Review
Neurosciences
Stanislas Lagarde, Christian-G Benar, Fabrice Wendling, Fabrice Bartolomei
Summary: This article reviews the concept of the epileptogenic network, explains the basic notions of functional connectivity, and reports the current body of published data using intracranial EEG. The data show that there are differential changes in functional connectivity between epileptic and non-epileptic areas even at temporal distance from seizures. These findings may help locate epileptic areas and predict surgical outcomes.
BRAIN CONNECTIVITY
(2022)
Article
Medicine, General & Internal
Beatriz Garcia-Lopez, Maria Sueiras-Gil, Ana Isabel Gomez-Menendez, Fernando Vazquez-Sanchez, Maria Carmen Lloria-Gil, Jeronimo J. Gonzalez-Bernal, Josefa Gonzalez-Santos, Mirian Santamaria-Pelaez, Raul Soto-Camara, Troels Wesenberg Kjaer
Summary: This study examines the clinical and EEG features of frontal lobe epilepsy patients and identifies variables that can aid in the differentiation and diagnosis of cases. The morphological seizure pattern in frontal lobe seizures remains consistent over time, with isolated sharp waves being the most common waveforms in EEG expression. Frontal lobe seizures are often short in duration, sometimes appearing in clusters within the same recording.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Clinical Neurology
Felipe Castro-Villablanca, Friederike Moeller, Suresh Pujar, Felice D'Arco, Rod C. Scott, M. Zubair Tahir, Martin Tisdall, J. Helen Cross, Christin Eltze
Summary: This study found that an ictal EEG may not be mandatory for presurgical evaluation, particularly when a well-defined single unilateral MRI lesion has been identified and the interictal EEG is concordant.
Article
Clinical Neurology
Z. Irene Wang, Se-Hong Oh, Mark Lowe, Mykol Larvie, Paul Ruggieri, Virginia Hill, Volodymyr Statsevych, Doksu Moon, Jonathan Lee, Todd Emch, James Bena, Ingmar Blumcke, William Bingaman, Jorge A. Gonzalez-Martinez, Imad Najm, Stephen E. Jones
Summary: The study aimed to evaluate the radiological and clinical value of 7T MRI in patients with pharmacoresistant focal epilepsy and 3T-visible lesions, finding that 7T can detect additional smaller lesions and provide better lesion conspicuity and boundary.
FRONTIERS IN NEUROLOGY
(2021)
Article
Clinical Neurology
Graham W. Johnson, Derek J. Doss, Victoria L. Morgan, Danika L. Paulo, Leon Y. Cai, Jared S. Shless, Aarushi S. Negi, Abhijeet Gummadavelli, Hakmook Kang, Shilpa B. Reddy, Robert P. Naftel, Sarah K. Bick, Shawniqua Williams Roberson, Benoit M. Dawant, Mark T. Wallace, Dario J. Englot
Summary: Why are people with epilepsy not continuously having seizures? Johnson et al. use intracranial electrical recordings to analyse brain network interactions in people with epilepsy, and provide evidence that the seizure-onset network is actively suppressed by the rest of the brain during interictal states.
Article
Multidisciplinary Sciences
Arjan Hillebrand, Niall Holmes, Ndedi Sijsma, George C. C. O'Neill, Tim M. M. Tierney, Niels Liberton, Anine H. H. Stam, Nicole van Klink, Cornelis J. J. Stam, Richard Bowtell, Matthew J. J. Brookes, Gareth R. R. Barnes
Summary: Magneto- and electroencephalography (MEG/EEG) are important techniques for the diagnosis and pre-surgical evaluation of epilepsy. However, current cryogen-based MEG systems have limitations, which can be overcome by using Optically Pumped Magnetometers (OPMs) directly on the scalp. OPM-based MEG shows promise in improving signal-to-noise ratio, sensitivity to deep sources, and wearability, making it a potential alternative for epilepsy evaluation and diagnosis.
