Article
Infectious Diseases
Sofie Haglund, Malin Lager, Paula Gyllemark, Garda Andersson, Oskar Ekelund, Martin Sundqvist, Anna J. Henningsson
Summary: The study compared the semi-quantitative, cassette-based ReaScan CXCL13 assay with the quantitative recomBead CXCL13 assay in the diagnostics of Lyme neuroborreliosis (LNB), showing an 87% categorical agreement between the two methods. The recomBead assay demonstrated higher diagnostic sensitivity, while the ReaScan assay showed higher specificity. With few manual steps and a short turn-around time, the ReaScan CXCL13 assay is an attractive complement to serology in the diagnostics of LNB.
EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES
(2022)
Article
Immunology
Sanna Avellan, Daniel Bremell
Summary: The study found that adjunctive corticosteroids do not improve or impair the outcome for patients with LNB PFP treated with doxycycline.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Infectious Diseases
Dita Smiskova, Olga Dzupova, Lenka Moravcova, Dusan Picha
Summary: This study evaluated the levels of CXCL13 in the cerebrospinal fluid of patients with different types of CNS infections. It found that the levels of CXCL13 were significantly elevated in patients with Lyme neuroborreliosis. However, elevated levels of CXCL13 were also found in other types of infections, indicating that caution should be taken in diagnosing Lyme neuroborreliosis based solely on CXCL13 levels.
INFECTIOUS DISEASES
(2023)
Article
Microbiology
Tamara van Gorkom, Gijs H. J. van Arkel, Michiel Heron, Willem Voet, Steven F. T. Thijsen, Kristin Kremer
Summary: Recent studies have shown elevated levels of CXCL13 in the CSF of patients with early Lyme neuroborreliosis. The Quantikine CXCL13 ELISA and recomBead CXCL13 assay were found to be sensitive and specific in diagnosing LNB, with potential additional value in the diagnostic process.
JOURNAL OF CLINICAL MICROBIOLOGY
(2021)
Article
Behavioral Sciences
Silje Andreassen, Anne Marit Solheim, Unn Ljostad, Ase Mygland, Aslaug Rudjord Lorentzen, Harald Reiso, Mona Kristiansen Beyer, Hanne Flinstad Harbo, Gro Christine Christensen Lohaugen, Randi Eikeland
Summary: This study re-assessed patients with neuroborreliosis and evaluated the long-term outcomes after treatment. The results showed no changes in attention or processing speed, but a reduction in the level of fatigue.
BRAIN AND BEHAVIOR
(2022)
Article
Medical Laboratory Technology
Ivar Tjernberg, Paula Gyllemark, Henrik Zetterberg, Kaj Blennow, Jan Ernerudh, Pia Forsberg, Johanna Sjowall, Anna J. Henningsson
Summary: The levels and kinetics of cerebrospinal fluid markers of inflammation and brain injury were evaluated in patients with Lyme neuroborreliosis. The results indicate a predominance of microglial and neuroinflammatory involvement in CSF at diagnosis of LNB and a prompt decline after antibiotic treatment.
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
(2022)
Article
Infectious Diseases
Kristina Gubanova, Julia Lang, Juliane Latzko, Bianka Novotna, Julian Perneczky, Stefan Pingitzer, Petra Purer, Bianca Wuchty, Christoph Waiss, Johann Sellner
Summary: This case study highlights rare early diagnostic findings in peripheral neuropathy caused by Lyme neuroborreliosis, emphasizing the ineffectiveness of CXCL13 in cerebrospinal fluid for early diagnosis and the development of intrathecal immune response against Borrelia at a later stage.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Medicine, General & Internal
Kaien Gu, Carl Boodman, Pamela Orr, Terence Wuerz
Summary: Lyme disease is a tick-borne disease with a wide range of symptoms and challenging diagnosis. This article presents a case of Lyme disease presenting as brachial plexopathy and meningitis.
Article
Public, Environmental & Occupational Health
Boby Varkey Maramattom, Balram Rathish
Summary: This case report describes a 57-year-old male patient who developed neuro-melioidosis following a penetrating injury, leading to severe neurological complications and eventually death. Brain tissue biopsy revealed growth of Burkholderia pseudomallei, a rare bacterium known to invade the central nervous system.
