Review
Clinical Neurology
Sina R. Potel, Sara Marceglia, Sara Meoni, Suneil K. Kalia, Rubens G. Cury, Elena Moro
Summary: This review discusses the application of deep brain stimulation (DBS) in various movement disorders and explores recent advances in the field. New DBS technologies, such as innovative stimulation patterns and adaptive DBS, have improved treatment outcomes. A better understanding of the pathophysiology and functional anatomy of movement disorders is crucial for studying the effects of DBS. Neurosurgical practice has also been enhanced, leading to more accurate targeting. A growing research domain focuses on the combination of neuromodulation and neuroprotection.
CURRENT NEUROLOGY AND NEUROSCIENCE REPORTS
(2022)
Article
Clinical Neurology
Jurgen Germann, Brendan Santyr, Alexandre Boutet, Can Sarica, Clement T. Chow, Gavin J. B. Elias, Artur Vetkas, Andrew Yang, Mojgan Hodaie, Alfonso Fasano, Suneil K. Kalia, Michael L. Schwartz, Andres M. Lozano
Summary: Comparing the efficacy maps of DBS and MRgFUS suggests a potential alternative location for lesioning, more antero-superiorly. This may reduce complications, without sacrificing efficacy, and individualise targeting.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2023)
Article
Neurosciences
Bart E. K. S. Swinnen, Arthur W. Buijink, Dan Pina-Fuentes, Rob M. A. de Bie, Martijn Beudel
Summary: This article provides an extensive overview of the current state and potential of subcortical sensing, particularly in the treatment of movement disorders. It also discusses the barriers and future directions for the clinical implementation of this technology.
Review
Clinical Neurology
Yiping Li, Anadjeet Khahera, Jason Kim, Mauricio Mandel, Summer S. Han, Gary K. Steinberg
Summary: Reports on basal ganglia cavernous malformations are rare, with headache being the most common presenting symptom. Lesions involving the caudate nucleus are more likely to present with intraventricular hemorrhage and hydrocephalus. Surgery is a safe and effective treatment modality for managing BGCMs, with an estimated long-term permanent morbidity rate of around 10%.
JOURNAL OF NEUROSURGERY
(2021)
Article
Multidisciplinary Sciences
Youngcho Kim, Dennis Jung, Mayu Oya, Morgan Kennedy, Tomas Lence, Stephanie L. Alberico, Nandakumar S. Narayanan
Summary: Brain rhythms are linked with behavior, and abnormal rhythms can indicate pathological conditions. However, the relevance of phase in brain stimulation is still unclear. In this study, a phase-adaptive, real-time, closed-loop algorithm was developed to control the instantaneous phase of brain rhythms. The findings provide causal evidence that phase is important for brain stimulation, allowing for more precise and individualized treatments. These findings have implications for preclinical brain stimulation and circuit-specific neuromodulation in human brain disease.
SCIENTIFIC REPORTS
(2022)
Article
Neurosciences
Junichi Yoshida, Maritza Onate, Leila Khatami, Jorge Vera, Farzan Nadim, Kamran Khodakhah
Summary: The cerebellum and basal ganglia are connected through direct pathways, influencing motor coordination and dopamine release, and impacting motor deficits and addictive behavior.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Clinical Neurology
Sinem Balta Beylergil, Palak Gupta, Mohamed ElKasaby, Camilla Kilbane, Aasef G. Shaikh
Summary: Postural instability and balance impairment are common in Parkinson's disease, and recent studies have found abnormal perception of self-motion in the vestibular domain in PD patients. Balance function measures, such as perception of motion, correlate with disease duration and severity, particularly tremor symptoms. These findings suggest that visual function can potentially be utilized for balance rehabilitation in PD patients.
JOURNAL OF NEUROLOGY
(2022)
Article
Neurosciences
Demetrio Milardi, Gianpaolo Antonio Basile, Joshua Faskowitz, Salvatore Bertino, Angelo Quartarone, Giuseppe Pio Anastasi, Alessia Bramanti, Rosella Ciurleo, Alberto Cacciola
Summary: This study aimed to test the effects of different tractography-based approaches for the reconstruction of subthalamic nucleus (STN) functional territories. Four parcellation pipelines were compared, and it was found that each parcellation provided consistent results in terms of location of the identified parcels, but with variations in size and shape. It is suggested that fine-tuning of tractography-based parcellation may lead to higher reproducibility and aid the development of an optimized surgical targeting protocol.
