Article
Neurosciences
Tomotaka Tanaka, Bibek Gyanwali, Steven Gayoles Villaraza, Francis N. Saridin, Henri Vrooman, Masafumi Ihara, Anthonin Reilhac, Christopher L. H. Chen, Saima Hilal
Summary: The study found that P-wave terminal force in lead V1 (PTFV1) on electrocardiography is associated with cerebral small vessel disease (CSVD) markers and etiological subtypes of cognitive impairment and dementia. Elevated PTFV1 is related to a higher burden of lacunes, cerebral microbleeds, and cortical microinfarcts. It suggests that PTFV1 may be a potential surrogate marker of brain-heart connection and vascular brain damage.
JOURNAL OF ALZHEIMERS DISEASE
(2022)
Article
Clinical Neurology
Young Min Choe, Hyewon Baek, Hyo Jung Choi, Min Soo Byun, Dahyun Yi, Bo Kyung Sohn, Chul-Ho Sohn, Dong Young Lee
Summary: This study examines the relationship between enlarged perivascular spaces (EPVS) in different brain regions and cognitive impairment in a memory clinic population. The findings suggest that EPVS may not be a specific marker for cognitive impairment, although there is an association between a high degree of EPVS in the basal ganglia and executive dysfunction. Controlling for other markers of small vessel disease weakened this association.
Article
Geriatrics & Gerontology
Oscar H. Del Brutto, Robertino M. Mera, Aldo F. Costa, Denisse A. Rumbea, Bettsy Y. Recalde, Victor J. Del Brutto
Summary: The progression patterns of cerebral small vessel disease markers in older adults of Amerindian ancestry were found to be different from those in other races/ethnic groups. The independent progression of lacunes suggests different pathogenic mechanisms compared to other markers of cerebral small vessel disease.
AGING CLINICAL AND EXPERIMENTAL RESEARCH
(2022)
Article
Clinical Neurology
Lina Ryden, Simona Sacuiu, Hanna Wetterberg, Jenna Najar, Xinxin Guo, Silke Kern, Anna Zettergren, Sara Shams, Joana B. Pereira, Lars-Olof Wahlund, Eric Westman, Ingmar Skoog
Summary: This study aimed to investigate the association between AF and a broad range of cerebrovascular diseases beyond symptomatic stroke, including silent infarcts and markers of small vessel disease.
Article
Biochemistry & Molecular Biology
Paula Marazuela, Berta Paez-Montserrat, Anna Bonaterra-Pastra, Montse Sole, Mar Hernandez-Guillamon
Summary: The study evaluated the progression of Aβ deposition in parenchymal and vascular in transgenic mouse models and found that APP23 mice have more prominent CAA pathology compared to 5xFAD mice.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Clinical Neurology
Payam Tabaee Damavandi, Benedetta Storti, Natalia Fabin, Elisa Bianchi, Carlo Ferrarese, Jacopo C. DiFrancesco
Summary: Cerebral amyloid angiopathy (CAA) is a common cause of spontaneous intracranial hemorrhage in older adults, and epilepsy can be a potential consequence of the disease. However, there is a lack of studies on epilepsy in CAA, with limited available data primarily focusing on CAA-related inflammation (CAA-ri).
Article
Endocrinology & Metabolism
Tang-Chuan Wang, Chien-Jen Chiu, Pei-Chun Chen, Ta-Yuan Chang, Richard S. Tyler, Eveling Rojas-Roncancio, Claudia Barros Coelho, Patricia C. Mancini, Cheng-Li Lin, Chia-Der Lin, Ming-Hsui Tsai
Summary: This study found that patients with hyperthyroidism are more likely to develop tinnitus, with a higher proportion of insomnia and anxiety among hyperthyroidism patients. Adjusting for age, gender, and comorbidities, hyperthyroidism patients had a 1.38-fold higher risk of tinnitus than those without hyperthyroidism.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Clinical Neurology
Tracey H. Fan, Sung-Min Cho, Richard A. Prayson, Catherine E. Hassett, Randall C. Starling, Ken Uchino
Summary: The study examined post-mortem neuropathological findings of LVAD patients and found a high prevalence of cerebral injuries, with 90% of patients showing cerebral microvascular injuries. Multiple types of cerebral injuries coexisted, suggesting that subclinical microvascular injuries and cerebral microbleeds in LVAD patients may contribute to the frequent occurrence of cerebral injury.
