Review
Cell Biology
Augoustos Tsamourgelis, Peter Swann, Leonidas Chouliaras, John T. O'Brien
Summary: Dementia with Lewy Bodies (DLB) is the second most common neurodegenerative dementia. Proteomics has revealed protein dysregulation in the brain and peripheral tissues in DLB, which shares common features with other dementias but also has unique protein signatures. Identifying novel protein targets and diagnostic biomarkers could lead to new therapeutics and improved clinical trials for DLB.
AGEING RESEARCH REVIEWS
(2023)
Review
Clinical Neurology
Rotem Iris Orad, Tamara Shiner
Summary: Dementia with Lewy bodies presents a diagnostic challenge due to clinical overlap with other neurodegenerative conditions, such as Parkinson's disease dementia and Alzheimer's disease. Neuroimaging plays a central role in improving diagnostic accuracy and management of this disorder.
JOURNAL OF NEUROLOGY
(2022)
Article
Clinical Neurology
Martyna M. Grochowska, Ana Carreras Mascaro, Valerie Boumeester, Domenico Natale, Guido J. Breedveld, Hanneke Geut, Wiggert A. van Cappellen, Agnita J. W. Boon, Anneke J. A. Kievit, Esther Sammler, Piero Parchi, Pietro Cortelli, Dario R. Alessi, Wilma D. J. van de Berg, Vincenzo Bonifati, Wim Mandemakers
Summary: Loss-of-function variants in the LRP10 gene are linked to Parkinson's disease, dementia, and other neurodegenerative disorders. LRP10 is highly expressed in astrocytes and interacts with SORL1, potentially playing a crucial role in vesicle trafficking pathways. The specific pattern of LRP10 incorporation into Lewy bodies suggests its involvement in neurodegenerative diseases.
ACTA NEUROPATHOLOGICA
(2021)
Review
Clinical Neurology
Melissa J. Armstrong
Summary: Dementia with Lewy bodies (DLB) is a specific presentation of a pathological alpha-synucleinopathy, with recent advances including updated diagnostic criteria and recognition of prodromal states. Research shows common co-occurrence of Alzheimer's disease pathology in individuals with DLB, impacting biomarker use and progression. Identifying biomarkers and effective therapies remain key areas of focus for future research in DLB.
THERAPEUTIC ADVANCES IN NEUROLOGICAL DISORDERS
(2021)
Review
Pharmacology & Pharmacy
Evans D. Pope, Laura Cordes, Jiong Shi, Zoltan Mari, Boris Decourt, Marwan Noel Sabbagh
Summary: DLB is characterized by toxic accumulation of alpha-synuclein protein and shares features with PD and PDD, as well as overlaps with Alzheimer's disease. Treatments for DLB should not be solely duplicative of AD or PD, opening up numerous possibilities for disease-specific or repurposed therapeutic approaches.
EXPERT OPINION ON INVESTIGATIONAL DRUGS
(2021)
Article
Clinical Neurology
Mariana L. Laporta, S. Chandralekha Kruthiventi, Cole D. Stang, Emanuele Camerucci, David P. Martin, Toby N. Weingarten, Andrew C. Hanson, Darrell R. Schroeder, David O. Warner, Rodolfo Savica, Juraj Sprung
Summary: This study did not find a significant association between exposure to general anesthesia and the development of alpha-synucleinopathies.
PARKINSONISM & RELATED DISORDERS
(2021)
Article
Biochemistry & Molecular Biology
Matthieu Lilamand, Josue Clery, Agathe Vrillon, Francois Mouton-Liger, Emmanuel Cognat, Sinead Gaubert, Claire Hourregue, Matthieu Martinet, Julien Dumurgier, Jacques Hugon, Elodie Bouaziz-Amar, Claire Paquet
Summary: This study found that cerebrospinal fluid levels of alpha-synuclein differ significantly between DLB and AD, suggesting its potential as a biomarker for distinguishing between these two diseases. CSF alpha-synuclein is associated with other AD biomarkers.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Clinical Neurology
A. Surendranathan, J. Kane, A. Bentley, S. Barker, R. McNally, C. Bamford, J. -P. Taylor, A. Thomas, I. McKeith, D. Burn, J. T. O'Brien
Summary: The introduction of an assessment toolkit significantly increased the rate of DLB diagnosis, suggesting structured assessment can help clinicians recognize cases. However, the toolkit did not affect the overall rate of PDD diagnosis, indicating the need for alternate means to improve diagnosis of dementia in Parkinson's disease.
