Article
Clinical Neurology
Ruwei Ou, Qianqian Wei, Yanbing Hou, Lingyu Zhang, Kuncheng Liu, Junyu Lin, Zheng Jiang, Bi Zhao, Bei Cao, Huifang Shang
Summary: Facial tremor (FT) in Parkinson's disease (PD) was found in 18.1% of patients, increasing with disease duration and H&Y score. Factors like age, gender, disease duration, speech, rigidity, tremor, and axial symptoms were associated with FT. However, FT did not show significant association with long-term clinical outcomes in PD. Further studies are needed to explore the predictive value of FT on PD progression.
Review
Clinical Neurology
Somayye Nadi Ravandi, Ebrahim Kouchaki, Fatemeh Sadat Asgarian
Summary: This study conducted a systematic review of 32 studies and found that the prevalence of hallucinations in Parkinson's patients is 28%. The highest prevalence was in developing countries at 34%, and in developed countries it was 27%. The prevalence in men was 30% and in women it was 23%. It is recommended to check for hallucinations in Parkinson's patients during every visit and provide appropriate treatment.
NEUROLOGICAL SCIENCES
(2023)
Article
Clinical Neurology
Jingru Ren, Ronggui Zhang, Chenxi Pan, Jianxia Xu, Haochen Sun, Ping Hua, Li Zhang, Wenbin Zhang, Pingyi Xu, Changyan Ma, Weiguo Liu
Summary: This study aimed to determine the frequency of GBA-related PD and the relationship between GBA variant severity and clinical characteristics in a large Chinese cohort. The results showed that GBA-PD is highly prevalent in the Chinese population, and patients carrying severe and complex variants have more severe symptoms.
EUROPEAN JOURNAL OF NEUROLOGY
(2022)
Review
Behavioral Sciences
Shengri Cong, Chunchen Xiang, Shun Zhang, Taiming Zhang, Hailong Wang, Shuyan Cong
Summary: Depression is an independent and frequent non-motor symptom in Parkinson's disease (PD), appearing in the early stage and persisting throughout the disease duration. It is associated with several clinical characteristics and other symptoms that negatively impact on quality of life.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2022)
Article
Clinical Neurology
Marta Francisca Corra, Nuno Vila-Cha, Ana Sardoeira, Clint Hansen, Ana Paula Sousa, Ines Reis, Firmina Sambayeta, Joana Damasio, Margarida Calejo, Andreas Schicketmueller, Ines Laranjinha, Paula Salgado, Ricardo Taipa, Rui Magalhaes, Manuel Correia, Walter Maetzler, Luis F. Maia
Summary: Peripheral neuropathy is common in Parkinson's disease patients and has a negative impact on gait and balance.
Review
Geriatrics & Gerontology
Adriana Ponsoni, Amanda Veiga Sardeli, Flavia Pereira Costa, Lucia Figueiredo Mourao
Summary: This study conducted a meta-analysis to compare the prevalence of sarcopenia among patients with Parkinson's disease (PD) and a control group, and examined the effects of age, sex, sarcopenia assessments, and PD progression on the prevalence of sarcopenia. The analysis found that the prevalence of sarcopenia in PD patients was 3 times higher than in the control group. Subgroup analyses showed that among individuals aged >= 70 years, PD patients had a higher prevalence of sarcopenia compared to controls, with no significant difference in the group < 70 years. PD progression did not affect the prevalence of sarcopenia based on the Hoehn and Yahr scale. Patients with PD have a higher probability of developing sarcopenia compared to the control group, and older PD patients have an even higher chance of sarcopenia than their older controls.
Article
Clinical Neurology
Noor E. Taams, Judith Drenthen, Rens Hanewinckel, M. Arfan Ikram, Pieter A. van Doorn
Summary: Chronic axonal polyneuropathy is a common disease that affects the quality of life and is more prevalent with aging. This study aimed to estimate the prevalence and risk factors of polyneuropathy in the general population. It found that the prevalence of polyneuropathy is expected to increase in the next 20 years, and multiple risk factors often coexist in affected individuals. These findings highlight the importance of comprehensive diagnostic workup in individuals with polyneuropathy.
