期刊
NEURON
卷 99, 期 5, 页码 1069-+出版社
CELL PRESS
DOI: 10.1016/j.neuron.2018.08.018
关键词
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资金
- BBSRC AFL Fellowship [BB/R010803/1]
- Christ Church College Oxford Junior Research Fellowship
- MRC Skills Development Fellowship [MR/N014448/1]
- Wellcome Trust [WT100973AIA, 203139/Z/16/Z]
- MRC [G0902373]
- BBSRC [BB/R010803/1] Funding Source: UKRI
- MRC [MR/N014448/1, G0902373] Funding Source: UKRI
Real-world decisions have benefits occurring only later and dependent on additional decisions taken in the interim. We investigated this in a novel decision-making task in humans (n = 76) while measuring brain activity with fMRI (n = 24). Modeling revealed that participants computed the prospective value of decisions: they planned their future behavior taking into account how their decisions might affect which states they would encounter and how they themselves might respond in these states. They considered their own likely future behavioral biases (e.g., failure to adapt to changes in prospective value) and avoided situations in which they might be prone to such biases. Three neural networks in adjacent medial frontal regions were linked to distinct components of prospective decision making: activity in dorsal anterior cingulate cortex, area 8 m/9, and perigenual anterior cingulate cortex reflected prospective value, anticipated changes in prospective value, and the degree to which prospective value influenced decisions.
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