Article
Biochemistry & Molecular Biology
Esther Garcia-Garcia, Nerea Chaparro-Cabanillas, Albert Coll-Manzano, Maria Carreras-Caballe, Albert Giralt, Daniel Del Toro, Jordi Alberch, Merce Masana, Manuel J. Rodriguez
Summary: Loss-of-function mutations in the VPS13A gene cause Chorea-acanthocytosis. The study reveals stable and widespread expression of VPS13A in the mouse brain, with the strongest profiles in the pons, hippocampus, and cerebellum. VPS13A is mainly located in neurons, co-localizing with the endoplasmic reticulum and mitochondria.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Neurosciences
Zixiao Yin, Yin Jiang, Timon Merk, Wolf-Julian Neumann, Ruoyu Ma, Qi An, Yutong Bai, Baotian Zhao, Yichen Xu, Houyou Fan, Quan Zhang, Guofan Qin, Ning Zhang, Jun Ma, Hua Zhang, Huanguang Liu, Lin Shi, Anchao Yang, Fangang Meng, Guanyu Zhu, Jianguo Zhang
Summary: This study found that the oscillatory pattern of the pallidum in multiple movement disorders changes during sleep, and these changes can be used to differentiate sleep stages. Machine learning approaches can classify sleep stages in patients with different diseases based on the pallidal oscillatory features. These findings have broad translational prospects for the development of adaptive deep brain stimulation systems targeting sleep problems.
NEUROBIOLOGY OF DISEASE
(2023)
Article
Neurosciences
Olivier Darbin, Erwin B. Montgomery
Summary: Current theories on the basal ganglia-thalamic-cortical circuitry cannot explain the orchestration of motor units. Nonmonotonic nonlinear dynamics is proposed as an alternative approach to better understand the complex orchestration of the motor system.
NEUROSCIENCE RESEARCH
(2022)
Article
Neurosciences
C. Dastolfo-Hromack, A. Bush, A. Chrabaszcz, A. Alhourani, W. Lipski, D. Wang, D. J. Crammond, S. Shaiman, M. W. Dickey, L. L. Holt, R. S. Turner, J. A. Fiez, R. M. Richardson
Summary: Speaking precisely is crucial for effective verbal communication. This study examined the contribution of the basal ganglia to articulatory gain by recording neural activity from different brain regions. The findings showed that articulatory gain was associated with neural activity in the precentral gyrus and subthalamic nucleus, but not the postcentral gyrus. Additionally, higher beta synchrony between the subthalamic nucleus and precentral gyrus was related to impaired articulatory precision.
Review
Neurosciences
Yangfan Peng, Nina Schoeneberg, Maria Soleded Esposito, Joerg R. P. Geiger, Andrew Sharott, Philip Tovote
Summary: Accelerating technological progress in experimental neuroscience has led to increased scale and specificity in observational and perturbational approaches to study circuit physiology. This review introduces classic and novel methods, including electrophysiological recordings, calcium imaging, and specific stimulation techniques, and focuses on their application in rodent models of Parkinson's disease and motor control. By discussing the scope and limitations of each method, the review highlights their potential in understanding pathophysiological mechanisms at cellular and circuit levels and bridging different scales.
EXPERIMENTAL NEUROLOGY
(2022)
Article
Clinical Neurology
Alessia Putorti, Michele Corrado, Micol Avenali, Daniele Martinelli, Marta Allena, Silvano Cristina, Valentina Grillo, Luca Martinis, Stefano Tamburin, Mariano Serrao, Antonio Pisani, Cristina Tassorelli, Roberto De Icco
Summary: The study demonstrates the beneficial effects of a 4-week intensive rehabilitative program on destination sequence effect in patients with Parkinson's disease, especially those with freezing of gait. Improvement in destination sequence effect after training is associated with enhancements in speed, cadence, stride duration, and stride length.
FRONTIERS IN NEUROLOGY
(2021)
Article
Neurosciences
Laura Andreoli, Morteza Abbaszadeh, Xiao Cao, Maria Angela Cenci
Summary: The study compared the effects of different dopamine receptor agonists on dyskinesia in mice with 6-hydroxydopamine lesions. The results indicated that D2 receptors play a predominant role in mediating the dystonic components of LID.
