Article
Clinical Neurology
Francis Nicole Saridin, Kimberly Ann Chew, Anthonin Reilhac, Bibek Gyanwali, Steven Gayoles Villaraza, Tomotaka Tanaka, Phillip Scheltens, Wiesje M. van der Flier, Christopher Li Hsian Chen, Saima Hilal
Summary: This study found a high prevalence of cerebrovascular disease (CeVD) in individuals with Suspected non-Alzheimer's pathophysiology (SNAP), and SNAP patients with CeVD had a more rapid decline in global cognition over 5 years. Therefore, careful assessment and treatment for CeVD should be conducted in SNAP patients.
EUROPEAN JOURNAL OF NEUROLOGY
(2022)
Article
Geriatrics & Gerontology
Michal S. Beeri, Sue E. Leugrans, Osvaldo Delbono, David A. Bennett, Aron S. Buchman
Summary: In this study, poor muscle function, rather than reduced lean muscle mass, was found to be associated with late-life cognitive impairment, including incident Alzheimer's dementia, mild cognitive impairment, and cognitive decline. Further research is needed to identify muscle structure features that may enhance the specificity of sarcopenia in identifying older adults at risk for late-life cognitive impairment.
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
(2021)
Article
Public, Environmental & Occupational Health
Srishti Shrestha, Xiaoqian Zhu, Stephanie J. London, Kevin J. Sullivan, Pamela L. Lutsey, B. Gwen Windham, Michael E. Griswold, Thomas H. Mosley Jr
Summary: The study found that higher forced expiratory volume in 1 second (FEV1) and forced vital capacity (FVC) were associated with reduced risk of dementia. Each 1-liter increase in FEV1 and FVC was associated with a 0.08 and 0.05 standard deviation reduction in cognitive decline, respectively.
AMERICAN JOURNAL OF EPIDEMIOLOGY
(2023)
Article
Geriatrics & Gerontology
Catherine A. Browning, Claire L. Thompson, Nicole A. Kochan, Henry Brodaty, Perminder S. Sachdev, Julie D. Henry
Summary: This study examined whether prospective memory (PM) could serve as an early cognitive marker of future cognitive decline and incident dementia. The results showed that decreased PM accuracy and missed PM responses were associated with cognitive decline over 8 years and risk of incident dementia over 4 years. The effects remained significant even after controlling for baseline cognition and were strongest for event-based and regular PM tasks. These findings suggest that PM tasks could be useful in clinical assessments.
JOURNALS OF GERONTOLOGY SERIES B-PSYCHOLOGICAL SCIENCES AND SOCIAL SCIENCES
(2023)
Article
Neurosciences
Valerie Turcotte, Carol Hudon, Olivier Potvin, Mahsa Dadar, Simon Duchesne
Summary: This study aimed to predict cognitive decline in older adults using birth cohorts and cognitive reserve (CR). The findings showed that CR was only associated with slower decline in verbal episodic memory, while more recent birth cohorts predicted slower decline in all cognitive domains except for executive functions. This suggests that both CR and birth cohorts have significant implications for future cognitive decline.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Article
Cardiac & Cardiovascular Systems
Zhen Zhou, Joanne Ryan, Michael E. Ernst, Sophia Zoungas, Andrew M. Tonkin, Robyn L. Woods, John J. McNeil, Christopher M. Reid, Andrea J. Curtis, Rory Wolfe, Jo Wrigglesworth, Raj C. Shah, Elsdon Storey, Anne Murray, Suzanne G. Orchard, Mark R. Nelson
Summary: The study found that statin therapy in adults aged 65 and older was not associated with incident dementia, MCI, or declines in individual cognition domains. The impact of statin lipophilicity and baseline neurocognitive ability on these associations was also explored. Further confirmation from ongoing randomized trials is needed.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2021)
Article
Clinical Neurology
Fang Yi, Mengfei Cai, Mina A. Jacob, Jose Marques, David G. Norris, Marco Duering, Anil M. Tuladhar, Frank-Erik de Leeuw
Summary: This study investigated the spatial distribution pattern and MRI predictors of incident lacunes in relation to white matter hyperintensity (WMH) in sporadic small vessel disease. The results suggest that the different distribution patterns of lacunes in relation to WMH may imply distinct underlying mechanisms, possibly linked to the pathophysiology of WMH.
