Article
Neuroimaging
Anne Stankewitz, Leonie Keidel, Mathias Rehm, Stephanie Irving, Stephan Kaczmarz, Christine Preibisch, Viktor Witkovsky, Claus Zimmer, Enrico Schulz, Thomas R. Toelle
Summary: This study used fMRI to observe cyclic changes in brain perfusion and hypothalamic connectivity throughout the migraine cycle in migraine patients. The limbic circuit exhibited increased perfusion during headache attacks, while hypothalamic connectivity to the limbic system strengthened over the interictal interval and weakened during the headache phase. These findings suggest the hypothalamus plays a significant role in regulating migraine attacks.
NEUROIMAGE-CLINICAL
(2021)
Article
Multidisciplinary Sciences
Anthony Renard, Evan Harrell, Brice Bathallier
Summary: This study investigates how the combination of olfactory and tactile inputs affects sensory representations in the cortex. The research shows that odors can alter the activity of barrel cortex neurons through enhancing whisking and a central mechanism. Odor responses have little impact on tactile information, but they are sufficient for decoding odor identity.
NATURE COMMUNICATIONS
(2022)
Article
Clinical Neurology
Pavel Leahu, Manuel Bange, Dumitru Ciolac, Stefanie Scheiter, Alexandru Matei, Gabriel Gonzalez-Escamilla, Venkata C. Chirumamilla, Stanislav A. Groppa, Muthuraman Muthuraman, Sergiu Groppa
Summary: This study conducted an experimental, double-blind, randomized controlled trial applying a multifocal rTMS paradigm in patients with episodic migraine. The results showed that, over a 12-week period, the real rTMS group had significantly reduced migraine days and attack frequency compared to the sham group, indicating a higher response rate in the real rTMS group.
Article
Clinical Neurology
Katherine Podraza, Nitin Bangera, Akira Feliz, Andrew Charles
Summary: This study investigates the changes in retinal vasculature during and between migraine attacks using OCTA. It finds that there is reduced perfusion in the parafoveal retina during migraine attacks, and interictally, the foveal retina in migraine with aura has reduced perfusion compared to migraine without aura.
Article
Anesthesiology
Casper E. Christensen, Samaira Younis, Ulrich Lindberg, Patrick de Koning, Daniel Tolnai, Olaf B. Paulson, Henrik B. W. Larsson, Faisal M. Amin, Messoud Ashina
Summary: The study found that during migraine attacks induced by calcitonin gene-related peptide and sildenafil, both the intradural middle meningeal artery and the middle cerebral artery dilated, indicating that intradural vasculature is affected by trigeminal nociceptor activation during migraine attacks.
Article
Clinical Neurology
Fu-Jung Hsiao, Wei-Ta Chen, Li-Ling Hope Pan, Hung-Yu Liu, Yen-Feng Wang, Shih-Pin Chen, Kuan-Lin Lai, Gianluca Coppola, Shuu-Jiun Wang
Summary: This study compares neuronal excitability in the brainstem and primary somatosensory region between different phases of migraine attacks and finds that migraine is a cyclic excitatory disorder involving the somatosensory system, starting in the brainstem and subsequently spanning to the S1 area, which contributes to a better understanding of the pathophysiology of migraine.
JOURNAL OF HEADACHE AND PAIN
(2022)
Article
Clinical Neurology
Faisal Mohammad Amin, Roberto De Icco, Mohammad Al-Mahdi Al-Karagholi, Jayachandra Raghava, Frauke Wolfram, Henrik B. W. Larsson, Messoud Ashina
Summary: This study found that during spontaneous migraine attacks, there is a reduction in cortical thickness and volume in pain-related areas compared to the inter-ictal phase. Additionally, hippocampal volume increased during attacks, but no correlations were found between pain side or other clinical parameters and the reduced cortical size.
JOURNAL OF HEADACHE AND PAIN
(2021)
Article
Emergency Medicine
Nihat M. Hokenek, Mehmet O. Erdogan, Ummahan Dalkilinc Hokenek, Abdullah Algin, Davut Tekyol, Avni U. Seyhan
Summary: The study aimed to evaluate the effectiveness of TENS therapy in the emergency department, and the results showed that TENS therapy is significantly effective for the treatment of acute migraine with a fast-acting mechanism.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2021)
Article
Multidisciplinary Sciences
Luis Flores Horgue, Alexis Assens, Leon Fodoulian, Leonardo Marconi, Joel Tuberosa, Alexander Haider, Madlaina Boillat, Alan Carleton, Ivan Rodriguez
Summary: This study reveals that the diversity of olfactory neurons in mice is influenced by both the chemoreceptor expressed by each neuron and the experience of that neuron. The transcriptomic profiles of mouse olfactory sensory neurons are already divergent at rest, specific to the olfactory receptor they express, and can further evolve in response to environmental stimuli. These findings contribute to our understanding of the complexity and adaptability of sensory coding.
