Article
Multidisciplinary Sciences
Guo Wanjia, Serra E. Favila, Ghootae Kim, Robert J. Molitor, Brice A. Kuhl
Summary: The study demonstrates that abrupt remapping of activity patterns in the human hippocampal CA3 and dentate gyrus resolves memory interference caused by similar memories, with the magnitude of decorrelation influenced by initial pattern overlap. Remapped activity patterns carry relatively more information about learned episodic associations, highlighting the learning-related significance of remapping.
NATURE COMMUNICATIONS
(2021)
Article
Cell Biology
Jhoseph Shin, Hyun-Woo Lee, Seung-Woo Jin, Inah Lee
Summary: Environmental changes can affect the formation and modification of memories, but the neural mechanisms behind this process are not well understood. In this study, hippocampal place cells were observed in a virtual reality environment, and it was found that place cells in CA3 were more tolerant of individual landmark changes compared to CA1. When visual noise was introduced, place cells in CA1 exhibited two different responses, maintaining their field locations while changing firing rates or exhibiting global remapping in response to contextual changes. In contrast, place cells in CA3 mainly showed rate remapping. These findings suggest that CA1 may simultaneously represent heterogeneous maps of the same environment when subtle visual noise induces both sensory and contextual changes.
Article
Multidisciplinary Sciences
Tomoyuki Murano, Ryuichi Nakajima, Akito Nakao, Nao Hirata, Satoko Amemori, Akira Murakami, Yukiyasu Kamitani, Jun Yamamoto, Tsuyoshi Miyakawa
Summary: The dentate gyrus (DG) plays a critical role in cognitive functions, but its information representation mechanism is not fully understood. In this study, neuronal activity in the DG of freely moving mice was recorded using Ca2+ imaging and analyzed using machine learning. The results showed that multiple types of information can be independently decoded from the activity patterns of DG neurons, and different types of information are encoded by different populations of neurons.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Review
Biochemistry & Molecular Biology
Gabriel Berdugo-Vega, Shonali Dhingra, Federico Calegari
Summary: This article reviews a wealth of research in cellular, anatomical, behavioral, and computational studies on the mammalian hippocampus, aiming to understand the fundamental mechanisms underlying cognition. Despite accumulating knowledge on how the hippocampus processes and stores information for learning and memory, our understanding of hippocampal cognitive function remains incomplete. The article discusses the structural separability of the two blades of the dentate gyrus in the hippocampus and proposes a model that suggests differences in connectivity and adult neurogenesis in the two blades may contribute to subtly different cognitive functions.
Correction
Biochemistry & Molecular Biology
Jasper O. Nuninga, Rene C. W. Mandl, Iris E. C. Sommer
Summary: The amended version of the paper has been published and is accessible via a link at the top of the paper.
MOLECULAR PSYCHIATRY
(2021)
Article
Biology
Martin Pofahl, Negar Nikbakht, Andre N. Haubrich, Theresa M. Nguyen, Nicola Masala, Fabian J. Distler, Oliver Braganza, Jakob H. Macke, Laura A. Ewell, Kurtulus Golcuk, Heinz Beck
Summary: The hippocampal dentate gyrus exhibits structured activity patterns during immobility, which are associated with entorhinal cortex activation and incorporate place- and speed cells. These patterns are important for the formation of spatial memories dependent on the dentate gyrus.
Article
Multidisciplinary Sciences
Kyle R. Jensen, Coralie Berthoux, Kaoutsar Nasrallah, Pablo E. Castillo
Summary: Recurrent excitatory neural networks in the hippocampus involving excitatory mossy cells (MCs) can promote epilepsy. Physiologically relevant activity patterns of MCs induce robust presynaptic long-term potentiation (LTP) of MC-GC transmission. Type-1 cannabinoid receptors (CB1Rs) at MC axon terminals play a crucial role in modulating presynaptic metaplasticity and excitatory transmission onto granule cells (GCs).
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Review
Neurosciences
Jesse D. Cushman, Michael R. Drew, Franklin B. Krasne
Summary: The primary function of juvenile and adult hippocampal neurogenesis appears to be allowing behavioral experience to shape connectivity in the dentate gyrus and optimize hippocampal circuits for future learning. This environmental sculpting reduces overlap among memory representations, provides more information, and allows for more memories to be stored accurately. The decline of neurogenesis prior to adulthood may be explained by this prospective function of sculpting hippocampal circuits.
