Review
Medicine, General & Internal
Shicheng Yang, Mia Wallach, Apurva Krishna, Raushan Kurmasheva, Srinivas Sridhar
Summary: Cancer is the second leading cause of death in children in the US, with chemotherapy increasing overall survival rates. However, many survivors of pediatric cancer experience long-term adverse effects from treatments. Nanotechnology shows promise in overcoming limitations of traditional chemotherapy methods and improving clinical outcomes.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Buddolla Anantha Lakshmi, Young-Joon Kim
Summary: Nanotechnology plays a crucial role in the treatment and diagnosis of glioblastoma. The multifunctional nanomaterials with specific features such as real-time tracking, in-depth tissue penetration, and drug-loading capacity offer effective theranostics for glioblastoma.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Multidisciplinary
Bharti Sethi, Virender Kumar, Kalika Mahato, Donald W. Coulter, Ram I. Mahato
Summary: The article discusses the blood-brain barrier (BBB) and the challenges in delivering drugs to the brain. Nanomedicine is proposed as a promising approach, with nanoparticles (NPs) carrying specific ligands for controlled drug delivery. The article also summarizes the recent advancements in brain-specific NPs for different pathological conditions and discusses the fundamental properties of brain-targeted NPs.
JOURNAL OF CONTROLLED RELEASE
(2022)
Review
Engineering, Biomedical
Xing Tian, Taojian Fan, Wentian Zhao, Ghulam Abbas, Bo Han, Ke Zhang, Nan Li, Ning Liu, Weiyuan Liang, Hao Huang, Wen Chen, Bing Wang, Zhongjian Xie
Summary: This review focuses on the potential applications of nanotechnology in stroke treatment. It discusses the main molecular pathological mechanisms of ischemic stroke, the role of the blood-brain barrier, and summarizes the challenges and future prospects of nanomedicine-based stroke treatments.
BIOACTIVE MATERIALS
(2021)
Review
Nanoscience & Nanotechnology
SeongHoon Jo, In-Cheol Sun, Cheol-Hee Ahn, Sangmin Lee, Kwangmeyung Kim
Summary: The blood-brain barrier poses a challenge to the delivery of imaging probes and therapeutic agents to the brain. Methods like ultrasound-mediated nano-particle delivery and photoacoustic brain imaging have emerged as potential solutions. Focused ultrasound is a popular means of enhancing drug delivery through temporary opening of the blood-brain barrier, while photoacoustic brain imaging uses light-to-heat conversion and ultrasound detection to visualize brain morphologies or diseases. The versatility of nanoparticles allows for successful brain imaging and treatment through the combined action of ultrasound and nanoparticulate agents.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Review
Chemistry, Multidisciplinary
Alireza Poustforoosh, Mohammad Hadi Nematollahi, Hassan Hashemipour, Abbas Pardakhty
Summary: This review discusses the challenges and barriers in drug delivery to the brain, as well as strategies and pathways to overcome the blood-brain barrier. The application of bioconjugated vesicles as nanocarriers for enhancing drug loading into the brain is emphasized.
JOURNAL OF CONTROLLED RELEASE
(2022)
Review
Biotechnology & Applied Microbiology
Danping Zhuang, Huifen Zhang, Genwen Hu, Bing Guo
Summary: This review summarizes the recent advances in MRI contrast agents and dual-modal or triple-modal nanoprobes for glioblastoma (GBM) imaging, and discusses potential obstacles and prospects for future research and clinical translation of these contrast agents.
JOURNAL OF NANOBIOTECHNOLOGY
(2022)
Review
Chemistry, Multidisciplinary
Jun Liao, Li Fan, Yi Li, Qing-Qiang Xu, Li-Yan Xiong, Shan-Shan Zhang, Ji-Hao Liu, Zhi-Cheng Xiao, Chuan Zhang, Jian Yang, Zhe-Sheng Chen, Kai Xiao, Ting-Fang Wang, Ying Lu
Summary: In recent years, brain diseases have become a serious threat to human health due to their high incidence and mortality rates. The main challenge in treating these diseases is delivering drugs efficiently to the brain. Biomimetic nanodelivery systems (BNDSs) have been developed to overcome the obstacles posed by the brain's unique structure and the blood-brain barrier. The enhanced drug-carrying ability and lesion-targeting selectivity of BNDSs offer new opportunities for safe and effective therapies. This review summarizes brain-targeting nanotherapies, particularly those with biomimetic nano-assistance, and discusses the prospects and challenges of their clinical application.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Clinical Neurology
Johannes Boltze, Miguel A. Perez-Pinzon
Summary: Local and systemic inflammation play a significant role in stroke risk factors and outcomes. Neuroimmunology research is important for understanding the mechanisms of stroke and finding potential therapeutic targets.
