Article
Cardiac & Cardiovascular Systems
Xin-Ni Lv, Jing Cheng, Xue-Yun Liu, Jin-Cheng Liu, Lan Deng, Zuo-Qiao Li, Ming-Jun Pu, Chu Chen, Qi Li
Summary: This study found that ultraearly intraventricular hemorrhage growth is associated with early neurologic deterioration and poor functional outcomes in patients with intracerebral hemorrhage.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Clinical Neurology
Haoli Xu, Yuting Li, Jinjin Liu, Zhonggang Chen, Qian Chen, Yilan Xiang, Mingyue Zhang, Wenwen He, Yuandi Zhuang, Yunjun Yang, Weijian Chen, Yongchun Chen
Summary: The study found that patients with acute spontaneous intracerebral hemorrhage who had enlarged ONSD had a worse prognosis. ONSD was related to hematoma volume and independently associated with poor outcome in multivariable analysis.
CEREBROVASCULAR DISEASES
(2022)
Article
Critical Care Medicine
Wen-Song Yang, Yi-Qing Shen, Xiao-Dong Zhang, Li-Bo Zhao, Xiao Wei, Xin Xiong, Xiong-Fei Xie, Rui Li, Lan Deng, Xin-Hui Li, Xin-Ni Lv, Fa-Jin Lv, Qi Li, Peng Xie
Summary: The study suggests that hydrocephalus growth is strongly predictive of short- or long-term mortality and poor outcome at 90 days, showing higher accuracy in predicting outcomes compared to intraventricular hemorrhage growth or hematoma expansion.
NEUROCRITICAL CARE
(2021)
Article
Clinical Neurology
Wen-Juan Wang, Jing-Jing Lu, Li-Ping Liu, Jiao-Kun Jia, Xing-Quan Zhao
Summary: The study found that ultraearly hematoma growth speed is significantly associated with in-hospital mortality, 90-day, and 1-year poor outcomes after acute intracerebral hemorrhage.
FRONTIERS IN NEUROLOGY
(2021)
Article
Surgery
Heling Chu, Chuyi Huang, Zaiying Zhou, Yuping Tang, Qiang Dong, Qihao Guo
Summary: This study aimed to develop an inflammatory score that can predict hematoma expansion and poor outcomes in patients with intracerebral hemorrhage (ICH). The inflammatory score was developed by integrating several inflammatory markers and was found to be significantly associated with hematoma expansion and poor outcomes. The inflammatory score showed good diagnostic accuracy in predicting these outcomes compared to individual markers.
INTERNATIONAL JOURNAL OF SURGERY
(2023)
Article
Behavioral Sciences
Qi Zhou, Daming Zhang, Xin Chen, Zhao Yang, Zhihui Liu, Baixing Wei, Mei Jin, Kairu Feng, Chunmei Guo, Junying Sun, Sheng Chen, Ruijia Zhang, Xiai Piao, Ilgiz Gareev, Zhenying Sun, Xiaoxiong Wang, Lili Li, Shiguang Zhao, Guang Yang
Summary: The elevated plasma D-dimer level after spontaneous ICH is associated with poor functional outcome and mortality. This suggests that the elevated D-dimer level has a predictive value for the outcome and mortality in patients with spontaneous ICH.
BRAIN AND BEHAVIOR
(2021)
Article
Clinical Neurology
Christopher P. Kellner, Rui Song, Muhammad Ali, Dominic A. Nistal, Milan Samarage, Neha S. Dangayach, John Liang, Ian McNeill, Xiangnan Zhang, Joshua B. Bederson, J. Mocco
Summary: This retrospective analysis of 90 patients undergoing minimally invasive endoscopic intracerebral hemorrhage evacuation found that younger age, absence of intraventricular hemorrhage, lobar location, and early time to evacuation were independently associated with good long-term functional outcomes. The odds ratio for time to evacuation suggests a 5% reduction in the odds of achieving a favorable outcome for each additional hour.
