Article
Medicine, General & Internal
Charlotte Greer, Sarah L. Harris, Richard Troughton, Philip D. Adamson, John Horwood, Chris Frampton, Brian A. Darlow
Summary: Being born preterm and at very low birth weight is associated with increased cardiopulmonary disorders in childhood and potential late cardiac effects, including right ventricular remodeling and occult pulmonary hypertension as survivors age. In a population-based study, young adults born PT at VLBW exhibited smaller RV dimensions compared to normal-weight term-born controls, with slightly reduced RV function detected using strain imaging. Birth weight and gestational age were related to these differences, highlighting the potential importance of echocardiographic strain imaging in detecting RV function disparities in this population.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Pediatrics
Sylvia M. van der Pal, Sanne A. van der Meulen, Sophie M. Welters, Leonhard A. Bakker, Christianne J. M. de Groot, Anton H. van Kaam, Erik (G. H. W. ) Verrips
Summary: The reproduction process is more problematic for individuals born VPT/VLBW at 35 years old, with lower fertility rates, higher risks for conception problems and pregnancy complications, but their offspring do not have an increased risk for preterm birth.
EUROPEAN JOURNAL OF PEDIATRICS
(2021)
Article
Psychology, Multidisciplinary
Siri Weider, Astrid M. W. Laerum, Kari Anne I. Evensen, Solveig Klaebo Reitan, Stian Lydersen, Ann Mari Brubakk, Jon Skranes, Marit S. Indredavik
Summary: This study aimed to assess neurocognitive function in adults born with low birthweight compared with controls and explore associations between neurocognitive function and psychopathology in these groups. The results showed that the very low birthweight group scored significantly lower than the control group on multiple neurocognitive measures, while the small for gestational age group scored lower on IQ and psychomotor speed. Adjusted for sex and parental socioeconomic status, lower IQ was associated with attention problems. These findings have important clinical implications.
FRONTIERS IN PSYCHOLOGY
(2023)
Article
Oncology
Vicky A. Cameron, Gregory T. Jones, L. John Horwood, Anna P. Pilbrow, Julia Martin, Chris Frampton, Wendy T. Ip, Richard W. Troughton, Charlotte Greer, Jun Yang, Michael J. Epton, Sarah L. Harris, Brian A. Darlow
Summary: This study found differences in DNA methylation between very low birthweight (VLBW) individuals and normal birthweight controls in both infancy and adulthood, which were associated with cardiovascular and respiratory outcomes in adulthood. The results suggest that DNA methylation patterns in infancy may be indicative of future risk for cardiovascular and respiratory diseases in adulthood, highlighting the potential for early preventative care to improve adult health.
CLINICAL EPIGENETICS
(2023)
Article
Multidisciplinary Sciences
Qinchuan Shi, Jingjing Zhang, Chong Fan, Aixia Zhang, Zhu Zhu, Yingying Tian
Summary: This study systematically evaluated the risk factors of hypothermia in very low/extremely low birth weight infants. Factors including body weight, failure to keep warm in time, neonatal resuscitation, gestational age, premature rupture of membranes, maternal combined complications, cesarean section, antenatal steroids, multiple birth, small for gestational age, 1 min Apgar score, and 5 min Apgar score were identified. These findings provide a theoretical basis for the prevention and intervention of hypothermia in VLBW/ELBW infants.
Article
Environmental Sciences
Mengge Liu, Tong Han, Yue Wu, Jingliang Cheng, Longjiang Zhang, Bing Zhang, Xi-Nian Zuo, Wenzhen Zhu, Shijun Qiu, Zuojun Geng, Xiaochu Zhang, Guangbin Cui, Quan Zhang, Yongqiang Yu, Hui Zhang, Bo Gao, Xiaojun Xu, Zhenwei Yao, Wen Qin, Meng Liang, Feng Liu, Lining Guo, Qiang Xu, Jilian Fu, Jiayuan Xu, Jie Tang, Nana Liu, Kaizhong Xue, Peng Zhang, Wei Li, Dapeng Shi, Caihong Wang, Jia-Hong Gao, Su Lui, Zhihan Yan, Feng Chen, Jiance Li, Jing Zhang, Wen Shen, Yanwei Miao, Junfang Xian, Le Yu, Kai Xu, Meiyun Wang, Zhaoxiang Ye, Wei-Hua Liao, Dawei Wang, Chunshui Yu
Summary: This study investigates the effects of pre-adulthood urbanicity on hippocampal subfield volumes and neurocognitive abilities, as well as the sensitive age windows of the urbanicity effects. The findings show that higher urbanicity is associated with larger hippocampal subfield volumes and better neurocognitive abilities. The effects of urbanicity on hippocampus and visuospatial memory exhibit bilateral mediations and vary across different age windows.