NEUROBIOLOGY OF DISEASE
(2021)
Letter
Clinical Neurology
Marwan Hariz, Jeff M. Bronstein, G. Rees Cosgrove, Rob M. A. de Bie, Mahlon R. DeLong, Robert E. Gross, Paul Krack, Joachim K. Krauss, Anthony E. Lang, Andrew J. Lees, Andres M. Lozano, Jose A. Obeso, P. Richard Schuurman, Jerold L. Vitek
MOVEMENT DISORDERS
(2023)
Article
Neurosciences
Isabel Sastre-Bataller, Marina Campins-Romeu, Andres Marcos-Carrion, Antonio Gutierrez-Martin, Rebeca Conde-Sardon, Mireya Losada-Lopez, Jose M. Santabarbara-Gomez, Jose L. Leon-Guijarro, Vicente Belloch, Andres M. Lozano, Irene Martinez-Torres
Summary: Magnetic resonance image-guided high-intensity focused ultrasound (MRIgFUS) can effectively control essential tremor (ET) with minimal side effects. This study showed that hand tremor scores improved by 76% after 6 months of follow-up, and 87% of patients reported significant improvement in symptoms. Objective measurements of balance using the Berg Balance Scale remained stable throughout the follow-up period for most patients.
STEREOTACTIC AND FUNCTIONAL NEUROSURGERY
(2023)
Article
Clinical Neurology
Martin Jakobs, Mohammad Mehdi Hajiabadi, David Hernan Agiorre-Padilla, Peter Giaccobe, Andreas W. Unterberg, Andres M. Lozano
Summary: This study investigated the convenience of recharging in psychiatric patients who received deep brain stimulation (DBS) with rechargeable implantable pulse generators (r-IPGs). The results showed that although the patients rated the recharging process as easy, they had a higher charge burden and higher rates of usage-related complications compared to movement disorder DBS patients.
WORLD NEUROSURGERY
(2023)
Review
Clinical Neurology
Artur Vetkas, Juergen Germann, Alexandre Boutet, Nardin Samuel, Can Sarica, Kazuaki Yamamoto, Brendan Santyr, Cletus Cheyuo, Christopher R. R. Conner, Stefan M. M. Lang, Andres M. M. Lozano, George M. M. Ibrahim, Taufik Valiante, Paul N. N. Kongkham, Suneil K. K. Kalia
Summary: This systematic review summarizes the clinical indications, outcomes, and adverse effects of insular laser interstitial thermal therapy (LITT) through a review of the literature. The results show that LITT is effective in treating both insular seizures and insular tumors. However, the lack of prospective studies highlights the need for randomized and controlled trials to evaluate the efficacy of LITT.
FRONTIERS IN NEUROLOGY
(2023)
Letter
Clinical Neurology
Arjun Balachandar, Alexandre Boutet, Artur Vetkas, Jurgen Germann, Ian Y. M. Chan, David Mikulis, Renato P. Munhoz, Alfonso Fasano, Suneil K. Kalia, Andres M. Lozano
MOVEMENT DISORDERS CLINICAL PRACTICE
(2023)
Editorial Material
Neurosciences
Brendan Santyr, Renato P. Munhoz, Andres M. Lozano
Summary: Dystonia is a movement disorder characterized by involuntary muscular contractions that cause twisting and repetitive movements and/or abnormal postures. Deep brain stimulation (DBS) has emerged as an effective treatment option for medically intractable, disabling dystonias. The benefits of DBS include reversibility, adjustability, and continuing access to the therapeutic target. DBS has shown promising results for generalized dystonia.
ARQUIVOS DE NEURO-PSIQUIATRIA
(2023)
Review
Clinical Neurology
Yuri Ferreira Felloni Borges, Cletus Cheyuo, Andres M. Lozano, Alfonso Fasano
Summary: This review compares unilateral ventral intermedius nucleus deep brain stimulation (VIM DBS) with bilateral DBS using Magnetic Resonance-guided Focused Ultrasound (MRgFUS) thalamotomy for the treatment of Essential Tremor (ET). The discussion includes the impact on tremor reduction and potential complications of these two surgical methods. The authors provide their expert opinion.
EXPERT REVIEW OF NEUROTHERAPEUTICS
(2023)
Article
Neurosciences
Diellor Basha, Suneil K. K. Kalia, Mojgan Hodaie, Adriana L. Lopez L. Rios, Andres M. M. Lozano, William D. D. Hutchison
Summary: This study investigates the role of beta oscillations in the basal ganglia and cerebellar regions in visuomotor coordination. The recordings during the visuomotor task showed a decrease in beta oscillations and an increase in firing rates. These findings suggest that beta oscillations are modulated by novel visuomotor tasks and facilitate information transmission to the thalamocortical circuit.