Review
Chemistry, Medicinal
Sara G. Pedrero, Davide Staedler, Sandrine Gerber-Lemaire
Summary: Epilepsy, affecting over 40 million people worldwide, is a debilitating disorder with limited and often accompanied by adverse effects treatment options. Nanotechnology offers promising therapeutic approaches for epilepsy by inhibiting calcium channels or improving drug delivery.
MINI-REVIEWS IN MEDICINAL CHEMISTRY
(2022)
Review
Cell Biology
Wangyu Bi, Shanglin Cai, Tong Lei, Lei Wang
Summary: The complex structure of the blood-brain barrier (BBB) poses challenges for modeling and treating brain diseases. Microfluidic BBB-on-a-chip platforms have been developed using microfluidic technology to replicate the intricate brain microenvironment and physiological responses. Compared to traditional trans-well technology, microfluidic BBB-on-a-chip offers technical advantages in terms of flexible control of fluid shear stress and efficient fabrication, which can be further enhanced by lithography and 3D printing. Integration of an automatic super-resolution imaging sensing platform enables accurate monitoring of dynamic changes in biochemical parameters of individual cells in the model. Biomaterials, especially hydrogels and conductive polymers, address the limitations of microfluidic BBB-on-a-chip by providing a 3D space and specific performance. Microfluidic BBB-on-a-chip has promoted advancements in basic research related to cell migration, neurodegenerative diseases, drug permeability, and SARS-CoV-2 pathology. This study summarizes recent advances, challenges, and future prospects of microfluidic BBB-on-a-chip, which can facilitate the development of personalized medicine and drug discovery.
AGEING RESEARCH REVIEWS
(2023)
Review
Cell Biology
Liqiang Hu, Yiran Tao, Yanjiao Jiang, Feng Qin
Summary: Alzheimer's disease is the most common cause of memory disruption in elderly individuals, and the lack of effective therapy is due to low drug potency and challenges in drug delivery. Recent advances in nanomedicine have shown promising developments in Alzheimer's disease treatment, using various nano-carriers to develop successful strategies. This review comprehensively summarizes the efficacy of different nanomedicine in pre-clinical studies and provides insights and future research directions. It can guide the design and evaluation of nanomedicine in Alzheimer's disease treatment.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Review
Polymer Science
Jisan Ahamed, B. H. Jaswanth Gowda, Waleed H. Almalki, Neelima Gupta, Amirhossein Sahebkar, Prashant Kesharwani
Summary: Malignant brain tumors have a poor prognosis and low survival rate due to the challenges in drug delivery, including crossing the blood-brain barrier, achieving optimal drug distribution within the tumor, and minimizing damage to healthy cells. Nanotechnology has emerged as a promising approach for brain tumor treatment by using nanoparticles to overcome these obstacles.
EUROPEAN POLYMER JOURNAL
(2023)
Review
Pharmacology & Pharmacy
Garima Rai, Pammi Gauba, Shweta Dang
Summary: Nanotechnology has shown great potential in drug delivery and targeting, especially in the treatment of Central Nervous System Disorders. However, traditional routes of drug administration face limitations in brain targeting due to the Blood Brain Barrier. The Intranasal route has been extensively studied as an alternative approach to deliver drugs to different areas of the brain through the olfactory or trigeminal pathway.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Immunology
Mark Mizrachi, Erik Anderson, Kaitlin R. Carroll, Nazila Tehrani, Bruce T. Volpe, Betty Diamond
Summary: Neuropsychiatric lupus is a debilitating manifestation of SLE which affects a majority of SLE patients. Cognitive dysfunction is a common and underdiagnosed symptom in NPSLE, lacking specific therapy. Studies have shown that impaired blood brain barrier and activated microglia play a pivotal role in neuronal injury, suggesting potential therapeutic options for cognitive impairment.
JOURNAL OF AUTOIMMUNITY
(2022)