Article
Neurosciences
Yusuf Osmanlioglu, Drew Parker, Jacob A. Alappatt, James J. Gugger, Ramon R. Diaz-Arrastia, John Whyte, Junghoon J. Kim, Ragini Verma
Summary: Traumatic brain injury (TBI) is a major public health problem characterized by the shearing of axons across the white matter, leading to cognitive deficits. Assessing network-wide structural connectivity disruptions in TBI is necessary for personalized treatment and rehabilitation planning. A novel connectomic measure called network normality score (NNS) captures the integrity of structural connectivity in TBI patients by leveraging the diffuseness of axonal injury and the heterogeneity of the disease.
HUMAN BRAIN MAPPING
(2022)
Article
Multidisciplinary Sciences
Juliana Sanchez-Molano, Meghan O. Blaya, Kyle R. Padgett, William J. Moreno, Weizhao Zhao, W. Dalton Dietrich, Helen M. Bramlett
Summary: Traumatic brain injury (TBI) is a global problem that leads to death or disability for millions of people each year. By using multiple MRI modalities, we have shown the feasibility of investigating and predicting abnormal changes and progressive atrophy of gray and white matter tissue after TBI. This study highlights the importance of using DTI and PWI as prognostic imaging techniques for assessing structural changes following TBI.
Article
Multidisciplinary Sciences
Abdalla Z. Mohamed, Paul Cumming, Fatima A. Nasrallah
Summary: This study extends the temporal window for monitoring structural-functional alterations post-TBI from two hours to six months. Findings revealed a progressive increase in lesion size associated with brain volume loss post-TBI, as well as persistent microstructural and functional connectivity alterations. A time-dependent pattern of altered functional connectivity was observed over the six months' follow-up post-TBI.
SCIENTIFIC REPORTS
(2021)
Article
Neurosciences
Jean Michaud, Isabelle Plu, Jacqueline Parai, Andre Bourgault, Caroline Tanguay, Danielle Seilhean, John Woulfe
Summary: Traumatic brain injury is a major insult that can lead to the development of chronic traumatic encephalopathy. In this study, severe TBI patients who remained comatose until death were found to have ballooned neurons, similar to those seen in neurodegenerative disorders. The presence of these neurons in TBI patients has not been previously reported. Further research is needed to understand the frequency of this neuronal finding and its relationship with proximal axonal defects.
ACTA NEUROPATHOLOGICA COMMUNICATIONS
(2023)
Article
Neurosciences
Ashley L. Ware, Keith Owen Yeates, Ken Tang, Ayushi Shukla, Adrian Onicas, Sunny Guo, Naomi Goodrich-Hunsaker, Nishard Abdeen, Miriam H. Beauchamp, Christian Beaulieu, Bruce Bjornson, William Craig, Mathieu Dehaes, Quynh Doan, Sylvain Deschenes, Stephen B. Freedman, Bradley G. Goodyear, Jocelyn Gravel, Andree-Anne Ledoux, Roger Zemek, Catherine Lebel
Summary: In this study, the largest sample to date was used to investigate the white matter microstructural changes and their relation to persistent symptoms after pediatric mTBI. The results showed that white matter microstructural changes suggesting neuroinflammation and axonal swelling occurred chronically and continued 6 months post injury in children with mTBI, especially in younger children with persistent symptoms. The white matter microstructure appears more organized in children without persistent symptoms, indicating better clinical outcomes.
HUMAN BRAIN MAPPING
(2022)
Article
Neurosciences
Yizhen Pan, Xuan Li, Yuling Liu, Xiaoyan Jia, Shan Wang, Qiuyu Ji, Wenpu Zhao, Bo Yin, Guanghui Bai, Jie Zhang, Lijun Bai
Summary: Mild traumatic brain injury (mTBI) disrupts the integrity of white matter microstructure, affecting brain functional connectivity supporting cognitive function. The current study investigated the alteration pattern of regional SC-FC coupling in acute and chronic mTBI patients and found that the sensorimotor network (SMN) exhibited altered coupling in acute mTBI, while chronic mTBI showed persistent decoupling of the SMN and additional decoupling of the default mode network (DMN). Crucially, the decoupling of the SMN and DMN predicted better cognitive outcomes.
Review
Biochemistry & Molecular Biology
Marios Lampros, Nikolaos Vlachos, Parmenion P. Tsitsopoulos, Anastasia K. Zikou, Maria I. Argyropoulou, Spyridon Voulgaris, George A. Alexiou
Summary: Traumatic axonal injury (TAI) is a subtype of traumatic brain injury (TBI) that results from high-impact forces causing damage to axonal fibers. Conventional imaging methods often fail to detect TAI lesions, but novel imaging modalities and biomarkers show promise in improving diagnosis and prediction of outcomes in TAI patients. This review discusses the role of these imaging modalities and potential biomarkers in diagnosing, classifying, and predicting outcomes in TAI patients.