ALZHEIMERS RESEARCH & THERAPY
(2021)
Article
Clinical Neurology
Parichita Choudhury, Nan Zhang, Charles H. Adler, Kewei Chen, Christine Belden, Erika Driver-Dunckley, Shyamal H. Mehta, David R. Shprecher, Geidy E. Serrano, Holly A. Shill, Thomas G. Beach, Alireza Atri
Summary: This study compared the progression of motor function in patients with dementia with or without Parkinson's syndrome, and found that patients with Parkinson's syndrome had poorer motor function initially, while patients with dementia with Parkinson's syndrome showed faster progression in motor function.
ALZHEIMERS & DEMENTIA
(2023)
Article
Clinical Neurology
Alice Tisserand, Benjamin Cretin, Mary Mondino, Anne Botzung, Lea Sanna, Catherine Demuynck, Pierre Anthony, Candice Muller, Olivier Bousiges, Nathalie Philippi, Frederic Blanc
Summary: This study aimed to investigate the association between photophobia and dementia with Lewy bodies (DLB). The study found that photophobia was more frequent in DLB patients and was associated with decreased gray matter in the right precentral cortex and the eyelid motor region. This finding is important for understanding the pathological mechanism of DLB.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Review
Clinical Neurology
Shannon Y. Chiu, Kathryn A. Wyman-Chick, Tanis J. Ferman, Ece Bayram, Samantha K. Holden, Parichita Choudhury, Melissa J. Armstrong
Summary: This review summarizes the current knowledge on sex differences in dementia with Lewy bodies (DLB) in terms of epidemiology, clinical features, neuropathology, biomarkers, disease progression, and caregiving. The prevalence of DLB in men is higher in many studies, but this finding is inconsistent. Women with DLB may experience more visual hallucinations, while men may have a higher frequency of REM sleep behavior disorder and parkinsonism. Women tend to be older, have greater cognitive impairment, and meet DLB criteria later than men. The impact of sex on DLB progression and the lack of research on sex differences in biomarkers and treatment are mixed. Women provide the majority of caregiving in DLB, but the effects of this on the caregiving experience are uncertain. Understanding sex differences will aid in developing sex-specific strategies in DLB.
PARKINSONISM & RELATED DISORDERS
(2023)
Review
Neurosciences
Joshua Harvey, Ehsan Pishva, Leonidas Chouliaras, Katie Lunnon
Summary: In this review, the clinical and pathological characteristics of Lewy body dementias are summarized before discussing research on genetic, epigenetic, transcriptional, and protein signatures associated with these diseases. These studies provide insights into the etiology of these diseases and suggest future research directions.
NEUROBIOLOGY OF DISEASE
(2023)
Article
Clinical Neurology
Frederic Blanc, Vincent Bouteloup, Claire Paquet, Marie Chupin, Florence Pasquier, Audrey Gabelle, Mathieu Ceccaldi, Paulo Loureiro de Sousa, Pierre Krolak-Salmon, Renaud David, Clara Fischer, Jean-Francois Dartigues, David Wallon, Olivier Moreaud, Mathilde Sauvee, Catherine Belin, Sandrine Harston, Anne Botzung, Timothee Albasser, Catherine Demuynck, Izzie Namer, Marie-Odile Habert, Stephane Kremer, Olivier Bousiges, Marc Verny, Candice Muller, Nathalie Philippi, Genevieve Chene, Benjamin Cretin, Jean-Francois Mangin, Carole Dufouil
Summary: This study compared SCI and MCI patients with symptoms of prodromal DLB to other patients in terms of baseline characteristics. It was found that patients with symptoms of prodromal DLB had slower cognition, more behavioral disorders, autonomic symptoms, and photophobia. The brain MRI also showed specific involvement in certain brain areas.
ALZHEIMERS RESEARCH & THERAPY
(2022)
Article
Clinical Neurology
Laura M. Wright, Paul C. Donaghy, David J. Burn, John -Paul Taylor, John T. O'Brien, Alison J. Yarnall, Fiona E. Matthews, Michael J. Firbank, Alan J. Thomas, Rachael A. Lawson
Summary: There is a limited longitudinal relationship between neuropsychiatric symptoms (NPS) and cognitive decline in prodromal Lewy body dementias (LBD). Core neuropsychiatric symptoms are not strongly associated with cognition, suggesting different underlying neuropathological mechanisms.