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
(2021)
Article
Clinical Neurology
Carla Palleis, Robert Forbrig, Louisa Lehner, Stefanie Quach, Nathalie L. Albert, Matthias Brendel, Florian Schoeberl, Andreas Straube
Summary: This is a case report on Lyme disease, in which the patient developed central nervous system large vessel vasculitis, ischemic stroke, and tumefactive contrast-enhancing brain lesions, which are unusual complications of neuroborreliosis. The diagnosis was confirmed through magnetic resonance imaging and transcranial ultrasound, and the patient was successfully treated.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Clinical Neurology
Carla Palleis, Robert Forbrig, Louisa Lehner, Stefanie Quach, Nathalie L. Albert, Matthias Brendel, Florian Schoeberl, Andreas Straube
Summary: This article reports a patient with neuroborreliosis who presented with central nervous system large vessel vasculitis, ischemic stroke, and tumefactive contrast-enhancing brain lesions, which are unusual complications of Lyme disease. The case highlights the importance of considering vasculopathy and cerebrovascular events in patients with neuroborreliosis, despite being rare.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Infectious Diseases
Karina M. Forde, Joanne O'Gorman, Patrick J. Gavin, Matthew S. Dryden, Deirbhile Keady, Belinda Hanahoe, Colm McDonnell, Lorraine Power, Bartley Cryan, James Sweeney, Karl F. Conyard, Michael J. O'Grady
Summary: Serologically confirmed Lyme disease in children is relatively rare in the Republic of Ireland, with 98% of children tested being seronegative. Among the seropositive cases, 40% could have been diagnosed based on clinical findings alone. Neurological presentations were common (40%), and almost all cases (97%) where data were available reported full resolution of symptoms.
EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES
(2021)
Article
Immunology
Elizabeth A. Eckman, Dana M. Clausen, Aimee R. Herdt, Javier Pacheco-Quinto, John J. Halperin
Summary: Intrathecal CXCL13 and IgG production are closely interrelated. CXCL13 is disproportionately increased in definite LNB, defined as having demonstrable Borrelia-specific ITAb, but not probable LNB, without ITAb. This disproportionate increase may help identify patients with very early infection or those with active vs treated LNB, or may help to differentiate ITAb-defined active LNB from other neuroinflammatory disorders. However, its reported specificity is closely related to the diagnostic requirement for LTAb. It may add little specificity to the demonstration of a pleocytosis or increased overall or specific IgG production in the CSF.
CLINICAL INFECTIOUS DISEASES
(2021)
Review
Pediatrics
R. A. Bruinsma, T. P. Zomer, B. H. Skogman, M. Boele Van Hensbroek, J. W. Hovius
Summary: Lyme neuroborreliosis (LNB) is a manifestation of Lyme disease that affects the central and peripheral nervous system. It is caused by the bacteria Borrelia burgdorferi, transmitted through tick bites. LNB presents differently in children and adults, with adults commonly experiencing painful meningoradicultis and children often presenting with facial nerve palsy and/or subacute meningitis. Other symptoms, such as subacute headache and non-specific symptoms like loss of appetite and fatigue, may also occur. Early recognition and diagnosis are crucial for effective management of LNB in children.
EUROPEAN JOURNAL OF PEDIATRICS
(2023)
Article
Immunology
Benjamin S. Avner
Summary: This study retrospectively reviewed hospitalizations for Lyme disease in two southwest Michigan hospital systems from 2017 to 2021. Lyme admissions showed a sharp increase, with parallel increases in admissions for Lyme carditis and neuroborreliosis. Southwest Michigan is becoming an endemic area for Lyme disease.
