Article
Chemistry, Medicinal
Rachel J. J. Stephenson, Istvan Toth
Summary: Cocaine is a widely used illegal drug that has significant medical and social consequences. The lack of effective pharmacological treatments has led to the development of anti-cocaine vaccines. Despite years of research, no approved pharmacological treatments exist to help individuals overcome cocaine addiction or prevent relapse.
JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Nursing
Barbara Riegel, Sandra B. Dunbar, Donna Fitzsimons, Kenneth E. Freedland, Christopher S. Lee, Sandy Middleton, Anna Stromberg, Ercole Vellone, David E. Webber, Tiny Jaarsma
Summary: This article discusses the importance and objectives of self-care research, proposes a future research agenda, and shares the vision and mission of a research center dedicated to self-care. It emphasizes the importance of addressing challenges in self-care and strategies to tackle knowledge gaps.
INTERNATIONAL JOURNAL OF NURSING STUDIES
(2021)
Review
Oncology
Albert Jang, David M. Adler, Grant P. Rauterkus, Mehmet A. Bilen, Pedro C. Barata
Summary: Genitourinary malignancies encompass various cancers along the urinary and male reproductive tracts. Traditional immunotherapies have shown success in treating certain types of these cancers, while immune checkpoint inhibitors have emerged as a more precise method to enhance the immune system's ability to fight tumor cells. Despite promising data from clinical trials, there is still limited understanding of biomarkers that can predict response to these inhibitors, and the efficacy of ICIs varies across different tumor types in the genitourinary system.
Review
Biochemistry & Molecular Biology
Zuming Zhang, Zihui Xu, Fa Yuan, Kangxin Jin, Mengqing Xiang
Summary: This article discusses the historical background of retinal organoid technology, current methods of organoid induction, obstacles and potential solutions for next-generation retinal organoids, research progress in cell/tissue transplantation to treat retinal diseases, and the pros and cons of transplanting single-cell suspension versus retinal organoid sheet for cell therapies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Medicine, General & Internal
Melissa J. Alldred, Alessandra C. Martini, David Patterson, James Hendrix, Ann-Charlotte Granholm
Summary: Down syndrome is a form of accelerated aging due to the overexpression of multiple genes on Chromosome 21, leading to a predisposition to aging-related conditions and significant accumulation of abnormalities in the brain. This review highlights the major advancements in research over the past few decades, current research status, and essential areas for future studies, as well as discussing comorbidities and clinical research efforts in the United States and Europe. The review also addresses funding efforts and recent recommendations to the NIH regarding research on Down syndrome.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Immunology
Shruti Srivastava, Sajal Dey, Sangita Mukhopadhyay
Summary: Tuberculosis (TB) is a major cause of death, killing over 30,000 people per week and surpassing other infectious diseases like AIDS and malaria. TB treatment is affected by factors such as ineffective drugs, lack of advanced vaccines, misdiagnosis, improper treatment, and social stigma. Different vaccine strategies have been employed, including protein subunit vaccines, viral vector vaccines, whole-cell inactivation vaccines, and recombinant BCG vaccines. Currently, there are approximately 19 vaccine candidates in clinical trials. Advanced vaccines that generate heterologous immune responses are needed to enhance long-lasting immunity against both drug-sensitive and drug-resistant TB.
Review
Pharmacology & Pharmacy
Neda Rahimian, Hamid Reza Miraei, Atefeh Amiri, Mohammad Saeid Ebrahimi, Javid Sadri Nahand, Hossein Tarrahimofrad, Michael R. Hamblin, Haroon Khan, Hamed Mirzaei
Summary: Therapeutic vaccines are effective in treating cancer at later stages, with the recent approval of the first therapeutic cancer vaccine by the FDA. Further studies are expected to lead to the development of vaccines with improved efficacy.
