Article
Cell Biology
Joon Sung Park, Jungyuen Choi, Longxing Cao, Jyotidarsini Mohanty, Yoshihisa Suzuki, Andy Park, David Baker, Joseph Schlessinger, Sangwon Lee
Summary: The mini-protein mb7 is found to bind with high affinity to the c-isoforms of FGFR, inhibiting cellular signaling induced by specific FGFs and blocking interaction between FGFR with Klotho proteins. This makes mb7 an antagonist of the metabolic hormones FGF19 and FGF21, providing insights and strategies for developing therapeutics for diseases caused by aberrantly activated FGFRs.
Article
Chemistry, Multidisciplinary
Yuefan Wang, Hanjing Peng, Zufeng Guo, Brett R. Ullman, Kana Yamamoto, Sam Y. Hong, Jun O. Liu
Summary: Rapadocin is a novel polyketide-tetrapeptide hybrid macrocycle inspired by rapamycin, showing potent and isoform-specific inhibitory activity against hENT1. The stereochemistry of phenylglycine plays a more dominant role in its activity than the configuration of the olefin.
Article
Cell Biology
Wenxiang Hu, Chunjie Jiang, Mindy Kim, Yang Xiao, Hannah J. Richter, Dongyin Guan, Kun Zhu, Brianna M. Krusen, Arielle N. Roberts, Jessica Miller, David J. Steger, Mitchell A. Lazar
Summary: This study provides insights into the specific metabolic functions of PPAR gamma isoforms, suggesting that they can be targeted for improving therapy for insulin resistance and diabetes.
GENES & DEVELOPMENT
(2022)
Article
Biochemistry & Molecular Biology
Thanasis Rogdakis, Despoina Charou, Alessia Latorrata, Eleni Papadimitriou, Alexandros Tsengenes, Christina Athanasiou, Marianna Papadopoulou, Constantina Chalikiopoulou, Theodora Katsila, Isbaal Ramos, Kyriakos C. Prousis, Rebecca C. Wade, Kyriaki Sidiropoulou, Theodora Calogeropoulou, Achille Gravanis, Ioannis Charalampopoulos
Summary: A new NGF mimetic, ENT-A013, has been identified to selectively activate TrkA receptor and exert neuroprotective effects, showing potential for therapeutic development against neurodegenerative disorders, such as Alzheimer's Disease.
Article
Cell Biology
Yanqiu Zhang, Yue Li, Yuhua Fan, Xiaoyuan Zhang, Zhihong Tang, Jing Qi, Baoshan Zhao, Fuyuan Li, Xiaofeng Chen, Huan Liang, Haiyan Xu, Dongliang Li
Summary: We found that SorCS3 is significantly downregulated in GBM, and low expression of SorCS3 predicts poor prognosis in patients. SorCS3 primarily suppresses cell invasion and proliferation via the NGF/p75(NTR) pathway, playing a critical role in inhibiting glioma progression.
CELL DEATH & DISEASE
(2022)
Article
Cell Biology
Jiacheng Wu, Ye Hu, Jiaying Song, Jia Xu, Qian Zhang, Yangyang Chai, Xin Wang, Bingjing Wang, Yong Zhao, Xuetao Cao, Xiaoqing Xu
Summary: Phosphorylation of IRF3 is critical for inducing IFN-I production in antiviral innate response. This study identifies SMYD2 as a negative regulator of IFN-I production by inhibiting IRF3 phosphorylation in macrophages during viral infections. SMYD2 interacts with IRF3 domains and recruits phosphatase PP1α to decrease IRF3 phosphorylation, thereby modulating the antiviral innate response.
CELL DEATH & DISEASE
(2023)
Article
Medicine, Research & Experimental
Brandon M. Wagner, Jerid W. Robinson, Yun-Wen Lin, Yi-Ching Lee, Nabil Kaci, Laurence Legeai-Mallet, Lincoln R. Potter
Summary: Preventing GC-B dephosphorylation rescues reduced skeletal growth in a mouse model of achondroplasia.
Article
Oncology
Annalisa Saltari, Andreas Dzung, Marika Quadri, Natascia Tiso, Nicola Facchinello, Alberto Hernandez-Barranco, Susana Garcia-Silva, Laura Nogues, Corinne Isabelle Stoffel, Phil F. Cheng, Patrick Turko, Ossia M. Eichhoff, Francesca Truzzi, Alessandra Marconi, Carlo Pincelli, Hector Peinado, Reinhard Dummer, Mitchell P. Levesque
Summary: CD271 has been extensively studied for its role in melanoma and its potential therapeutic implications. Activation of CD271 induces apoptosis in melanoma cells, reduces metastasis, and overcomes drug resistance, highlighting it as a promising target for melanoma therapy.
