Review
Clinical Neurology
Feng Zhang, Yukun Ping, Xuejiao Jin, Xiaoli Hou, Jinggui Song
Summary: This review study found a significant association between PVWMHs and PSD after stroke, with a stronger correlation compared to WMHs and DWMHs. However, high-quality prospective studies are still needed to fully resolve this relationship.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Review
Behavioral Sciences
He-Ying Hu, Ya-Nan Ou, Xue-Ning Shen, Yi Qu, Ya-Hui Ma, Zuo-Teng Wang, Qiang Dong, Lan Tan, Jin-Tai Yu
Summary: The presence of white matter hyperintensities (WMH) is linked to an increased risk of cognitive impairment and dementia, including Alzheimer's disease and vascular dementia. Higher grade WMH and progressive increases in WMH volume or severity are associated with greater risks of dementia. These findings suggest that WMH could serve as a neuroimaging indicator of dementia.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2021)
Review
Radiology, Nuclear Medicine & Medical Imaging
Luca Melazzini, Paolo Vitali, Emanuele Olivieri, Marco Bolchini, Moreno Zanardo, Filippo Savoldi, Giovanni Di Leo, Ludovica Griffanti, Giuseppe Baselli, Francesco Sardanelli, Marina Codari
Summary: The study aimed to determine a point estimate and reference standard for WMH volume in the healthy aging population. However, lack of standardization in WMH definition and high technical variability in assessment explain observed heterogeneity. Currently, volumes of WMH in healthy subjects are not comparable between studies.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2021)
Article
Psychiatry
Antonio Terracciano, Bertin Cenatus, Xianghe Zhu, Selin Karakose, Yannick Stephan, Sofia Marcolini, Peter P. De Deyn, Martina Luchetti, Angelina R. Sutin
Summary: Neuroticism is associated with white matter hyperintensities, which partly mediate the association between neuroticism and cognitive function. This finding suggests that white matter integrity is a potential neurobiological pathway underlying the relationship between neuroticism and cognitive health.
JOURNAL OF PSYCHIATRIC RESEARCH
(2023)
Review
Geriatrics & Gerontology
Wenjuan Guo, Jing Shi
Summary: There is a relationship between white matter hyperintensities (WMH) volume and cognitive decline in patients with cerebral small vessel disease (CSVD). WMH is associated with an increased risk of mild cognitive impairment (MCI) and dementia, with a higher risk observed in longer follow-up periods.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Review
Clinical Neurology
Imogen Wilkinson, Alastair John Stewart Webb
Summary: The study quantified the relationship between blood pressure and white matter hyperintensities, showing that an increase in systolic blood pressure is associated with 10% of a standard deviation increase in white matter hyperintensity volume. The association with diastolic blood pressure was weaker but minimally affected by adjustment for age.
INTERNATIONAL JOURNAL OF STROKE
(2022)
Article
Clinical Neurology
Bin Liu, Guifeng Zhao, Ling Jin, Jingping Shi
Summary: The severity of WMHs in lacunar infarct patients is associated with age, cognitive decline, and impairment in balance. The track length in the anteroposterior direction with eyes closed may serve as a potential marker for disease progression in WMHs.
FRONTIERS IN NEUROLOGY
(2021)
Article
Multidisciplinary Sciences
Junyan Huo, Gan Zhang, Wenjing Wang, Wen Cao, Mengxia Wan, Tao Huang, Dongsheng Fan, Yu Fu
Summary: In this study, the bidirectional causal relationship between migraine and white matter lesions was explored using a two-sample mendelian randomization method. The analysis of a recent large-scale genome-wide association study data did not provide evidence for causality between white matter lesions and migraine.
SCIENTIFIC REPORTS
(2023)
Article
Neurosciences
Yanpeng Liu, Yiwei Xia, Xiaoxiao Wang, Yanming Wang, Du Zhang, Benedictor Alexander Nguchu, Jiajie He, Yi Wang, Lumeng Yang, Yiqing Wang, Yunqing Ying, Xiaoniu Liang, Qianhua Zhao, Jianjun Wu, Zonghui Liang, Ding Ding, Qiang Dong, Bensheng Qiu, Xin Cheng, Jia-Hong Gao
Summary: The study found that a high burden of white matter hyperintensities (WMH) is associated with worse diffusion characteristics of distal white matter tracts, which in turn affects attention and executive function.