ENVIRONMENT INTERNATIONAL
(2023)
Article
Medicine, General & Internal
Adrien Flahault, Gabriel Altit, Aurelie Sonea, Anne-Sophie Gervais, Muhammad Oneeb Rehman Mian, Rong Wu, Eva Desbrousses, Ly Mai, Anik Cloutier, Jessica Simoneau, Anie Lapointe, Andreanne Villeneuve, Patrick Garceau, Michel White, Jean-Luc Bigras, Thuy Mai Luu, Anne Monique Nuyt
Summary: The study found alterations in LV dimensions and function in adults born preterm, even after adjusting for factors like body surface area. The use of antenatal steroids may lead to further reduced cardiac output in preterm individuals, indicating an increased risk of cardiovascular disease in this population.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Endocrinology & Metabolism
Thang Dao, Dale Lee Robinson, Lex W. Doyle, Peter V. S. Lee, Joy Olsen, Ashwini Kale, Jeanie L. Y. Cheong, John D. Wark
Summary: This study investigated the bone structure and estimated bone strength of young adults born extremely preterm or extremely low birth weight. The results showed that the EP/ELBW survivors had lower bone parameters compared to the controls, especially among males. These findings suggest a higher long-term fracture risk in EP/ELBW survivors.
JOURNAL OF BONE AND MINERAL RESEARCH
(2023)
Article
Critical Care Medicine
Jun Yang, Michael J. Epton, Sarah L. Harris, John Horwood, Rachel A. Kingsford, Richard Troughton, Charlotte Greer, Brian A. Darlow
Summary: Exercise capacity is significantly reduced in adults with very low birth weight (VLBW), which may be due to a combination of impaired lung function, altered heart structure and function, and decreased physical activity.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2022)
Article
Pediatrics
Nina Kaseva, Juho Kuula, Samuel Sandboge, Helena Hauta-alus, Johan Bjorkqvist, Petteri Hovi, Johan G. Eriksson, Terhi Vihervaara, Kirsi H. Pietilaeinen, Eero Kajantie
Summary: Preterm survivors have impaired fatty acid metabolism and glucose regulation. However, the differences in cardiometabolic biomarkers between preterm survivors and their siblings are smaller, possibly due to shared familial, genetic, or environmental factors.
PEDIATRIC RESEARCH
(2023)
Article
Nutrition & Dietetics
Xiaotong Wang, Jiajia Jing, Saijun Huang, Xiaoying He, Pingming Gao, Hailin Li, Zongyu Lin, Per Torp Sangild, Yanna Zhu
Summary: Early anemia in very-low-birth-weight (VLBW) preterm infants is negatively correlated with neurodevelopment, especially with behavioral ability, but is not associated with brain injury.
Article
Physiology
Ying Qi, Jingni He
Summary: LBW-VLBW neonates show significantly lower CMRO2 and greater physiological deficits compared to term controls. Physiological parameters are valuable for distinguishing different subsets of LBW-VLBW newborns.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Pediatrics
Kayla Rodriguez, Matthew J. J. Nudelman, Priya Jegatheesan, Angela Huang, Kamakshi Devarajan, Jessica E. Haas, Rosemarie Cervantes, Kelle Falbo, Sudha Rani Narasimhan, Machelnil Cormier, Mary Beth Stewart, Rupalee Patel, Balaji Govindaswami
Summary: This study compared the rates of preterm birth (PTB) and very low birth weight (VLBW) in 5 hospitals during the early COVID era (Jan-Dec 2020) to the pre-COVID period (Jan 2017-Dec 2019). The results showed no significant change in the rates of PTB or VLBW between the two time periods.
FRONTIERS IN PEDIATRICS
(2023)
Article
Ophthalmology
Maarit Kulmala, Anna Perregaard Munch Jorgensen, Kristina Anna Djupvik Aakvik, Laura Jussinniemi, Silje Dahl Benum, Sigrid Hegna Ingvaldsen, Dordi Austeng, Eero Kajantie, Kari Anne I. Evensen, Anna Majander, Tora Sund Morken
Summary: The purpose of this study was to investigate visual function and vision-related general health in adults born preterm with very low birth weight (VLBW) in their 30s-40s. The study found that VLBW adults had lower visual function and scored lower in self-reported vision-related health compared to term-born controls. These results suggest that prematurity and VLBW may have long-term consequences on visual function and health.
ACTA OPHTHALMOLOGICA
(2023)
Article
Cardiac & Cardiovascular Systems
Soichiro Henmi, Yasin Essa, Mahmut Ozturk, Aybala Tongut, Manan Desai, Can Yerebakan, Yves d'Udekem
Summary: This study retrospectively evaluated the outcomes of cardiovascular surgery in very low birth weight patients. The study found that the occurrence of postoperative intracerebral hemorrhage was significantly higher in low birth weight patients compared to slightly higher weight patients. The early and late mortality rates were also higher in the low birth weight group. Early surgery was acceptable for simple lesions, while delayed surgery may provide better long-term outcomes for complex lesions.