NATURE COMMUNICATIONS
(2022)
Article
Clinical Neurology
Amparo Ruiz-Tagle, Patricia Figueiredo, Joana Pinto, Pedro Vilela, Isabel Pavao Martins, Raquel Gil-Gouveia
Summary: This study aimed to investigate the neural correlates of working memory during a spontaneous migraine attack compared to the interictal phase using fMRI. The results showed that migraine patients exhibited greater activation of the left frontal pole and orbitofrontal cortex while performing a working memory task during a migraine attack, suggesting that patients recruit inhibitory areas to accomplish the cognitive task during migraine attacks.
NEUROLOGICAL SCIENCES
(2023)
Article
Clinical Neurology
Kirill Markin, Artem Trufanov, Daria Frunza, Igor Litvinenko, Dmitriy Tarumov, Alexander Krasichkov, Victoria Polyakova, Alexander Efimtsev, Dmitriy Medvedev
Summary: The aim of this study was to identify neuroimaging markers associated with rTMS therapy in patients with migraine. The results showed that rTMS treatment significantly altered the connectivity of brain networks associated with pain and antinociceptive brain systems.
FRONTIERS IN NEUROLOGY
(2022)
Article
Medicine, General & Internal
Elena Garcia-Martin, Santiago Navarro-Munoz, Gemma Amo, Christopher Rodriguez, Mercedes Serrador, Hortensia Alonso-Navarro, Marisol Calleja, Laura Turpin-Fenoll, Marta Recio-Bermejo, Rafael Garcia-Ruiz, Jorge Millan-Pascual, Francisco Navacerrada, Jose Francisco Plaza-Nieto, Esteban Garcia-Albea, Jose A. G. Agundez, Felix Javier Jimenez-Jimenez
Summary: This study investigated the relationship between serum diamine oxidase (DAO) activity and histamine levels, as well as three polymorphisms in the DAO gene, and the risk for migraine. The results showed that serum DAO activity was significantly higher in migraine patients, especially in females, while serum histamine levels were similar in both study groups. None of the studied polymorphisms were associated with the risk for migraine.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2022)
Article
Neurosciences
Yiting Huang, Yue Zhang, Sierra Hodges, Hui Li, Zhaoxian Yan, Xian Liu, Xiaoyan Hou, Weicui Chen, Thalia Chai-Zhang, Jian Kong, Bo Liu
Summary: This study aimed to investigate the modulation effect of repeated transcutaneous vagus nerve stimulation (taVNS) on the brainstem regions of the vagus nerve pathway. The results showed that repeated taVNS can modulate the functional connectivity between the brainstem regions and brain regions associated with the limbic system, pain processing and modulation, and basal ganglia. The change in functional connectivity between the raphe nucleus and putamen was significantly associated with the reduction in the number of migraine days.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2023)
Article
Anesthesiology
Roberto De Icco, Rosaria Greco, Chiara Demartini, Pietro Vergobbi, Annamaria Zanaboni, Elena Tumelero, Angelo Reggiani, Natalia Realini, Grazia Sances, Valentina Grillo, Marta Allena, Cristina Tassorelli
Summary: This study found a role for PEA in the ictal phase of episodic migraine and no significant correlations between the endocannabinoid system (ES) and neurophysiological parameters. NTG-induced central sensitization and the observed increase in PEA levels and spinal sensitization were parallel and likely unrelated phenomena.
Article
Anesthesiology
Flavia S. Domingues, Maisa Gayoso, Shafaq Sikandar, Leopoldo Muniz da Silva, Ronaldo G. Fonseca, Guilherme A. M. de Barros
Summary: In this study, the analgesic efficacy of a portable, disposable, and home self-applied transcutaneous electrical nerve stimulation (TENS) device during migraine attacks was evaluated. A double-blind, randomized controlled trial showed a statistically significant reduction in pain scores in the intervention group compared to the sham group. Participants in the intervention group demonstrated improvement in pain and functional disability scores.