Article
Immunology
Lina S. Silva-Bermudez, Tatyana N. Sevastyanova, Christina Schmuttermaier, Carolina De La Torre, Leonie Schumacher, Harald Klueter, Julia Kzhyshkowska
Summary: Titanium nanoparticles (TiNPs) have a dual effect on the GDF-15/stabilin-1 interaction in macrophage system, by increasing the production of GDF-15 and suppressing stabilin-1-mediated clearance function. This can lead to unbalanced pro-fibrotic reactions and implant complications.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Medicine, Research & Experimental
Costanza Lo Cascio, James B. McNamara, Ernesto L. Melendez, Erika M. Lewis, Matthew E. Dufault, Nader Sanai, Christopher L. Plaisier, Shwetal Mehta
Summary: This study highlights the important role of HDAC1 in glioblastoma and the necessity to develop isoform-specific drugs targeting glioma stem cells.
Article
Multidisciplinary Sciences
Lian Xu, Zhifeng Chen, Xiaodi Li, Hui Xu, Yu Zhang, Weiwei Yang, Jing Chen, Shuqiang Zhang, Lingchi Xu, Songlin Zhou, Guicai Li, Bin Yu, Xiaosong Gu, Jian Yang
Summary: This study re-analyzed 21 RNA-seq datasets and identified 53 evolutionarily conserved injury response genes, including species-preference injury response candidates and genes related to pre-regenerative and regenerating states. Furthermore, a large sex difference in response to sciatic nerve injury was found.
Article
Cell Biology
Kirsten M. Smith, Doan T. Dinh, Lisa K. Akison, Matilda Nicholls, Kylie R. Dunning, Atsushi Morimoto, John P. Lydon, Darryl L. Russell, Rebecca L. Robker
Summary: This study examined the cell- and isoform-specific effects of progesterone receptor (PGR) in the ovary. The results showed that PGR expression in ovarian granulosa and stromal cells is necessary for ovulation. Additionally, novel functional pathways and gene networks regulated by PGR during ovulation were identified. These findings provide potential targets for fertility therapeutics and nonhormonal contraceptive development.
Article
Multidisciplinary Sciences
Carlos Fernandez Moro, Natalie Geyer, Sara Harrizi, Yousra Hamidi, Sara Soderqvist, Danyil Kuznyecov, Evelina Tidholm Qvist, Media Salmonson Schaad, Laura Hermann, Amanda Lindberg, Rainer L. Heuchel, Alfonso Martin-Bernabe, Soniya Dhanjal, Anna C. Navis, Christina Villard, Andrea C. del Valle, Lorand Bozoky, Ernesto Sparrelid, Luc Dirix, Carina Strell, Arne Ostman, Bernhard Schmierer, Peter B. Vermeulen, Jennie Engstrand, Bela Bozoky, Marco Gerling
Summary: The perimetastatic capsule is a strong positive prognostic factor in liver metastases. This study reveals that survival is associated with the extent of encapsulation and tumor-hepatocyte contact. The capsule exhibits a gradual zonation, with different cellular composition in different regions. Capsule formation is correlated with decreased tumor viability and preoperative chemotherapy.
NATURE COMMUNICATIONS
(2023)
Article
Multidisciplinary Sciences
Carlos Fernandez Moro, Natalie Geyer, Sara Harrizi, Yousra Hamidi, Sara Soderqvist, Danyil Kuznyecov, Evelina Tidholm Qvist, Media Salmonson Schaad, Laura Hermann, Amanda Lindberg, Rainer L. Heuchel, Alfonso Martin-Bernabe, Soniya Dhanjal, Anna C. Navis, Christina Villard, Andrea C. del Valle, Lorand Bozoky, Ernesto Sparrelid, Luc Dirix, Carina Strell, Arne Ostman, Bernhard Schmierer, Peter B. Vermeulen, Jennie Engstrand, Bela Bozoky, Marco Gerling
Summary: The presence of a perimetastatic capsule is a positive prognostic factor in liver metastases, and its origin is linked to tumor invasion and reparative processes.