TRANSLATIONAL STROKE RESEARCH
(2022)
Article
Clinical Neurology
Shannon M. Fernando, Danial Qureshi, Robert Talarico, Peter Tanuseputro, Dar Dowlatshahi, Manish M. Sood, Eric E. Smith, Michael D. Hill, Victoria A. McCredie, Damon C. Scales, Shane W. English, Bram Rochwerg, Kwadwo Kyeremanteng
Summary: A retrospective cohort study of spontaneous intracerebral hemorrhage (ICH) patients in Ontario, Canada over a decade showed a decrease in short- and long-term mortality rates. Most survivors were discharged to long-term care facilities, and the use of oral anticoagulation was associated with mortality following ICH.
Article
Clinical Neurology
Xin-Bin Wang, Hao Dong, Yong-Gang Qiu, Cun-Cheng Lou, De-Yun Huang, Jing Zhang, Di-Hong Chen, Han Feng, Xu Fang
Summary: A combined model based on clinical and CT characteristics has been developed and validated to predict >5 CMBs in hypertensive patients.
FRONTIERS IN NEUROLOGY
(2022)
Article
Clinical Neurology
Cindy W. W. Yoon, Joung-Ho Rha, Hee-Kwon Park, Soo-Hyun Park, Soonwook Kwon, Byeong C. Kim, Young Chul Youn, Jee Hyang Jeong, Hyun Jeong Han, Seong Hye Choi
Summary: Sex plays an important role in the progression of cerebral microbleeds (CMBs). Women have a significantly greater increase in the number of CMBs after 2 years compared to men.
FRONTIERS IN NEUROLOGY
(2022)
Review
Clinical Neurology
N. Parsons, A. Outsikas, A. Parish, R. Clohesy, F. D'Aprano, F. Toomey, S. Advani, G. R. Poudel
Summary: This study quantitatively evaluated small neurologic events in COVID-19 patients and explored the spread of these events using a network diffusion model. The findings provide insights into the distribution and association of neurologic events in different brain regions.
AMERICAN JOURNAL OF NEURORADIOLOGY
(2021)
Article
Neurosciences
Shao-Yuan Chuang, Yin-Chen Hsu, Kuang-Wei Chou, Kuo-Song Chang, Chiong-Hee Wong, Ya-Hui Hsu, Hao-Min Cheng, Chien-Wei Chen, Pang-Yen Chen
Summary: Cerebral Small Vessel Disease (CSVD) is frequently seen in elderly individuals and is associated with inflammation. The Neutrophil-Lymphocyte Ratio (NLR) may serve as a biomarker for the progression of CSVD. A study of 720 adults aged 50 years or older found a positive association between NLR and CSVD, as measured by the presence of white matter hyperintensity, microbleed, and lacune on brain MRI.
Article
Clinical Neurology
Ashkan Shoamanesh, Saloua Akoudad, Jayandra J. Himali, Alexa S. Beiser, Charles DeCarli, Sudha Seshadri, M. Arfan Ikram, Jose R. Romero, Meike W. Vernooij
Summary: In community-dwelling older adults, cortical superficial siderosis is associated with cerebral amyloid angiopathy, indicating that individuals with this condition may be at a higher risk for intracerebral hemorrhage and future neurological events.
INTERNATIONAL JOURNAL OF STROKE
(2021)
Article
Clinical Neurology
Hyemin Jang, Min Young Chun, Hee Jin Kim, Duk L. Na, Sang Won Seo
Summary: This study investigated the relevance of different imaging markers in cerebral amyloid angiopathy (CAA) patients and their clinical trajectories. The presence of cortical superficial siderosis and previous lobar intracerebral hemorrhage were predictors for the development of CAA, while lobar cerebral microbleeds were not. The presence of cerebral microinfarcts (CMIs) and A beta positivity were associated with worse cognitive trajectories in CAA patients.
