期刊
NEURON
卷 79, 期 3, 页码 541-554出版社
CELL PRESS
DOI: 10.1016/j.neuron.2013.06.011
关键词
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资金
- National Eye Institute
- Pew Charitable Trusts
- McKnight Endowment Fund for Neuroscience
- Alfred P. Sloan Foundation
- E. Matilda Ziegler Foundation
- Stanford Medical Scientist Training Program
- National Science Foundation
Sensory systems change their sensitivity based on recent stimuli to adjust their response range to the range of inputs and to predict future sensory input. Here, we report the presence of retinal ganglion cells that have antagonistic plasticity, showing central adaptation and peripheral sensitization. Ganglion cell responses were captured by a spatiotemporal model with independently adapting excitatory and inhibitory subunits, and sensitization requires GABAergic inhibition. Using a simple theory of signal detection, we show that the sensitizing surround conforms to an optimal inference model that continually updates the prior signal probability. This indicates that small receptive field regions have dual functionality to adapt to the local range of signals but sensitize based upon the probability of the presence of that signal. Within this framework, we show that sensitization predicts the location of a nearby object, revealing prediction as a functional role for adapting inhibition in the nervous system.
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