Article
Radiology, Nuclear Medicine & Medical Imaging
Xuehan Hu, Xun Sun, Fan Hu, Fang Liu, Weiwei Ruan, Tingfan Wu, Rui An, Xiaoli Lan
Summary: The study aimed to construct multivariate radiomics models using hybrid F-18-FDG PET/MRI to distinguish between PD and MSA, showing that the radiomics signature with metabolic, structural, and functional information may achieve promising diagnostic efficacy. The clinical-radiomics integrated model performed best in distinguishing between PD and MSA.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Su Jin Lim, Chong Hyun Suh, Woo Hyun Shim, Sang Joon Kim
Summary: The diagnostic performance of T2*-weighted GRE imaging, SWI, or QSM in differentiating MSA-P from PD was investigated in this study, showing promising results with high sensitivity and specificity. Further large multicenter prospective studies are needed to confirm the findings and explore the potential clinical utility of these imaging techniques.
EUROPEAN RADIOLOGY
(2022)
Article
Medicine, General & Internal
Lingyu Zhang, Yanbing Hou, Bei Cao, Qianqian Wei, Ruwei Ou, Kuncheng Liu, Junyu Lin, Tianmi Yang, Yi Xiao, Yongping Chen, Wei Song, Bi Zhao, Huifang Shang
Summary: The study investigated the progression of motor and non-motor symptoms in early-stage MSA patients over a two-year period. It found that items related to motor functions in the UMSARS were more sensitive to change, while those associated with autonomic dysfunction showed less sensitivity. The prevalence and severity of NMS significantly increased over the 2-year follow-up.
Article
Clinical Neurology
Wen-Zheng Hu, Ling-Xiao Cao, Jin-Hui Yin, Xue-Song Zhao, Ying-Shan Piao, Wei-Hong Gu, Jing-Hong Ma, Zhi-Rong Wan, Yue Huang
Summary: The aim of this study was to compare the burden of non-motor symptoms (NMS) between multiple system atrophy (MSA), Parkinson's disease (PD), and progressive supranuclear palsy (PSP) and to determine the timing of NMS presentation in MSA. The results showed that MSA patients had a higher NMS burden compared to PD and PSP patients, with depression, anxiety, and cognitive impairment being the most prominent NMS symptoms in MSA.
FRONTIERS IN NEUROLOGY
(2023)
Article
Clinical Neurology
Kelvin L. Chou, Praveen Dayalu, Robert A. Koeppe, Sid Gilman, C. Chauncey Spears, Roger L. Albin, Vikas Kotagal
Summary: This study compared the serotoninergic innervation in patients with multiple system atrophy (MSA) and Parkinson's disease (PD) using serotonin transporter [C-11]3-amino-4-(2-dimethylaminomethyl-phenylsulfaryl)-benzonitrile positron emission tomography (PET). The results showed that MSA patients exhibited more severe deficits in brainstem and some forebrain subcortical regions compared to PD patients, and these deficits correlated with the severity of motor impairments in MSA.
MOVEMENT DISORDERS
(2022)
Article
Clinical Neurology
Victoria Sidoroff, Cecilia Raccagni, Christine Kaindlstorfer, Sabine Eschlboeck, Alessandra Fanciulli, Roberta Granata, Bjorn Eskofier, Klaus Seppi, Werner Poewe, Johann Willeit, Stefan Kiechl, Philipp Mahlknecht, Heike Stockner, Kathrin Marini, Oliver Schorr, Gregorio Rungger, Jochen Klucken, Gregor Wenning, Heiko Gassner
Summary: The study compared gait variability at different walking speeds between patients with Parkinson-variant multiple system atrophy, idiopathic Parkinson's disease, and a control group of older adults. Multiple system atrophy patients displayed higher gait variability in various parameters compared to controls, while Parkinson's patients did not. Variability parameters were significantly correlated with the postural instability/gait difficulty subscore in both disease groups.
JOURNAL OF NEUROLOGY
(2021)
Article
Clinical Neurology
Yalan Chen, Hongyan Huang, Peng Zhang, Yanming Xu, Yangmei Chen
Summary: This study investigated the prevalence and clinical characteristics of subjective constipation in Chinese patients with multiple system atrophy (MSA) and its timing relative to the occurrence of motor symptoms. The results showed that the frequency of constipation was 53.5%, 59.7%, and 39.3% in MSA, MSA with predominately parkinsonism (MSA-P), and MSA with predominately cerebellar ataxia (MSA-C), respectively. Constipation was associated with high total UMSARS scores in MSA, MSA-P, and MSA-C patients. Among the patients with constipation, 59.8% experienced it before the onset of motor symptoms, with a significantly longer interval between constipation and motor symptom occurrence.
