期刊
NEURON
卷 81, 期 6, 页码 1417-1428出版社
CELL PRESS
DOI: 10.1016/j.neuron.2014.01.026
关键词
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资金
- Fondation Plan Alzheimer
- Programme Hospitalier de Recherche Clinique
- Agence Nationale de la Recherche
- Region Basse Normandie
- Institut National de la Sante et de la Recherche Medicale (Inserm)
- Ecole de l'Inserm-Liliane Bettencourt
- Fondation Philippe Chatrier
Alzheimer's disease (AD) and semantic dementia (SD) are both characterized by severe atrophy in the hippocampus, a brain region underlying episodic memory; paradoxically, episodic memory is relatively preserved in SD. Here, we used intrinsic connectivity analyses and showed that the brain networks differentially vulnerable to each disease converge to the hippocampus in the healthy brain. As neurodegeneration is thought to spread within preexisting networks, the common hippocampal atrophy in both diseases is likely due to its location at the crossroad between both vulnerable networks. Yet, we showed that in the normal brain, these networks harbor different functions, with episodic memory relying on the AD-vulnerable network only. Overall, disease-associated cognitive deficits seem to reflect the disruption of targeted networks more than atrophy in specific brain regions: in AD, over hippocampal atrophy, episodic memory deficits are likely due to disconnection within a memory-related network.
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