Article
Oncology
Mohamed Abdelaal, Pamela J. Mosher, Abha Gupta, Breffni Hannon, Christine Cameron, Malka Berman, Rahim Moineddin, Jonathan Avery, Laura Mitchell, Madeline Li, Camilla Zimmermann, Ahmed Al-Awamer
Summary: Adolescents and young adults with cancer often experience high levels of distress and lack effective palliative care services. Establishing a specialized integrated palliative care and psychiatry clinic has shown promising results in improving symptom scores and end-of-life planning.
Review
Medicine, General & Internal
Syed Bukhari, Shadi Yaghi, Zubair Bashir
Summary: Stroke in young adults is becoming more common in the United States due to the increasing prevalence of traditional risk factors and non-modifiable risk factors. The unique mechanisms causing stroke in this population include cervical dissection, cardioembolic phenomenon, vasculitis and vasculopathy, connective tissue disease, patent foramen ovale, and cerebral venous thrombosis. Diagnosing stroke in young adults can be challenging because of its diverse clinical presentations. This article provides an overview of the epidemiology, explores the mechanisms, and updates the literature on the management and prevention of stroke in young adults.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Oncology
Jeanne M. Erickson, Anna Kamke-Jordan, Ilissa Jasmine Lancaster, Akasha Palou-Torres, Marloe Esch, Alyssa Gonzalez, John Charlson, Kristin Bingen
Summary: The study aims to describe the medication self-management behaviors of adolescents and young adults with cancer and examine the barriers and facilitators to optimal use of medications. The findings suggest that most participants had accurate knowledge and average self-efficacy for managing medications but still required support and reminders.
SUPPORTIVE CARE IN CANCER
(2023)
Article
Cell Biology
Jun Ah Lee, Jiwon Lim, Hye Young Jin, Meerim Park, Hyeon Jin Park, Jong Woong Park, June Hyuk Kim, Hyun Guy Kang, Young-Joo Won
Summary: The study compared the clinical features and survival rates of osteosarcoma in adolescents and young adults (AYA) with other age groups. It found that AYA had the highest male-to-female ratio, with most tumors located in extremities. The treatment mainly consisted of local treatment and systemic chemotherapy, and the 5-year overall survival rate of AYA was closer to that of children.
Article
Psychology, Social
Ma Regina Laya de Gracia, Marc de Rosnay, David J. Hawes, Maria Veronica Templo Perez
Summary: Developmental evidence on emotion knowledge and deafness has mainly been focused on Western populations. This study investigated the associations between deafness, emotion understanding, and affective recognition and labelling in individuals from the Philippines. Results showed that, after controlling for age and verbal ability, deaf and hearing individuals were similar in their total affective recognition and labelling skills, but deaf individuals performed poorer in total emotion understanding compared to hearing controls. Several possible explanations for these findings were discussed.
PERSONALITY AND INDIVIDUAL DIFFERENCES
(2021)
Review
Oncology
Atsushi Makimoto
Summary: Due to their rarity, there is limited understanding of rhabdomyosarcomas (RMS) in adolescents and young adults (AYA), resulting in poor treatment outcomes. This review aims to integrate new developments with existing evidence to explore factors and potential solutions in RMS in AYA.
Article
Endocrinology & Metabolism
Lauren A. Reid, Siyu Zheng, Jason A. Mendoza, Beth A. Reboussin, Alissa J. Roberts, Katherine A. Sauder, Jean M. Lawrence, Elizabeth Jensen, Leora Henkin, Kate Flory, Lisa M. Knight, Catherine Pihoker, Lawrence M. Dolan, Elaine M. Apperson, Angela D. Liese
Summary: This study aimed to evaluate the relationship between household food insecurity (HFI) and fear of hypoglycemia among young adults and adolescents with type 1 and type 2 diabetes, as well as their parents. The results showed that adults with type 1 and type 2 diabetes experiencing HFI had higher fear of hypoglycemia scores compared to those without HFI. Screening for HFI and fear of hypoglycemia can help healthcare providers customize diabetes education for individuals who have HFI and fear hypoglycemia.