FRONTIERS IN NEUROLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Jinju Sun, Chao Cong, Xinpeng Li, Weicheng Zhou, Renxiang Xia, Huan Liu, Yi Wang, Zhiqiang Xu, Xiao Chen
Summary: This study aims to differentiate Parkinson's disease (PD) and multiple system atrophy (MSA) using multimodal PET/MRI radiomics and clinical characteristics. A total of 119 patients (81 with PD and 38 with MSA) underwent PET/CT and MRI scans, and radiomics features were extracted from the putamina and caudate nuclei to construct predictive models. The results showed that the combined PET/MRI radiomics-clinical model performed better in differentiating PD from MSA.
EUROPEAN RADIOLOGY
(2023)
Article
Geriatrics & Gerontology
Wen-biao Xian, Xin-chong Shi, Gan-hua Luo, Chang Yi, Xiang-song Zhang, Zhong Pei
Summary: The study demonstrated that co-registration analysis of F-18-flurodeoxyglucose and F-18-fluorodopa PET images can effectively differentiate between Parkinson's disease and multiple system atrophy parkinsonian subtype (MSA-P). Parkinson's disease patients showed hypermetabolism in the bilateral putamen, while MSA-P patients exhibited hypometabolism in this region.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Priyanka Tupe-Waghmare, Archith Rajan, Shweta Prasad, Jitender Saini, Pramod Kumar Pal, Madhura Ingalhalikar
Summary: This study demonstrates the feasibility of using radiomics features extracted from T1-weighted MRI images to differentiate Parkinson's disease from atypical parkinsonian syndromes. The results showed high accuracy rates for classifiers distinguishing PD from HC, PD from APS, and a 3-way classifier for PD/MSA/PSP, highlighting the potential of radiomics in aiding clinical diagnosis in early stages of disease.
EUROPEAN RADIOLOGY
(2021)
Article
Geriatrics & Gerontology
Daji Chen, Linlin Wan, Zhao Chen, Xinrong Yuan, Mingjie Liu, Zhichao Tang, You Fu, Sudan Zhu, Xuewei Zhang, Rong Qiu, Beisha Tang, Hong Jiang
Summary: This study aimed to detect the changes in serum vitamin levels and investigate their correlation with disease severity in multiple system atrophy (MSA) patients. The results showed that MSA patients had decreased serum folate levels and increased serum vitamin A and C levels compared to healthy controls. Furthermore, the combination of vitamin A, folate, and vitamin C showed potential diagnostic value in distinguishing MSA patients from healthy controls.
FRONTIERS IN AGING NEUROSCIENCE
(2023)
Article
Clinical Neurology
Seong Ho Jeong, Hye Sun Lee, Seok Jong Chung, Han Soo Yoo, Jin Ho Jung, Kyoungwon Baik, Jong Sam Baik, Young H. Sohn, Phil Hyu Lee
Summary: This study found that cholesterol levels are associated with motor symptoms in drug-naive Parkinson disease (PD), especially in subjects with low cholesterol status. The severity of axial motor symptoms is negatively associated with cholesterol levels only in statin users.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Behavioral Sciences
Hong Zhou, Xia Wang, Di Ma, Yanyan Jiang, Fan Li, Yunchuang Sun, Jing Chen, Wei Sun, Elmar H. Pinkhardt, Bernhard Landwehrmeyer, Albert Ludolph, Lin Zhang, Guiping Zhao, Zhaoxia Wang
Summary: Eye movement tests can help differentiate between PD and MSA, with characteristics such as the presence of hypometria and hypermetria in saccadic eye movement, impaired gain of smooth pursuit movement with catch-up saccades, gaze-evoked nystagmus, square-wave jerks in gaze-holding test, and multiple-step pattern in MGS providing clues to the diagnosis of MSA.
BRAIN AND BEHAVIOR
(2021)
Article
Clinical Neurology
Hui Wang, Xiangdong Tang, Junying Zhou, Yanming Xu
Summary: This study found that the presence and severity of excessive daytime sleepiness (EDS) may be significantly associated with non-motor dysfunction in multiple system atrophy (MSA) patients, including fatigue, anxiety, depression, cognitive dysfunction, and sleep-related breathing disorder, but not with motor dysfunction.