Article
Public, Environmental & Occupational Health
Yi-Cheng Lin, Chih-Ping Chung, Pei-Lin Lee, Kun-Hsien Chou, Li-Hung Chang, Szu-Ying Lin, Yi-Jung Lee, Ching-Po Lin, Pei-Ning Wang
Summary: The coexistence of physical and cognitive impairments in older adults can predict incident disability, dementia, and mortality. This study investigated the natural course and prevalence of these impairments and found that skeletal muscle mass/function and memory function are crucial factors associated with the progression or reversal of functional impairments.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Clinical Neurology
Rachel E. E. Kopec, Daniel I. I. Chasman, Olivia I. I. Okereke, Howard D. D. Sesso
Summary: The global increase in lifespan has led to a rapid rise in the number of individuals affected by dementia. Research on dietary strategies to mitigate cognitive decline and reduce the risk of dementia is lacking. However, previous studies on micronutrients have shown potential in improving cognitive performance. For instance, a study found that subjects who were randomized to receive beta-carotene had a slower decline in cognitive performance and verbal memory compared to those who were given a placebo. Further investigation is needed to understand the role of dietary factors, including provitamin A, in mitigating cognitive decline and dementia risk.
ALZHEIMERS & DEMENTIA
(2023)
Article
Geriatrics & Gerontology
Katya Numbers, Ben C. P. Lam, John D. Crawford, Nicole A. Kochan, Perminder S. Sachdev, Henry Brodaty
Summary: The study found a negative longitudinal association between increasing subjective cognitive complaints (SCCs) and decline in global cognition scores over 6 years, and participants reporting increasing SCCs had a nearly fourfold increased risk of developing dementia over 10 years.
INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY
(2021)
Article
Clinical Neurology
Jessica Lebenberg, Ruiting Zhang, Lina Grosset, Jean Pierre Guichard, Fanny Fernandes, Eric Jouvent, Hugues Chabriat
Summary: This study developed and validated an automatic segmentation method for quantifying incident lacunes in a severe and progressive form of cerebral small vessel disease. The automatic method accurately identified and quantified the lacunes, providing a fast and efficient approach for measuring incident lacunes in large-scale studies.
FRONTIERS IN NEUROLOGY
(2023)
Article
Geriatrics & Gerontology
Tze Pin Ng, Tih Shih Lee, Wee Shiong Lim, Mei Sian Chong, Philip Yap, Chin Yee Cheong, Iris Rawtaer, Tau Ming Liew, Xinyi Gwee, Qi Gao, Keng Bee Yap
Summary: The decline in functional mobility predicts cognitive decline and the occurrence of MCI or early dementia. Among the measures studied, the Timed-Up-and-Go (TUG) test appears to be particularly accurate in predicting the future risks of adverse cognitive outcomes.
Article
Clinical Neurology
Salvatore Mazzeo, Filippo Emiliani, Silvia Bagnoli, Sonia Padiglioni, Vittoria Conti, Assunta Ingannato, Giulia Giacomucci, Juri Balestrini, Camilla Ferrari, Sandro Sorbi, Benedetta Nacmias, Valentina Bessi
Summary: This study assessed the impact of intermediate alleles on the progression of cognitive impairment in patients with subjective cognitive decline (SCD). The results showed that carrying intermediate alleles, age at baseline, and APOE e4 were associated with the rate of progression to mild cognitive impairment (MCI) in SCD patients. The interaction between intermediate alleles, age, and APOE e4 increased the risk of progressing to MCI in SCD patients.
EUROPEAN JOURNAL OF NEUROLOGY
(2022)
Article
Public, Environmental & Occupational Health
Yunzhi Wang, A. Richey Sharrett, Andrea L. C. Schneider, David Knopman, Jiaqi Hu, Rebecca Gottesman, Kevin J. Sullivan, Josef Coresh
Summary: The study found that DWRT, DSST, and combined 3-test z-scores were significantly lower more than 20 years prior to diagnosis in the dementia group compared to the non-dementia group. These results contribute to our understanding of the cognitive score changes in the prodromal period for both Black and White participants.
