期刊
NEURON
卷 65, 期 3, 页码 293-294出版社
CELL PRESS
DOI: 10.1016/j.neuron.2010.01.028
关键词
-
资金
- NIDA NIH HHS [R01 DA020812, R01 DA020812-03] Funding Source: Medline
The branching of dendrites and axons is a key determinant of neural circuit formation. In this issue of Neuron, Kawabe et al. demonstrate that the ubiquitin ligase Nedd4 promotes the branching of developing dendrites by targeting the small G protein Rap2. In a complementary study, Drinjakovic et al. show that Nedd4 promotes the branching of developing axons by ubiquitinating a different target, the phosphatase PTEN.
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