FRONTIERS IN NEUROLOGY
(2022)
Article
Clinical Neurology
Line Kuhnel, Lars Lau Raket, Daniel Oudin Astrom, Anna-Karin Berger, Ingeborg Helbech Hansen, Florian Krismer, Gregor K. Wenning, Klaus Seppi, Werner Poewe, JoseLuis Molinuevo
Summary: This study developed a novel disease-progression model to estimate the progression trajectory of multiple system atrophy (MSA) at a population level and predict patient-specific continuous disease stages. The predicted disease continuum was correlated with the time of symptom onset and predictive of survival time. MSA subtype was found to significantly affect disease progression.
MOVEMENT DISORDERS
(2022)
Article
Geriatrics & Gerontology
Florent Guerville, Philipe De Souto Barreto, Nicola Coley, Sandrine Andrieu, Jean-Francois Mangin, Marie Chupin, Pierre Payoux, Pierre-Jean Ousset, Yves Rolland, Bruno Vellas
Summary: This study found no association between mild to moderate renal insufficiency and brain imaging features of Alzheimer's disease, and the results do not support the involvement of Alzheimer's disease mechanisms in the incidence of cognitive impairment and functional decline associated with chronic kidney disease.
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
(2021)
Article
Pharmacology & Pharmacy
Pierre Payoux, Jean-Philippe Ranjeva
Summary: This manuscript reviews the contributions of neuroimaging methods such as PET and MRI, both conventional and advanced, in monitoring the effects of new disease modifying drugs in neurodegenerative diseases. The review highlights the increasing complementary nature of these techniques in various pathologies.
Article
Radiology, Nuclear Medicine & Medical Imaging
Federica Ribaldi, Daniele Altomare, Jorge Jovicich, Clarissa Ferrari, Agnese Picco, Francesca Benedetta Pizzini, Andrea Soricelli, Anna Mega, Antonio Ferretti, Antonios Drevelegas, Beatriz Bosch, Bernhard W. Muller, Camillo Marra, Carlo Cavaliere, David Bartres-Faz, Flavio Nobili, Franco Alessandrini, Frederik Barkhof, Helene Gros-Dagnac, Jean-Philippe Ranjeva, Jens Wiltfang, Joost Kuijer, Julien Sein, Karl-Titus Hoffmann, Luca Roccatagliata, Lucilla Parnetti, Magda Tsolaki, Manos Constantinidis, Marco Aiello, Marco Salvatore, Martina Montalti, Massimo Caulo, Mira Didic, Nuria Bargallo, Olivier Blin, Paolo M. Rossini, Peter Schonknecht, Piero Floridi, Pierre Payoux, Pieter Jelle Visser, Regis Bordet, Renaud Lopes, Roberto Tarducci, Stephanie Bombois, Tilman Hensch, Ute Fiedler, Jill C. Richardson, Giovanni B. Frisoni, Moira Marizzoni
Summary: This study aimed to evaluate the accuracy and reproducibility of two freely available segmentation algorithms for WMHs. A harmonized MRI protocol was implemented in 3T scanners across 13 European sites, with each site scanning volunteers twice to assess the difference between automated and manual segmentations, as well as the reproducibility between test and retest scans. The results showed that the LST algorithms exhibited moderate accuracy and good reproducibility, making them reliable tools for cross-sectional and longitudinal studies in multi-site settings.
MAGNETIC RESONANCE IMAGING
(2021)
Review
Biochemistry & Molecular Biology
Pierre Layrolle, Pierre Payoux, Stephane Chavanas
Summary: PPARγ plays a crucial role in viral infections of the brain, influencing inflammation, viral replication, and neuronogenesis. It may serve as a key target for designing new therapeutic strategies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Yuliya Piatkova, Pierre Payoux, Caroline Boursier, Manon Bordonne, Veronique Roch, Pierre-Yves Marie, Gabriela Hossu, Laetitia Imbert, Antoine Verger
Summary: This study compared I-123-FP-CIT SPECT imaging obtained from a 360 degrees CZT camera with different focus configurations to that from a conventional Anger camera. The results showed that the 360 degrees CZT camera provided higher image quality, shorter acquisition times, and fewer discordant cases compared to the conventional camera, possibly due to its higher spatial resolution.
