期刊
NEUROLOGY
卷 79, 期 9, 页码 871-877出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1212/WNL.0b013e318266fcc5
关键词
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资金
- NIH [NS 43209, NS 045911, NS 053998, NS 066929, 1U10NS077308, UL1 RR025759, NS043209, NS31146, NS078419, 5U01NS04911, HD042823, MH077745, CA096821, NS43209, NS20253, NS45911, 1R01HD060913, 7R01DK071485, 1U01HL101064, 1UL1RR031990, R01HD038356, 2R01HL040619, R01NS043209]
- CDC grants [DP002209, MM1002]
- AUCD grant [RT01]
- Maternal and Child Health Bureau [MC00007]
- Epilepsy Study Consortium
- Epilepsy Foundation of America
- Glaxo Smith Kline
- CDC
- Eisai
- Marinus
- Lundbeck
- Pfizer
- Questcor
- UCB
- Schwarz-UCB
- Ovation-Lundbeck
- Supernus
- AVI BioPharma
- Heffer Family Foundation
- NINDS [NS43209]
- NICHD [36867]
Objective: The FEBSTAT study is a prospective study that seeks to determine the acute and long-term consequences of febrile status epilepticus (FSE) in childhood. Methods: From 2003 to 2010, 199 children age 1 month to 5 years presenting with FSE (>30 minutes) were enrolled in FEBSTAT within 72 hours of the FSE episode. Of these, 191 had imaging with emphasis on the hippocampus. All MRIs were reviewed by 2 neuroradiologists blinded to clinical details. A group of 96 children with first simple FS who were imaged using a similar protocol served as controls. Results: A total of 22 (11.5%) children had definitely abnormal (n = 17) or equivocal (n = 5) increased T2 signal in the hippocampus following FSE compared with none in the control group (p < 0.0001). Developmental abnormalities of the hippocampus were more common in the FSE group (n = 20, 10.5%) than in controls (n = 2, 2.1%) (p = 0.0097) with hippocampal malrotation being the most common (15 cases and 2 controls). Extrahippocampal imaging abnormalities were present in 15.7% of the FSE group and 15.6% of the controls. However, extrahippocampal imaging abnormalities of the temporal lobe were more common in the FSE group (7.9%) than in controls (1.0%) (p = 0.015). Conclusions: This prospective study demonstrates that children with FSE are at risk for acute hippocampal injury and that a substantial number also have abnormalities in hippocampal development. Follow-up studies are in progress to determine the long-term outcomes in these children. Neurology (R) 2012;79:871-877
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