Article
Neurosciences
Jiapeng Huang, Chunlan Yang, Kehong Zhao, Ziqi Zhao, Yin Chen, Tingting Wang, Yun Qu
Summary: TENS shows promise in ameliorating neuropathic pain, but caution should be taken when interpreting the results, as the studies reviewed were conducted on animals. Further high-quality research is needed to validate the efficacy of TENS.
FRONTIERS IN NEUROSCIENCE
(2022)
Review
Biochemistry & Molecular Biology
Vincent Yaccarino, Max Y. Jin, Alaa Abd-Elsayed, Jacob M. Kraemer, Nalini Sehgal
Summary: This article briefly introduces the evolution, mechanisms, applications, and complications of peripheral nerve stimulation. The latest technology provides new treatment options for chronic neuropathic pain of the upper extremity.
Review
Anesthesiology
Eric J. Wang, Lauren E. Berninger, Olga Komargodski, Thomas J. Smith
Summary: The evidence for neuromodulation devices for the treatment of painful diabetic neuropathy (PDN) mainly consists of open-label prospective trials or case reports. Spinal cord stimulators (SCS) have the most evidence for efficacy, while studies on transcutaneous electrical nerve stimulators (TENS) show mixed results. Peripheral nerve stimulators (PNS) and scrambler therapy devices (ST) may hold promise but require further prospective controlled trials.
Article
Medicine, Research & Experimental
Selina Johnson, Anne Marshall, Dyfrig Hughes, Emily Holmes, Florian Henrich, Turo Nurmikko, Manohar Sharma, Bernhard Frank, Paul Bassett, Andrew Marshall, Walter Magerl, Andreas Goebel
Summary: Two interlinked studies examined the therapeutic LTD for chronic peripheral nerve injury pain, with the clinical trial showing non-significant results and the mechanistic study indicating improvement in mechanical hyperalgesia.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Engineering, Biomedical
Ali Asghar Zarei, Winnie Jensen, Armita Faghani Jadidi, Eugen Romulus Lontis, S. Farokh Atashzar
Summary: This study investigated the effect of high-frequency TENS on functional brain network connectivity and corresponding topographical changes. The results showed that the FC between the primary somatosensory cortex and the anterior cingulate cortex, as well as the FC between the somatosensory cortex and the medial prefrontal cortex, significantly increased in the gamma-band after TENS intervention. Significant changes in global and local characteristics of functional brain connectivity in the gamma-band were also observed using graph theory.
JOURNAL OF NEURAL ENGINEERING
(2022)
Article
Medicine, General & Internal
Lihua He, Keping Tan, Xianming Lin, Hui Yi, Xueliang Wang, Jiangsong Zhang, Jietao Lin, Lizhu Lin
Summary: The study showed that TENS significantly reduced pain in pancreatic cancer patients without increasing analgesic medication consumption. The pain relief provided by TENS lasted up to 3 weeks after treatment, demonstrating an alternative therapy option for pancreatic cancer pain.
Article
Clinical Neurology
Gurgen Soghoyan, Artur Biktimirov, Yury Matvienko, Ilya Chekh, Mikhail Sintsov, Mikhail A. Lebedev
Summary: By implanting stimulating electrodes near the medial, ulnar, and radial nerves in two bilateral transradial amputees, tactile and proprioceptive sensations in the phantom hand could be evoked using peripheral nerve stimulation (PNS). Both patients were able to determine the shape of invisible objects by scanning a computer tablet with a stylus while receiving feedback based on PNS or transcutaneous electrical nerve stimulation (TENS). PNS completely abolished phantom limb pain (PLP) in one patient and reduced it by 40-70% in the other. Incorporating PNS and/or TENS in active tasks is suggested to reduce PLP and restore sensations in amputees.