NATURE COMMUNICATIONS
(2023)
Article
Environmental Sciences
Shany Cohen, Mahde Hasan, Noa Frishman, Isam Khalaila
Summary: This article presents a sophisticated tool, called OSDel, for delivering dsRNA into developing oocytes for gene silencing. The tool exploits the process of receptor-mediated endocytosis to internalize dsRNA into oocytes. The authors successfully delivered dsRNA to developing oocytes and demonstrated gene silencing by targeting the eye development gene PAX6.
FRONTIERS IN MARINE SCIENCE
(2023)
Article
Multidisciplinary Sciences
Ami Patel, Naoya Yamashita, Maria Ascano, Daniel Bodmer, Erica Boehm, Chantal Bodkin-Clarke, Yun Kyoung Ryu, Rejji Kuruvilla
NATURE COMMUNICATIONS
(2015)
Review
Neurosciences
Naoya Yamashita, Rejji Kuruvilla
CURRENT OPINION IN NEUROBIOLOGY
(2016)
Article
Cell Biology
Jessica Houtz, Philip Borden, Alexis Ceasrine, Liliana Minichiello, Rejji Kuruvilla
DEVELOPMENTAL CELL
(2016)
Article
Multidisciplinary Sciences
Chih-Ming Chen, Lauren L. Orefice, Shu-Ling Chiu, Tara A. LeGates, Samer Hattar, Richard L. Huganir, Haiqing Zhao, Baoji Xu, Rejji Kuruvilla
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2017)
Article
Neurosciences
Emily Scott-Solomon, Rejji Kuruvilla
MOLECULAR AND CELLULAR NEUROSCIENCE
(2018)
Editorial Material
Cell Biology
Jessica Houtz, Rejji Kuruvilla
DEVELOPMENTAL CELL
(2014)
Article
Urology & Nephrology
Liwei Huang, An Xiao, Soo Young Choi, Quane Kan, Weibin Zhou, Maria F. Chacon-Heszele, Yun Kyoung Ryu, Sarah McKenna, Xiaofeng Zuo, Rejji Kuruvilla, Joshua H. Lipschutz
NEPHRON EXPERIMENTAL NEPHROLOGY
(2014)
Article
Biology
Alexis M. Ceasrine, Eugene E. Lin, David N. Lumelsky, Radhika Iyer, Rejji Kuruvilla
Article
Neurosciences
Hamish Crerar, Emily Scott-Solomon, Chantal Bodkin-Clarke, Catia Andreassi, Maria Hazbon, Emilie Logie, Marife Cano-Jaimez, Marco Gaspari, Rejji Kuruvilla, Antonella Riccio
Editorial Material
Multidisciplinary Sciences
Rejji Kuruvilla
Article
Multidisciplinary Sciences
Oshri Avraham, Pan-Yue Deng, Sara Jones, Rejji Kuruvilla, Clay F. Semenkovich, Vitaly A. Klyachko, Valeria Cavalli
NATURE COMMUNICATIONS
(2020)
Review
Neurosciences
Emily Scott-Solomon, Erica Boehm, Rejji Kuruvilla
Summary: The sympathetic regulation of bodily functions relies on precise connections between sympathetic neurons and peripheral organs. In this Review, Scott-Solomon and colleagues discuss the mechanisms underlying the development of the sympathetic nervous system and provide insight into disorders regulated by this branch of the nervous system.
NATURE REVIEWS NEUROSCIENCE
(2021)
Article
Multidisciplinary Sciences
Blaine Connor, Guillermo Moya-Alvarado, Naoya Yamashita, Rejji Kuruvilla
Summary: In neurons, transcytosis, an atypical transport mechanism, is essential for delivering TrkA neurotrophin receptors to axons, influencing neuronal connectivity and function. Disruption of PTP1B-dependent transcytosis in TrkAR685A mice leads to decreased axonal TrkA levels, loss of sympathetic neurons, and reduced inner-vation of targets. This axon targeting mechanism is crucial during development and also affects the nociceptive neurons in dorsal root ganglia.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Endocrinology & Metabolism
Alexis M. Ceasrine, Nelmari Ruiz-Otero, Eugene E. Lin, David N. Lumelsky, Erica D. Boehm, Rejji Kuruvilla
Article
Cell Biology
Naoya Yamashita, Rajshri Joshi, Sheng Zhang, Zhong-Yin Zhang, Rejji Kuruvilla
DEVELOPMENTAL CELL
(2017)