HUMAN BRAIN MAPPING
(2021)
Article
Neuroimaging
Wenyuan Zhang, Zicheng Cheng, Fangwang Fu, Zhenxiang Zhan
Summary: This study found that there is a high prevalence of white matter hyperintensities (WMHs) in migraineurs and these WMHs are associated with various clinical characteristics, especially age and symptom onset. This research is important for further understanding the relationship between WMHs and migraine.
NEUROIMAGE-CLINICAL
(2023)
Review
Cell Biology
Emma L. Twait, Britt Min, Magdalena Beran, Jet M. J. Vonk, Mirjam I. Geerlings
Summary: This systematic review and meta-analysis investigated the relationship between amyloid burden and white matter hyperintensities (WMH) in older adults without cognitive impairment. The findings revealed an association between amyloid pathology and WMH in cerebrospinal fluid (CSF) and positron emission tomography (PET), but the relationship in plasma remains unclear. Further studies should explore the relationship between plasma amyloid-beta and WMH to identify at-risk individuals in preclinical stages.
AGEING RESEARCH REVIEWS
(2023)
Review
Clinical Neurology
Qian You, Yi Yang, Hongtao Hu
Summary: This study investigated the relationship between white matter hyperintensities (WMH) and functional outcomes after spontaneous intracerebral hemorrhage (ICH). The results showed that moderate and severe WMH were associated with poor functional outcomes and all-cause mortality after ICH.
FRONTIERS IN NEUROLOGY
(2022)
Review
Medicine, General & Internal
Cun-Sheng Wei, Cai-Yun Yan, Xiao-Rong Yu, Lin Wang, Rui Zhang, Jun-Ying Jiang, Qi Dai, Jun-Rong Li, Xue Mei Chen
Summary: This study conducted a systematic review and meta-analysis to examine the association between white matter hyperintensities (WMH) and chronic kidney disease (CKD). The results showed that patients with CKD were more likely to have WMH in the brain compared to the normal controls. Additionally, patients with moderate to severe WMH had poorer renal function compared to those with no to mild WMH.
FRONTIERS IN MEDICINE
(2022)
Article
Neuroimaging
Junjun Wang, Ying Zhou, Yaode He, Qingqing Li, Wenhua Zhang, Zhongyu Luo, Rui Xue, Min Lou
Summary: This study aims to characterize the spatial patterns of white matter hyperintensities (WMH) associated with cognitive impairment and explore its risk factors. The results show that different patterns of WMH have different impacts on cognitive impairment, with anterior subcortical patches having the most significant and extensive impact.
NEUROIMAGE-CLINICAL
(2022)
Article
Neurosciences
Michele Porcu, Luigi Cocco, Sirio Cocozza, Giuseppe Pontillo, Annunziata Operamolla, Giovanni Defazio, Jasjit S. Suri, Arturo Brunetti, Luca Saba
Summary: The study found statistically significant correlations between white matter hyperintensities (WMH) and cognitive test scores, as well as an association between total WMH burden (tWMHb) and reduced neural activity in various brain regions, particularly the prefrontal cortex, precuneus, and cerebellar crus I/II. This suggests that WMH burden is linked to impairments in neurocognitive function among healthy individuals.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2021)
Article
Geriatrics & Gerontology
Willem S. Eikelboom, Jana Koch, Elizabeth Beattie, Nicola T. Lautenschlager, Colleen Doyle, Esther van den Berg, Janne M. Papma, Kaarin J. Anstey, Moyra E. Mortby
Summary: This study analyzed electronic care notes from residential aged care facilities to investigate the reporting and management of neuropsychiatric symptoms (NPS) by staff. The findings suggest that staff primarily focus on and respond to NPS they perceive as distressing, potentially leading to under-recognition of specific NPS types and a lack of routine assessment and management of underlying causes.
AGING & MENTAL HEALTH
(2023)
Article
Clinical Neurology
S. Franzen, E. van den Berg, Y. Ayhan, D. D. Satoer, O. Turkoglu, G. E. Genc Akpulat, E. G. Visch-Brink, E. A. Scheffers, J. Kranenburg, L. C. Jiskoot, J. van Hemmen, J. M. Papma
Summary: The study aimed to develop and validate a new naming impairment assessment test (NAME) for culturally, educationally, and linguistically diverse individuals. Through a multistage pilot study, a 60-item test with excellent reliability and robust correlations with other language tests was obtained. The study found that patients with AD/mixed dementia obtained lower scores on most items of the NAME test.