CLINICAL NUCLEAR MEDICINE
(2022)
Review
Neurosciences
Dominique Gouilly, Laure Saint-Aubert, Maria-Joao Ribeiro, Anne-Sophie Salabert, Clovis Tauber, Patrice Peran, Nicolas Arlicot, Jeremie Pariente, Pierre Payoux
Summary: This review provides an update on the results from 2018 and advances the characterization of TSPO imaging in Alzheimer's disease (AD) by re-examining TSPO function and expression. Although the biological basis of the TSPO PET signal is clearly related to microglia and astrocytes in AD, the exact process remains uncertain and may not be directly associated with neuroinflammation. Further studies are needed to explore the cellular significance underlying variations in the PET signal in AD.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2022)
Article
Physiology
Laurent Guillon, Marc Kermorgant, Thomas Charvolin, Fabrice Bonneville, Marie-Pierre Bareille, Emmanuelle Cassol, Arnaud Beck, Marie Beaurain, Patrice Peran, Jean-Albert Lotterie, Anne Pavy-Le Traon, Pierre Payoux
Summary: In a 5-day dry immersion study, a significant decrease in regional cerebral blood flow (rCBF) was observed in various cortical and subcortical regions, particularly in the basal ganglia, bilateral occipital regions, bilateral insula, and bilateral inferior temporal regions. However, thigh cuffs used as a countermeasure failed to prevent hypoperfusion in these regions. Further research is needed to understand the mechanisms underlying changes in cerebral blood flow after exposure to microgravity.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Medicine, General & Internal
Anis Krache, Charlotte Fontan, Carine Pestourie, Manuel Bardies, Yann Bouvet, Pierre Payoux, Etienne Chatelut, Melanie White-Koning, Anne-Sophie Salabert
Summary: Anti-PDL1 is a monoclonal antibody that restores the immune system response in several tumors by targeting PD-L1. Non-invasive imaging enables whole-body mapping of PD-L1 sites and could improve the assessment of tumor PD-L1 expression.
FRONTIERS IN MEDICINE
(2022)
Article
Neurosciences
Chadlia Karoui, Kuzma Strelnikov, Pierre Payoux, Anne-Sophie Salabert, Chris J. James, Olivier Deguine, Pascal Barone, Mathieu Marx
Summary: Cochlear implantation can restore the normal functional pattern of auditory cortical activity and improve sound localization in individuals with asymmetric hearing loss (AHL). The contralateral dominance for the nonimplanted ear strongly correlates with sound localization performance.
Meeting Abstract
Radiology, Nuclear Medicine & Medical Imaging
L. Collij, C. Buckley, A. Palombit, K. Gray, M. Shekari, G. Salvado, M. Battle, D. Altomare, R. Gismondi, A. Stephens, V. Garibotto, B. N. van Berckel, C. Ritchie, P. Payoux, B. Vellas, O. Grau, M. Boada, A. Drzezga, P. Scheltens, Z. Walker, J. Demonet, A. Nordberg, P. Visser, G. Frisoni, G. Farrar, F. Barkhof, J. Gispert
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2021)
Meeting Abstract
Radiology, Nuclear Medicine & Medical Imaging
A. Krache, C. Fontan, C. Pestouri, M. Bardies, P. Payoux, E. Chatelut, M. White-koning, A. Salabert
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2021)
Meeting Abstract
Radiology, Nuclear Medicine & Medical Imaging
Y. Piatkova, P. Payoux, C. Boursier, M. Bordonne, V. Roch, P. Y. Marie, L. Imbert, A. Verger
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2021)
Meeting Abstract
Radiology, Nuclear Medicine & Medical Imaging
L. Saint-Aubert, I. Carrie, A. Hitzel, A. Salabert, P. Payoux
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2021)
Meeting Abstract
Radiology, Nuclear Medicine & Medical Imaging
M. Beaurain, F. Talmont, D. Pierre, S. Boucher, P. Payoux, A. Salabert
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2021)
Article
Geriatrics & Gerontology
P. De Souto Barreto, S. Guyonnet, I Ader, S. Andrieu, L. Casteilla, N. Davezac, C. Dray, N. Fazilleau, P. Gourdy, R. Liblau, A. Parini, P. Payoux, L. Penicaud, C. Rampon, Y. Rolland, P. Valets, N. Vergnolle, B. Vellas
Summary: Aging is a key risk factor for chronic diseases and functional decline, and understanding the interplay between biological aging, disease biology, and a function-centered care approach is crucial for preventive strategies. The INSPIRE research program aims to explore how manipulation of biological aging and implementation of function-centered care pathways can contribute to healthy aging trajectories.
JOURNAL OF FRAILTY & AGING
(2021)