Article
Psychology, Multidisciplinary
Gerianne M. Alexander, Kendall John, Tracy Hammond, Joanna Lahey
Summary: This study found that individuals who perceive their forename as relatively gender-weak exhibit less gender-typical childhood social behavior and personality traits, indicating that forenames have an impact on gender socialization and role behavior.
FRONTIERS IN PSYCHOLOGY
(2021)
Article
Chemistry, Physical
Xingang Liu, Guobin Qi, Min Wu, Yutong Pan, Bin Liu
Summary: The new fluorescence light-up Gram-staining technique can selectively differentiate G(-) bacteria with high selectivity and sensitivity, providing a useful tool for specific discrimination of living G(+) and G(-) bacteria in both fundamental and clinical bacteria detection.
CHEMISTRY OF MATERIALS
(2021)
Article
Engineering, Biomedical
Isabella M. Goodchild-Michelman, George M. Church, Max G. Schubert, Tzu-Chieh Tang
Summary: Cyanobacteria are promising for developing carbon neutral and carbon negative technologies due to their efficient photosynthesis and easy genetic manipulation. Although researchers have demonstrated their ability to produce sustainable biomaterials, industrial application is still in its early stages.
MATERIALS TODAY BIO
(2023)
News Item
Physics, Multidisciplinary
Catherine Kealhofer
Summary: A new technique in cathodoluminescence allows for observing a sample's optical response with a time resolution shorter than an optical cycle.
Review
Biochemistry & Molecular Biology
Xin Zhang, Stephane Melik-Parsadaniantz, Christophe Baudouin, Annabelle Reaux-Le Goazigo, Nathan Moreau
Summary: The cornea, a crucial part of the eye, requires constant renewal and efficient healing to maintain ocular homeostasis. The Hedgehog signaling pathway plays a vital role in corneal wound healing, promoting cell proliferation, migration, and maintenance of the corneal epithelial barrier.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Materials Science, Multidisciplinary
Sara Molinari, Robert F. Tesoriero, Caroline M. Ajo-Franklin
Summary: The passage discusses the similar organization of biomaterials made by living systems and the growing interest in engineered living materials (ELMs) with tailored functions. It highlights the technologies still missing from the field of ELMs, such as designing novel matrix elements, producing and incorporating biominerals, and improving critical material properties. Overcoming these challenges will bring us closer to unlocking the potential and versatility of biomaterials in creating designer ELMs.
Article
Multidisciplinary Sciences
Ewa Sitarska, Silvia Dias Almeida, Marianne Sandvold Beckwith, Julian Stopp, Jakub Czuchnowski, Marc Siggel, Rita Roessner, Aline Tschanz, Christer Ejsing, Yannick Schwab, Jan Kosinski, Michael Sixt, Anna Kreshuk, Anna Erzberger, Alba Diz-Munoz
Summary: A curvature-sensing mechanism mediated by the BAR domain protein Snx33 is identified in immune-like cells for obstacle evasion. Actin polymerization at the leading edge of migrating cells is inhibited by Snx33 in regions with inward plasma membrane curvature. Genetic perturbation of this machinery reduces cells' ability to evade obstacles and increases their speed and persistence in obstacle-free environments. This study reveals how cells interpret their environment using actin and plasma membrane biophysics.
NATURE COMMUNICATIONS
(2023)
Article
Chemistry, Multidisciplinary
Huan Tan, Gustavo Castro, Jike Lyu, Pablo Loza-Alvarez, Florencio Sanchez, Josep Fontcuberta, Ignasi Fina
Summary: This study takes advantage of the built-in asymmetry at ferroelectric/electrode interfaces to achieve polarization reversal under illumination, and demonstrates the ability to optically control the resistance states in a ferroelectric capacitor.
MATERIALS HORIZONS
(2022)
Article
Business, Finance
Chih-Chiang Wu, Wei-Peng Chen
Summary: This study examines the impact of ETF names on the abnormal returns of constituent stocks, specifically focusing on U.S. AI ETFs. The results indicate that ETFs with AI names generate higher cumulative abnormal returns for their constituent stocks, suggesting the presence of name premiums in the market.
FINANCE RESEARCH LETTERS
(2022)
Editorial Material
Biochemistry & Molecular Biology
Dayu Lin
Summary: In the recent issue of Cell, Yang et al. identified hypothalamic aggression mirror neurons, which are activated during both physical fighting and observing fights, potentially representing a neural mechanism for understanding social experiences in other individuals' minds.