JOURNAL OF THE INTERNATIONAL NEUROPSYCHOLOGICAL SOCIETY
(2023)
Article
Psychology, Clinical
Sanne Franzen, Esther van den Berg, Willemijn Bossenbroek, Judi Kranenburg, Esther A. Scheffers, Moniek van Hout, Lotte van de Wiel, Miriam Goudsmit, Rozemarijn L. Van Bruchem-Visser, Judy van Hemmen, Lize C. Jiskoot, Janne M. Papma
Summary: This study aimed to develop a new neuropsychological test battery for culturally diverse populations and investigate its feasibility. The results showed that the completion rates of the test battery were generally high, but supplementary tests were administered less frequently. Complicating factors such as suboptimal effort, fatigue, and depression were frequently observed.
CLINICAL NEUROPSYCHOLOGIST
(2023)
Article
Clinical Neurology
Ellen H. Singleton, Jay L. P. Fieldhouse, Jochum J. van 't Hooft, Marta Scarioni, Marie-Paule E. van Engelen, Sietske A. M. Sikkes, Casper de Boer, Diana Bocancea, Esther van den Berg, Philip Scheltens, Wiesje M. van der Flier, Janne M. Papma, Yolande A. L. Pijnenburg, Rik Ossenkoppele
Summary: The study examines the social cognition impairments in patients with behavioural variant of Alzheimer's disease (bvAD) and compares them with patients with behavioural variant frontotemporal dementia (bvFTD) and typical Alzheimer's disease. The findings suggest that patients with bvAD exhibit similar but milder social cognition impairments compared to bvFTD, and greater impairments compared to typical Alzheimer's disease.
Editorial Material
Clinical Neurology
Rashid Ghaznawi, Ina Rissanen, Jeroen de Bresser, Hugo J. Kuijf, Nicolaas P. A. Zuithoff, Jeroen Hendrikse, Mirjam Geerlings
Summary: This study examined the association between carotid artery stenosis (CAS) and progression of hemispheric brain atrophy. The results showed that severe CAS on the right side was associated with a greater decrease in volume of both the left and right hemispheres, while increasing degrees of CAS on the left side were not associated with greater volume loss.
CEREBROVASCULAR DISEASES
(2023)
Letter
Clinical Neurology
Esther van den Berg, Meike W. W. Vernooij, Francesco U. S. Mattace-Raso, Frank J. J. Wolters
ALZHEIMERS & DEMENTIA
(2023)
Article
Neurosciences
Emma L. Twait, Kim Blom, Huiberdina L. Koek, Maarten H. T. Zwartbol, Rashid Ghaznawi, Jeroen Hendrikse, Lotte Gerritsen, Mirjam I. Geerlings
Summary: This study used high-field 7T MRI to explore the association between psychosocial factors and hippocampal (subfield) volumes. The results showed that depression and anxiety were not associated with specific hippocampal (subfield) volumes, while childhood maltreatment and recent stressful life events may have an impact on hippocampal volume. Additionally, low social support was associated with smaller CA3 volume.
HUMAN BRAIN MAPPING
(2023)
Article
Neurosciences
Willem S. Eikelboom, Esther van den Berg, Michiel Coesmans, Jeannette A. Goudzwaard, Marc Koopmanschap, Najoua Lazaar, Rozemarijn L. van Bruchem-Visser, Jan J. M. Driesen, Tom den Heijer, Susanne Hoogers, Frank Jan de Jong, Francesco Mattace-Raso, Elsbeth C. Thomeer, Suzanne Vrenken, Lilian J. H. M. Vroegindeweij, Sytse U. Zuidema, Ellen H. Singleton, John C. van Swieten, Rik Ossenkoppele, Janne M. Papma
Summary: This study evaluated the effectiveness of the Describe, Investigate, Create, Evaluate (DICE) method in improving neuropsychiatric symptoms (NPS) in Alzheimer's disease (AD) at the memory clinic. The results showed that the method did not provide significant benefits at the group level, but individuals with high levels of NPS and NPS-related distress may benefit from this intervention.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Article
Clinical Neurology
Lize C. Jiskoot, Lucy L. Russell, Caroline V. Greaves, Esther van Schaik, Esther van den Berg, Jackie M. Poos, Liset de Boer, Laura Donker Kaat, Harro Seelaar, Yolande A. L. Pijnenburg, John C. van Swieten, Jonathan D. Rohrer
Summary: This study developed and validated an FTD Module to be used in conjunction with the Neuropsychiatric Inventory (NPI) for the assessment of neuropsychiatric symptoms (NPS) in frontotemporal dementia (FTD). The FTD Module improved the diagnostic accuracy of the NPI and has potential for research and therapeutic trials in FTD.