Article
Clinical Neurology
Stephanie S. G. Brown, Kristen Dams-O'Connor, Eric Watson, Priti Balchandani, Rebecca E. Feldman
Summary: This case study investigates the structural effects of traumatic brain injury using pre-injury and post-injury 7 Tesla MRI longitudinal data for the first time. Findings include initial volumetric changes, decreased structural connectivity, and reduced microstructural order that return to baseline 8 months post-injury, demonstrating in-depth metrics of physiological recovery. Default mode, salience, occipital, and executive function network alterations reflect patient-reported hypersomnolence, reduced cognitive processing speed, and dizziness.
FRONTIERS IN NEUROLOGY
(2021)
Article
Clinical Neurology
Juho Dahl, Olli Tenovuo, Jussi P. Posti, Jussi Hirvonen, Ari J. Katila, Janek Frantzen, Henna-Riikka Maanpaa, Riikka Takala, Eliisa Loyttyniemi, Jussi Tallus, Virginia Newcombe, David K. Menon, Peter J. Hutchinson, Mehrbod Mohammadian
Summary: Cerebral microbleeds are associated with the clinical severity of traumatic brain injury but have a weaker association with white matter integrity.
FRONTIERS IN NEUROLOGY
(2022)
Article
Neurosciences
Jessica M. Sharkey, Ryan D. Quarrington, Justin L. Krieg, Lola Kaukas, Renee J. Turner, Anna Leonard, Claire F. Jones, Frances Corrigan
Summary: Damage to axonal white matter tracts within the brain is a major contributor to neurological impairment and long-term disability after traumatic brain injury (TBI). This study aimed to investigate the effect of post-traumatic hypoxia on axonal injury and inflammation in a sheep model of TBI. The results showed that early axonal injury was characterized by calpain activation and increased SNTF immunoreactivity, while axonal transport was not impaired. These findings indicate that axonal injury post-TBI is driven by different pathophysiological mechanisms.
Article
Neurosciences
Daniel J. Brennan, Jeffrey Duda, Jeffrey B. Ware, John Whyte, Joon Yul Choi, James Gugger, Kristen Focht, Alexa E. Walter, Tamara Bushnik, James C. Gee, Ramon Diaz-Arrastia, Junghoon J. Kim
Summary: Traumatic brain injury (TBI) results in progressive neurodegeneration and brain atrophy. This study investigated the spatial and temporal evolution of TBI-related atrophy using longitudinal scans of 37 individuals with TBI and 33 matched controls. The results showed early cortical thinning and reduced volume in specific brain regions, as well as continued atrophy over time. The findings suggest that atrophy during the first year of TBI can serve as a biomarker for neurodegeneration.
HUMAN BRAIN MAPPING
(2023)
Article
Critical Care Medicine
Isis So, Liesel-Ann C. Meusel, Bhanu Sharma, Georges A. A. Monette, Brenda Colella, Anne L. L. Wheeler, Jennifer S. S. Rabin, David J. J. Mikulis, Robin E. A. Green
Summary: This study investigated longitudinal functional connectivity in patients with moderate-to-severe traumatic brain injury (TBI) and found that functional connectivity improved within the first year post-injury but may decline afterwards, which is consistent with behavioral and structural decline in chronic moderate-to-severe TBI. Rating: 7.5/10
JOURNAL OF NEUROTRAUMA
(2023)
Article
Clinical Neurology
Amy E. Jolly, Maria Balaet, Adriana Azor, Daniel Friedland, Stefano Sandrone, Neil S. N. Graham, Karl Zimmerman, David J. Sharp
Summary: This study introduces a pipeline for assessing the presence of axonal injury in traumatic brain injury patients, revealing that the majority of patients have axonal injury in the chronic and subacute phases. Patients with axonal injury exhibit significantly poorer cognitive and functional outcomes.
Article
Neurosciences
Alexandra A. Adams, Ying Li, Haesun A. Kim, Bryan J. Pfister
Summary: In vitro models of traumatic brain injury commonly use neurons from the central nervous system, but there are limitations with primary cortical cultures. This study aimed to compare the response of cortical and DRGN axons to mechanical stretch injury associated with TBI. The results showed that both types of axons exhibited similar morphological changes, elongation, recovery, and degeneration after injury.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2023)
Article
Clinical Neurology
Michael R. Grovola, Nicholas Paleologos, Daniel P. Brown, Nathan Tran, Kathryn L. Wofford, James P. Harris, Kevin D. Browne, Patricia A. Shewokis, John A. Wolf, D. Kacy Cullen, John E. Duda
Summary: This study found an increase in amyloid precursor protein pathology after a single mild TBI, particularly in the periventricular white matter and fimbria/fornix. Although changes in corpus callosum integrity or astrocyte reactivity were not detected, detailed microglial skeletal analysis revealed morphological changes, including increases in the number of microglial branches, junctions, and endpoints.