PROGRESS IN NEUROBIOLOGY
(2021)
Article
Pharmacology & Pharmacy
Yeonggwang Hwang, Hyoung-Chun Kim, Eun-Joo Shin
Summary: In this study, it was found that repeated BKM120 treatment induced anxiety- and depression-like behaviors in mice and these behaviors were positively correlated with the extent of DCX-positive cell migration. The treatment also affected the activity of Akt, JNK, DCX, and RhoA.
PHARMACOLOGICAL RESEARCH
(2022)
Article
Behavioral Sciences
Kai Wei, Yiheng Liu, Xiamin Yang, Jin Liu, Yuan Li, Meng Deng, Yingwei Wang
Summary: Sevoflurane, as a GABA subtype A receptor agonist, can induce widespread apoptosis of immature dentate granule cells in postnatal day 21 mice. The study investigated whether NKCC1-mediated GABA depolarization of neurons plays a role in sevoflurane-induced neuroapoptosis, and found that bumetanide attenuated sevoflurane-induced apoptosis. Furthermore, exposure to sevoflurane did not significantly affect motor ability or anxiety levels in mice, but impaired pattern separation ability in a cognitive test, which was mitigated by bumetanide. Overall, bumetanide shows promise in protecting against anesthesia-induced neurotoxicity.
BRAIN AND BEHAVIOR
(2022)
Article
Nutrition & Dietetics
Xuansong Mao, Taylor J. Kelty, Nathan R. Kerr, Thomas E. Childs, Michael D. Roberts, Frank W. Booth
Summary: Mild cognitive impairment (MCI) represents a therapeutic window to prevent dementia, and oral creatine (Cr) supplementation ameliorates cognitive deficits induced by lipopolysaccharide (LPS) in a rat model, potentially via upregulation of mTORC1 signaling and enhancement of synaptogenesis in the dentate gyrus.
Article
Multidisciplinary Sciences
Ain Chung, Claudia Jou, Alejandro Grau-Perales, Eliott R. J. Levy, Dino Dvorak, Nida Hussain, Andre A. Fenton
Summary: Research suggests that cognitive control training can persistently alter hippocampal neural circuit function, facilitating learning of new tasks in novel environments and enhancing signal-to-noise ratio.
Article
Cell Biology
Julie Faitg, Clay Lacefield, Tracey Davey, Kathryn White, Ross Laws, Stylianos Kosmidis, Amy K. Reeve, Eric R. Kandel, Amy E. Vincent, Martin Picard
Summary: This study used quantitative three-dimensional electron microscopy to map mitochondrial network morphology and complexity in the mouse brain. Differences in mitochondrial morphology across different cell types and ages were identified, providing a foundation for further research on the role of neuronal mitochondria in the aging brain.
Article
Neurosciences
Ting Feng, Christian Alicea, Vincent Pham, Amanda Kirk, Simon Pieraut
Summary: The study found that using an enriched environment during the preweaning period affects the circuit plasticity of inhibitory cell types in the hippocampus, with CCK+ basket cells showing a significant increase in somatic inhibition and PV+ cells showing no changes. The change in somatic inhibition from CCK+ neurons increases CB1R-mediated inhibition in the circuit.
JOURNAL OF NEUROSCIENCE
(2021)
Review
Neurosciences
Gaifen Li, Jia Liu, Yuying Guan, Xunming Ji
Summary: Hypoxia plays a crucial role in regulating various cell functions, including stem cells and neural stem cells. Hypoxia stimulation in specific brain regions can promote proliferation, migration, and maturation of neural stem cells, potentially offering a promising strategy for treating central nervous system diseases.