Article
Geriatrics & Gerontology
Y. Lu, X. Gwee, D. Q. Chua, T. S. Lee, W. S. Lim, M. S. Chong, P. Yap, K. B. Yap, I. Rawtaer, T. M. Liew, F. Pan, Tze Pin Ng
Summary: Research suggests that older adults at high nutritional risk are more likely to develop cognitive decline and neurocognitive disorders, including MCI or dementia. Identifying vulnerable subpopulations for correction of malnutrition risk may help prevent neurocognitive disorders.
JOURNAL OF NUTRITION HEALTH & AGING
(2021)
Article
Endocrinology & Metabolism
Charlotte Dupe, Stephanie Guey, Lucie Biard, Sokhna Dieng, Jessica Lebenberg, Lina Grosset, Nassira Alili, Dominique Herve, Elisabeth Tournier-Lasserve, Eric Jouvent, Sylvie Chevret, Hugues Chabriat
Summary: The prevalence of cysteine mutations in the NOTCH3 gene responsible for CADASIL was found to be more than 100 times higher in the general population than in patients. The mutation location in the EGFr-like domains of the NOTCH3 receptor has a major impact on the clinical severity and imaging features of the disease. The exact mechanisms underlying the effects of mutation location on the disease still need to be determined.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2023)
Article
Clinical Neurology
Floor C. Loonstra, Lodewijk R. J. de Ruiter, Marleen J. A. Koel-Simmelink, Menno M. Schoonheim, Eva M. M. Strijbis, Bastiaan Moraal, Frederik Barkhof, Bernard M. J. Uitdehaag, Charlotte Teunissen, Joep Killestein
Summary: This study explores the association between novel blood biomarkers (sNfL, sGFAP, and sCNTN1) and disability outcome measures and MRI volumes in people with multiple sclerosis (MS). The results indicate that sNfL and sGFAP are associated with disease progression, while sCNTN1 is not related to clinical or MRI measures.
NEUROLOGY-NEUROIMMUNOLOGY & NEUROINFLAMMATION
(2023)
Article
Clinical Neurology
Heinz Wiendl, Klaus Schmierer, Suzanne Hodgkinson, Tobias Derfuss, Andrew Chan, Finn Sellebjerg, Anat Achiron, Xavier Montalban, Alexandre Prat, Nicola De Stefano, Frederik Barkhof, Letizia Leocani, Patrick Vermersch, Anita Chudecka, Claire Mwape, Kristina H. Holmberg, Ursula Boschert, Sanjeev Roy, MAGNIFY-MS Study Grp
Summary: Cladribine tablets cause a reduction in lymphocytes, with a predominant effect on B-cell and T-cell counts. The MAGNIFY-MS substudy reports the dynamic changes on multiple peripheral blood mononuclear cell (PBMC) subtypes and immunoglobulin (Ig) levels over 12 months after the first course of cladribine tablets in patients with highly active relapsing multiple sclerosis (MS).
NEUROLOGY-NEUROIMMUNOLOGY & NEUROINFLAMMATION
(2023)
Article
Neurosciences
Anna Inguanzo, Konstantinos Poulakis, Rosaleena Mohanty, Christopher G. Schwarz, Scott A. Przybelski, Patricia Diaz-Galvan, Val J. Lowe, Bradley F. Boeve, Afina W. Lemstra, Marleen van de Beek, Wiesje van der Flier, Frederik Barkhof, Frederic Blanc, Paulo Loureiro de Sousa, Nathalie Philippi, Benjamin Cretin, Catherine Demuynck, Zuzana Nedelska, Jakub Hort, Barbara Segura, Carme Junque, Ketil Oppedal, Dag Aarsland, Eric Westman, Kejal Kantarci, Daniel Ferreira
Summary: Using MRI data, we identified three subtypes of Dementia with Lewy bodies (DLB): older subtype with reduced cortical GM volumes and worse cognition, subtype with low GM volumes in fronto-occipital regions, and a younger subtype with the highest cortical GM volumes, lower GM volumes in basal ganglia, and cognitive fluctuations. These subtypes have implications for clinical practice, research, and treatment decisions.
