVID-19 infection, affecting cognitive function and performance. This study aimed to investigate the impact of post-COVID fatigue on neuropsychological performance. Participants with post-COVID fatigue and age-matched controls were randomly selected from a database. Both groups completed a health survey and a neuropsychological assessment test via telephone call. Statistical analysis revealed significant regression coefficients between post-COVID fatigue and global parameters of the assessment, indicating a decrease in neuropsychological performance.
EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE
(2023)
Article
Endocrinology & Metabolism
Andreia Biolchi Mayer, Henrique de Oliveira Amaral, Danilo Gustavo R. de Oliveira, Gabriel Avohay Alves Campos, Priscilla Galante Ribeiro, Solange Cristina Rego Fernandes, Adolfo Carlos Barros de Souza, Raffael Hinio Araijo de Castro, Anamelia Lorenzetti Bocca, Marcia Renata Mortari
Summary: This study synthesized three bioinspired peptides based on fraternine and tested their effects in a Parkinson's disease model. The peptides fra-10 and fra-14 improved motor coordination, but most of the peptides were toxic at the applied doses. All three peptides reduced the intensity of lesion-induced rotations. The peptide fra-24 increased the number of TH+ neurons in the substantia nigra and reduced the concentration of the cytokine TNF-alpha, suggesting it has neuroprotective effects in Parkinson's disease.