Article
Medicine, General & Internal
Lucia M. Li, Amanda Heslegrave, Eyal Soreq, Giovanni Nattino, Margherita Rosnati, Elena Garbero, Karl A. Zimmerman, Neil S. N. Graham, Federico Moro, Deborah Novelli, Primoz Gradisek, Sandra Magnoni, Ben Glocker, Henrik Zetterberg, Guido Bertolini, David J. Sharp
Summary: Traumatic brain injury (TBI) is a significant environmental risk factor for neurodegenerative disease, but it is unclear how TBI leads to ongoing chronic neurodegeneration. Animal studies suggest that TBI triggers systemic inflammation, which can result in sustained and aggressive microglial activation and widespread neurodegeneration. This study aims to evaluate systemic inflammation as a mediator of ongoing neurodegeneration after TBI.
Review
Medicine, General & Internal
Diyang Lyu, Taoran Li, Xuanxin Lyu
Summary: The incidence of Alzheimer's disease is rapidly increasing globally, posing a significant burden to health and economy. Early intervention for neurodegeneration may help prevent cognitive decline, but there is currently a lack of simple, rapid, and accurate diagnosis for early cognitive impairment. Resting-state functional MRI indicators such as ALFF, fALFF, and ReHo have shown promise as potential early diagnostic markers for Alzheimer's disease.
Article
Medicine, General & Internal
Chun Ka Wong, Duo Huang, Mi Zhou, JoJo Hai, Wen Sheng Yue, Wen-Hua Li, Li-Xue Yin, Ming-Liang Zuo, Ying Qing Feng, Ning Tan, Ji Yan Chen, Joseph Kwan, Chung Wah Siu
Summary: In elderly patients with atrial fibrillation, warfarin therapy is associated with a significantly lower risk of new-onset dementia compared to no therapy or aspirin.
POSTGRADUATE MEDICAL JOURNAL
(2022)
Article
Oncology
Feixia Wang, Danli Yao
Summary: The study showed that the application of continuous quality improvement (CQI) measures in gynecological nursing significantly increased patient nursing satisfaction and quality of life, while reducing the incidence of adverse nursing events.
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
(2021)
Article
Medicine, General & Internal
Seungji Kang, Seuhyun Eum, Yoonkyung Chang, Ai Koyanagi, Louis Jacob, Lee Smith, Jae Il Shin, Tae-Jin Song
Summary: According to the Global Burden of Disease study, the DALYs of neurological diseases in South-East Asia and Western Pacific regions were 64.4 million and 85.0 million in 2019, respectively. Stroke, migraine, Alzheimer's disease and other dementias had the highest DALYs in these regions in 2019.
Review
Medicine, General & Internal
Lili Chen, Xinhua Xu, Huizhen Cao, Hong Li
Summary: This study aims to evaluate the efficacy of different dietary interventions on cognitive function in patients with AD. The research will be conducted through a systematic review and meta-analysis of randomized controlled trials or clinical trials.
Article
Medicine, General & Internal
Yingxia Yang, Weiqi Wu, Honghong Huang, Haining Wu, Junying Huang, Liya Li, Lingxing Wang
Summary: This study investigated the effect of continuous positive airway pressure (CPAP) treatment on cognitive function in stroke patients with obstructive sleep apnoea (OSA) through randomized controlled trials. The findings suggest that early initiation of CPAP treatment may contribute to improvement in global cognition in stroke patients with OSA, but the effect on specific cognitive domains is not significant. CPAP therapy also significantly alleviates subjective sleepiness.
Article
Medicine, General & Internal
Mai-Carmen Requena-Komuro, Jessica Jiang, Lucianne Dobson, Elia Benhamou, Lucy Russell, Rebecca L. Bond, Emilie Brotherhood, Caroline Greaves, Suzie Barker, Jonathan D. Rohrer, Sebastian J. Crutch, Jason D. Warren, Chris J. D. Hardy
Summary: This study investigates the feasibility of adapting neuropsychological tests for online administration during the COVID-19 pandemic for dementia research. The findings suggest that remote delivery of neuropsychological tests is feasible for studying dementia.
