Article
Biology
Ji Xu, Bruce J. Nicholson
Summary: This study investigated the characteristics of Cx30 hemichannels using heterologous expression systems. It was found that Cx30 hemichannels are sensitive to voltage and extracellular Ca2+ and show minimal selectivity for small ions but increased permeability for larger anions. Comparison with Cx26 gap junctions in the cochlea revealed differences in ATP permeability, indicating distinct physiological functions of Cx30 and Cx26 in energy distribution.
Article
Biochemistry & Molecular Biology
Guobin Li, Lan Zhang, Zhe Lu, Baoqiang Yang, Hui Yang, Peng Shang, Jean X. Jiang, Dong'en Wang, Huiyun Xu
Summary: The roles of Cx43-based gap junctions and hemichannels in bone and muscle aging are investigated in this study, which found that enhancement of Cx43 hemichannels reduces bone mass and promotes muscle collagen synthesis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Multidisciplinary
Sin Hang Crystal Chan, Jarred M. Griffin, Connor A. Clemett, Margaret A. Brimble, Simon J. O'Carroll, Paul W. R. Harris
Summary: Peptide5 is a mimetic peptide with 12 amino acids that plays an important role in cell-to-cell communication. In order to improve its activity and stability, twenty-five novel mimetics were designed and synthesized. The results showed that one variant, H-VDCFLSRPTE-N-MeKT-OH, exhibited good activity and stability.
FRONTIERS IN CHEMISTRY
(2022)
Article
Cell Biology
Guobin Li, Lan Zhang, Kaiting Ning, Baoqiang Yang, Francisca M. Acosta, Peng Shang, Jean X. Jiang, Huiyun Xu
Summary: The study revealed that inhibition of different types of Cx43 channels has different effects on bone-muscle crosstalk: inhibition of osteocytic Cx43 HCs decreases fast-twitch muscle mass, while blockage of Cx43 GJ results in decreased fast-twitch muscle contractile force and myogenesis.
Article
Medicine, General & Internal
Louis Gerard Mercuri
Summary: The purpose of this article is to address the misconceptions and challenges surrounding TMJ disorders, and to provide evidence-based information. To fully appreciate the content, readers must have a open-minded approach and be willing to embrace new concepts based on the evolving evidence.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Nutrition & Dietetics
Reem S. S. Alazragi, Hanadi M. M. Baeissa
Summary: This study aimed to examine the anti-arthritic properties of grapefruit juice and found that it can reduce inflammation levels, slow down cartilage degradation, and improve joint function.
Article
Biochemistry & Molecular Biology
Wen Yin, Li Liu, Yuxi Zhou, Yunchun Zhang, Dexu Kong, Saihong Xu, Dan Tang, Dan Huang, Daxiang Wen, Yingfu Jiao, Yinghui Fan, Po Gao, Weifeng Yu
Summary: The study showed that CFA treatment suppressed behaviors and calcium responses associated with TRPV1-mediated histamine-dependent itch and TRPA1-mediated histamine-independent itch. Furthermore, CFA treatment increased nociceptive DRG neurons but decreased most known pruriceptors, which may explain itch suppression. This study suggested a unified adaptive change of increased pain and decreased itch under CFA-induced inflammatory conditions.
ACTA BIOCHIMICA ET BIOPHYSICA SINICA
(2021)
Article
Biochemistry & Molecular Biology
Yu-ting Wang, Kai Lu, Dan-dan Yao, Shu-xia Zhang, Gang Chen
Summary: In this study, Forsythoside B (FB) from Forsythia suspensa was found to be effective in relieving chronic inflammatory pain and exhibited anti-anxiety effects. The mechanisms involved the reduction of proinflammatory cytokines and modulation of microglia and astrocytes activation.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Biotechnology & Applied Microbiology
Prince Allawadhi, Amit Khurana, Nilofer Sayed, Chandraiah Godugu, Divya Vohora
Summary: This study assessed the mechanistic effects of cerium oxide nanoparticles (CONPs) on rheumatoid arthritis and found that CONPs exhibited anti-rheumatoid arthritis activity both in vitro and in vivo.