OPEN FORUM INFECTIOUS DISEASES
(2023)
Article
Genetics & Heredity
Verena Kufner, Andreas Plate, Stefan Schmutz, Dominique L. Braun, Huldrych E. Guenthard, Riccarda Capaul, Andrea Zbinden, Nicolas J. Mueller, Alexandra Trkola, Michael Huber
Article
Infectious Diseases
Andreas Plate, Andreas Kronenberg, Martin Risch, Yolanda Mueller, Stefania Di Gangi, Thomas Rosemann, Oliver Senn
Article
Infectious Diseases
A. Plate, V. Weichselbaumer, R. Schupbach, S. F. Fucentese, M. Berli, M. Hullner, Y. Achermann
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2020)
Article
Orthopedics
Lizzy Weigelt, Andreas Plate, Laura Stadler, Reto Sutter, Dario Frustaci, Reinhard Zbinden, Patrick O. Zingg, Christian Gerber, Yvonne Achermann
INTERNATIONAL ORTHOPAEDICS
(2020)
Article
Primary Health Care
Andreas Plate, Andreas Kronenberg, Martin Risch, Yolanda Mueller, Stefania Di Gangi, Thomas Rosemann, Oliver Senn
BMC FAMILY PRACTICE
(2020)
Review
Infectious Diseases
Nahara Anani Martinez-Gonzalez, Ellen Keizer, Andreas Plate, Samuel Coenen, Fabio Valeri, Jan Yvan Jos Verbakel, Thomas Rosemann, Stefan Neuner-Jehle, Oliver Senn
Article
Medicine, General & Internal
Stefania Di Gangi, Stefan Markun, Thomas Rosemann, Andreas Plate
PATIENT PREFERENCE AND ADHERENCE
(2020)
Article
Infectious Diseases
Nahara Anani Martinez-Gonzalez, Stefania Di Gangi, Giuseppe Pichierri, Stefan Neuner-Jehle, Oliver Senn, Andreas Plate
Article
Medicine, General & Internal
Stefania Di Gangi, Giuseppe Pichierri, Stefan Zechmann, Thomas Rosemann, Andreas Plate
Summary: In the Swiss primary care setting, approximately two-thirds of patients with acute low back pain were treated with pain medications. The prescribing patterns were conservative, with limited use of strong opioids and co-medications.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Immunology
Levy Jaeger, Oliver Senn, Thomas Rosemann, Andreas Plate
Summary: In Switzerland, there is a lower-than-desirable human papillomavirus vaccination coverage rate with general practitioners (GPs) and pediatricians playing important roles as providers of the HPV vaccine. However, differences in awareness, attitudes, and practices exist between GPs and pediatricians, with GPs showing more focus on HPV counseling for female patients. Factors influencing physicians' HPV vaccination practices include the number of patients seen and the perceived importance of the vaccine. Addressing these gaps in awareness and practice could help increase national HPV vaccination coverage rates.
Article
Medicine, General & Internal
Stefan Zechmann, Leana Hotz, Stefania Di Gangi, Klaus Baumgartl, Andreas Plate, Eliska Potlukova
Summary: The Swiss national lockdown due to the COVID-19 pandemic did not impact overall mean HbA1c values in patients with diabetes, but a subset of type 2 diabetes patients experienced worsened glycemic control post-lockdown. Individual risk factors such as inappropriate alcohol intake and hypothyroidism were associated with increased HbA1c levels in these patients.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Clinical Neurology
Stefania Di Gangi, Christophe Bagnoud, Giuseppe Pichierri, Thomas Rosemann, Andreas Plate
Summary: The study aimed to describe treatment patterns specific to patients with diagnostic imaging of the spine for low back pain. The majority of patients received non-opioid short-term therapies, but there was also substantial use of opioids, particularly strong opioids. The results highlighted the importance of patient and healthcare provider awareness regarding the prudent treatment of low back pain.
JOURNAL OF PAIN RESEARCH
(2021)
Article
Economics
Stefania Di Gangi, Christophe Bagnoud, Giuseppe Pichierri, Thomas Rosemann, Andreas Plate
Summary: The study found that healthcare costs for patients with low back pain were 72% higher compared to patients without low back pain, highlighting the importance of improving prevention, diagnostics, and patient care for those with low back pain.
EUROPEAN JOURNAL OF HEALTH ECONOMICS
(2022)
Article
Infectious Diseases
Nahara Anani Martinez-Gonzalez, Andreas Plate, Levy Jaeger, Oliver Senn, Stefan Neuner-Jehle
Summary: Research found that GPs rely heavily on C-reactive protein point-of-care testing (CRP-POCT) in making antibiotic prescribing decisions, showing a preference for using lower CRP cut-offs to guide prescribing for more severe respiratory tract infections. However, patient pressure, diagnostic uncertainty, fear of complications, and lack of understanding of antibiotic resistance are reported as the major barriers to appropriate antibiotic prescribing.
Article
Endocrinology & Metabolism
Ilker Uckay, Martin W. Huellner, Yvonne Achermann, Andreas Plate, Madlaina Schoeni, Andrea Rosskopf, Martin C. Berli
Summary: This study evaluated the clinical value of 99mTc-antigranulocyte SPECT/CT in DFO patients and found that it did not change the clinical approach.
CURRENT DIABETES REVIEWS
(2022)