Article
Clinical Neurology
Aya Bardugo, Boris Fishman, Carmit Libruder, David Tanne, Amit Ram, Yael Hershkovitz, Inbar Zucker, Ariel Furer, Roy Gilon, Gabriel Chodick, Shmuel Tiosano, Estela Derazne, Dorit Tzur, Arnon Afek, Orit Pinhas-Hamiel, Cole Daniel Bendor, Gal Yaniv, Ran Shmuel Rotem, Gilad Twig
Summary: The study found an association between adolescent obesity and stroke in young adults, particularly with ischemic stroke, while the correlation with hemorrhagic stroke was weaker. The increasing prevalence of adolescent obesity may contribute to the future burden of stroke in young adults.
Article
Public, Environmental & Occupational Health
Emily R. Rupe, Jonathan Rodean, Emily A. Hurley, Melissa K. Miller, Marie Daphnee Boncoeur, Abbey R. Masonbrink
Summary: Among adolescent and young adult females in rural Haiti, a majority have unmet menstrual health needs, leading to high rates of school absenteeism. Many lack a safe environment to change menstrual materials, impacting their psychosocial well-being and school attendance.
REPRODUCTIVE HEALTH
(2022)
Article
Surgery
Mackenzie N. Abraham, Steven L. Raymond, Russell B. Hawkins, Atif Iqbal, Shawn D. Larson, Moiz M. Mustafa, Janice A. Taylor, Saleem Islam
Summary: Numerous surgical techniques exist for treating pilonidal disease, but there is no significant difference in recurrence rates among them. Older patients have decreased risk of recurrence, while wound complication rates are lower in patients undergoing secondary healing, possibly due to differences in age and sex. Further research on newer, minimally invasive techniques is needed.
FRONTIERS IN SURGERY
(2021)
Article
Medicine, General & Internal
Evan S. Dellon, Marc E. Rothenberg, Margaret H. Collins, Ikuo Hirano, Mirna Chehade, Albert J. Bredenoord, Alfredo J. Lucendo, Jonathan M. Spergel, Seema Aceves, Xian Sun, Matthew P. Kosloski, Mohamed A. Kamal, Jennifer D. Hamilton, Bethany Beazley, Eilish McCann, Kiran Patel, Leda P. Mannent, Elizabeth Laws, Bolanle Akinlade, Nikhil Amin, Wei Keat Lim, Matthew F. Wipperman, Marcella Ruddy, Naimish Patel, David R. Weinreich, George D. Yancopoulos, Brad Shumel, Jennifer Maloney, Angeliki Giannelou, Arsalan Shabbir
Summary: Dupilumab improves histologic outcomes and alleviates symptoms of eosinophilic esophagitis.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Oncology
Wei-Heng Kao, Chang-Fu Kuo, Chia-Chun Chang, Yu-Cheng Liu, Chun-Chieh Wang, Jun-Te Hsu, Yi-Fang Chuang
Summary: Cancer treatment in AYA cancer survivors may negatively affect reproductive functions. A study found that these survivors have a higher risk of pregnancy complications and adverse obstetric outcomes compared to their peers, highlighting the need for individualized preconception and prenatal care.
BRITISH JOURNAL OF CANCER
(2023)
Article
Oncology
A. Trama, D. Stark, I. Bozovic-Spasojevic, N. Gaspar, F. Peccatori, A. Toss, A. Bernasconi, P. Quarello, K. Scheinemann, S. Jezdic, A. Blondeel, G. Mountzios, S. Bielack, E. Saloustros, A. Ferrari
Summary: The incidence and mortality rates of cancers in adolescents and young adults (AYAs) in Europe and EU member states vary widely, with the highest mortality seen in Eastern EU countries. Breast, thyroid, and testicular cancers are the most common types across countries, followed by melanoma of skin and cervical cancer. Differences in cancer incidence rates may be due to various risk factors, screening implementation or uptake, and overdiagnosis. Disparities in AYA cancer mortality might be attributed to differences in early-stage diagnoses, public education and awareness of cancer symptoms, and access to treatment. It is crucial to establish AYA-specialised services and preventive initiatives to address the future healthcare needs and mitigate the increasing burden.
Article
Hematology
Alexandra Schifferli, Gautier Le Gavrian, Nathalie Aladjidi, Guillaume Moulis, Bertrand Godeau, Thomas Kuhne
Summary: Defining immune thrombocytopenia (ITP) in two age groups, children and adults, does not consider the specific clinical features and needs of adolescents and young adults (AYAS). This study reveals that refractory ITP is uncommon in AYAS, but AYAS with refractory ITP display a high disease burden at all time points.