Article
Clinical Neurology
Danielle S. Abraham, Thanh Phuong Pham Nguyen, Leah J. Blank, Dylan Thibault, Shelly L. Gray, Sean Hennessy, Charles E. Leonard, Daniel Weintraub, Allison W. Willis
Summary: This study examined the differential prescribing patterns between new and established treatments for common neurological conditions. Using data from a national sample of US commercially insured adults from 2005-2019, the study compared new users of recently approved medications for three conditions: diabetic peripheral neuropathy, Parkinson disease psychosis, and epilepsy. The results showed that newer medications were more frequently prescribed to individuals with prior treatment, suggesting potential bias in comparative effectiveness and safety studies. The study emphasizes the importance of reporting propensity score non-overlap in comparative studies involving newer medications and suggests methodological approaches to address channeling bias.
Review
Clinical Neurology
Gianpaolo Maggi, Chiara Giacobbe, Federica Iannotta, Gabriella Santangelo, Carmine Vitale
Summary: OSA affects nearly half of PD patients and is associated with older age, male sex, higher BMI, more severe motor disturbances, and periodic limb movements. However, it has no relationship with cognitive functioning and neuropsychiatric manifestations. Future studies should focus on determining the impact of clinical features and dopaminergic medication on the development of PD-OSA.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Medicine, General & Internal
Seong-Min Choi, Soo Hyun Cho, Youngshik Choe, Byeong C. C. Kim
Summary: This study investigated the clinical determinants and impact of apathy on health-related quality of life in patients with early Parkinson disease (PD). Apathy was found to be an independent predictor of HRQoL, emphasizing the importance of identifying and managing apathy in patients with early PD.
Article
Medicine, Research & Experimental
Evan L. Reynolds, Gulcin Akinci, Mousumi Banerjee, Helen C. Looker, Adam Patterson, Robert G. Nelson, Eva L. Feldman, Brian C. Callaghan
Summary: In participants with longstanding diabetes, neuropathy and kidney disease worsened during follow-up, despite stable to improving MetS components. Early metabolic intervention is necessary to prevent complications in such patients. The number of MetS components was associated with an increased rate of neuropathy progression, and SBP was associated with each complication.
Article
Clinical Neurology
Zheng Jiang, Ruwei Ou, Yongping Chen, Lingyu Zhang, Qianqian Wei, Yanbing Hou, Xiaojing Gu, Bei Cao, Kuncheng Liu, Huifang Shang, Wei Song
Summary: This study found that the prevalence of malnutrition is higher in Parkinson's disease patients compared to healthy controls. The risk factors for malnutrition in Parkinson's disease should be taken seriously.
PARKINSONISM & RELATED DISORDERS
(2022)
Article
Medicine, General & Internal
Camilla Elefante, Giulio Emilio Brancati, Silvia Bacciardi, Sonia Mazzucchi, Eleonora Del Prete, Giovanni Palermo, Daniela Frosini, Ubaldo Bonuccelli, Roberto Ceravolo, Lorenzo Lattanzi, Icro Maremmani, Giulio Perugi
Summary: Mood and anxiety disorders are common neuropsychiatric syndromes associated with Parkinson's disease. Patients with anxiety disorders in PD tend to have a history of psychiatric symptoms, lifetime major depression, and higher anxiety scores. Current anxiety disorders in PD are linked to more severe psychopathology, depressive symptoms, and avoidant behavior.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Clinical Neurology
Christopher Simpson, Lisa Vinikoor-Imler, Feiby L. Nassan, Julia Shirvan, Cathy Lally, Tien Dam, Nancy Maserejian
Summary: Global studies show that except for G2019S, most of the LRRK2 variants are not common in majority of countries, with G2385R and R1628P primarily found in East Asian countries. Estimates adjusted for ethno-racial composition are generally lower than crude estimates, suggesting that clinic-based studies may overstate the true prevalence of some LRRK2 variants in Parkinson's disease.
PARKINSONISM & RELATED DISORDERS
(2022)
Review
Biochemistry & Molecular Biology
Melania Melis, Antje Haehner, Mariano Mastinu, Thomas Hummel, Iole Tomassini Barbarossa
Summary: Impairments in olfaction and taste are common non-motor symptoms in Parkinson's disease, often appearing before motor symptoms onset. The basis for these dysfunctions are likely multifactorial, potentially sharing determinants with other non-motor symptoms of PD. Associations with the microbiota may also represent risk factors associated with the disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)