Review
Medicine, General & Internal
Agustin Garcia-Collado, Juan A. Valera-Calero, Cesar Fernandez-de-las-Penas, Jose L. Arias-Buria
Summary: This paper assesses the effects of percutaneous electrical nerve stimulation (PENS) on pain- and function-related outcomes. The study found that PENS had positive effects on nerve tissue, but due to heterogeneity in populations, interventions, and follow-up periods, pooling analyses were not possible. Further research is needed to determine the application of PENS in clinical practice.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Biotechnology & Applied Microbiology
Nishant Verma, Robert D. Graham, Jonah Mudge, James K. Trevathan, Manfred Franke, Andrew J. Shoffstall, Justin Williams, Ashley N. Dalrymple, Lee E. Fisher, Douglas J. Weber, Scott F. Lempka, Kip A. Ludwig
Summary: Minimally invasive neuromodulation technologies aim to combine neural selectivity with low-cost and non-invasive transcutaneous electrical stimulation. The Injectrode is a needle-delivered electrode that reduces activation thresholds of deep nerves by serving as a conduit for transcutaneously delivered power. Optimization of energy transfer efficiency is crucial to minimize off-target recruitment of cutaneous fibers. Validation of an electroquasistatic model showed the importance of considering both tissue conductivity and permittivity for understanding transcutaneous power delivery to the Injectrode.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Orthopedics
Andrew A. Post, Dana L. Dailey, Emine O. Bayman, Ruth L. Chimenti, Michele Costigan, Carla Franck, Trevis Huff, Elizabeth Johnson, Maxine Koepp, David-Erick Lafontant, Megan E. McCabe, Tina Neill-Hudson, Carol G. T. Vance, Barb Van Gorp, Bridget M. Zimmerman, Dixie Ecklund, Leslie J. Crofford, Kathleen A. Sluka
Summary: This study aims to examine if adding TENS to routine physical therapy improves movement-evoked pain in individuals with fibromyalgia. The study will enroll 600 participants and utilize a randomized cluster design. The findings of this study will provide important data for healthcare policymakers, clinicians, and insurers.
Article
Neurosciences
Iago Malta, Goncalves Netto, Rafaela dos Santos, Flavio Veras, Giovane Galdino
Summary: Combining cannabidiol and TENS can enhance antinociception, especially in neuropathic pain. This combination increases the level of spinal IL-10, potentially contributing to its analgesic effect.
Review
Anesthesiology
Leonardo Rodriguez Lagos, Alberto Arribas-Romano, Josue Fernandez-Carnero, Yeray Gonzalez-Zamorano, Sofia Laguarta Val
Summary: This study conducted a systematic review and meta-analysis to investigate the effects of percutaneous electrical nerve stimulation (PENS) and transcutaneous electrical nerve stimulation (TENS) on endogenous pain mechanisms in patients with musculoskeletal pain. The results showed that PENS and TENS have a mild to moderate immediate effect on local mechanical hypersensitivity, but this effect is not sustained over time. Further studies are needed to determine the effects on central pain mechanisms.
Article
Anesthesiology
Carol G. T. Vance, M. Bridget Zimmerman, Dana L. Dailey, Barbara A. Rakel, Katharine M. Geasland, Ruth L. Chimenti, Jon M. Williams, Meenakshi Golchha, Leslie J. Crofford, Kathleen A. Sluka
Summary: The study indicates that transcutaneous electrical nerve stimulation (TENS) is effective in reducing pain and fatigue in women with fibromyalgia (FM), with the initial response to a 30-minute TENS treatment predicting long-term effectiveness. The predictor models show that initial pain response and widespread pain index are predictors of clinical improvement in pain, while marital status, sleep impairment, and initial response to TENS are predictors of clinical improvement in fatigue. The number needed to treat and number needed to harm suggest that TENS is an effective and safe treatment for managing pain and fatigue in FM.
Review
Biochemistry & Molecular Biology
Luke Juckett, Tiam Mana Saffari, Benjamin Ormseth, Jenna-Lynn Senger, Amy M. M. Moore
Summary: Peripheral nerve injuries (PNI) often result in lifelong disability with rare complete functional recovery. Intraoperative electrical stimulation (ES) is a promising surgical adjunct that can augment the intrinsic molecular pathways of nerve regeneration. Clinical trials have shown that ES can be an efficacious therapy to improve patient outcomes following PNIs.
Article
Immunology
Wei Li, Jie Liang, Shaohua Li, Luoyang Wang, Shuo Xu, Suli Jiang, Meiying Song, Haining Meng, Dongchang Zhai, Lei Tang, Yanyan Yang, Li Zhang, Bei Zhang
Summary: This article summarizes the mechanisms of nerve damage and pain caused by excessive activation of the NLRP3 inflammasome.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)