Review
Biochemistry & Molecular Biology
Ana R. P. Goncalves, Xavier Paredes, A. F. Cristino, F. J. V. Santos, Carla S. G. P. Queiros
Summary: Ionic liquids were initially touted as environmentally friendly replacements for traditional solvents, but research on their interactions with organisms is lacking. Lipophilicity and the type of cation play key roles in toxicity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Mo R. Ebrahimkhani, Michael Levin
Summary: Increased control of biological growth and form is crucial for transformative medical advances, but gaps remain in our understanding of meso-scale rules of morphogenesis. The engineering approach of creating novel synthetic living forms extends available model systems and is essential for the next generation of synthetic biology. Emphasizing emergent self-organization, tissue-level guided self-assembly, and active functionality will greatly increase our understanding of evolutionary developmental and cell biology.
Article
Chemistry, Applied
Jing Yang, Wen Ting Wang, Zheng Dou Shi, Rui Yang, Xia Li Liao, Bo Yang, Chuan Zhu Gao
Summary: By altering the reaction ratio of precursor Ir-2(ppy)(4)Cl-2 and bridging ligand of 4,4-bipyridine (bpy), a series of phosphorescent cyclometalated iridium(III) complexes of mono-, di-, and tetranuclear have been successfully obtained and characterized for the first time. The dissociation of bpy ligand can be accelerated by light irradiation or placing these complexes in glutathione (GSH) abundant aqueous solution, bpy releasing rate follows the order Ir1 > Ir2 > Ir3 > Ir4, and with an addition of histidine, a significant blue shift from orange to green phosphorescence was observed. Furthermore, the cellular dissociation of bpy can be monitored by an orange-to-green phosphorescent blue shift, and the translocation of Ir complexes from cytoplasm to nucleus can be observed within 4 h in living cells through confocal imaging. Additionally, the changes of cellular phosphorescence intensity recorded by flow cytometry reflect different speed of bpy release in human normal and cancer cells. Moreover, the iridium complexes exert significant anticancer effect in the dark with low photocytotoxicity, inducing reactive oxygen species generation, mitochondrial membrane potential depletion, and interacting with biomolecules, ultimately leading to late apoptosis of Hela cell.
APPLIED ORGANOMETALLIC CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Celine Landon, Yanyu Zhu, Mainak Mustafi, Jean-Baptiste Madinier, Dominique Lelievre, Vincent Aucagne, Agnes F. Delmas, James C. Weisshaar
Summary: This study used single-cell fluorescence imaging to investigate the effects of the β-defensin AvBD103b on living E. coli at physiological salt concentrations. The results provide key parameters for understanding the mechanism of action. The study found that AvBD103b interacts non-specifically with various polyanionic targets after penetrating the cell membranes, leading to cell death.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Editorial Material
Cell Biology
Pierre Lapaquette, Amandine Ducreux, Etienne Morel, Frederic Dalle
Summary: This study demonstrates the protective role of autophagy in epithelial cells during Candida albicans infection by repairing cell membrane damage, maintaining cell integrity, and preventing cell death.
Article
Biochemistry & Molecular Biology
Nivedita Natarajan, Ombretta Foresti, Kim Wendrich, Alexander Stein, Pedro Carvalho
Article
Cell Biology
Vedran Vasic, Niels Denkert, Claudia C. Schmidt, Dietmar Riedel, Alexander Stein, Michael Meinecke
NATURE CELL BIOLOGY
(2020)
Article
Multidisciplinary Sciences
Ilona Kondratiuk, Shrutee Jakhanwal, Jialin Jin, Udhayabhaskar Sathyanarayanan, Benjamin Kroppen, Ajaybabu Pobbati, Anita Krisko, Uri Ashery, Michael Meinecke, Reinhard Jahn, Dirk Fasshauer, Ira Milosevic
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2020)
Article
Multidisciplinary Sciences
Yelda Birinci, Julia Preobraschenski, Marcelo Ganzella, Reinhard Jahn, Yongsoo Park
SCIENTIFIC REPORTS
(2020)
Article
Biochemistry & Molecular Biology
Nicole Scott-Hewitt, Fabio Perrucci, Raffaella Morini, Marco Erreni, Matthew Mahoney, Agata Witkowska, Alanna Carey, Elisa Faggiani, Lisa Theresia Schuetz, Sydney Mason, Matteo Tamborini, Matteo Bizzotto, Lorena Passoni, Fabia Filipello, Reinhard Jahn, Beth Stevens, Michela Matteoli
Article
Biochemistry & Molecular Biology
Xiandeng Wu, Marcelo Ganzella, Jinchuan Zhou, Shihan Zhu, Reinhard Jahn, Mingjie Zhang
Summary: The tethering of synaptic vesicles to the active zone is determined by phase separation, forming two distinct SUV pools, which have general implications in cellular processes like vesicular formation and trafficking.