Article
Medicine, General & Internal
Neil S. N. Graham, Grace Blissitt, Karl Zimmerman, Daniel Friedland, Marc-Emmanuel Dumas, Emma Coady, Amanda Heslegrave, Henrik Zetterberg, Valentina Escott-Price, Susie Schofield, Nicola T. Fear, Christopher Boos, Anthony M. J. Bull, Paul Cullinan, Alexander Bennett, David J. Sharp
Summary: This study aims to investigate the relationship between military head injury exposure and long-term outcomes, providing insights into underlying disease mechanisms and informing prevention interventions.
Article
Neurosciences
Francine Grodstein, Bernardo Lemos, Lei Yu, Artemis Iatrou, Philip L. De Jager, David A. Bennett
Summary: Epigenetic clocks are valuable biomarkers for aging, especially in understanding brain aging and neurodegenerative diseases. This study compared different epigenetic clocks in blood and brain samples, finding that the Cortical clock showed the highest correlation with chronological age in brain specimens. Further research is needed to explore CpG sites that are conserved across blood and brain for better understanding of neurodegeneration.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Medicine, General & Internal
Karine Fauria, Carolina Minguillon, Iva Knezevic, Nuria Tort-Colet, Laura Stankeviciute, Laura Hernandez, Andreea Radoi, Carme Deulofeu, Sherezade Fuentes-Julian, Israel Turull, David Fuste, Gonzalo Sanchez-Benavides, Eider M. Arenaza-Urquijo, Marc Suarez-Calvet, Sebastian C. Holst, Pilar Garces, Thomas Mueggler, Henrik Zetterberg, Kaj Blennow, Aurora Arqueros, Alex Iranzo, Juan Domingo Gispert, Jose Luis Molinuevo, Oriol Grau-Rivera
Summary: Sleep disruption plays an important role in the onset and early signs of Alzheimer's disease. The ALFASleep project aims to characterize sleep in cognitively unimpaired middle-aged/late middle-aged adults at increased risk of AD using subjective and objective measurements, with the goal of understanding the pathophysiological mechanisms linking sleep and AD and developing non-invasive biomarkers and preventive strategies targeting sleep.
Article
Clinical Neurology
Patrick Oeckl, Sarah Anderl-Straub, Christine A. F. Von Arnim, Ines Baldeiras, Janine Diehl-Schmid, Timo Grimmer, Steffen Halbgebauer, Anna M. Kort, Marisa Lima, Taina M. Marques, Marion Ortner, Isabel Santana, Petra Steinacker, Marcel M. Verbeek, Alexander E. Volk, Albert C. Ludolph, Markus Otto
Summary: This study reveals differences in serum levels of GFAP in AD and bvFTD, showing an early increase in MCI-AD and superior diagnostic performance for AD compared to NfL.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2022)
Article
Medicine, General & Internal
Nikolas Dietzel, Lara Kuerten, Linda Karrer, Michael Reichold, Laura Koehler, Andreas Nagel, Christina Chmelirsch, Kathrin Seebahn, Markus Hladik, Sebastian Meuer, Anna Kirchner, Kristina Holm, Marina Selau, Marco Wendel, Jorg Trinkwalter, Hans-Ulrich Prokosch, Elmar Graessel, Peter L. Kolominsky-Rabas
Summary: The 'Digital Dementia Registry Bavaria-digiDEM Bayern' aims to improve dementia care in Bavaria through digitalization, by providing digital services and conducting a three-year study on dementia patients and their caregivers. The project will collect data on various aspects of dementia care to better understand the complexity and long-term progression of the disease.
Article
Medicine, General & Internal
Melissa J. Armstrong, Henry L. Paulson, Susan M. Maixner, Julie A. Fields, Angela M. Lunde, Bradley F. Boeve, Carol Manning, James E. Galvin, Angela S. Taylor, Zhigang Li
Summary: This multisite longitudinal cohort study aims to investigate factors predicting approaching end of life or associated with end-of-life quality in individuals with dementia with Lewy bodies. Data will be analyzed using terminal trend models to identify significant predictors of imminent death and assess caregiver factors post-death. The study results will be disseminated through traditional scientific strategies and partnerships with relevant organizations.
