Article
Clinical Neurology
Neil Kulkarni, Rachel Ayn Nageotte, Brett G. Klamer, Harold L. Rekate, Ruth E. Bristol, Travis Scharnweber, Margaret Bobrowitz, John F. Kerrigan
Summary: The purpose of this study was to determine the long-term outcome and clinical predictors for seizure freedom in patients undergoing surgical treatment for epilepsy associated with hypothalamic hamartoma (HH). The results showed that long-term seizure control following HH surgical treatment is comparable to other forms of epilepsy surgery. Late relapse and sudden unexpected death in epileptic persons (SUDEP) did occur, but in a relatively small number of treated patients.
Review
Clinical Neurology
Hussein Hamdi, Faisal Albader, Giorgio Spatola, Virginie Laguitton, Agnes Trebuchon, Fabrice Bartolomei, Jean Regis
Summary: In this study, stereotactic radiosurgery was evaluated as an effective treatment for hypothalamic hamartoma in epilepsy patients. The results showed significant cognitive improvement in a high percentage of patients without decline in intellectual ability or memory three years after the surgery. Patients with better cognitive performance before surgery were more likely to achieve seizure cessation post-surgery, and those who were seizure-free also experienced significant cognitive improvement compared to non-seizure-free patients.
Article
Clinical Neurology
Constantin Tuleasca, Hussein Hamdi, Geraldine Daquin, Nathalie Villeneuve, Patrick Chauvel, Anne Lepine, Fabrice Bartolomei, Jean Regis
Summary: The study found that pretherapeutic gray matter density is correlated with seizure outcomes in patients with hypothalamic hamartomas.
Article
Behavioral Sciences
Chang Liu, Zhong Zheng, Xiao-qiu Shao, Chun-de Li, Xiao-li Yang, Chao Zhang, Lin Sang, Fei Xie, Feng Zhou, Wen-han Hu, Kai Zhang
Summary: Radiofrequency thermocoagulation (RFTC) guided by stereo-electroencephalography (SEEG) is a safe and effective method for treating drug-resistant epilepsy caused by hypothalamic hamartoma (HH). In a study of 27 patients, 70.4% achieved Engel's class I outcome, and disconnecting the attachment of HH was found to be the appropriate strategy for obtaining the best seizure outcome.
EPILEPSY & BEHAVIOR
(2021)
Review
Clinical Neurology
Aditya M. Kondajji, Audree Evans, Meachelle Lum, Daniel Kulinich, Ansley Unterberger, Kevin Ding, Courtney Duong, Kunal Patel, Isaac Yang
Summary: Stereotactic Radiofrequency Ablation (SRFA) appears to be a potential therapy for patients with hypothalamic hamartomas (HHs) suffering from refractory seizures, with the majority of patients experiencing some extent of therapeutic benefit and a significant percentage achieving complete freedom from seizures. Common transient complications include hyponatremia, hyperphagia, hyperthermia, Horner's syndrome, and weight gain. Further case series and clinical trials are needed to establish the efficacy of SRFA for HHs due to limited available data.
JOURNAL OF THE NEUROLOGICAL SCIENCES
(2021)
Article
Clinical Neurology
Scott C. Seaman, Carolina Deifelt Streese, Kenneth Manzel, Janina Kamm, Arnold H. Menezes, Daniel Tranel, Brian J. Dlouhy
Summary: The study aimed to assess cognitive and psychological performance in CM-I patients and found no significant changes after surgical decompression, indicating stable cognition and psychological functioning. Preoperatively, patients had below average performance in visuospatial and visuoconstructional abilities, but postoperatively, there was improved neurological status.
Article
Medicine, General & Internal
Yuan Yao, Xiu Wang, Wenhan Hu, Chao Zhang, Lin Sang, Zhong Zheng, Jiajie Mo, Chang Liu, Jiaji Qiu, Xiaoqiu Shao, Jianguo Zhang, Kai Zhang
Summary: The study demonstrates that using magnetic resonance-guided laser interstitial thermal therapy to treat hypothalamic hamartoma is safe and effective, with 72.3% of patients remaining seizure-free postoperatively. Factors such as the Delalande classification, hamartoma volume, and ablation rate of the hamartoma body are associated with gelastic seizure prognosis.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Sophie Lombardi, Domenico Tortora, Stefania Picariello, Sniya Sudhakar, Enrico De Vita, Kshitij Mankad, Sophia Varadkar, Alessandro Consales, Lino Nobili, Jessica Cooper, Martin M. Tisdall, Felice D'Arco
Summary: Laser ablation is a minimally invasive and effective technique used to treat hypothalamic hamartoma. In this study, different MRI sequences were used to evaluate the extent of tissue damage during and after laser ablation. The results showed that DWI images obtained immediately after ablation were more accurate in assessing the extent of tissue damage compared to other sequences. Therefore, intraoperative DWI can provide valuable real-time information about the heating damage on the hamartomatous tissue.
