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Medicine, Research & Experimental
Kate E. Mastraccio, Celeste Huaman, Si'Ana A. Coggins, Caitlyn Clouse, Madeline Rader, Lianying Yan, Pratyusha Mandal, Imran Hussain, Anwar E. Ahmed, Trung Ho, Austin Feasley, Bang K. Vu, Ina L. Smith, Wanda Markotter, Dawn L. Weir, Eric D. Laing, Christopher C. Broder, Brian C. Schaefer
Summary: Rabies is a fatal viral disease of humans, but this study demonstrates that a single-dose monoclonal (mAb) therapy can lead to a functional cure even after robust replication in the CNS. The therapeutic efficacy of F11, a human IgG1 antibody, requires a functional Fc region, suggesting the involvement of immune cells bearing FcR gamma. The effectiveness of F11 depends on the intact host adaptive immune response, particularly CD4 T cells. The administration of F11 alters the proportions and phenotypes of immune cells in the brain, and although the virus persists at a low level, the animals remain free of disease signs.
EMBO MOLECULAR MEDICINE
(2023)
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Multidisciplinary Sciences
Tamar Szoke, Nitsan Albocher, Sutharsan Govindarajan, Anat Nussbaum-Shochat, Orna Amster-Choder
Summary: TmaR, a previously unannotated protein in E. coli, localizes to the cell pole when phosphorylated on a tyrosine residue and controls the subcellular localization and activity of Enzyme I (EI) by binding and polar sequestration. The absence of TmaR leads to detrimental effects on cell survival in mild acidic conditions and affects the ability of cells to enter stationary phase, demonstrating the importance of TmaR in regulating cellular processes.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
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Robin J. Vigouroux, Karine Duroure, Juliette Vougny, Shahad Albadri, Peter Kozulin, Eloisa Herrera, Kim Nguyen-Ba-Charvet, Ingo Braasch, Rodrigo Suarez, Filippo Del Bene, Alain Chedotal
Summary: The study reveals that bilateral visual projections exist in non-teleost fishes, and that the developmental program specifying visual system laterality differs between fishes and mammals. The presence of ipsilateral projections in fish ganglion cells appears to be absent due to the lack of the Zic2 transcription factor.
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