ALZHEIMERS RESEARCH & THERAPY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Ivar J. H. G. Wamelink, Joost P. A. Kuijer, Beatriz E. Padrela, Yi Zhang, Frederik Barkhof, Henk J. M. M. Mutsaerts, Jan Petr, Elsmarieke van de Giessen, Vera C. Keil
Summary: This study investigates the reproducibility of cerebral APT-CEST imaging in healthy tissue and gliomas at 3 T. The results indicate that cerebral APT-CEST shows good scan-rescan reproducibility in healthy tissue and tumors, and short-term measurement effects may be the dominant components for reproducibility.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2023)
Article
Endocrinology & Metabolism
Khazar Ahmadi, Joana B. Pereira, David Berron, Jacob Vogel, Silvia Ingala, Olof T. Strandberg, Shorena Janelidze, Frederik Barkhof, Josef Pfeuffer, Linda Knutsson, Danielle van Westen, Sebastian Palmqvist, Henk J. M. M. Mutsaerts, Oskar Hansson
Summary: This study investigated the role of decreased cerebral blood flow in Alzheimer's disease and found that tau tangles and neurodegeneration are more closely connected with GM-CBF changes than A beta pathology.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Junjie Li, Peng Zhang, Liying Qu, Ting Sun, Yunyun Duan, Minghao Wu, Jinyuan Weng, Zhaohui Li, Xiaodong Gong, Xing Liu, Yongzhi Wang, Wenqing Jia, Xiaorui Su, Qiang Yue, Jianrui Li, Zhiqiang Zhang, Frederik Barkhof, Raymond Y. Huang, Ken Chang, Haris Sair, Chuyang Ye, Liwei Zhang, Zhizheng Zhuo, Yaou Liu
Summary: A deep learning approach was developed to predict H3 K27M mutation in diffuse midline glioma using T2-weighted images. The segmentation performance and predictive accuracy of H3 K27M mutation status in both midline brain gliomas and spinal cord gliomas were evaluated. The method showed good predictive performance across different institutions.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2023)
Article
Clinical Neurology
H. Vrenken, M. Battaglini, M. L. de Vos, G. J. Nagtegaal, B. C. A. Teixeira, A. Seitzinger, D. Jack, M. P. Sormani, B. M. J. Uitdehaag, A. Versteeg, G. Comi, L. Kappos, N. De Stefano, F. Barkhof
Summary: A post hoc analysis found that subcutaneous interferon ss-1a (sc IFN ss-1a) treatment can reduce the number of new lesions and the likelihood of these lesions evolving into black holes in patients with a first clinical demyelinating event (FCDE), compared to placebo.
JOURNAL OF NEUROLOGY
(2023)
Article
Clinical Neurology
C. Mallinckrodt, Y. Tian, P. S. Aisen, F. Barkhof, S. Cohen, G. Dent, O. Hansson, K. Harrison, T. Iwatsubo, C. J. Mummery, K. K. Muralidharan, I. Nestorov, L. Nisenbaum, R. Rajagovindan, C. von Hehn, C. H. van Dyck, B. Vellas, S. Wu, Y. Zhu, A. Sandrock, T. Chen, S. Budd Haeberlein
Summary: Post-hoc analyses of the EMERGE and ENGAGE studies showed that the outcomes in the high-dose group of ENGAGE were affected by an imbalance in a small number of rapidly progressing patients and lower exposure to the target dose. However, these factors were only present in early enrolled patients and did not affect later enrolled patients. Baseline characteristics and amyloid-related imaging abnormalities did not contribute to the difference in results between the high-dose arms.
JPAD-JOURNAL OF PREVENTION OF ALZHEIMERS DISEASE
(2023)
Article
Clinical Neurology
Eline Coerver, Sophie Janssens, Aroosa Ahmed, Mark Wessels, Zoe van Kempen, Bas Jasperse, Frederik Barkhof, Marcus Koch, Jop Mostert, Bernard Uitdehaag, Joep Killestein, Eva Strijbis
Summary: Inflammatory disease activity in multiple sclerosis (MS) decreases with advancing age, and this study investigated the relation between age and MRI measures of inflammatory disease activity in a real-world cohort of people with relapse onset MS.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Denise Visser, Sander C. J. Verfaillie, Iris Bosch, Iman Brouwer, Hayel Tuncel, Emma M. Coomans, Roos M. Rikken, Sophie E. Mastenbroek, Sandeep S. V. Golla, Frederik Barkhof, Elsmarieke van de Giessen, Bart N. M. van Berckel, Wiesje M. van der Flier, Rik Ossenkoppele
Summary: The purpose of this study was to investigate the association between Tau pathology, atrophy, and cerebral blood flow (CBF) in Alzheimer's disease (AD). The results showed that increased Tau load was associated with cortical thinning, but not with decreased relative CBF. Baseline Tau PET load was a stronger predictor of cortical thinning than changes in Tau PET signal over time.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2023)
Article
Neurosciences
Mathijs B. J. Dijsselhof, Michelle Barboure, Michael Stritt, Wibeke Nordhoy, Alle Meije Wink, Dani Beck, Lars T. Westlye, James H. Cole, Frederik Barkhof, Henk J. M. M. Mutsaerts, Jan Petr
Summary: This study investigated the optimal combination of structural and physiological MRI features and algorithms for brain age prediction. The addition of ASL features to structural brain age, combined with the ElasticNetCV algorithm, improved brain age prediction the most and performed best in a cross-sectional and repeatability comparison.