SCIENTIFIC REPORTS
(2023)
Article
Multidisciplinary Sciences
Arjan Hillebrand, Niall Holmes, Ndedi Sijsma, George C. O'Neill, Tim M. Tierney, Niels Liberton, Anine H. Stam, Nicole van Klink, Cornelis J. Stam, Richard Bowtell, Matthew J. Brookes, Gareth R. Barnes
Summary: Magneto- and electroencephalography (MEG/EEG) are important techniques for the diagnosis and pre-surgical evaluation of epilepsy. Optically Pumped Magnetometers (OPMs) placed on the scalp improve signal-to-noise ratio and enable recordings during seizures. OPM-based MEG could be a more affordable alternative to current MEG systems, with increased sensitivity to deep sources.
SCIENTIFIC REPORTS
(2023)
Article
Biochemistry & Molecular Biology
Gaetano Zazzaro, Luigi Pavone
Summary: This study evaluated the performance of a seizure detection method using EEG signals, and found that the method performed very well in detecting seizures in one patient and achieved good performance in six other patients from the same dataset.
Article
Biochemical Research Methods
Jin Jing, Emile D'Angremont, Sahar Zafar, Eric S. Rosenthal, Mohammad Tabaeizadeh, Senan Ebrahim, Justin Dauwels, M. Brandon Westover
Summary: The study evaluated an automated clustering method to accelerate expert annotation of cEEG, and found that its validity was comparable to manual labeling and significantly more efficient. Experts using the method were able to label cEEG data over 45 times faster than traditional manual review methods.
JOURNAL OF NEUROSCIENCE METHODS
(2021)
Review
Behavioral Sciences
Rene Andrade-Machado, Vanesa Benjumea Cuartas, Irshad Khan Muhammad
Summary: The article reviewed EEG findings in patients with focal epilepsy, highlighting the characteristics of discharges during the interictal period and the differences from generalized epilepsy. It discussed the coexistence of focal and generalized epilepsy, as well as methods for correctly diagnosing focal epilepsy.
EPILEPSY & BEHAVIOR
(2021)
Article
Multidisciplinary Sciences
Yoon Gi Chung, Woo-Jin Lee, Sung Min Na, Hunmin Kim, Hee Hwang, Chang-Ho Yun, Ki Joong Kim
Summary: This study proposes deep learning-based models to detect and classify interictal epileptiform discharges (IEDs) in the frontal, temporal, and occipital scalp regions. The models achieved high accuracies in detecting and categorizing IEDs, but improvements are still needed.
SCIENTIFIC REPORTS
(2023)
Article
Clinical Neurology
Scellig S. D. Stone, Eun-Hyoung Park, Jeffrey Bolton, Chellamani Harini, Mark H. Libenson, Alexander Rotenberg, Masanori Takeoka, Melissa Tsuboyama, Phillip L. Pearl, Joseph R. Madsen
Summary: Statistical analysis of interictal sEEG can help identify surgical target sites and predict surgical outcomes. Granger causality can identify seizure foci and correlate with favorable treatment outcomes.
Article
Clinical Neurology
Julie Lerond, Bertrand Mathon, Melina Scopin, Lucia Nichelli, Justine Guegan, Celine Bertholle, Brigitte Izac, Muriel Andrieu, Thomas Gareau, Florian Donneger, Badreddine Mohand Oumoussa, Franck Letourneur, Suzanne Tran, Mathilde Bertrand, Isabelle Le Roux, Mehdi Touat, Sophie Dupont, Jean Christophe Poncer, Vincent Navarro, Franck Bielle
Summary: This study identified a BRAF(V600E) oncogenic variant associated with MTLE-HS and epileptogenic non-expansive neocortical focal lesions. CD34+ cells played a role in these samples and were associated with cellular senescence and oligodendrocyte development. Epilepsy surgery led to seizure freedom in most patients with BRAF mutant lesions.
NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY
(2023)
Article
Biochemical Research Methods
Wendong Ge, Jin Jing, Sungtae An, Aline Herlopian, Marcus Ng, Aaron F. Struck, Brian Appavu, Emily L. Johnson, Gamaleldin Osman, Hiba A. Haider, Ioannis Karakis, Jennifer A. Kim, Jonathan J. Halford, Monica B. Dhakarl, Rani A. Sarkis, Christa B. Swisher, Sarah Schmitt, Jong Woo Lee, Mohammad Tabaeizadeh, Andres Rodriguezi, Nicolas Gaspard, Emily Gilmore, Susan T. Herman, Peter W. Kaplan, Jay Pathmanathan, Shenda Hong, Eric S. Rosenthal, Sahar Zafar, Jimeng Sun, M. Brandon Westover
Summary: The study demonstrated that active learning (AL) can efficiently label large EEG datasets in critically ill patients. Label spreading and high confidence spread-based balanced querying (HCSBBQ) method achieved better training results.
JOURNAL OF NEUROSCIENCE METHODS
(2021)
Article
Clinical Neurology
Taha Gholipour, Xiaozhen You, Steven M. Stufflebeam, Murray Loew, Mohamad Z. Koubeissi, Victoria L. Morgan, William D. Gaillard
Summary: This study identified shared functional network characteristics among focal epilepsies of different etiologies using functional connectivity measures derived from resting state functional magnetic resonance imaging (MRI). The study successfully distinguished epilepsy patients from controls and accurately lateralized the hemisphere of seizure onset in patients using machine learning models. The findings suggest the existence of common functional alterations beyond the seizure onset zone and its epileptic network.
Article
Clinical Neurology
Jun Thorsteinsdottir, Christian Vollmar, Joerg-Christian Tonn, Friedrich-Wilhelm Kreth, Soheyl Noachtar, Aurelia Peraud
JOURNAL OF NEUROLOGY
(2019)
Letter
Clinical Neurology
O. Kremmyda, V. Kirsch, S. Bardins, H. Lohr, C. Vollmar, S. Noachtar, M. Dieterich
JOURNAL OF NEUROLOGY
(2019)
Article
Clinical Neurology
Britta Wandschneider, Seok-Jun Hong, Boris C. Bernhardt, Fatemeh Fadaie, Christian Vollmar, Matthias J. Koepp, Neda Bernasconi, Andrea Bernasconi
Article
Astronomy & Astrophysics
Christian Brem, Juergen Lutz, Christian Vollmar, Matthias Feuerecker, Claudia Strewe, Igor Nichiporuk, Galina Vassilieva, Gustav Schelling, Alexander Chouker
LIFE SCIENCES IN SPACE RESEARCH
(2020)
Article
Clinical Neurology
Jan Remi, Sophie Shen, Moritz Tacke, Philipp Probst, Lucia Gerstl, Aurelia Peraud, Mathias Kunz, Christian Vollmar, Soheyl Noachtar, Ingo Borggraefe
CLINICAL EEG AND NEUROSCIENCE
(2020)
Article
Clinical Neurology
Elisabeth Kaufmann, Magdalena Seethaler, Michael Lauseker, Min Fan, Christian Vollmar, Soheyl Noachtar, Jan Remi
Article
Clinical Neurology
Lorenzo Caciagli, Britta Wandschneider, Maria Centeno, Christian Vollmar, Sjoerd B. Vos, Karin Trimmel, Lili Long, Fenglai Xiao, Alexander J. Lowe, Meneka K. Sidhu, Pamela J. Thompson, Gavin P. Winston, John S. Duncan, Matthias J. Koepp
Article
Clinical Neurology
Magdalena Seethaler, Michael Lauseker, Katharina Ernst, Jan Remi, Christian Vollmar, Soheyl Noachtar, Elisabeth Kaufmann
Summary: The study revealed significantly longer seizure durations in cases of left-hemispheric seizure onset, especially in temporal lobe seizures. Seizures starting in the left hemisphere also showed prolonged duration when commencing during waking state, but not during sleep. Gender differences were observed, with a similar hemispheric difference in seizure duration found in female patients, but not in men.
