Article
Medicine, General & Internal
Yu-Sheng Yang, Chi-Hsiang Tseng, Wei-Chien Fang, Ia-Wen Han, Shyh-Chour Huang
Summary: In this study, a new dynamic splint was found to significantly reduce wrist and finger flexor muscle spasticity in chronic stroke survivors, leading to improvements in functional movements. The experimental group showed better results compared to the control group after the intervention, with high user satisfaction reported for muscle tone reduction, comfort, and ease of use. These findings suggest that this new splint can be effectively used for at-home rehabilitation in chronic stroke patients with hemiparesis.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Rehabilitation
Songjin Ri, Stefanie Glaess-Leistner, Joerg Wissel
Summary: Using MRI data, this study identified brain imaging predictors for post-stroke spasticity, finding that larger volumes of brain lesions involving motor network areas increase the risk of developing spasticity. Patients with brain lesion volumes less than 0.5 cm³ had a low risk of post-stroke spasticity.
JOURNAL OF REHABILITATION MEDICINE
(2021)
Article
Medicine, General & Internal
Alberto Esquenazi, Wolfgang H. Jost, Catherine C. Turkel, Theodore Wein, Rozalina Dimitrova
Summary: Upper and lower limb spasticity often occurs after a stroke or in patients with neurological disorders, causing difficulties in mobility and daily living. The use of onabotulinumtoxinA has significantly improved the quality of life for these patients. Challenges in the treatment process included determining the muscles to inject and assessing the effectiveness. Despite these challenges, clinical trials targeting post-stroke spasticity have shown significant improvements and gained approval.
Article
Food Science & Technology
Jen-Wen Hung, Yen-Wei Chen, Yi-Ju Chen, Ya-Ping Pong, Wen-Chi Wu, Ku-Chou Chang, Ching-Yi Wu
Summary: This study compared two RT approaches as adjunct to BoNT-A injections and found that both condensed and distributed RT could significantly improve spasticity symptoms and activity levels in patients with chronic post-stroke upper limb spasticity.
Article
Rehabilitation
Serife Yoldas Aslan, Sehim Kutlay, Ebru Dusunceli Atman, Atilla Halil Elhan, Haydar Gok, Ayse Adile Kucukdeveci
Summary: This study evaluated the effectiveness of radial extracorporeal shock wave therapy on ankle flexor spasticity in stroke survivors. Results showed significant short-term anti-spastic effects, but these effects were not maintained at follow-up, and there was no difference in terms of improvement in elastography among the groups.
CLINICAL REHABILITATION
(2021)
Article
Clinical Neurology
Sanjana Rao, Meizhen Huang, Sun Gun Chung, Li-Qun Zhang
Summary: Intelligent stretching using an intelligent stretching device had short-term positive effects on the passive movement range of motion in chronic spastic stroke survivors, potentially reducing upper limb impairments post-stroke.
FRONTIERS IN NEUROLOGY
(2021)
Article
Rehabilitation
Javier Gonzalez-buonomo, Alexander H. Pham, Jaskiran Ghuman, Aila Malik, Nuray Yozbatiran, Gerard E. Francisco, Walter R. Frontera, Sheng LI
Summary: The objective of this study was to investigate the correlation between ultrasound characteristics of spastic muscles and clinical and functional measurements in chronic stroke survivors. The results showed that muscle thickness in the affected side was decreased, especially in the upper limb muscles. However, there was no correlation between muscle thickness and echogenicity of spastic muscles with spasticity, motor assessment scores, age, or time since stroke. Grip strength was negatively correlated with the percentage decrease in muscle thickness of the spastic flexor carpi ulnaris (FCU) muscle, while muscle thickness of the rectus femoris (RF) muscle was positively correlated with ambulatory function. These findings suggest that muscle thickness changes in chronic stroke survivors are function-dependent.