HUMAN BRAIN MAPPING
(2023)
Article
Clinical Neurology
Alberto Calvi, Zoe Mendelsohn, Weaam Hamed, Declan Chard, Carmen Tur, Jon Stutters, David MacManus, Baris Kanber, Claudia A. M. Gandini Wheeler-Kingshott, Frederik Barkhof, Ferran Prados
Summary: This study retrospectively analyzed a fingolimod trial in patients with primary progressive MS (PPMS) and found that newly appearing lesions are common and can develop into chronic active lesions. Treatment can reduce the number of these lesions.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Peripheral Vascular Disease
Julia H. I. Wiersinga, Hanneke F. M. Rhodius-Meester, Frank J. Wolters, Marijke C. Trappenburg, Afina W. Lemstra, Frederik Barkhof, Mike J. L. Peters, Wiesje M. van der Flier, Majon Mueller
Summary: Orthostatic hypotension (OH) is associated with cognitive decline and dementia, possibly through cerebral small vessel disease (CSVD). This study found that longer duration and larger magnitude of blood pressure drop were associated with increased risk of CSVD, but these associations were largely explained by high supine blood pressure.
JOURNAL OF HYPERTENSION
(2023)
Article
Clinical Neurology
Ying Jin, Dan Cheng, Yunyun Duan, Zhizheng Zhuo, Jinyuan Weng, Chengzhou Zhang, Mingwang Zhu, Xing Liu, Jiang Du, Tiantian Hua, Hongfang Li, Sven Haller, Frederik Barkhof, Yaou Liu
Summary: The purpose of this study was to investigate the predictive value of the soap bubble sign on molecular subtypes of posterior fossa ependymomas (PF-EPNs). The soap bubble sign was observed in PFB cases but not in PFA cases. The findings suggest that the soap bubble sign is a highly specific imaging marker for the PFB molecular subtype of PF-EPNs.
Article
Clinical Neurology
Yanaika S. S. Hok-A-Hin, Katharina Bolsewig, Daimy N. N. Ruiters, Alberto Lleo, Daniel Alcolea, Afina W. W. Lemstra, Wiesje M. M. van der Flier, Charlotte E. E. Teunissen, Marta del Campo
Summary: Our study showed that THOP1 can serve as an early specific biomarker for Alzheimer's Disease (AD). We developed THOP1 immunoassays and validated our findings in two independent cohorts.
ALZHEIMER'S & DEMENTIA: DIAGNOSIS, ASSESSMENT & DISEASE MONITORING
(2023)
Review
Clinical Neurology
Janine Hendriks, Henk-Jan Mutsaerts, Richard Joules, Oscar Pena-Nogales, Paulo R. Rodrigues, Robin Wolz, George L. Burchell, Frederik Barkhof, Anouk Schrantee
Summary: This systematic review provides an overview of the available (semi-)automatic QC algorithms and software packages for raw, structural T1-weighted (T1w) MRI datasets, and analyzes the differences among these algorithms in terms of their features, performance, and benchmarks.
Article
Clinical Neurology
Rozemarijn M. Mattiesing, Eline Kramer, Eva M. M. Strijbis, Iman Brouwer, Ronald A. van Schijndel, Giordano Gentile, Marco Battaglini, Nicola De Stefano, Bernard M. J. Uitdehaag, Frederik Barkhof, Hugo Vrenken, Menno M. Schoonheim
Summary: The degree of inflammation and neurodegeneration after treatment initiation in multiple sclerosis (MS) can predict disease progression. This study found that global atrophy and/or pseudo-atrophy as well as positive lesion activity in MRI results during the first and second years of treatment were related to an increased probability and faster conversion to clinically definite MS. Negative lesion activity in the first year and slower central atrophy in the second year were predictive of disability progression.
MULTIPLE SCLEROSIS JOURNAL
(2023)
Article
Clinical Neurology
Nitin Sahi, Lukas Haider, Karen Chung, Ferran Prados Carrasco, Baris Kanber, Rebecca Samson, Alan J. Thompson, Claudia A. M. Gandini Wheeler-Kingshott, S. Anand Trip, Wallace Brownlee, Olga Ciccarelli, Frederik Barkhof, Carmen Tur, Henry Houlden, Declan Chard
Summary: This retrospective study explores the genetic influences on long-term disease course and severity in multiple sclerosis. The findings show that specific genes are associated with different pathological mechanisms of the disease, such as white matter inflammation, disability worsening, and the risk of developing secondary progressive multiple sclerosis. These findings are significant for a better understanding of the genetic factors and prognosis of multiple sclerosis.
BRAIN COMMUNICATIONS
(2023)