Article
Cell Biology
Cyril Cheret, Marcelo Ganzella, Julia Preobraschenski, Reinhard Jahn, Gudrun Ahnert-Hilger
Summary: VGLUTs play a dual role in neurons by filling synaptic vesicles with glutamate and regulating intracellular Pi levels through transport activity. Studies have shown that VGLUT-mediated Pi influx is counteracted by Pi efflux, highlighting the importance of VGLUTs in both glutamate loading and Pi restoration.
Article
Biochemical Research Methods
Ivan Silbern, Kuan-Ting Pan, Maksims Fiosins, Stefan Bonn, Silvio O. Rizzoli, Eugenio F. Fornasiero, Henning Urlaub, Reinhard Jahn
Summary: The study investigates the impact of synaptic vesicle cycling-dependent phosphorylation events on various functions in synaptic transmission, including exo- and endocytosis processes.
MOLECULAR & CELLULAR PROTEOMICS
(2021)
Article
Multidisciplinary Sciences
Sabine Wittig, Marcelo Ganzella, Marie Barth, Susann Kostmann, Dietmar Riedel, Angel Perez-Lara, Reinhard Jahn, Carla Schmidt
Summary: The protein interactions within synaptic vesicles are complex and can be categorized into specific modules or interactions caused by 'crowding'. Understanding these interactions provides insights into the composition and function of synaptic vesicles.
NATURE COMMUNICATIONS
(2021)
Review
Biophysics
Tobias Grothe, Julia Nowak, Reinhard Jahn, Peter Jomo Walla
Summary: The passage describes various fluorescence-based methods developed over the past decade to monitor membrane fusion, docking, distances, and curvature. These tools were primarily developed using liposomes as model systems, and their application range and limitations are discussed with examples from protein-mediated vesicle docking and fusion studies.
EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS
(2021)
Article
Biochemistry & Molecular Biology
Judyta K. Juranek, Konark Mukherjee, Reinhard Jahn, Jia-Yi Li
Summary: Synaptic transmission relies on neurotransmitters stored in synaptic vesicles and released at the active zone. Research shows a robust bi-directional, coordinated trafficking of synaptic vesicle and active zone proteins in peripheral nerves, which plays a critical role in neuronal function and neurodegenerative diseases.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Multidisciplinary Sciences
Agata Witkowska, Leonard P. Heinz, Helmut Grubmueller, Reinhard Jahn
Summary: Proteins driving membrane fusion must overcome energy barriers to induce intermediate steps where lipid bilayers' integrity is lost. The metastable intermediate preceding hemifusion does not require but is enhanced by divalent cations, characterized by the absence of proteins and local membrane thickening, induced by lipid rearrangements due to dehydration of the membrane surface revealed by simulations.
NATURE COMMUNICATIONS
(2021)
Article
Multidisciplinary Sciences
Changwon Kim, Min Ju Shon, Sung Hyun Kim, Gee Sung Eun, Je-Kyung Ryu, Changbong Hyeon, Reinhard Jahn, Tae-Young Yoon
Summary: Using single-molecule methods, researchers demonstrated the cooperativity between NSF and the SNARE complex to prevent ATP consumption without productive disassembly.
NATURE COMMUNICATIONS
(2021)
Review
Biochemistry & Molecular Biology
Seiichi Koike, Reinhard Jahn
Summary: Membrane traffic in eukaryotic cells is regulated by transport vesicles that contain targeting signals recognized by tethering factors. The final step, membrane fusion, is mediated by SNARE proteins. The role of SNARE proteins in targeting specificity is still a topic of debate.
BIOCHEMICAL JOURNAL
(2022)
Review
Cell Biology
Reinhard Jahn, David C. Cafiso, Lukas K. Tamm
Summary: This article reviews the SNARE-mediated fusion pathway, including the assembly of SNARE proteins into complexes, the regulation of this assembly by accessory proteins, and the overcoming of energy barriers that prevent membrane fusion.
NATURE REVIEWS MOLECULAR CELL BIOLOGY
(2023)