Review
Biochemistry & Molecular Biology
R. Steven Esworthy, James H. Doroshow, Fong-Fong Chu
Summary: GPX2 is a selenoenzyme with glutathione peroxidase activity. It is closely related to GPX1 in terms of structure, substrate specificities, and subcellular localization. GPX2 is widely expressed in epithelial tissues, with concentration in stem cell and proliferative compartments. Its expression is regulated by many pathways, but its significance needs to be evaluated in the context of other peroxidase activities.
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Article
Business, Finance
Narasimhan Jegadeesh, Sheridan Titman
Summary: This paper evaluates various explanations for the momentum effect, reviews recent literature, and analyzes the performance of momentum strategies in different markets after 2000.
PACIFIC-BASIN FINANCE JOURNAL
(2023)
Review
Behavioral Sciences
Luca Bonini, Cristina Rotunno, Edoardo Arcuri, Vittorio Gallese
Summary: Mirror neurons are a class of neurons that discharge during both action execution and observation. Recent studies have revealed that beyond traditional mirror neurons, there are other cell types distributed in multiple brain areas that form a more complex and flexible 'mirror mechanism', which plays an important role in social interaction. This discovery has inspired translational research and the development of new neurorehabilitation approaches, and is a milestone in social and affective neuroscience.
TRENDS IN COGNITIVE SCIENCES
(2022)
Review
Cell Biology
Yahir A. Loissell-Baltazar, Svetlana Dokudovskaya
Summary: The SEA complex was first described in yeast and its human homologue, the GATOR complex, two years later. Over the past decade, significant advances have been made in understanding the multiple functions of the SEA/GATOR complex in different organisms, highlighting its role as an essential upstream regulator of the mTORC1 pathway. Additionally, the consequences of GATOR mutations in cancer and neurodegenerative diseases have been emphasized.
Article
Medicine, General & Internal
Silva Heslley Machado
Summary: The last two pandemics that hit humanity were separated by about 100 years, but it seems that scientific development has not had an impact on Brazilian society, including its leaders. This has led to the use of remedies without scientific proof, causing tragic consequences in the fight against pandemics.
AFRICAN HEALTH SCIENCES
(2021)
Article
Clinical Neurology
Heather Angus-Leppan, Thomas A. Clay
Summary: This study investigated adult occipital lobe epilepsies (OLE) patients, finding that most patients experienced visual hallucinations and had a high rate of misdiagnosis. The majority of patients had comorbid migraines, with only a minority having the rarer form of migralepsy characterized by longer auras and better prognosis. Overall, remission rates were lower than in childhood OLE and general adult epilepsy populations.
JOURNAL OF NEUROLOGY
(2021)
Article
Psychology, Multidisciplinary
Isobel G. Bond, Keitaro Machida, Katherine A. Johnson
Summary: This study aimed to investigate the effects of arousal on sustained attention performance in humans using two approaches: a small-N study and a larger sample study. The results showed a curvilinear relationship in the small-N study, but no significant relationship in the large-N study. Overall, the hypothesized inverted-U relation between arousal and sustained attention performance was not found.
CURRENT PSYCHOLOGY
(2023)
Article
Education & Educational Research
Andrew Bacher-Hicks, Olivia L. Chi, Alexis Orellana
Summary: The challenges of teaching during COVID-19 led to fears of a mass exodus from the profession, and this study examines if those fears were realized among Massachusetts teachers. The turnover rates were similar to pre-pandemic levels in fall 2020 but increased by 17% in fall 2021. Newly hired teachers had a higher increase in turnover rates, while Black and Hispanic/Latinx teachers had lower increases. The study also found that the gaps in turnover rates between schools serving economically disadvantaged students and schools serving higher concentrations of these students, as well as between schools serving Black and Hispanic/Latinx students and schools serving lower shares of them, narrowed during the first 18 months of the pandemic.
EDUCATIONAL RESEARCHER
(2023)
Article
Nursing
Mary C. Sullivan, Amy L. D'Agata, Zachary Stanley, Pamela Brewer, Michelle M. Kelly
Summary: This study aims to share a comprehensive protocol of a 10th follow-up study of premature infants in their 30s. The study utilizes a prospective, five-group longitudinal design and includes 215 term-born and preterm-born individuals. Adult outcomes include health, adaptive function, executive function, work, and social competence. The protocol takes into account stress during the neonatal period, the cumulative context of development, biological and epigenetic mechanisms, and individual resilience.
Article
Clinical Neurology
Fred D. Lublin, Stephen C. Krieger
Summary: Thirty years ago, the first disease-modifying therapy for relapsing multiple sclerosis was approved in the United States and globally. Since then, research in MS therapeutics, immunopathogenesis, and genetics has advanced our understanding of the disease and raised hope for better treatments, nervous system repair, and ultimately a cure. However, there is a growing divide between the successes in treating relapsing disease and the challenges posed by progressive MS, which remains a major unmet need. In this Personal Viewpoint, we discuss the lessons learned from the first era of therapeutic development and consider the future of MS research and treatment.
MULTIPLE SCLEROSIS JOURNAL
(2023)
Article
Biochemistry & Molecular Biology
Christopher J. L. Murray
Summary: The Global Burden of Disease Study has evolved over the past 30 years and is now a collaborative effort involving over 8,000 scientists and analysts from more than 150 countries, providing assessments of thousands of outcomes for diseases, injuries, and risk factors in over 200 countries and territories.
Article
Geochemistry & Geophysics
Han Wang, Mengwan Wang, Meiru Zhao, Leiku Yang
Summary: This study investigates the role of shadow in the spectral response of urban SPR using in situ and airborne measurements. The results show that shadow has little effect on spectral responses of urban SPR, which can be used in quantitative remote sensing of the atmosphere over urban areas.
IEEE GEOSCIENCE AND REMOTE SENSING LETTERS
(2021)
Article
Multidisciplinary Sciences
Olga Flegontova, Julius Lukes, Ales Horak
Summary: Intragenomic diversity of molecular barcodes may lead to overestimation of diversity in metabarcoding data.
Article
Physics, Multidisciplinary
M. Elbistan, P. M. Zhang, P. A. Horvathy
Summary: Particles at rest are moved along diverging geodesics with constant velocity after the arrival of a gravitational wave. The motion is particularly simple in Baldwin-Jeffery-Rosen (BJR) coordinates, but requires the solution of a Sturm-Liouville equation in Brinkmann coordinates. The theory is illustrated using examples of linearly polarized and circularly polarized approximate sandwich waves.
Article
Clinical Neurology
Christian Hoppe, Kassandra Beeres, Juri-Alexander Witt, Robert Sassen, Christoph Helmstaedter
Summary: Pediatric epilepsy surgery has the potential to cure epilepsy in some children and significantly control seizures in most patients. The reporting of surgical complications and adverse events may be underestimated and requires further evaluation.