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2022)
Article
Psychology, Developmental
Sara Sammallahti, Elisa Holmlund-Suila, Runyu Zou, Saara Valkama, Jenni Rosendahl, Maria Enlund-Cerullo, Helena Hauta-Alus, Marius Lahti-Pulkkinen, Hanan El Marroun, Henning Tiemeier, Outi Makitie, Sture Andersson, Katri Raikkonen, Kati Heinonen
Summary: Higher maternal vitamin D concentration during pregnancy is associated with better child mental health, particularly in relation to negative affectivity, a trait indicating increased risk of psychopathology. The study found that higher maternal early/mid-pregnancy vitamin D levels were associated with lower negative affectivity in infants, while cord blood vitamin D levels showed less clear associations. These findings suggest that maternal vitamin D status during early- and mid-pregnancy may play a role in the behavioral development of offspring.
EUROPEAN CHILD & ADOLESCENT PSYCHIATRY
(2023)
Review
Pediatrics
Rachel Robinson, Polina Girchenko, Anna Pulakka, Kati Heinonen, Anna Lahdepuro, Marius Lahti-Pulkkinen, Petteri Hovi, Marjaana Tikanmaki, Peter Bartmann, Aulikki Lano, Lex W. Doyle, Peter J. Anderson, Jeanie L. Y. Cheong, Brian A. Darlow, Lianne J. Woodward, L. John Horwood, Marit S. Indredavik, Kari Anne Evensen, Neil Marlow, Samantha Johnson, Marina Goulart de Mendonca, Eero Kajantie, Dieter Wolke, Katri Raikkonen
Summary: This study examined the differences in ADHD symptoms and diagnosis between preterm and term-born adults and found that while preterm adults may not report higher levels of ADHD symptoms, they have a higher risk of receiving an ADHD diagnosis in adulthood.
PEDIATRIC RESEARCH
(2023)
Article
Psychology, Developmental
Anna Lahdepuro, Marius Lahti-Pulkkinen, Riikka Pyhala, Soile Tuovinen, Jari Lahti, Kati Heinonen, Hannele Laivuori, Pia M. Villa, Rebecca M. Reynolds, Eero Kajantie, Polina Girchenko, Katri Raikkonen
Summary: The study found that positive maternal mental health during pregnancy is associated with a reduced risk of mental and behavioral disorders in children. This association is also seen in children of mothers facing mental health issues.
JOURNAL OF CHILD PSYCHOLOGY AND PSYCHIATRY
(2023)
Article
Psychology, Social
Sointu Leikas, Marius Lahti-Pulkkinen, Katri Raikkonen
Summary: This study investigated the effects of parenthood on mothers' personality development and found that mothers experienced changes in neuroticism and extraversion from early pregnancy to 6 months post-partum. Furthermore, mother-perceived child difficult temperament attenuated desirable personality change and amplified the increases in impulsivity.
EUROPEAN JOURNAL OF PERSONALITY
(2023)
Article
Psychiatry
Mia D. Eriksson, Johan G. Eriksson, Paivi Korhonen, Hannu Koponen, Minna K. Salonen, Tuija M. Mikkola, Eero Kajantie, Niko S. Wasenius, Mikaela von Bonsdorff, Hannu Kautiainen, Merja K. Laine
Summary: Individuals with depression, specifically melancholic subtype, have a higher risk of mortality compared to non-depressed individuals. The underlying pathophysiological differences between depressive subtypes may contribute to this phenomenon.
ACTA PSYCHIATRICA SCANDINAVICA
(2023)
Article
Pediatrics
Suvi Alenius, Eero Kajantie, Reijo Sund, Markku Nurhonen, Peija Haaramo, Pieta Nasanen-Gilmore, Marja Vaarasmaki, Sakari Lemola, Katri Raikkonen, Daniel D. Schnitzlein, Dieter Wolke, Mika Gissler, Petteri Hovi
Summary: This population-based study found that individuals born preterm have a lower risk of sexually transmitted infections and teenage pregnancies, but a higher risk of payment defaults. Extremely preterm individuals have a lower risk of criminal offending, whereas very preterm individuals have a higher risk of payment defaults.