Article
Clinical Neurology
Shen-Zhong Qiu, Guan-Rong Zheng, Cai-Yan Ma, Bin Chen, Jian-Jun Huang, Ge Huang, Hai Hua
Summary: The study found that high serum S100A12 levels in intracerebral hemorrhage patients are strongly associated with the extent of inflammatory response, severity, poor functional outcomes, and early neurological deterioration, making serum S100A12 a promising prognostic biomarker for ICH.
NEUROPSYCHIATRIC DISEASE AND TREATMENT
(2021)
Article
Clinical Neurology
Likun Wang, Sheng Luo, Siying Ren, Hui Yu, Guiquan Shen, Guofeng Wu, Qingwu Yang
Summary: This study found that irregular-shaped hematoma was an independent predictor of postoperative rehemorrhage after sMIS, which can be used to assess the risk of rehemorrhage in patients before surgery.
FRONTIERS IN NEUROLOGY
(2022)
Article
Behavioral Sciences
Juexian Song, Yuting Nie, Pingping Wang, Huiqiang Lu, Li Gao
Summary: In acute SICH patients, Naoxueshu oral liquid can help reduce hematoma volume and cerebral edema, with the potential to improve short-term neurological function.
BRAIN AND BEHAVIOR
(2021)
Article
Clinical Neurology
Stefan P. Haider, Adnan Qureshi, Abhi Jain, Hishan Tharmaseelan, Elisa R. Berson, Shahram Majidi, Christopher G. Filippi, Adrian Mak, David J. Werring, Julian N. Acosta, Ajay Malhotra, Jennifer A. Kim, Lauren H. Sansing, Guido J. Falcone, Kevin N. Sheth, Seyedmehdi Payabvash
Summary: The study found that in deep intracerebral hemorrhage, measuring the maximum coronal diameter offers greater prognostic value than hematoma volume, potentially serving as a potential biomarker for hematoma size eligibility criteria in clinical trials.
INTERNATIONAL JOURNAL OF STROKE
(2022)
Article
Clinical Neurology
Christopher J. Love, Daniel Kirschenbaum, Magdy Selim, Eng H. Lo, Elisabeth Rushing, Myron Spector, Adriano Aguzzi
Summary: The study found that chronic hemorrhagic stroke lesions contain abundant collagenous material, primarily consisting of collagen 3. The collagenase rat model successfully reproduced the morphology and composition of chronic human hemorrhagic stroke lesions. By identifying new pathological features of hemorrhagic stroke lesions, these results are important for treatment and recovery strategies.
Article
Clinical Neurology
Sanjula D. Singh, Marco Pasi, Floris H. B. M. Schreuder, Andrea Morotti, Jasper R. Senff, Andrew D. Warren, Brenna N. McKaig, Kristin Schwab, M. Edip Gurol, Jonathan Rosand, Steven M. Greenberg, Anand Viswanathan, Catharina J. M. Klijn, Gabriel J. E. Rinkel, Joshua N. Goldstein, H. Bart Brouwers
Summary: In patients with spontaneous cerebellar ICH treated conservatively, the spot sign is associated with speed of hematoma expansion, case fatality, and poor functional outcome. In surgically treated patients, the spot sign is associated with 90-day case fatality.
Article
Clinical Neurology
Vignan Yogendrakumar, Tim Ramsay, Bijoy K. Menon, Adnan Qureshi, Jeffrey L. Saver, Dar Dowlatshahi
Summary: This proof-of-concept study introduced an HE shift analysis model to enhance the evaluation of ICH therapies using data from the ATACH-2 trial. Results from analyzing 863 patients indicated that intensive blood pressure lowering treatment may reduce hematoma growth in high-risk patients, suggesting the potential benefits of the shift analysis model in assessing hemostatic agents for future studies.