Article
Public, Environmental & Occupational Health
S. Islamoska, J. M. Hansen, A. M. Hansen, A. H. Garde, G. Waldemar, K. Nabe-Nielsen
Summary: This study examined the association between migraine and dementia. It found that individuals with a migraine diagnosis had a higher dementia rate, while the use of prescribed migraine medication was not associated with dementia. Among migraine cases, individuals with MA who used migraine medication had the highest dementia rate, while those with MO who also used medication had the lowest rate. The number of migraine medication prescriptions was not linked to dementia.
Editorial Material
Medicine, General & Internal
John R. Absher
ANNALS OF INTERNAL MEDICINE
(2015)
Article
Clinical Neurology
Nathan B. Fountain, Paul G. Van Ness, Amy Bennett, John Absher, Anup D. Patel, Kevin N. Sheth, David S. Gloss, Diego A. Morita, Mona Stecker
Editorial Material
Clinical Neurology
Amy E. Sanders, James Nininger, John Absher, Amy Bennett, Samantha Shugarman, Robert Roca
Editorial Material
Geriatrics & Gerontology
Helen H. Kyomen
AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY
(2014)
Article
Geriatrics & Gerontology
Germaine Odenheimer, Soo Borson, Amy E. Sanders, Rebecca J. Swain-Eng, Helen H. Kyomen, Samantha Tierney, Laura Gitlin, Mary Ann Forciea, John Absher, Joseph Shega, Jerry Johnson
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
(2014)
Letter
Geriatrics & Gerontology
James M. Ellison, Helen H. Kyomen
AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY
(2019)
Editorial Material
Medicine, General & Internal
John R. Absher
ANNALS OF INTERNAL MEDICINE
(2019)
Article
Clinical Neurology
Joseph P. Hanna, John R. Absher, David S. Enyart
Summary: Expanding the differential diagnosis of sentinel headache to include spontaneous spinal epidural hematoma and emphasizing the importance of lumbar puncture in evaluation. Sentinel headache may be the only symptom of spontaneous spinal epidural hemorrhage, highlighting the need for early diagnosis to prevent spinal cord injury.
Editorial Material
Medicine, General & Internal
John R. Absher
ANNALS OF INTERNAL MEDICINE
(2022)
Meeting Abstract
Clinical Neurology
Enrique Urrea-Mendoza, Kimberly Okafor, Senthuran Ravindran, John Absher, Varun Chaubal, Fredy J. Revilla
Article
Clinical Neurology
Enrique Urrea-Mendoza, Kimberly Okafor, Senthuran Ravindran, John Absher, Varun Chaubal, Fredy J. Revilla
Summary: The novel coronavirus SARS-CoV-2 is the cause of the COVID-19 pandemic with partial resemblance to SARS-CoV and MERS-CoV in phylogenetic analysis, clinical manifestations, and pathological findings; ataxia has been described as a neurological symptom of the SARS-CoV-2 infection in reports from China. Opsoclonus-Myoclonus-Ataxia syndrome (OMAS) associated with COVID-19 infection has been recently reported.
TREMOR AND OTHER HYPERKINETIC MOVEMENTS
(2021)
Meeting Abstract
Clinical Neurology
John Absher, Morgan Fretwell, Tatsuhiro Kato, Wes Wimpey, Enrique Urrea-Mendoza, Fanny Guillerminet
Article
Rehabilitation
Germaine Odenheimer, Soo Borson, Amy E. Sanders, Rebecca J. Swain-Eng, Helen H. Kyomen, Samantha Tierney, Laura Gitlin, Mary Ann Forciea, John Absher, Joseph Shega, Jerry Johnson
AMERICAN JOURNAL OF OCCUPATIONAL THERAPY
(2013)