BRITISH JOURNAL OF HAEMATOLOGY
(2023)
Editorial Material
Medicine, General & Internal
[Anonymous]
Summary: This interactive feature discusses screening for atrial fibrillation in asymptomatic older adults through a case vignette and two essays that present arguments for and against screening.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Review
Neuroimaging
Jean-Francois Hak, Gregoire Boulouis, Basile Kerleroux, Sandro Benichi, Sarah Stricker, Florent Gariel, Lorenzo Garzelli, Philippe Meyer, Manoelle Kossorotoff, Nathalie Boddaert, Vincent Vidal, Nadine Girard, Volodia Dangouloff-Ros, Francis Brunelle, Heather Fullerton, Steven W. Hetts, Thomas Blauwblomme, Olivier Naggara
Summary: The study analyzed the rates and risk factors for AVM recurrence in a cohort of children with ruptured AVMs. The findings suggest that infratentorial location and younger age at presentation may be associated with earlier and more frequent recurrences.
JOURNAL OF NEUROINTERVENTIONAL SURGERY
(2022)
Article
Clinical Neurology
Kevin N. Sheth, Christopher D. Anderson, Alessandro Biffi, Nomazulu Dlamini, Guido J. Falcone, Christine K. Fox, Heather J. Fullerton, Steven M. Greenberg, J. Claude Hemphill, Anthony Kim, Helen Kim, Nerissa U. Ko, Jarod L. Roland, Lauren H. Sansing, Susanne J. van Veluw, Jonathan Rosand
Meeting Abstract
Clinical Neurology
Ariana J. Andere, Jasmin Dao, Amy Gelfand, Heather J. Fullerton, Christine K. Fox
Article
Clinical Neurology
Joseph H. Garcia, Caleb Rutledge, Ethan A. Winkler, Luis Carrete, Ramin A. Morshed, Alex Y. Lu, Satvir Saggi, Christine K. Fox, Heather J. Fullerton, Helen Kim, Daniel L. Cooke, Steven W. Hetts, Michael T. Lawton, Nalin Gupta, Adib A. Abla
Summary: Pediatric brain arteriovenous malformations (AVMs) are a leading cause of spontaneous intracranial hemorrhage (SICH) in children. This study validates the recently created Ruptured Arteriovenous Malformation Grading Scale (RAGS) in a cohort of pediatric patients with AVMs, and demonstrates that the RAGS score outperforms other clinical grading scales in predicting clinical outcomes.
JOURNAL OF NEUROSURGERY-PEDIATRICS
(2022)
Article
Clinical Neurology
Marie-Coralie Cornet, Yi Li, Roxanne L. Simmons, Amanda Baker, Heather J. Fullerton, Steven W. Hetts, Hannah C. Glass
Summary: This study retrospectively analyzed a group of neonates with cerebral arteriovenous fistulas (AVFs) and found a high mortality rate in cases that did not receive embolization treatment, with survivors often experiencing neurodevelopmental impairments.
PEDIATRIC NEUROLOGY
(2022)
Letter
Clinical Neurology
Adam Kirton, Lori C. Jordan, Darren B. Orbach, Heather J. Fullerton
CLINICAL NEURORADIOLOGY
(2022)
Article
Medicine, General & Internal
Peter B. Sporns, Heather J. Fullerton, Sarah Lee, Helen Kim, Warren D. Lo, Mark T. Mackay, Moritz Wildgruber
Summary: This Primer provides an overview of the mechanisms, epidemiology, diagnosis and treatment of stroke in children. Childhood stroke is a significant cause of neurological damage and survivors often carry lifelong neurological deficits. While progress has been made in pediatric stroke research, the evidence for interventions, such as rapid reperfusion therapies, remains limited and delays in diagnosis and treatment continue to pose challenges.
NATURE REVIEWS DISEASE PRIMERS
(2022)
Article
Clinical Neurology
Satvir Saggi, Ethan A. Winkler, Simon G. Ammanuel, Ramin A. Morshed, Joseph H. Garcia, Jacob S. Young, Alexa Semonche, Heather J. Fullerton, Helen Kim, Daniel L. Cooke, Steven W. Hetts, Adib Abla, Michael T. Lawton, Nalin Gupta
Summary: This study utilized machine learning to identify predictors of hemorrhagic presentation in pediatric patients, which were not identified using conventional regression methods.
