期刊
NEURON
卷 84, 期 1, 页码 137-151出版社
CELL PRESS
DOI: 10.1016/j.neuron.2014.08.035
关键词
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资金
- CNRS
- INSERM
- French Ministere de la Recherche
- French Agence Nationale de la Recherche [06-BLAN-0178, 11-BSV4-010 INNET]
- HFSP [P60/2003]
- FRC/Rotary (Espoir en Tete)
- Ministry of Education, Culture, Sports, Science and Technology, Japan [21220006, 25000015, 21300118]
- FRM
- Region Ile de France
- European Research Council
- Wellcome Trust [WT094513]
- French Government
- Grants-in-Aid for Scientific Research [25000015, 21300118] Funding Source: KAKEN
In cerebellar Purkinje cell dendrites, heterosynaptic calcium signaling induced by the proximal climbing fiber (CF) input controls plasticity at distal parallel fiber (PF) synapses. The substrate and regulation of this long-range dendritic calcium signaling are poorly understood. Using high-speed calcium imaging, we examine the role of active dendritic conductances. Under basal conditions, CF stimulation evokes T-type calcium signaling displaying sharp proximodistal decrement. Combined mGluR1 receptor activation and depolarization, two activity-dependent signals, unlock P/Q calcium spikes initiation and propagation, mediating efficient CF signaling at distal sites. These spikes are initiated in proximal smooth dendrites, independently from somatic sodium action potentials, and evoke high-frequency bursts of all-or-none fast-rising calcium transients in PF spines. Gradual calcium spike burst unlocking arises from increasing inactivation of mGluR1-modulated low-threshold A-type potassium channels located in distal dendrites. Evidence for graded activity-dependent CF calcium signaling at PF synapses refines current views on cerebellar supervised learning rules.
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