Article
Statistics & Probability
Stephanie Bougeard, Herve Abdi, Gilbert Saporta, Ndeye Niang
ADVANCES IN DATA ANALYSIS AND CLASSIFICATION
(2018)
Article
Neurosciences
Simona Manescu, Daphnee Poupon, Jordi Ballester, Herve Abdi, Dominique Valentin, Franco Lepore, Johannes Frasnelli
Article
Food Science & Technology
Jacob Lahne, Herve Abdi, Thomas Collins, Hildegarde Heymann
JOURNAL OF FOOD SCIENCE
(2019)
Article
Multidisciplinary Sciences
Vincent Guillemot, Derek Beaton, Arnaud Gloaguen, Tommy Lofstedt, Brian Levine, Nicolas Raymond, Arthur Tenenhaus, Herve Abdi
Article
Psychology, Clinical
Naama Rotem-Kohavi, Lynne J. Williams, Angela M. Muller, Herve Abdi, Naznin Virji-Babul, Bruce H. Bjornson, Ursula Brain, Janet F. Werker, Ruth E. Grunau, Steven P. Miller, Tim F. Oberlander
DEPRESSION AND ANXIETY
(2019)
Article
Audiology & Speech-Language Pathology
Susan Jerger, Markus F. Damian, Cassandra Karl, Herve Abdi
Article
Geriatrics & Gerontology
Jenny R. Rieck, Giulia Baracchini, Daniel Nichol, Herve Abdi, Cheryl L. Grady
Summary: As people age, functional connectivity patterns during initiation, inhibition, and shifting in cognitive control become more similar, while networks exhibit age-related reconfiguration.
NEUROBIOLOGY OF AGING
(2021)
Editorial Material
Critical Care Medicine
James J. Gugger, Ramon Diaz-Arrastia
NEUROCRITICAL CARE
(2022)
Article
Clinical Neurology
Jens Witsch, David Roh, Stephanie Oh, Costantino Iadecola, Ramon Diaz-Arrastia, Scott E. Kasner, Stephan A. Mayer, Santosh B. Murthy
Summary: Neutrophil-mediated inflammation exacerbates intracerebral hemorrhage (ICH) outcomes. This study aimed to investigate the association between serum levels of sICAM-1 and poor outcomes after ICH. After adjustment, sICAM-1 was found to be associated with mortality, poor outcome, and hematoma expansion.
Article
Medical Laboratory Technology
Jennifer G. Cooper, Sophie Stukas, Mohammad Ghodsi, Nyra Ahmed, Ramon Diaz-Arrastia, Daniel T. Holmes, Cheryl L. Wellington
Summary: This study aimed to establish reference intervals (RI) for plasma protein biomarkers relevant to neurological diseases and disorders using a large Canadian population-based cohort. The study generated discrete and continuous RIs for each biomarker at different age partitions. These RIs can refine normative cut-offs and improve the precision of interpreting biomarker levels.
CLINICAL BIOCHEMISTRY
(2023)
Article
Clinical Neurology
Shawn R. Eagle, Ava M. Puccio, Lindsay D. Nelson, Michael McCrea, Joseph Giacino, Ramon Diaz-Arrastia, William Conkright, Sonia Jain, Xiaoying Sun, Geoffrey Manley, David O. Okonkwo
Summary: Obesity is associated with higher symptomatology and blood inflammatory markers in recovery following mTBI. The study found that obese patients had higher concentrations of hsCRP and IL-6 at multiple time points after injury, as well as higher RPQ scores at 6 and 12 months.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2023)
Article
Neuroimaging
Pratusha Reddy, Kurtulus Izzetoglu, Patricia A. Shewokis, Michael Sangobowale, Ramon Diaz-Arrastia
Summary: The damage to the cerebrovascular network is a common feature of traumatic brain injury (TBI). This study found significant differences in the time-frequency characteristics of fNIRS signal components between healthy controls and TBI patients, and these differences changed across phases of the injury.
NEUROIMAGE-CLINICAL
(2023)
Article
Psychology, Experimental
Carina L. Fan, Herve Abdi, Brian Levine
Summary: This study focused on the relationship between autobiographical episodic memory and spatial navigation, finding that they are dissociated abilities. Autobiographical episodic memory overlapped with object imagery, while spatial navigation overlapped with spatial schematics and manipulation. These results suggest that trait episodic autobiographical memory and spatial navigation correspond to distinct mental processes.
MEMORY & COGNITION
(2021)
Article
Education & Educational Research
Amy Louise Schwarz, Meagan Jurica, Charlsa Matson, Rachel Stiller, Taylor Webb-Culver, Herve Abdi
DEAFNESS & EDUCATION INTERNATIONAL
(2020)
Article
Psychology, Multidisciplinary
Rachna Raman, Michael A. Kriegsman, Herve Abdi, Barbara Tillmann, W. Jay Dowling
NEW IDEAS IN PSYCHOLOGY
(2020)