CNS NEUROSCIENCE & THERAPEUTICS
(2021)
Article
Health Care Sciences & Services
Belen Rubio Ballester, Jens Nirme, Irene Camacho, Esther Duarte, Susana Rodriguez, Ampar Cuxart, Armin Duff, Paul F. M. J. Verschure
JMIR SERIOUS GAMES
(2017)
Article
Multidisciplinary Sciences
Klaudia Grechuta, Jelena Guga, Giovanni Maffei, Belen Ballester Rubio, Paul F. M. J. Verschure
SCIENTIFIC REPORTS
(2017)
Article
Behavioral Sciences
Cesar Renno-Costa, Ana Claudia Costa da Silva, Wilfredo Blanco, Sidarta Ribeiro
NEUROBIOLOGY OF LEARNING AND MEMORY
(2019)
Article
Mathematical & Computational Biology
Marco A. P. Idiart, Aline Villavicencio, Boris Katz, Cesar Renno-Costa, John Lisman
FRONTIERS IN COMPUTATIONAL NEUROSCIENCE
(2019)
Article
Neurosciences
Cesar Renno-Costa, Daniel Garcia Teixeira, Ivan Soltesz
Article
Medicine, General & Internal
Ivan Herreros, Laia Miquel, Chrysanthi Blithikioti, Laura Nuno, Belen Rubio Ballester, Klaudia Grechuta, Antoni Gual, Merce Balcells-Olivero, Paul Verschure
JOURNAL OF CLINICAL MEDICINE
(2019)
Article
Neurosciences
J. -Y. Puigbo, X. D. Arsiwalla, M. A. Gonzalez-Ballester, P. F. M. J. Verschure
MOLECULAR NEUROBIOLOGY
(2020)
Article
Multidisciplinary Sciences
Daniel Pacheco Estefan, Riccardo Zucca, Xerxes Arsiwalla, Alessandro Principe, Hui Zhang, Rodrigo Rocamora, Nikolai Axmacher, Paul F. M. J. Verschure
Summary: Active navigation enhances hippocampal theta oscillations and promotes a more accurate reactivation of stimulus-specific information during memory retrieval. Active learning improves memory performance by segregating conceptually similar items into more distant theta phases based on the temporal structure of intracycle reactivations in theta.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Review
Behavioral Sciences
Diogo Santos-Pata, Adrian F. Amil, Ivan Georgiev Raikov, Cesar Renno-Costa, Anna Mura, Ivan Soltesz, Paul F. M. J. Verschure
Summary: The key difference between biological cognition and artificial intelligence lies in the ability to autonomously acquire knowledge. Research suggests that the entorhinal-hippocampal complex combines epistemic autonomy with error backpropagation. The hippocampus minimizes the error between input and output signals through a modulatory counter-current inhibitory network.
TRENDS IN COGNITIVE SCIENCES
(2021)
Article
Multidisciplinary Sciences
Diogo Santos-Pata, Adrian F. Amil, Ivan Georgiev Raikov, Cesar Renno-Costa, Anna Mura, Ivan Soltesz, Paul F. M. J. Verschure
Summary: The study proposes a self-supervised model using a closed loop to learn to reconstruct inputs through error backpropagation, suggesting that the hippocampus generates place cells by building conjunctive representations of the environment via its own inputs.
Article
Neurosciences
Isis M. Ornelas, Felipe A. Cini, Isabel Wiessner, Encarni Marcos, Draulio B. Araujo, Livia Goto-Silva, Juliana Nascimento, Sergio R. B. Silva, Marcelo N. Costa, Marcelo Falchi, Rodolfo Olivieri, Fernanda Palhano-Fontes, Eduardo Sequerra, Daniel Martins-de-Souza, Amanda Feilding, Cesar Renno-Costa, Luis Fernando Tofoli, Stevens K. Rehen, Sidarta Ribeiro
Summary: The therapeutic use of LSD has increased in recent years due to its ability to enhance neural plasticity and improve cognition.
EXPERIMENTAL NEUROLOGY
(2022)
Article
Biochemical Research Methods
Dhiego Souto Andrade, Patrick Terrematte, Cesar Renno-Costa, Alona Zilberberg, Sol Efroni
Summary: This paper introduces GENTLE, an open-source and user-friendly web application tool for TCR repertoire researchers. It allows for the discovery of important features, creation and evaluation of classifier models, and quick generation of visualizations. A case study on TRegs and TConvs repertoire data showed the effectiveness of diversity features in distinguishing between healthy controls and breast cancer patients, and the accuracy of classifiers built with these features.
BMC BIOINFORMATICS
(2023)
Article
Neurosciences
Sock Ching Low, Paul F. M. J. Verschure, Diogo Santos-Pata
Summary: Working memory relies on theta oscillations' phase synchronicity for encoding and recall, and saccadic eye movements may be involved in mnemonic processing.
Article
Mathematics, Interdisciplinary Applications
Adrian F. Amil, Paul F. M. J. Verschure
Summary: Through the attractor model of the canonical cortical circuit, it was found that an increase in the SST+/PV+ ratio leads to the emergence of persistent activity, with the optimal sensitivity found at the edge of chaos. Furthermore, the study indicates that both the optimal SST+/PV+ ratio and the region of the phase transition decrease monotonically with increasing input noise.
JOURNAL OF PHYSICS-COMPLEXITY
(2021)