Article
Clinical Neurology
Pantaleo Romanelli, Francesco Tuniz, Sara Fabbro, Giancarlo Beltramo, Alfredo Conti
Summary: This study reports the experience of using frameless LINAC SRS to treat HH-related epilepsy. The results show that this method provides good seizure control and long-term neuropsychosocial outcomes, without the risks of neurological complications associated with microsurgical resection.
FRONTIERS IN NEUROLOGY
(2022)
Review
Clinical Neurology
Michele Rizzi, Michele Nichelatti, Lorenzo Ferri, Alessandro Consales, Alessandro De Benedictis, Massimo Cossu
Summary: This study analyzed the efficacy and safety profiles of various surgical options for treating hypothalamic hamartoma-related epilepsy. The results showed that minimally invasive surgical techniques, including endoscopic surgery, radiofrequency thermocoagulation, and laser ablation, achieved a desirable balance between efficacy and safety in treating hypothalamic hamartoma-related epilepsy.
Review
Nursing
Tracey Bowden, Catherine S. Hurt, Julie Sanders, Leanne M. Aitken
Summary: The study aimed to examine the effectiveness of cognitive interventions after general anesthesia to improve cognitive functioning. The results showed that cognitive interventions demonstrated some efficacy in improving cognitive function, particularly in memory. These findings suggest that implementing cognitive interventions in clinical practice could be promising for improving patient outcomes.
JOURNAL OF CLINICAL NURSING
(2023)
Article
Behavioral Sciences
Sofia Ljunggren, Stefan Winblad, Ulla Hallgren Graneheim, Kristina Malmgren, Anneli Ozanne
Summary: This study explores the cognitive, emotional, and social cognitive functioning experiences of patients and their relatives after frontal lobe epilepsy surgery. The findings show both positive and negative consequences of the surgery, with most patients considering the risk well worth taking despite some negative outcomes.
EPILEPSY & BEHAVIOR
(2021)
Review
Clinical Neurology
Pierre Bourdillon, S. Ferrand-Sorbet, C. Apra, M. Chipaux, E. Raffo, S. Rosenberg, C. Bulteau, N. Dorison, O. Bekaert, V. Dinkelacker, C. Le Guerinel, M. Fohlen, G. Dorfmuller
Summary: Hypothalamic hamartomas are abnormal masses composed of abnormally distributed neurons and glia, causing neurological, endocrine, cognitive symptoms, and epileptic seizures. Surgical treatment is effective for drug-resistant hamartoma epilepsy, however, the choice of surgical approach and associated outcomes require careful consideration.
NEUROSURGICAL REVIEW
(2021)
Article
Clinical Neurology
Jason K. Hsieh, Francesco G. Pucci, Swetha J. Sundar, Efstathios Kondylis, Akshay Sharma, Shehryar R. Sheikh, Deborah Vegh, Ahsan N. Moosa, Ajay Gupta, Imad Najm, Richard Rammo, William Bingaman, Lara Jehi
Summary: The study aims to understand the long-term palliative and disease-modifying effects of surgical resection on patients with drug-resistant epilepsy. Results show that patients who continue to have seizures after resection often experience considerable reductions in seizure frequency and many are able to achieve seizure freedom after a delayed period.
Review
Neurosciences
Timothy E. Green, Atsushi Fujita, Navid Ghaderi, Erin L. Heinzen, Naomichi Matsumoto, Karl Martin Klein, Samuel F. Berkovic, Michael S. Hildebrand
Summary: Hypothalamic hamartoma (HH) is a rare brain lesion associated with a specific epilepsy phenotype. Most patients have no additional developmental anomalies or family history of the disease. It has been discovered that some patients with HH have post-zygotic mosaic variants in genes related to Shh signaling and cilia development and function, providing insights into the functional role of these genes.
NEUROBIOLOGY OF DISEASE
(2023)