ACTA NEUROLOGICA SCANDINAVICA
(2021)
Review
Clinical Neurology
Filipp M. Filippopulos, Christian Brem, Klaus Seelos, Thomas Koeglsperger, Stefan Sonnenfeld, Lars Kellert, Christian Vollmar
Summary: This study reviews the historical and current literature of crossing pathologies of the corticospinal tract (CST) and presents a rare case of asymmetric crossing of the CST in healthy humans. While descriptions of CST crossing pathologies are rare in healthy individuals, they appear to be more common in genetic disorders.
EUROPEAN JOURNAL OF NEUROLOGY
(2021)
Article
Clinical Neurology
Elisabeth Kaufmann, Joanna Bartkiewicz, Nicholas Fearns, Katharina Ernst, Christian Vollmar, Soheyl Noachtar
Summary: The study found that involuntary unilateral blinking is associated with activation of the anterior temporal region. Probabilistic tractography showed widespread projections to ipsilateral frontal, pericentral, occipital, limbic, and cerebellar regions. Blinking was predominantly observed in female patients with temporal lobe epilepsies.
Article
Clinical Neurology
Frederik Jan Moorhouse, Sonia Cornell, Lucia Gerstl, Johanna Wagner, Moritz Tacke, Timo Roser, Florian Heinen, Celina von Stuelpnagel, Christian Vollmar, Mathias Kunz, Georgia Ramantani, Ingo Borggraefe
Summary: The study aimed to determine the relationship between cognitive impairment and the extent of the presumed epileptogenic zone in pediatric focal epilepsies. Results showed that pediatric multilobar epilepsy patients tend to have more cognitive issues compared to unilobar epilepsy patients on average. Identifying children and adolescents who are most at risk for impaired cognitive development is important based on these findings.
EUROPEAN JOURNAL OF PAEDIATRIC NEUROLOGY
(2022)
Article
Clinical Neurology
Mathias Kunz, Philipp Karschnia, Ingo Borggraefe, Soheyl Noachtar, Joerg-Christian Tonn, Christian Vollmar
Summary: This study aimed to investigate the effectiveness and safety of repeated epilepsy surgery in patients with persistent or recurrent seizures. The results showed that 71% of patients had improved seizure control after reoperation. Additionally, the incidence of perioperative complications was low, with no fatalities.
JOURNAL OF NEUROSURGERY
(2023)
Meeting Abstract
Clinical Neurology
L. Caciagli, C. Paquola, X. He, C. Vollmar, M. Centeno, B. Wandschneider, U. Braun, K. Trimmel, S. B. Vos, M. K. Sidhu, P. J. Thompson, S. Baxendale, G. P. Winston, J. S. Duncan, D. S. Bassett, M. J. Koepp, B. C. Bernhardt
Article
Clinical Neurology
Elisabeth Kaufmann, Kai Boetzel, Christian Vollmar, Jan-Hinnerk Mehrkens, Soheyl Noachtar
Summary: The study retrospectively analyzed the long-term outcomes of 23 patients with anterior nucleus of the thalamus (ANT) deep brain stimulation (DBS), showing that most patients experienced a reduction in seizure frequency of over 50% and had positive treatment effects. Bilateral implantation and successful stimulation of the ANT appeared to be more effective in controlling seizures.
JOURNAL OF NEUROSURGERY
(2021)
Article
Clinical Neurology
Theresa Halder, Thomas Schenk, Elisabeth Wlasich, Christian Vollmar, Ingo Uttner, Adrian Danek
Summary: In this case study, patient C.H. experienced global amnesia and cognitive limitations due to herpes simplex encephalitis at a young age. Despite persistent explicit memory impairment and limited vocabulary, C.H. was able to develop effective strategies and achieve a high level of autonomy in daily life, serving as an inspirational example for implementing creative methods to compensate for cognitive limitations.