Article
Chemistry, Medicinal
Amany Belal, Rehab Mahmoud, Mohamed Taha, Fatma Mohamed Halfaya, Ahmed Hassaballa, Esraa Salah Elbanna, Esraa Khaled, Ahmed Farghali, Fatma I. Abo El-Ela, Samar M. Mahgoub, Mohammed M. Ghoneim, Mohamed Y. Zaky
Summary: The therapeutic potential of a novel zeolite/vitamin B12 nanocomposite (Nano ZT/Vit B12) in complete Freund's adjuvant (CFA)-induced arthritis was assessed in this study. The results showed that Nano ZT/Vit B12 exhibited anti-arthritic, anti-inflammatory, and antioxidant activities, and significantly improved CFA-induced joint injuries. Therefore, Nano ZT/Vit B12 may be a promising option for the future treatment of rheumatoid arthritis.
Article
Pharmacology & Pharmacy
Muhammad Asif Faheem, Tasleem Akhtar, Nadia Naseem, Usman Aftab, Muhammad Shoaib Zafar, Safdar Hussain, Muhammad Shahzad, Glenda Carolyn Gobe
Summary: The study evaluated the anti-arthritic activity of chrysin and compared it with the non-steroidal anti-inflammatory agent, piroxicam. Results showed that chrysin significantly reduced arthritis score, inflammatory cells, erythrocyte sedimentation rate, and rheumatoid factor. Chrysin also regulated the mRNA levels of tumor necrosis factor, nuclear factor kappa-B, and toll-like recepter-2, and increased anti-inflammatory cytokines interleukin-4 and -10, thereby reducing the severity of arthritis.
Review
Medicine, General & Internal
Felix Jose Amarista, Daniel E. Perez
Summary: The treatment of severe temporomandibular joint disorders and associated skeletal discrepancies is a complex challenge for oral and maxillofacial surgeons. It is important to address these disorders prior to or in conjunction with orthodontic or surgical interventions to achieve optimal and long-lasting results. Alloplastic temporomandibular joint replacement and orthognathic surgery have emerged as the standard approach for end-stage TMJ disease and dentofacial deformities, providing a comprehensive solution for both functional and aesthetic aspects of these conditions.
Review
Medicine, General & Internal
Blanca Gonzalez-Sanchez, Pablo Garcia Monterey, Maria del Valle Ramirez-Duran, Elisa M. Garrido-Ardila, Juan Rodriguez-Mansilla, Maria Jimenez-Palomares
Summary: This article summarizes various physiotherapy treatment techniques for temporomandibular disorders (TMDs) and analyzes their effectiveness in addressing the primary symptoms of TMDs. The study shows that the application of physiotherapy techniques can effectively control pain, functionality, and quality of life in patients with TMDs and is supported by sufficient scientific evidence as a conservative intervention method. Combining different physiotherapy therapies achieves the best treatment results, with therapeutic exercise protocols and manual therapy techniques being the most commonly utilized method according to the analyzed studies.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Eleuterio A. Sanchez Romero, Oliver Martinez-Pozas, Maria Garcia-Gonzalez, Miguel De-Pedro, Maria Elena Gonzalez-Alvarez, Pablo Esteban-Gonzalez, Rosana Cid-Verdejo, Jorge Hugo Villafane
Summary: This systematic review examines whether there is scientific evidence indicating that patients with temporomandibular joint osteoarthritis (TMJ-OA) are associated with increased sleep disorders or impaired sleep quality. After screening and analyzing 7 relevant articles, the review finds insufficient evidence to support the association between TMJ OA and increased sleep disorders or poorer sleep quality.
Article
Biochemical Research Methods
Weibo Zhang, Jie Lyu, Juxiang Xu, Piao Zhang, Shuxia Zhang, Yeru Chen, Yongjie Wang, Gang Chen
Summary: This study revealed that chronic inflammation pain induced by CFA injection resulted in abnormal expression of 27 metabolites and enrichment of seven metabolic pathways, potentially implicating neurotransmitter release and pain conductivity.
BIOMEDICAL CHROMATOGRAPHY
(2021)