Article
Medicine, Research & Experimental
Fred Friedberg, Jenna L. Adamowicz, Patricia Bruckenthal, Maria Milazzo, Sameera Ramjan, Xiaoyue Zhang, Jie Yang
Summary: This study aimed to assess the relationship between illness worsening and the trajectories of social and non-social uplifts and hassles in patients with chronic fatigue syndrome. It was found that patients with worsening illness had an increase in hassles and a deficit in uplifts over a six-month period compared to patients with improving illness.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Immunology
Borre Fevang, Vegard Bruun Bratholm Wyller, Tom Eirik Mollnes, Maria Pedersen, Tarjei Torre Asprusten, Annika Michelsen, Thor Ueland, Kari Otterdal
Summary: The CEBA project followed 200 adolescents with infectious mononucleosis, finding that patients developing chronic fatigue syndrome showed signs of T-cell activation and low-grade chronic inflammation at baseline and after 6 months.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Microbiology
Fabrice Simon, Remi Bossy, Denise Federico, Julien Dezaunay, Anne-Laurence Demoux, Nadia Rugard, Giulia Calusi, Andrea Nizzardo, Hugh Watson, Franciane Gane-Troplent
Summary: Chronic chikungunya disease is associated with a poor quality of life and a variety of symptoms. In addition to musculoskeletal involvement, fatigue, poor sleep quality, and anxiodepressive syndromes are important determinants of quality of life.
Article
Nursing
Chao-Pin Hsiao, Barbara Daly, Mei-Kuang Chen, Marty Veigl, Jennifer Dorth, Lee Evan Ponsky, Charles Hoppel
Summary: This study identified that in men with prostate cancer undergoing radiation therapy, the PROMIS-F score significantly increased over time, while BC1 ubiquinol-cytochrome c reductase synthesis-like (BCS1L) mRNA was significantly downregulated. Post-radiation therapy, the trend of increased PROMIS-F score was associated with downregulated BCS1L mRNA.
Review
Biology
Marcin Wlodarczyk, Adam Makaro, Mateusz Prusisz, Jakub Wlodarczyk, Marta Nowocien, Kasper Marynczak, Jakub Fichna, Lukasz Dziki
Summary: Crohn's disease (CD) is a chronic, relapsing inflammatory bowel disease characterized by transmural inflammation in the gastrointestinal tract. Chronic fatigue is a common and often underestimated symptom in CD patients, with a higher prevalence compared to the general population. Its underlying causes and mechanisms are complex and not fully understood. Routine screening and a comprehensive, multidisciplinary approach, including psychological support, may play a crucial role in managing CD patients with chronic fatigue. Further research is needed to predict, prevent, identify, and treat fatigue associated with CD. This review aims to summarize the current knowledge on the etiology, diagnosis, and treatment of chronic fatigue in CD patients.
Review
Biochemistry & Molecular Biology
Andrej Rusin, Colin Seymour, Alan Cocchetto, Carmel Mothersill
Summary: Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME) and Cancer-Related Fatigue (CRF) have overlapping symptoms and their etiologies may be linked. Studies suggest that multiple stressors including HPA-axis dysfunction, the serotonergic system, cytokines and inflammation, metabolic insufficiency and mitochondrial dysfunction, and genetic changes are involved in both CRF and CFS/ME. There may be a continuum of potential biological effects occurring in response to stress, influenced by factors such as genetic background. Future research should focus on identifying common biomarkers in CFS/ME and CRF patients to further understand their commonalities.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Virology
Huawei Xia, Zeming Zhang, Fuping You
Summary: The study revealed that MHV-A59 can induce various forms of cell death, including pyroptosis, apoptosis, necroptosis, and the recently identified ferroptosis; inhibiting ferroptosis helps protect hosts from inflammation and tissue injuries caused by MHV-A59 infection; inhibiting ACSL1 and ferroptosis effectively reduces viral propagation and cell fusion in the viral infection pathological process.
Review
Medicine, General & Internal
Jun Ren, Tianxiang He, Xin Zhou, Zhiwei Wu, Lingjun Kong
Summary: This study aims to investigate the effects of Tuina in the management of Chronic Fatigue Syndrome through a systematic review and meta-analysis, providing evidence for the treatment of CFS in the future. The conclusions drawn from this review are expected to benefit patients, clinical practitioners, and policy makers.
Article
Immunology
Franz Martin, Manuel Blanco-Suarez, Paola Zambrano, Oscar Caceres, Miriam Almirall, Jose Alegre-Martin, Beatriz Lobo, Ana Maria Gonzalez-Castro, Javier Santos, Joan Carles Domingo, Joanna Jurek, Jesus Castro-Marrero
Summary: This study found that biomarkers of intestinal barrier function and inflammation are associated with autonomic dysfunction in patients with fibromyalgia and myalgic encephalomyelitis/chronic fatigue syndrome. Anti-beta-lactoglobulin antibodies, zonulin-1, lipopolysaccharides, and soluble CD14 may be potential predictors of intestinal barrier dysfunction in these conditions.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Medicine, General & Internal
Tianna Magel, Emily Meagher, Travis Boulter, Arianne Albert, Melody Tsai, Carola Munoz, Chris Carlsten, James Johnston, Alyson W. Wong, Aditi Shah, Chris Ryerson, Rhonda Jane Mckay, Luis Nacul
Summary: This study aims to examine the prevalence and outcome predictors of post-viral fatigue and related symptoms 3- and 6-months following SARS CoV-2 infection. The results show that fatigue and substantial fatigue are common after COVID-19 infection but often diminish over time. Except for shortness of breath, self-care, and follow-up time, all follow-up variables were found to be associated with fatigue and substantial fatigue at 3 months. This study is important for understanding the relationship between viral infections and fatigue symptoms, as well as meeting diagnostic criteria for post-viral fatigue syndrome or ME/CFS.