JOURNAL OF REHABILITATION MEDICINE
(2023)
Article
Clinical Neurology
Xiaoxue Zhai, Qiong Wu, Xin Li, Quan Xu, Yanlin Zhang, Senchao Fan, Li-Qun Zhang, Yu Pan
Summary: The study compared the effects of robot-aided versus manual ankle stretching training on ankle properties and balance function in stroke survivors. Both groups showed significant improvements in muscle strength, motor assessment, balance, and daily living abilities post-training, with differences observed in ankle stiffness and Pro-Kin balance test results.
FRONTIERS IN NEUROLOGY
(2021)
Article
Food Science & Technology
Sheng Li
Summary: Stiff knee gait (SKG), characterized by decreased knee flexion during the swing phase, is a common gait disorder following stroke. Knee extensor spasticity is considered the primary cause, and clinical management focuses on reducing this spasticity. However, recent research suggests that SKG can result from mechanical consequences between muscle spasticity, weakness, and ground reactions during walking. Sample cases in this article present various underlying mechanisms, including ankle plantar flexor spasticity, knee extensor spasticity, knee flexor and extensor coactivation, and hip flexor spasticity. Careful clinical assessment is advised to determine the primary cause in each patient, and understanding these different presentations of SKG can aid in selecting appropriate muscles for intervention.
Review
Engineering, Biomedical
Duchun Zeng, Wei Lei, Yurou Kong, Fenghao Ma, Kun Zhao, Xiangming Ye, Tongcai Tan
Summary: This comprehensive meta-analysis found that vibration therapy (VT) significantly alleviated spasticity and pain in people with post-stroke spasticity (PSS) and improved motor function. However, its effect on gait performance was unclear. Further studies are needed to validate these findings.
BIOMEDICAL ENGINEERING ONLINE
(2023)
Article
Neurosciences
Caitlyn Seim, Bingxian Chen, Chuzhang Han, David Vacek, Laura Song Wu, Maarten Lansberg, Allison Okamura
Summary: This study investigates the effectiveness of different approaches of vibrotactile stimulation in reducing spastic hypertonia in post-stroke patients. The results show that cutaneous stimulation of the hand is the most effective method in reducing spastic hypertonia, compared to muscle stimulation and antagonist muscle stimulation.
FRONTIERS IN HUMAN NEUROSCIENCE
(2023)
Article
Engineering, Biomedical
Caitlyn E. Seim, Steven L. Wolf, Thad E. Starner
Summary: The study evaluated the feasibility and potential impacts of using a wearable stimulation device (the VTS Glove) on hand function in chronic stroke survivors. Results showed improvements in tactile perception, tone, spasticity, and voluntary range of motion with the use of the VTS Glove.
JOURNAL OF NEUROENGINEERING AND REHABILITATION
(2021)
Article
Rehabilitation
Cameron Lindsay, Ioan Humphreys, Ceri Phillips, Anand Pandyan
Summary: This study aimed to estimate the cost and consequences of early treatment with botulinum toxin for spasticity in the acute stroke unit. The analysis found that early treatment significantly reduced contracture costs and was more effective in improving function. Therefore, early intervention with botulinum toxin is important for stroke patients' rehabilitation.
CLINICAL REHABILITATION
(2023)
Article
Biology
Tae-sung In, Jin-hwa Jung, Kyoung-sim Jung, Hwi-young Cho
Summary: This study demonstrated the efficacy of STS training in reducing spasticity in stroke patients, with additional taping intervention further enhancing this effect. Significant decrease in ankle spasticity was observed alongside improvement in muscle strength and gait function for the participants.
Article
Neurosciences
Adina Turcu-Stiolica, Mihaela-Simona Subtirelu, Ana-Maria Bumbea
Summary: This study in Romania evaluated the quality of life among patients with post-stroke spasticity for the first time, and found that botulinum toxin type A therapy significantly improved quality of life, particularly in terms of movement, daily activities, and mental health. The results suggest that incobotulinumtoxin-A may be more effective in improving quality of life and muscle tone compared to conventional therapy, laying the foundation for future comparator studies.