Article
Clinical Neurology
Tua Gyldenholm, Christine L. Hvas, Anne-Mette Hvas, Claus V. B. Hviid
Summary: This study aimed to investigate blood biomarkers in patients with intracerebral and subarachnoid hemorrhage. The results showed that GFAP levels were associated with patient outcome and combining GFAP measurements with clinical indicators improved outcome prediction accuracy.
NEUROLOGICAL SCIENCES
(2022)
Article
Clinical Neurology
Manuel Requena, Carlos Pinana, Marta Olive-Gadea, David Hernandez, Sandra Boned, Marta De Dios, Marc Rodrigo, Eila Rivera, Marian Muchada, Jose Luis Cuevas, Marta Rubiera, Alvaro Garcia-Tornel, Laura Ludovica Gramegna, Carlos Molina, Marc Ribo, Alejandro Tomasello
Summary: This study evaluated the effectiveness and safety of a combined MT technique using a stent retriever and REACT catheter in patients with AIS due to LVO. The results showed a high rate of successful recanalization and first pass recanalization, as well as low rates of procedural complications and symptomatic intracranial hemorrhage.
INTERVENTIONAL NEURORADIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Jorge Pagola, Jesus Juega, Jaume Francisco-Pascual, Maite Rodriguez, Laura Dorado, Raquel Martinez, Mercedes De Lera-Alfonso, Juan F. Arenillas, Juan Antonio Cabezas, Francisco Moniche, Reyes de Torres, Joan Montaner, Marian Muchada, Sandra Boned, Manuel Requena, Alvaro Garcia-Tornel, Noelia Rodriguez-Villatoro, David Rodriguez-Luna, Matias Deck, Marta Olive, Marta Rubiera, Marc Ribo, Jose Alvarez-Sabin, Carlos A. Molina
Summary: The feasibility of 90-day cardiac monitoring with an external Holter device was demonstrated in stroke patients, with a high percentage of pAF detected. Older patients and those with enlarged left atria benefited more from the monitoring.
Article
Clinical Neurology
David Hernandez, Jose Luis Cuevas, Laura Ludovica Gragmegna, Manuel Requena, Carlos Pinana, Marta de Dios, Pilar Coscojuela, Marielle Esteves, Jiahui Li, Alberto Gil, Marc Ribo, Alejandro Tomasello
Summary: The number of stentriever passes during endovascular thrombectomy affects vascular wall injury. The simultaneous double stent retriever technique (DSRT) shows higher severity of histological damage compared to single stent retriever technique (SSRT), but the damage in distal arteries is relatively similar.
TRANSLATIONAL STROKE RESEARCH
(2023)
Article
Clinical Neurology
Marc Rodrigo-Gisbert, Manuel Requena, Marta De Dios Lascuevas, Alvaro Garcia-Tornel, Marta Olive-Gadea, Sandra Boned, Marian Muchada, Matias Deck, Noelia Rodriguez-Villatoro, David Rodriguez-Luna, Jesus Juega, Jorge Pagola, Alejandro Tomasello, Carlos Pinana, David Hernandez, Pilar Coscojuela, Marc Ribo, Carlos A. Molina, Marta Rubiera
Summary: This study aimed to explore the neuroimaging parameters and their association with non-contrast computed tomography (NCCT) findings in late-window large vessel occlusion (LVO) patients. The results showed that the majority of LVO patients in the late window fulfilled the imaging criteria for endovascular treatment (EVT), especially those with high ASPECTS scores. This study provides meaningful data for stroke treatment selection in the late window.
CEREBROVASCULAR DISEASES
(2023)
Article
Clinical Neurology
Beatriz Gomez-Vicente, Maria Hernandez-Perez, Elena Martinez-Velasco, Margarita Rodriguez-Velasco, Josep Munuera, Marta Rubiera, Carla Vert, Laura Dorado, Mercedes de Lera, Ana Isabel Calleja, Elisa Cortijo, Jesus Agulla, Elena Lopez-Cancio, Juan Francisco Arenillas
Summary: This study aimed to evaluate whether the radiological sign predicts long-term new stroke in ICAD patients. The results showed that the enhancement ratio and cerebral microbleeds can serve as independent predictors of future strokes. These findings contribute to a better understanding of whether enhancement ratio reflects the inflammatory activity of ICAD.
