期刊
NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY
卷 39, 期 5, 页码 458-484出版社
WILEY
DOI: 10.1111/nan.12020
关键词
amyotrophic lateral sclerosis; autism; multiple sclerosis; Parkinson's disease; schizophrenia; vitamin D
资金
- AANF/CMSC John F. Kurtzke Clinician-Scientist Award
- a Goodger Scholarship (University of Oxford)
- NIHR Biomedical Research Centre, Oxford
Vitamin D and its metabolites have pleomorphic roles in both nervous system health and disease. Animal models have been paramount in contributing to our knowledge and understanding of the consequences of vitamin D deficiency on brain development and its implications for adult psychiatric and neurological diseases. The conflation of in vitro, ex vivo, and animal model data provide compelling evidence that vitamin D has a crucial role in proliferation, differentiation, neurotrophism, neuroprotection, neurotransmission, and neuroplasticity. Vitamin D exerts its biological function not only by influencing cellular processes directly, but also by influencing gene expression through vitamin D response elements. This review highlights the epidemiological, neuropathological, experimental and molecular genetic evidence implicating vitamin D as a candidate in influencing susceptibility to a number of psychiatric and neurological diseases. The strength of evidence varies for schizophrenia, autism, Parkinson's disease, amyotrophic lateral sclerosis, Alzheimer's disease, and is especially strong for multiple sclerosis.
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