NPJ PARKINSONS DISEASE
(2023)
Article
Clinical Neurology
C. Mallinckrodt, Y. Tian, P. S. Aisen, F. Barkhof, S. Cohen, G. Dent, O. Hansson, K. Harrison, T. Iwatsubo, C. J. Mummery, K. K. Muralidharan, I. Nestorov, L. Nisenbaum, R. Rajagovindan, C. von Hehn, C. H. van Dyck, B. Vellas, S. Wu, Y. Zhu, A. Sandrock, T. Chen, S. Budd Haeberlein
Summary: Post-hoc analyses of the EMERGE and ENGAGE studies showed that the outcomes in the high-dose group of ENGAGE were affected by an imbalance in a small number of rapidly progressing patients and lower exposure to the target dose. However, these factors were only present in early enrolled patients and did not affect later enrolled patients. Baseline characteristics and amyloid-related imaging abnormalities did not contribute to the difference in results between the high-dose arms.
JPAD-JOURNAL OF PREVENTION OF ALZHEIMERS DISEASE
(2023)
Article
Clinical Neurology
Liu Shi, Jin Xu, Rebecca Green, Asger Wretlind, Jan Homann, Noel J. Buckley, Betty M. Tijms, Stephanie J. B. Vos, Christina M. Lill, Mara ten Kate, Sebastiaan Engelborghs, Kristel Sleegers, Giovanni B. Frisoni, Anders Wallin, Alberto Lleo, Julius Popp, Pablo Martinez-Lage, Johannes Streffer, Frederik Barkhof, Henrik Zetterberg, Pieter Jelle Visser, Simon Lovestone, Lars Bertram, Alejo J. Nevado-Holgado, Petroula Proitsi, Cristina Legido-Quigley
Summary: This study employed an integrative system and causal inference approach to explore molecular signatures in blood and CSF, the AT(N) framework, MCI conversion to AD, and genetic risk for AD. Using the EMIF-AD cohort, the researchers measured proteins and metabolites in blood and CSF, as well as genotyped whole-blood samples. They found associations between AT(N) framework and protein/lipid hubs, and identified Proprotein Convertase Subtilisin/Kexin Type 7 as a potential causative factor for AD.
ALZHEIMERS & DEMENTIA
(2023)
Article
Clinical Neurology
Emma M. Coomans, Jori Tomassen, Rik Ossenkoppele, Betty M. Tijms, Luigi Lorenzini, Mara ten Kate, Lyduine E. Collij, Fiona Heeman, Roos M. Rikken, Sophie M. van der Landen, Marijke E. den Hollander, Sandeep S. Golla, Maqsood Yaqub, Albert D. Windhorst, Frederik Barkhof, Philip Scheltens, Eco J. C. de Geus, Pieter Jelle Visser, Bart N. M. van Berckel, Anouk den Braber
Summary: The amyloid cascade hypothesis has played a significant role in Alzheimer's disease research and clinical trial designs. This study investigated the relationship between amyloid-beta and tau at the individual and twin-pair levels, aiming to rule out genetic and shared environmental effects as confounders. The findings suggest that the associations between amyloid-beta, tau, neurodegeneration, and cognition are unbiased by genetic factors, and the effects of amyloid-beta on neurodegeneration and cognitive decline are mediated by tau.
Article
Clinical Neurology
Diana I. Bocancea, Anna L. Svenningsson, Anna C. van Loenhoud, Colin Groot, Frederik Barkhof, Olof Strandberg, Ruben Smith, Renaud La Joie, Howard J. Rosen, Michael J. Pontecorvo, Gil D. Rabinovici, Wiesje M. van der Flier, Oskar Hansson, Rik Ossenkoppele
Summary: The mechanisms of resilience against tau pathology in Alzheimer's disease spectrum are not well understood. This longitudinal study investigates the factors that contribute to cognitive and brain resilience against tau pathology and finds that education is the most important determinant of resilience. However, resilience may be depleted in advanced stages of the disease.