JOURNAL OF NEUROLOGY
(2023)
Article
Clinical Neurology
Willem S. Eikelboom, Ellen H. Singleton, Esther van den Berg, Casper de Boer, Michiel Coesmans, Jeannette A. Goudzwaard, Everard G. B. Vijverberg, Michel Pan, Cornalijn Gouw, Merel O. Mol, Freek Gillissen, Jay L. P. Fieldhouse, Yolande A. L. Pijnenburg, Wiesje M. van der Flier, John C. van Swieten, Rik Ossenkoppele, Jan A. Kors, Janne M. Papma
Summary: This study used natural language processing (NLP) to classify neuropsychiatric symptoms (NPS) in electronic health records (EHRs) and compared them with NPS reported by caregivers on the Neuropsychiatric Inventory (NPI). The results showed that clinicians frequently reported more NPS in EHRs than caregivers reported on the NPI.
ALZHEIMERS RESEARCH & THERAPY
(2023)
Article
Psychology, Clinical
Lize C. Jiskoot, Jackie M. Poos, Kristof van Boven, Liset de Boer, Lucia A. A. Giannini, Djaina D. Satoer, Evy G. Visch-Brink, Judy van Hemmen, Sanne Franzen, Yolande A. L. Pijnenburg, Esther van den Berg, Harro Seelaar
Article
Geriatrics & Gerontology
Lisanne Tap, Meike W. Vernooij, Frank Wolters, Esther van den Berg, Francesco U. S. Mattace-Raso
Summary: Cerebral small vessel disease (cSVD) is commonly seen in brain imaging of older adults, especially those with cardiovascular disease risk factors. The link between cSVD and cognitive impairment is established, but how and when these vascular changes lead to cognitive decline is still uncertain. Technological advances allow for more accurate identification and quantification of cSVD, which can aid in diagnosing vascular cognitive impairment and identifying individuals at higher risk of cognitive and functional deterioration. This study explores how improved assessment of cSVD through neuropsychological testing, comprehensive geriatric assessment, and modern imaging techniques can enhance diagnosis and prognosis of cognitive impairment. The study also discusses new treatment approaches for cSVD and how these insights can optimize screening and treatment strategies for older adults with cognitive impairment and multiple morbidities.
Article
Clinical Neurology
Lize C. C. Jiskoot, Esther van den Berg, Sascha A. A. M. Laenen, Jackie M. M. Poos, Lucia A. A. Giannini, Djaina D. D. Satoer, Judy van Hemmen, Yolande A. L. Pijnenburg, Jet M. J. Vonk, Harro Seelaar
Summary: Research suggests that qualitative measures of semantic fluency can provide valuable insights into the progression of different genetic mutations associated with Frontotemporal Dementia (FTD). Specifically, GRN mutation carriers show a decrease in clustering and an increase in cluster size, which is associated with decline in executive function. On the other hand, MAPT mutation carriers display an increase in lexical frequency and a decline in age of acquisition, which is associated with decline in semantic processing. These qualitative measures have the potential to serve as sensitive cognitive biomarkers for the diagnosis and monitoring of FTD.
JOURNAL OF NEUROLOGY
(2023)
Article
Clinical Neurology
Annick Kronenburg, Pieter T. Deckers, Esther van den Berg, Monique M. van Schooneveld, Evert-Jan Vonken, Albert van der Zwan, Bart N. M. van Berckel, Maqsood Yaqub, Willem Otte, Catharina J. M. Klijn, Kees P. J. Braun
Summary: This study investigated the profile of neurocognitive impairment in moyamoya vasculopathy patients and its relationship with ischemic brain lesions and hemodynamic compromise. The majority of patients had cognitive impairment, with adults performing better in visuospatial functioning and children performing better in processing speed. However, no association was found between cognitive impairment and imaging findings.
JOURNAL OF NEUROSURGERY
(2023)
Article
Psychology
Ellen Collee, Esther van den Berg, Evy Visch-Brink, Arnaud Vincent, Clemens Dirven, Djaina Satoer
Summary: Glioma patients often experience deficits in language and executive functioning, which affect their performance in verbal fluency. This study aims to investigate glioma patients' performance in verbal and nonverbal fluency and explore the influence of language and executive functioning on verbal fluency. Results showed that preoperatively, patients exhibited impairments in verbal fluency tasks but not in nonverbal fluency. Different language and executive functioning tests predicted performance in different verbal fluency tasks. Postoperatively, category fluency professions deteriorated while nonverbal fluency improved.
JOURNAL OF NEUROPSYCHOLOGY
(2023)