JOURNAL OF NEUROIMAGING
(2023)
Meeting Abstract
Clinical Neurology
Marian Muchada, Marta Rubiera, Jesus Juega, Jorge Pagola, Marta Olive-Gadea, Alvaro Garcia-Tornel Garcia, Sandra Boned, Noelia Rodriguez, Prudencio Lozano, David Rodriguez-Luna, Estefania Montiel, Ester Sanchez, Marc Ribo, Carlos A. Molina
Meeting Abstract
Clinical Neurology
Marta Olive-Gadea, Manuel Requena, Alvaro Garcia-Tornel, Federica Rizzo, Marta Rubiera, Marian Muchada, Jesus Juega, Jorge Pagola, David Rodriguez-Luna, Noelia Rodriguez Villatoro, Alejandro Tomasello, Carlos A. Molina, Marc Ribo
Meeting Abstract
Clinical Neurology
Albert J. Yoo, Serdar Geyik, Michael Froehler, Christoph Maurer, Tareq Kass-Hout, Osama Zaidat, Raul G. Nogueira, Ricardo Hanel, Laurent Pierot, Laurent Spelle, Demetrius Lopes, Ameer E. Hassan, Audrius Sirvinskas, Eugene Lin, Marc Ribo, Jordi Blasco, Muhammad Taqi, Aamir Badruddin, Adnan H. Siddiqui, Muhammad Hussain, Diogo C. Haussen
Article
Medicine, General & Internal
Amrou Sarraj, Ameer E. Hassan, Michael G. Abraham, Santiago Ortega-Gutierrez, Scott E. Kasner, M. Shazam Hussain, Michael Chen, Spiros Blackburn, Clark W. Sitton, Leonid Churilov, Sophia Sundararajan, Yin C. Hu, Nabeel A. Herial, Pascal Jabbour, Daniel Gibson, Adam N. Wallace, Juan F. Arenillas, Jenny P. Tsai, Ronald F. Budzik, William J. Hicks, Osman Kozak, Bernard Yan, Dennis J. Cordato, Nathan W. Manning, Mark W. Parsons, Ricardo A. Hanel, Amin N. Aghaebrahim, Teddy Y. Wu, Pere Cardona-Portela, Natalia Perez de la Ossa, Joanna D. Schaafsma, Jordi Blasco, Navdeep Sangha, Steven Warach, Chirag D. Gandhi, Timothy J. Kleinig, Daniel Sahlein, Lucas Elijovich, Wondwossen Tekle, Edgar A. Samaniego, Laith Maali, M. Ammar Abdulrazzak, Marios N. Psychogios, Ashfaq Shuaib, Deep K. Pujara, Faris Shaker, Hannah Johns, Gagan Sharma, Vignan Yogendrakumar, Felix C. Ng, Mohammad H. Rahbar, Chunyan Cai, Philip Lavori, Scott Hamilton, Thanh Nguyen, Johanna T. Fifi, Stephen Davis, Lawrence Wechsler, Vitor M. Pereira, Maarten G. Lansberg, Michael D. Hill, James C. Grotta, Marc Ribo, Bruce C. Campbell, Gregory W. Albers
Summary: This study is a trial on the efficacy and safety of endovascular thrombectomy in patients with large ischemic strokes. The results show that compared to medical care alone, endovascular thrombectomy can improve functional independence in patients, but it also carries the risk of vascular complications.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Article
Clinical Neurology
Thanh N. Nguyen, Muhammad M. Qureshi, Davide Strambo, Daniel Strbian, Silja Raety, Christian Herweh, Mohamad Abdalkader, Marta Olive-Gadea, Marc Ribo, Marios Psychogios, Urs Fischer, Anh Nguyen, Joji B. Kuramatsu, David Haupenthal, Martin Koehrmann, Cornelius Deuschl, Jordi Kuehne Escola, Shadi Yaghi, Liqi Shu, Volker Puetz, Daniel P. O. Kaiser, Johannes Kaesmacher, Adnan Mujanovic, Dominique Cornelius Marterstock, Tobias Engelhorn, Piers Klein, Diogo C. Haussen, Mahmoud H. Mohammaden, Hend Abdelhamid, Lorena