JOURNAL OF NEUROSURGERY-PEDIATRICS
(2022)
Article
Clinical Neurology
Sharon N. Poisson, Nancy K. Hills, Stephen Sidney, Heather J. Fullerton
Summary: Incidence of arterial ischemic stroke (AIS) has decreased overall in recent decades, but has increased in young adults. This study found that the risk factors associated with stroke in older adults are present in childhood and increase with age, highlighting the importance of early prevention and control of these risk factors.
Article
Oncology
Cassie Kline, Schuyler Stoller, Lennox Byer, David Samuel, Janine M. Lupo, Melanie A. Morrison, Andreas M. Rauschecker, Pierre Nedelec, Walter Faig, Dena B. Dubal, Heather J. Fullerton, Sabine Mueller
Summary: This study investigated predictors of neurocognition in pediatric cancer survivors and found factors associated with neurocognitive deficits in survivors of central nervous system tumors exposed to radiation. The presence of cerebral microbleeds (CMB), APOE epsilon 4 carrier status, hydrocephalus, and seizures were correlated with worse neurocognitive outcomes.
FRONTIERS IN ONCOLOGY
(2022)
Meeting Abstract
Clinical Neurology
Ethan A. Winkler, Joseph Garcia, Cynthia Tsang, Jeffrey Nelson, Charles McCulloch, Shantel Weinsheimer, Christine K. Fox, Heather Fullerton, Nerissa Ko, Hua Su, Tomasz Nowakowski, Daniel L. Cooke, Steven Hetts, Ekin Guney, Melike Pekmezci, Tarik Tihan, Michael Lawton, Adib Abla, Nalin Gupta, Helen Kim
Meeting Abstract
Clinical Neurology
Shweta A. Chawla, Shantel Weinsheimer, Jeffrey Nelson, Charles McCulloch, Adib Abla, Nalin Gupta, Daniel L. Cooke, Steven Hetts, David Saloner, Yi Li, Christine K. Fox, Heather J. Fullerton, Helen Kim
Article
Neuroimaging
Conner D. Reynolds, M. Travis Caton, Amanda Baker, Eric R. Smith, Matthew R. Amans, Daniel L. Cooke, Christopher F. Dowd, Randall T. Higashida, Nalin Gupta, Adib A. Abla, Kurtis Auguste, Christine H. Fox, Heather Fullerton, Steven W. Hetts
Summary: This study evaluated the clinical characteristics, angioarchitecture, and outcomes of pediatric spinal arteriovenous shunts (SAVS) through a large cohort analysis and meta-analysis of individual patient data. The findings showed that SAVS in children are most commonly located in the cervical region, and treatment can lead to symptom improvement.
JOURNAL OF NEUROINTERVENTIONAL SURGERY
(2023)
Article
Clinical Neurology
Alex Y. Lu, Ethan A. Winkler, Joseph H. Garcia, Kunal P. Raygor, Heather J. Fullerton, Christine K. Fox, Helen Kim, Kurtis I. Auguste, Peter P. Sun, Steven W. Hetts, Michael T. Lawton, Adib A. Abla, Nalin Gupta
Summary: This study describes the largest series to date comparing the presentation, angioarchitecture, and management of incidental versus symptomatic unruptured brain arteriovenous malformations (AVMs) in children. The results showed that incidental AVMs are more common in pediatric patients and are characterized by smaller size, less deep venous drainage, earlier age of onset, and longer duration to treatment compared to symptomatic AVMs.
JOURNAL OF NEUROSURGERY-PEDIATRICS
(2023)
Letter
Clinical Neurology
Joseph H. Garcia, Ethan A. Winkler, Ramin A. Morshed, Alex Y. Lu, Simon G. Ammanuel, Satvir Saggi, Elaina J. Wang, Steve Braunstein, Christine K. Fox, Heather J. Fullerton, Helen Kim, Daniel L. Cooke, Steven W. Hetts, Michael T. Lawton, Adib A. Abla, Nalin Gupta
JOURNAL OF NEUROSURGERY-PEDIATRICS
(2022)
