Article
Anesthesiology
Mahmoud Mohammed Alseoudy, Mohamed Osama Nasr, Tamer Ahmed Abdelsalam
Summary: Prophylactic administration of 10-mg midodrine tablets before spinal anesthesia is an effective method in preventing hypotension in young adult patients undergoing elective orthopedic knee surgery.
ANESTHESIA AND ANALGESIA
(2022)
Article
Clinical Neurology
Robert A. Hauser, Antonella Favit, L. Arthur Hewitt, Annika Lindsten, Stephen Gorny, Steven Kymes, Stuart H. Isaacson
Summary: This study evaluated the long-term efficacy and tolerability of droxidopa in patients with neurogenic orthostatic hypotension (nOH). The results showed significant improvement in symptoms and daily activities after 12 weeks of treatment with droxidopa, and no clinically important changes in supine hypertension or adverse events of concern were observed.
NEUROLOGY AND THERAPY
(2022)
Article
Biochemistry & Molecular Biology
Stephen A. Harrison, Rebecca Taub, Guy W. Neff, K. Jean Lucas, Dominic Labriola, Sam E. Moussa, Naim Alkhouri, Mustafa R. Bashir
Summary: This study evaluated the safety of resmetirom in adults with nonalcoholic fatty liver disease and presumed NASH. The findings demonstrated that resmetirom was safe and well tolerated, and showed positive effects on some key secondary endpoints.
Review
Medicine, General & Internal
Pranvera Hoxhaj, Shruti Shah, Veronica E. Muyolema Arce, Wajiha Khan, Amirali Sadeghzadegan, Saumya Singh, Gaudy F. Collado, Abhishek Goyal, Imran Khawaja, Deepti Botlaguduru, Waleed Razzaq, Zain U. Abdin, Ishita Gupta
Summary: Neurogenic orthostatic hypotension (nOH) is a disabling problem in Parkinson's disease patients, but the efficacy and safety of droxidopa and ampreloxetine in its treatment have been explored in this literature review. The results show that both drugs significantly improve the quality of life and mortality rates in patients with nOH. However, the long-term efficacy of droxidopa and the potential worsening of standing systolic blood pressure after ampreloxetine withdrawal need further research to improve the therapeutic approach for nOH in Parkinson's disease patients.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2023)
Article
Pharmacology & Pharmacy
Jitendra Kanodia, Arthur Lo, R. Michael Baldwin, Richard A. Graham, David L. Bourdet
Summary: The study characterized the pharmacokinetics of Ampreloxetine using a population pharmacokinetic model, showing an extended half-life and sustained drug concentrations at steady state. Sex and smoking status were identified as statistically significant covariates affecting Ampreloxetine exposure, although not clinically meaningful at the recommended dose.
CLINICAL PHARMACOKINETICS
(2021)
Article
Gastroenterology & Hepatology
Satish S. C. Rao, Eamonn M. M. Quigley, William D. Chey, Amol Sharma, Anthony J. Lembo
Summary: This study examined the efficacy and safety of a vibrating capsule in patients with chronic constipation. The results showed that the vibrating capsule was superior to placebo in improving bowel symptoms and quality of life. The vibrating capsule was also found to be safe and well tolerated.
Article
Anesthesiology
Mehmet Aksoy, Aysenur Dostbil, Ayse Nur Aksoy, Ilker Ince, Zehra Bedir, Ozgur Ozmen
Summary: Prophylactic IV administration of 3 mg of granisetron or 8 mg of ondansetron before spinal anesthesia leads to a significantly lower ephedrine requirement during surgery, compared to placebo.
JOURNAL OF CLINICAL ANESTHESIA
(2021)
Review
Clinical Neurology
Yu Jin Jung, Aryun Kim, Luis E. Okamoto, Woi-Hyun Hong
Summary: This study found that atomoxetine is an effective and safe option for the pharmacological treatment of neurogenic orthostatic hypotension (nOH) in patients with alpha-synucleinopathies. It effectively increases systolic blood pressure and improves OH-related symptoms, especially in cases with central autonomic failure. However, further investigation is needed due to the limited evidence available.
JOURNAL OF CLINICAL NEUROLOGY
(2023)
Review
Clinical Neurology
Jake Ryan Gibbon, James Frith
Summary: The review of five studies indicated that caffeine can improve symptoms and reduce orthostatic blood pressure drop in adults with neurogenic orthostatic hypotension. However, most studies had high risk of bias, suggesting that caffeine should only be considered when other treatments have failed.