Souza Viana, Bruno Cunha, Isabel Fragata, Michele Romoli, Francesco Diana, Pekka Virtanen, Kimmo Lappalainen, Judith Clark, Stavros Matsoukas, Johanna T. Fifi, Sunil A. Sheth, Sergio Salazar-Marioni, Joao Pedro Marto, Joao Nuno Ramos, Milena Miszczuk, Christoph Riegler, Ashutosh P. Jadhav, Shashvat M. Desai, Volker Maus, Maximilian Kaeder, Adnan H. Siddiqui, Andre Monteiro, Hesham E. Masoud, Neil Suryadevara, Maxim Mokin, Shail Thanki, James E. Siegler, Jane Khalife, Italo Linfante, Guilherme Dabus, Negar Asdaghi, Vasu Saini, Christian H. Nolte, Eberhard Siebert, Thomas R. Meinel, Stefanos Finitsis, Markus A. Moehlenbruch, Peter A. Ringleb, Anne Berberich, Raul G. Nogueira, Uta Hanning, Lukas Meyer, Patrik Michel, Simon Nagel
Summary: This study compared the clinical outcomes of endovascular therapy (EVT) and medical management (MM) in patients with isolated posterior cerebral artery occlusion. The results showed no difference between the two groups in terms of the modified Rankin Scale and National Institutes of Health Stroke Scale at 90 days. However, the EVT group had a higher likelihood of excellent outcome and complete vision recovery, despite higher rates of symptomatic intracranial hemorrhage and mortality.
Article
Clinical Neurology
Alvaro Garcia-Tornel, Alan Flores, Mikel Terceno, Pedro Cardona, Sergi Amaro, Meritxell Gomis, Josep Zaragoza, Jerzy Krupinski, Manuel Gomez-Choco, Natalia Mas, Dolores Cocho, Esther Catena, Francesc Purroy, Matias Deck, Marta Rubiera, Jorge Pagola, David Rodriguez-Luna, Jesus Juega, Noelia Rodriguez-Villatoro, Carlos A. Molina, Cristina Soro, Xavier Jimenez, Merce Salvat-Plana, Antoni Davalos, Tudor G. Jovin, Sonia Abilleira, Natalia Perez de la Ossa, Marc Ribo
Summary: This study aims to assess the treatment effect of direct transportation to a thrombectomy-capable center versus nearest local stroke center in patients with large vessel stroke, and found that direct transport during nighttime was associated with lower disability at 90 days.
Review
Clinical Neurology
E. Sanjuan, O. Pancorbo, K. Santana, O. Minarro, V. Sala, M. Muchada, S. Boned, J. M. Juega, J. Pagola, A. Garcia-Tornel, M. Requena, N. Rodriguez-Villatoro, D. Rodriguez-Luna, M. Deck, M. Ribo, C. A. Molina, P. Meler, V. Romero, G. Dalmases, M. T. Rodriguez-Samaniego, L. Calleja, T. Gutierrez, L. Pena, J. C. Gallego, E. Lorenzo, Y. Gonzalez, R. Moreno, M. Rubiera
Summary: This study provides updated, evidence-based recommendations for the management of acute stroke, serving as a reference for nursing care protocols. The available evidence and national and international guidelines were reviewed to establish levels of evidence and degrees of recommendation. The study covers various aspects of acute stroke care, including prehospital care, code stroke protocol, stroke team care, reperfusion treatments, stroke unit admission, nursing care, and discharge from hospital. However, more research is needed for certain aspects of acute stroke management.