FRONTIERS IN HUMAN NEUROSCIENCE
(2023)
Article
Neurosciences
Frhan I. Alanazi, Suneil K. Kalia, Mojgan Hodaie, Adriana Lopez L. Rios, Andres M. Lozano, Luka Milosevic, William D. Hutchison
Summary: The neurophysiology of selective attention in visual and auditory systems was studied in animal models and recorded neuronal activity in human patients with parkinsonian and non-parkinsonian tremors. The results showed that the firing rate of neurons decreased during the auditory oddball task, specifically related to auditory attention. The study also found that dopamine modulates thalamic beta oscillations for selective attention in Parkinson's disease patients.
NPJ PARKINSONS DISEASE
(2023)
Article
Clinical Neurology
Stefan Lang, Artur Vetkas, Christopher Conner, Lorraine V. Kalia, Andres M. Lozano, Suneil K. Kalia
Summary: This study identified features at early diagnosis that can predict the need for deep brain stimulation surgery in newly diagnosed Parkinson's disease patients. The results from the logistic regression and linear mixed effect models suggest that these features can be used for early identification and surgical decision-making.
MOVEMENT DISORDERS CLINICAL PRACTICE
(2023)
Letter
Clinical Neurology
Daniel G. Di Luca, Talyta C. Grippe, John Adams, Robert Chen, Alfonso Fasano, Andres Lozano, Anthony E. Lang
CANADIAN JOURNAL OF NEUROLOGICAL SCIENCES
(2023)
Article
Clinical Neurology
Jurgen Germann, Brendan Santyr, Alexandre Boutet, Can Sarica, Clement T. Chow, Gavin J. B. Elias, Artur Vetkas, Andrew Yang, Mojgan Hodaie, Alfonso Fasano, Suneil K. Kalia, Michael L. Schwartz, Andres M. Lozano
Summary: Comparing the efficacy maps of DBS and MRgFUS suggests a potential alternative location for lesioning, more antero-superiorly. This may reduce complications, without sacrificing efficacy, and individualise targeting.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2023)
Article
Clinical Neurology
Brendan Santyr, Aaron Loh, Artur Vetkas, Dave Gwun, Wilson K. W. Fung, Shakeel Qazi, Jurgen Germann, Alexandre Boutet, Can Sarica, Andrew Yang, Gavin Elias, Suneil K. Kalia, Alfonso Fasano, Andres M. Lozano
Summary: We report a case of a cervical dystonia patient who lost the ability to swim and dance during active stimulation of the globus pallidus internus. Using unique functional and structural imaging analysis, we investigated the anatomical underpinning of this phenomenon. The results showed significant stimulation-evoked responses during fMRI.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2023)
Review
Psychiatry
Nour Shaheen, Ahmed Shaheen, Can Sarica, Arun Singh, Mario Zanaty, Karim Johari, Andrew Yang, Theresa Zesiewicz, Brian Dalm, Yarema Bezchlibnyk, Andres M. Lozano, Oliver Flouty
Summary: A meta-analysis was conducted to evaluate the efficacy of deep brain stimulation (DBS) in treating substance use disorder (SUD) and reducing relapse rates. The results showed that DBS treatment significantly improved clinical SUD scales with an average improvement of 59.6%. The relapse rate was observed to be 8%. However, there was a large degree of heterogeneity among the included studies and more research is needed to better understand the factors that influence its effectiveness.
FRONTIERS IN PSYCHIATRY
(2023)
Article
Computer Science, Artificial Intelligence
Simon Oxenford, Ana Sofia Rios, Barbara Hollunder, Clemens Neudorfer, Alexandre Boutet, Gavin J. B. Elias, Jurgen Germann, Aaron Loh, Wissam Deeb, Bryan Salvato, Leonardo Almeida, Kelly D. Foote, Robert Amaral, Paul B. Rosenberg, David F. Tang-Wai, David A. Wolk, Anna D. Burke, Marwan N. Sabbagh, Stephen Salloway, M. Mallar Chakravarty, Gwenn S. Smith, Constantine G. Lyketsos, Michael S. Okun, William S., Zoltan Mari, Francisco A. Ponce, Andres Lozano, Wolf-Julian Neumann, Bassam Al-Fatly, Andreas Horn
Summary: Spatial normalization is a method to map subject brain images to an average template brain, allowing comparison of brain imaging results. We introduce a novel tool called WarpDrive, which enables manual refinements of image alignment after automated registration. The tool improves accuracy of data representation and aids in understanding patient outcomes.
MEDICAL IMAGE ANALYSIS
(2024)