PHARMACOLOGICAL RESEARCH
(2021)
Article
Endocrinology & Metabolism
Ruediger Gross, Alexander Kleger
Summary: As emerging clinical analyses suggest an increased risk of new-onset diabetes following COVID-19, a causal link and underlying mechanisms are yet to be established. Persistence of hyperglycaemia after disease regression and the potential infection of non-pancreatic tissue are adding another layer of complexity to the relationship between COVID-19 and diabetes mellitus.
Review
Chemistry, Physical
Swaminath Bharadwaj, Bart-Jan Niebuur, Katja Nothdurft, Walter Richtering, Nico F. A. van der Vegt, Christine M. Papadakis
Summary: Cononsolvency is an intriguing phenomenon where a polymer collapses in a mixture of good solvents. It has been widely observed in different systems and has applications in various fields. In the past decade, there has been a renewed interest in understanding the molecular mechanisms driving cononsolvency.
Editorial Material
Cell Biology
Md Mobashir Hasan Shandhi, Jessilyn P. Dunn
Summary: Advancements in AI have enabled personalized healthcare by investigating disease origins at the genetic or molecular level, understanding individual drug effects, and integrating multi-modal personal data to uncover new aspects of pathophysiology. Future efforts should focus on addressing equity, fairness, explainability, and generalizability of AI models.
CELL REPORTS MEDICINE
(2022)
Editorial Material
Gastroenterology & Hepatology
Xi Wang, Xuchen Zhang
Summary: This article provides updated information on the clinical, pathological, and molecular features of different subtypes of hepatocellular adenoma (HCA), with a focus on the development of a phenotype-genotype classification system to identify high-risk subtypes and improve clinical management.
WORLD JOURNAL OF GASTROENTEROLOGY
(2022)
Review
Peripheral Vascular Disease
John W. Funder, Robert M. Carey
Summary: Primary aldosteronism, the most common secondary form of hypertension, may have a higher prevalence than previously estimated. The screening rate for primary aldosteronism is currently low, and more research is needed to explore screening and treatment methods.
Article
Biochemistry & Molecular Biology
Monica Cejuela, Begona Martin-Castillo, Javier A. Menendez, Sonia Pernas
Summary: Breast cancer is the most common cancer among women worldwide, and metabolic traits associated with type 2 diabetes such as hyperglycemia, hyperinsulinemia, inflammation, oxidative stress, and obesity are known risk factors. Metformin, a widely prescribed medication for diabetes, has been suggested to have anti-tumor effects based on previous studies. However, recent randomized controlled trials have shown disappointing results, particularly in metastatic breast cancer. This article reviews the mechanisms of action of metformin, discusses past and current clinical trials, and briefly explores future perspectives for incorporating metformin into the prevention and treatment of breast cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Chemistry, Multidisciplinary
Lan Yuan, Zhaoyi Geng, Jikun Xu, Fen Guo, Chuang Han
Summary: This review provides a comprehensive understanding of the structure-property-catalysis interplays of metal-semiconductor heterostructures (MSHs) for photoredox reactions, focusing on monitoring key photophysical/photochemical processes and design parameters. Applications of MSHs for solar energy conversion and the challenges/opportunities for further promoting this field are also discussed.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Article
Green & Sustainable Science & Technology
Maryam Hina, Chetna Chauhan, Puneet Kaur, Sascha Kraus, Amandeep Dhir
Summary: The literature on the circular economy business model (CEBM) has been growing rapidly in recent years. However, there has been a lack of critical analysis of the existing literature. This systematic literature review (SLR) aims to critically analyze and evaluate the prior findings on CEBM, identify research gaps, and propose future research agendas. Through analyzing 126 studies, the paper provides a comprehensive assessment of the drivers and barriers of CEBM and presents a conceptual framework based on actor-network theory for further investigation. The study also offers theoretical and practical implications for overcoming barriers and addressing challenges in CEBM implementation.
JOURNAL OF CLEANER PRODUCTION
(2022)