JOURNAL OF PEDIATRICS
(2023)
Article
Biochemistry & Molecular Biology
Jolien Rijlaarsdam, Marta Cosin, Laura Schellhas, Sarina Abrishamcar, Anni Malmberg, Alexander Neumann, Janine F. Felix, Jordi Sunyer, Kristine B. Gutzkow, Regina Grazuleviciene, John Wright, Mariza Kampouri, Heather J. Zar, Dan J. Stein, Kati Heinonen, Katri Raikkonen, Jari Lahti, Anke Huels, Doretta Caramaschi, Silvia Alemany, Charlotte A. M. Cecil
Summary: The general psychopathology factor (GPF) has been proposed as a way to capture variance shared between psychiatric symptoms. In this study, epigenome-wide meta-analyses were conducted to identify associations of DNA methylation (DNAm) with school-age general psychopathology, revealing evidence of an association between DNAm at school-age and GPF.
MOLECULAR PSYCHIATRY
(2023)
Article
Multidisciplinary Sciences
Suvi Alenius, Eero Kajantie, Reijo Sund, Markku Nurhonen, Peija Haaramo, Pieta Nasanen-Gilmore, Sakari Lemola, Katri Raikkonen, Daniel D. Schnitzlein, Dieter Wolke, Mika Gissler, Petteri Hovi
Summary: Attendance in special education is more common among individuals born preterm. However, the minor differences in school grades according to gestational age do not translate into educational differences in young adulthood.
SCIENTIFIC REPORTS
(2023)
Article
Multidisciplinary Sciences
Petteri Hovi, Arto A. Palmu, Tuomo A. Nieminen, Miia Artama, Jukka Jokinen, Esa Ruokokoski, Riitta Lassila, Hanna Nohynek, Terhi Kilpi
Summary: Reports of serious cerebral venous sinus thrombosis (CVST) with thrombocytopenia have emerged following COVID-19 vaccinations. A study in Finland found a very low proportion of CVST with thrombocytopenia cases within four weeks after receiving the AstraZeneca vaccine, while no cases were found following mRNA vaccine doses. Accurate estimation of the baseline incidence is crucial for evaluating the benefit-risk of any vaccination program.
Article
Endocrinology & Metabolism
Erik Somersalo, Krista Kuuliala, Antti Kuuliala, Niko S. Wasenius, Miira M. Klemetti, Anne S. Kivimaki, Hannu Kautiainen, Johan G. Eriksson, Merja K. Laine
Summary: This study investigated the cytokine levels in young adult offspring of women with type 1 diabetes. The results showed that, although the levels of interferon-gamma were lower in the case group, cytokine levels were generally similar between the groups. Therefore, this study did not support the association between serum cytokine profile and cardiovascular disease risk in offspring of women with type 1 diabetes. Further research is needed to explore whether cytokines could serve as early biomarkers or be used to monitor CVD progression in this population.
Article
Medicine, General & Internal
Samuel Sandboge, Katri Raikkonen, Marius Lahti-Pulkkinen, Helena Hauta-alus, Elisa Holmlund-Suila, Polina Girchenko, Eero Kajantie, Outi Makitie, Sture Andersson, Kati Heinonen
Summary: This study found that high-dose (1200 IU) vitamin D-3 supplementation during the first 2 years reduced the risk of internalizing problems in children aged 6 to 8 years, especially in those with lower maternal vitamin D-3 levels.
Article
Pediatrics
Ingrid Marie Husby Hollund, Kristina Anna Djupvik Aakvik, Silje Dahl Benum, Sigrid Hegna Ingvaldsen, Stian Lydersen, Marjaana Tikanmaki, Petteri Hovi, Katri Raikkonen, Eero Kajantie, Samantha Johnson, Neil Marlow, Nicole Baumann, Dieter Wolke, Marit S. Indredavik, Kari Anne I. Evensen
Summary: The associations between mental health, pain, and tiredness in adults are independent of gestation or birthweight. Further research should explore other potential mechanisms to explain the increased risk of mental health problems in the preterm population.
Article
Endocrinology & Metabolism
Cedric A. Korpijaakko, Johan G. Eriksson, Hannu Kautiainen, Miira M. Klemetti, Merja K. Laine
Summary: The study found that there was no difference in fatty liver index between young adult offspring of women with type 1 diabetes and offspring of women without diabetes. Additionally, there were no significant metabolic characteristic differences between the two groups. Further research on the impact of pregestational type 1 diabetes on offspring's risk of nonalcoholic fatty liver disease is needed.
DIABETOLOGY & METABOLIC SYNDROME
(2023)
Article
Psychology, Developmental
Anna Lahdepuro, Marius Lahti-Pulkkinen, Polina Girchenko, Pia M. Villa, Kati Heinonen, Jari Lahti, Riikka Pyhala, Hannele Laivuori, Eero Kajantie, Katri Raikkonen
Summary: Positive maternal mental health during pregnancy has a positive impact on children's psychiatric problems. This study found that higher positive maternal mental health scores during pregnancy were associated with lower total psychiatric problem scores in both early and late childhood.
DEVELOPMENT AND PSYCHOPATHOLOGY
(2023)