CLINICAL AUTONOMIC RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Jennifer M. Mitchell, G. Marcela Ot'alora, Bessel van der Kolk, Scott Shannon, Michael Bogenschutz, Yevgeniy Gelfand, Casey Paleos, Christopher R. Nicholas, Sylvestre Quevedo, Brooke Balliett, Scott Hamilton, Michael Mithoefer, Sarah Kleiman, Kelly Parker-Guilbert, Keren Tzarfaty, Charlotte Harrison, Alberdina de Boer, Rick Doblin, Berra Yazar-Klosinski
Summary: This study evaluated the efficacy and safety of MDMA-AT in participants with moderate to severe PTSD. The results showed that MDMA-AT significantly reduced the severity of symptoms and functional impairment, and was well tolerated by a diverse population.
Article
Multidisciplinary Sciences
Prasanna Jagannathan, Jason R. Andrews, Hector Bonilla, Haley Hedlin, Karen B. Jacobson, Vidhya Balasubramanian, Natasha Purington, Savita Kamble, Christiaan R. de Vries, Orlando Quintero, Kent Feng, Catherine Ley, Dean Winslow, Jennifer Newberry, Karlie Edwards, Colin Hislop, Ingrid Choong, Yvonne Maldonado, Jeffrey Glenn, Ami Bhatt, Catherine Blish, Taia Wang, Chaitan Khosla, Benjamin A. Pinsky, Manisha Desai, Julie Parsonnet, Upinder Singh
Summary: A randomized, single-blind, placebo-controlled trial on 120 outpatients with mild to moderate COVID-19 showed that a single subcutaneous dose of Peginterferon Lambda-1a (Lambda) did not shorten the duration of SARS-CoV-2 viral shedding or improve symptoms. The treatment was well tolerated but did not have a significant impact on the outcomes of the patients.
NATURE COMMUNICATIONS
(2021)
Article
Gastroenterology & Hepatology
Miriam B. Vos, Mark L. Van Natta, Niviann M. Blondet, Srinivasan Dasarathy, Mark Fishbein, Paula Hertel, Ajay K. Jain, Saul J. Karpen, Joel E. Lavine, Saeed Mohammad, Laura A. Miriel, Jean P. Molleston, Marialena Mouzaki, Arun Sanyal, Emily P. Sharkey, Jeffrey B. Schwimmer, James Tonascia, Laura A. Wilson, Stavra A. Xanthakos
Summary: This study aimed to evaluate the effect of losartan on ALT levels in children with NAFLD. The results showed that losartan did not significantly reduce ALT levels, but it did significantly decrease alkaline phosphatase and systolic blood pressure.
Article
Pharmacology & Pharmacy
Yao-Hua Shen, Fan Yang, Li-Dan Jin, Yu-Jia Qian, Li Xing, Ya-Li Huang, Su-Feng Lin, Fei Xiao
Summary: The prophylactic infusion of phenylephrine to prevent post-spinal hypotension during cesarean delivery was associated with a higher dose of oxytocin, potentially leading to an increased need for secondary uterotonic agents. However, further studies are needed to confirm these findings and understand the clinical implications.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Transplantation
Finnian R. Mc Causland, Katherine Scovner Ravi, Katherine A. Curtis, Zoe A. Kibbelaar, Samuel A. P. Short, Anika T. Singh, Simon Correa, Sushrut S. Waikar
Summary: This study found no significant difference in systolic blood pressure decline or risk of intra-dialytic hypotension between hospitalized hemodialysis patients receiving higher or lower dialysate sodium concentrations. Adjusted analyses suggested a lower risk of intra-dialytic hypotension with higher dialysate sodium concentration, warranting further larger, multi-center studies to confirm these findings.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2022)
Article
Allergy
Soren Helbo Skaarup, Johannes Martin Schmid, Tina Skjold, Ole Graumann, Hans Jurgen Hoffmann
Summary: ILIT can significantly reduce grass pollen allergy symptoms and use of rescue medication, particularly in the first season after treatment. A booster injection one year later had no additional effect. Repeated measures of IgE and IgG4 in the ILIT groups showed significant between-group differences and within-group changes.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2021)