Article
Clinical Neurology
Eline Coerver, Sophie Janssens, Aroosa Ahmed, Mark Wessels, Zoe van Kempen, Bas Jasperse, Frederik Barkhof, Marcus Koch, Jop Mostert, Bernard Uitdehaag, Joep Killestein, Eva Strijbis
Summary: Inflammatory disease activity in multiple sclerosis (MS) decreases with advancing age, and this study investigated the relation between age and MRI measures of inflammatory disease activity in a real-world cohort of people with relapse onset MS.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Editorial Material
Clinical Neurology
Frederik Barkhof, David S. Knopman
Summary: One puzzling observation in Alzheimer's disease therapeutic trials is that treatment with anti-amyloid-beta agents does not preserve brain volume. In a recent study, Alves et al. conducted a meta-analysis and found that these agents do not slow the rate of brain volume loss. In fact, depending on the drug class, they can even accelerate loss of whole-brain and hippocampal volume and increase ventricular volume.
Article
Clinical Neurology
Alberto Calvi, Zoe Mendelsohn, Weaam Hamed, Declan Chard, Carmen Tur, Jon Stutters, David MacManus, Baris Kanber, Claudia A. M. Gandini Wheeler-Kingshott, Frederik Barkhof, Ferran Prados
Summary: This study retrospectively analyzed a fingolimod trial in patients with primary progressive MS (PPMS) and found that newly appearing lesions are common and can develop into chronic active lesions. Treatment can reduce the number of these lesions.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Neurosciences
Ariane Bollack, Pawel J. Markiewicz, Alle Meije Wink, Lloyd Prosser, Johan Lilja, Pierrick Bourgeat, Jonathan M. Schott, William Coath, Lyduine E. Collij, Hugh G. Pemberton, Gill Farrar, Frederik Barkhof, David M. Cash
Summary: This study evaluated the performance of four novel data-driven metrics against conventional techniques for quantifying amyloid-beta (Aβ) pathology. The results showed that the Aβ load, Aβ index, and CLNMF metrics can provide comparable performance to established quantification methods. These new metrics may offer more precise alternatives and further studies in larger cohorts should be conducted.
Article
Clinical Neurology
Emma M. Coomans, Lotte A. de Koning, Roos M. Rikken, Sander C. J. Verfaillie, Denise Visser, Anouk den Braber, Jori Tomassen, Marleen van de Beek, Lyduine E. Collij, Afina W. Lemstra, Albert D. Windhorst, Frederik Barkhof, Sandeep S. V. Golla, Pieter Jelle Visser, Philip Scheltens, Wiesje M. van der Flier, Rik Ossenkoppele, Bart N. M. van Berckel, Elsmarieke van de Giessen
Summary: This study evaluated the performance of the visual read method in participants along the AD continuum and dementia with Lewy bodies (DLB), showing excellent inter-reader agreement, strong correspondence with semiquantification, and associations with clinically relevant variables. The visual read status remained stable over a two-year follow-up period and was associated with a decline in Mini-Mental State Examination scores, indicating its reliability and prognostic potential. Future studies in unselected cohorts are needed for better generalizability to the clinical population.
Article
Clinical Neurology
Ying Jin, Dan Cheng, Yunyun Duan, Zhizheng Zhuo, Jinyuan Weng, Chengzhou Zhang, Mingwang Zhu, Xing Liu, Jiang Du, Tiantian Hua, Hongfang Li, Sven Haller, Frederik Barkhof, Yaou Liu
Summary: The purpose of this study was to investigate the predictive value of the soap bubble sign on molecular subtypes of posterior fossa ependymomas (PF-EPNs). The soap bubble sign was observed in PFB cases but not in PFA cases. The findings suggest that the soap bubble sign is a highly specific imaging marker for the PFB molecular subtype of PF-EPNs.
Review
Clinical Neurology
Janine Hendriks, Henk-Jan Mutsaerts, Richard Joules, Oscar Pena-Nogales, Paulo R. Rodrigues, Robin Wolz, George L. Burchell, Frederik Barkhof, Anouk Schrantee
Summary: This systematic review provides an overview of the available (semi-)automatic QC algorithms and software packages for raw, structural T1-weighted (T1w) MRI datasets, and analyzes the differences among these algorithms in terms of their features, performance, and benchmarks.