Editorial Material
Clinical Neurology
Geoffrey A. Donnan
INTERNATIONAL JOURNAL OF STROKE
(2016)
Article
Clinical Neurology
Nawaf Yassi, Bruce C. V. Campbell, Bradford A. Moffat, Christopher Steward, Leonid Churilov, Mark W. Parsons, Geoffrey A. Donnan, Patricia M. Desmond, Stephen M. Davis, Andrew Bivard
Article
Clinical Neurology
Ramesh Sahathevan, Thomas Linden, Victor L. Villemagne, Leonid Churilov, John V. Ly, Christopher Rowe, Geoffrey Donnan, Amy Brodtmann
Article
Clinical Neurology
Hemasse Amiri, Erich Bluhmki, Martin Bendszus, Christoph C. Eschenfelder, Geoffrey A. Donnan, Didier Leys, Carlos Molina, Peter A. Ringleb, Peter D. Schellinger, Stefan Schwab, Danilo Toni, Nils Wahlgren, Werner Hacke
INTERNATIONAL JOURNAL OF STROKE
(2016)
Editorial Material
Clinical Neurology
Geoffrey A. Donnan
INTERNATIONAL JOURNAL OF STROKE
(2016)
Article
Clinical Neurology
Marie Luby, Steven J. Warach, Gregory W. Albers, Jean-Claude Baron, Christophe Cognard, Antoni Davalos, Geoffrey A. Donnan, Jochen B. Fiebach, Jens Fiehler, Werner Hacke, Maarten G. Lansberg, David S. Liebeskind, Heinrich P. Mattle, Catherine Oppenheim, Peter D. Schellinger, Joanna M. Wardlaw, Max Wintermark
INTERNATIONAL JOURNAL OF STROKE
(2016)
Editorial Material
Clinical Neurology
Geoffrey A. Donnan
INTERNATIONAL JOURNAL OF STROKE
(2016)
Editorial Material
Clinical Neurology
Geoffrey A. Donnan
INTERNATIONAL JOURNAL OF STROKE
(2016)
Article
Cardiac & Cardiovascular Systems
H. Y. Lim, C. Ng, G. Donnan, H. Nandurkar, Prahlad Ho
JOURNAL OF THROMBOSIS AND THROMBOLYSIS
(2016)
Article
Medicine, General & Internal
Mayank Goyal, Bijoy K. Menon, Wim H. van Zwam, Diederik W. J. Dippel, Peter J. Mitchell, Andrew M. Demchuk, Antoni Davalos, Charles B. L. M. Majoie, Aad van der Lugt, Maria A. de Miquel, Geoff Rey A. Donnan, Yvo B. W. E. M. Roos, Alain Bonafe, Reza Jahan, Hans-Christoph Diener, Lucie A. van den Berg, Elad I. Levy, Olvert A. Berkhemer, Vitor M. Pereira, Jeremy Rempel, Monica Millan, Stephen M. Davis, Daniel Roy, John Thornton, Luis San Roman, Marc Ribo, Debbie Beumer, Bruce Stouch, Scott Brown, Bruce C. V. Campbell, Robert J. van Oostenbrugge, Jeff Rey L. Saver, Michael D. Hill, Tudor G. Jovin
Article
Medicine, General & Internal
Michael D. Hill, Mayank Goyal, Bijoy K. Menon, Raul G. Nogueira, Ryan A. McTaggart, Andrew M. Demchuk, Alexandre Y. Poppe, Brian H. Buck, Thalia S. Field, Dar Dowlatshahi, Brian A. van Adel, Richard H. Swartz, Ruchir A. Shah, Eric Sauvageau, Charlotte Zerna, Johanna M. Ospel, Manish Joshi, Mohammed A. Almekhlafi, Karla J. Ryckborst, Mark W. Lowerison, Kathy Heard, David Garman, Diogo Haussen, Shawna M. Cutting, Shelagh B. Coutts, Daniel Roy, Jeremy L. Rempel, Axel C. R. Rohr, Daniela Lancu, Demetrios J. Sahlas, Amy Y. X. Yu, Thomas G. Devlin, Ricardo A. Hanel, Volker Puetz, Frank L. Silver, Bruce C. Campbell, Rene Chapot, Jeanne Teitelbaum, Jennifer L. Mandzia, Timothy J. Kleinig, David Turkel-Parrella, Donald Heck, Michael E. Kelly, Aditya Bharatha, Oh Young Bang, Ashutosh Jadhav, Rishi Gupta, Donald F. Frei, Jason W. Tarpley, Cameron G. McDougall, Staffan Holman, Joung-Ho Rha, Ajit S. Puri, Marie-Christine Camden, Gotz Thomalla, Hana Choe, Stephen J. Phillips, Joseph L. Schindler, John Thornton, Simon Nagel, Ji Hoe Heo, Sung- Sohn, Marios-Nikos Psychogios, Ronald F. Budzik, Sidney Starkman, Coleman O. Martin, Paul A. Burns, Sean Murphy, George A. Lopez, Joey English, Michael Tymianski