FRONTIERS IN MEDICINE
(2023)
Review
Medicine, General & Internal
Michal Swiatczak, Krzysztof Mlodzinski, Katarzyna Sikorska, Alicja Raczak, Pawel Lipinski, Ludmila Danilowicz-Szymanowicz
Summary: Fatigue is a common symptom that can impair patients' quality of life. Iron metabolism disorders, whether it is deficiency or overload, often lead to fatigue. Current knowledge on fatigue in patients with deteriorated iron metabolism is not precise, especially in chronic fatigue syndrome.
Article
Oncology
Tom I. Bootsma, Melanie P. J. Schellekens, Rosalie A. M. van Woezik, Jenny Slatman, Marije L. van der Lee
Summary: This study examines how patients respond to chronic cancer-related fatigue, identifying five interrelated themes of responses and emphasizing the importance of developing new habits and positive beliefs in the coping process. This experiential knowledge on helpful responses can be used to inform patients and improve self-efficacy.
SUPPORTIVE CARE IN CANCER
(2021)
Article
Oncology
Melanie P. J. Schellekens, Fieke Z. Bruggeman-Everts, Marije D. J. Wolvers, Miriam M. R. Vollenbroek-Hutten, Marije L. van der Lee
Summary: This study explored whether baseline characteristics moderated the effect of web-based mindfulness-based cognitive therapy (eMBCT) on fatigue in patients suffering from chronic cancer-related fatigue (CCRF). The findings indicate that baseline fatigue severity and fatigue catastrophizing can influence the intervention effect, highlighting the potential benefit of personalized treatment.
SUPPORTIVE CARE IN CANCER
(2022)
Article
Biochemistry & Molecular Biology
Zahid Ijaz Tarar, Umer Farooq, Ahmad Nawaz, Mustafa Gandhi, Yezaz A. Ghouri, Asmeen Bhatt, Brooks D. Cash
Summary: The study found a significant correlation between IBS and fibromyalgia and chronic fatigue syndrome (CFS), with higher prevalence rates in IBS patients compared to the general adult population without IBS. Different subtypes of IBS, age, gender, and race were identified as predictors for increased odds of fibromyalgia and CFS.
Article
Biochemistry & Molecular Biology
Sarah Schlick, Marianna Lucio, Gerd Wallukat, Alexander Bartsch, Adam Skornia, Jakob Hoffmanns, Charlotte Szewczykowski, Thora Schroeder, Franziska Raith, Lennart Rogge, Felix Heltmann, Michael Moritz, Lorenz Beitlich, Julia Schottenhamml, Martin Herrmann, Thomas Harrer, Marion Ganslmayer, Friedrich E. Kruse, Robert Laemmer, Christian Mardin, Bettina Hohberger
Summary: This study investigated the potential association between self-reported chronic fatigue and retinal microcirculation in patients with Post-COVID-19 syndrome (PCS). The results suggest that retinal microcirculation may serve as an objective biomarker for chronic fatigue in PCS patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Oncology
Ugo Rovigatti
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2015)
Letter
Hematology
Andrea Piccin, Sergio Cortelazzo, Ugo Rovigatti, Billy Bourke, Owen P. Smith
AMERICAN JOURNAL OF HEMATOLOGY
(2010)
Editorial Material
Urology & Nephrology
Ugo Rovigatti, Cesare Selli, Riccardo Bartoletti
Letter
Oncology
Andrea Piccin, Klaus Eisendle, Ugo Rovigatti, Michael Steurer, Martina Tauber, Daisy Corvetta, Guido Mazzoleni, Mirija Svaldi, Guenther Gastl, Sergio Cortelazzo
LEUKEMIA & LYMPHOMA
(2014)
Letter
Cell Biology
Andrea Piccin, Daisy Corvetta, Ugo Rovigatti, Guido Mazzoleni, Irene Pusceddu, Mirija Svaldi, Michael Steurer, Guether Gastl, Sergio Cortelazzo
Review
Oncology
Ugo Rovigatti
Summary: Neuroblastoma is a common and lethal pediatric cancer with extreme heterogeneity, utilizing GD2-IMT to target GD2 on NBL cells can increase remission length in high-risk cases. The alternative model of Micro-Foci inducing virus (MFV) suggests a potential association between GD2 and the efficacy of anti-GD2 therapies.
Meeting Abstract
Oncology
Ugo Rovigatti, Amedeo Vannacci, Simone Del Corto, Ignacio Martin-Loeches, Andrea Piccin, Nizar Naji, Carmel Mothersill
CLINICAL CANCER RESEARCH
(2020)
Meeting Abstract
Infectious Diseases
G. Guidotti, C. Moscatelli, L. Palombi, M. C. Marazzi, C. Carrilho, E. S. F. Walle, I. Zimba, M. Magnano San Lio, F. Erba, M. Cunha, U. Rovigatti, I. Marchetti, M. P. Cioni, G. Bevilacqua
Meeting Abstract
Hematology
A. Piccin, U. Rovigatti, C. Mc Mahon, J. Kelly, B. Bourke, A. O'Marcaigh, O. P. Smith
HAEMATOLOGICA-THE HEMATOLOGY JOURNAL
(2009)
Article
Oncology
A. Piccin, R. Raimondi, S. Laspina, M. Marchi, F. Rodeghiero, U. Rovigatti
Meeting Abstract
Biochemistry & Molecular Biology
Ugo Rovigatti