Article
Geriatrics & Gerontology
Johannes Tobias Neumann, Le T. P. Thao, Anne M. Murray, Emily Callander, Prudence R. Carr, Mark R. Nelson, Rory Wolfe, Robyn L. Woods, Christopher M. Reid, Raj C. Shah, Anne B. Newman, Jeff D. Williamson, Andrew M. Tonkin, John J. McNeil
Summary: This study analyzed data from ASPREE and found that age, cognitive function, and gait speed were the strongest predictors of disability-free survival in healthy older people. Other factors, such as body mass index and smoking status, were also associated with a worse prognosis.
Article
Clinical Neurology
Vignan J. Yogendrakumar, Leonid J. Churilov, Peter Mitchell, Timothy Kleinig, Nawaf Yassi, Vincent Thijs, Teddy Wu, Darshan M. Shah, Peter Bailey, Helen Dewey, Philip M. C. Choi, Alice Ma, Tissa Wijeratne, Carlos V. Garcia-Esperon, Geoffrey J. Cloud, Ronil Chandra, Dennis Cordato, Bernard M. Yan, Gagan W. Sharma, Patricia A. Desmond, Mark M. Parsons, Geoffrey Donnan, Stephen Davis, Bruce C. V. Campbell, EXTEND IA TNK Investigators
Summary: This study compared the safety and efficacy of tenecteplase and alteplase in patients with tandem lesion stroke. The results showed that both drugs had similar effects on intracranial reperfusion and 90-day modified Rankin scale. Further research is needed to determine clinically important differences.
Article
Health Care Sciences & Services
Kathleen L. Bagot, Tara Purvis, Shaun Hancock, Henry Zhao, Skye Coote, Damien Easton, Bruce C. Campbell, Stephen M. Davis, Geoff A. Donnan, Shane Foster, Francesca Langenberg, Karen Smith, Michael Stephenson, Stephen Bernard, Sharon McGowan, Bernard Yan, Peter Mitchell, Sandy Middleton, Dominique A. Cadilhac
Summary: This study aimed to investigate the factors influencing the sustainability of the Mobile Stroke Unit (MSU) model. The findings suggest that cohesive teamwork, effective communication, and identified benefits are crucial for ensuring the sustainability of this innovative model.
INTERNATIONAL JOURNAL OF HEALTH POLICY AND MANAGEMENT
(2023)
Article
Clinical Neurology
Julie Bernhardt, Karen Borschmann, Janice M. Collier, Amanda G. Thrift, Peter Langhorne, Sandy Middleton, Richard I. Lindley, Helen M. Dewey, Philip Bath, Catherine M. Said, Leonid Churilov, Fiona Ellery, Christopher Bladin, Christopher M. Reid, Judith H. Frayne, Velandai Srikanth, Stephen J. Read, Geoffrey A. Donnan
Summary: This tertiary analysis from the AVERT trial found that very early mobilization (VEM) poststroke increases mortality at 14 days when compared to usual care (UC), with a higher rate of stroke progression in the VEM group. There were no significant differences in nonfatal serious adverse events between the VEM and UC groups.