PARKINSONISM & RELATED DISORDERS
(2023)
Review
Clinical Neurology
Zina Hijazi, Nawaf Yassi, John T. O'Brien, Rosie Watson
Summary: This review examines cerebrovascular lesions in Lewy body dementia (LBD), finding that white matter changes and cerebral microbleeds are common pathological features. Compared to Parkinson's disease without dementia and age-matched controls, LBD patients have increased severity of white matter changes, which is not supported by neuropathological examination. The prevalence of cerebral microbleeds in LBD varies greatly, but is similar to Alzheimer's disease. Larger studies are needed to assess the impact of cerebrovascular lesions on clinical symptoms, disease progression, and outcomes.
EUROPEAN JOURNAL OF NEUROLOGY
(2022)
Letter
Dentistry, Oral Surgery & Medicine
Andrei Cristian Ionescu, Eugenio Brambilla, Lamberto Manzoli, Giovanna Orsini, Valentina Gentili, Roberta Rizzo
Article
Public, Environmental & Occupational Health
M. E. Flacco, C. Acuti Martellucci, G. Soldato, R. Carota, P. Fazii, A. Caponetti, L. Manzoli
Summary: This study suggests that the risk of SARS-CoV-2 reinfection is very low in minors and after 12 months of follow-up. The findings support the implementation of more targeted restriction policies for individuals who have recovered from a first infection.
JOURNAL OF PUBLIC HEALTH
(2022)
Article
Oncology
Cecilia Acuti Martellucci, Margherita Morettini, Julia M. L. Brotherton, Karen Canfell, Lamberto Manzoli, Maria Elena Flacco, Matthew Palmer, Paolo Giorgi Rossi, Mose Martellucci, Giusi Giacomini, Marcello Mario D'Errico, Francesca Pasqualini
Summary: In a study conducted in central Italy, catch-up HPV vaccination was found to significantly reduce the risk of cervical abnormalities detected in organized screening and provide herd protection to unvaccinated women.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2022)
Article
Chemistry, Applied
Federica Castellani, Federico Marini, Giulia Simonetti, Carmela Protano, Leila Fabiani, Lamberto Manzoli, Matteo Vitali
Summary: Concentrations of 7 PCDDs, 10 PCDFs and 18 PCBs were measured in 16 milk samples from sheep and goats in Bussi sul Tirino, central Italy. The samples complied with the maximum levels set in EU regulations for PCDD/Fs and the sum of PCDD/Fs and DL-PCBs. However, in two cases, contamination levels of the sum of PCDD/Fs and DL-PCBs exceeded the action levels recommended by the EU. The contamination profiles of the milk samples were independent of the distance from the illegal landfill but likely influenced by local emission sources.
FOOD ADDITIVES AND CONTAMINANTS PART A-CHEMISTRY ANALYSIS CONTROL EXPOSURE & RISK ASSESSMENT
(2023)
Review
Psychiatry
Anna Digiovanni, Paola Ajdinaj, Mirella Russo, Stefano L. Sensi, Marco Onofrj, Astrid Thomas
Summary: Psychiatric symptoms often occur before or with neurological disorders. Symptoms of bipolar spectrum disorders (BSD) can also be seen in neurological disorders such as Parkinson's disease and behavioral variant of frontotemporal dementia. Other neurological disorders also share clinical and biological characteristics with BSD, including neuroinflammation, ion channel dysfunctions, neurotransmission imbalance, and neurodegeneration. Although the pathophysiology of BSD is unclear, large-scale network dysfunctions play a role in mood disorders and psychotic symptoms. These functional alterations can manifest years before the development of organic central nervous system diseases.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Immunology
Maria Elena Flacco, Cecilia Acuti Martellucci, Graziella Soldato, Giuseppe Di Martino, Roberto Carota, Marco De Benedictis, Graziano Di Marco, Giustino Parruti, Rossano Di Luzio, Antonio Caponetti, Lamberto Manzoli
Summary: This cohort study examined the incidence of potentially vaccine-related serious adverse events (PVR-SAEs) in the entire population of an Italian Province based on COVID-19 vaccination status. The findings showed that vaccinated individuals did not have an increased risk of death or PVR-SAEs compared to the unvaccinated. These results were consistent across different demographics, vaccine types, and infection statuses. Further research is needed to assess the long-term safety of COVID-19 vaccines.
Review
Clinical Neurology
Giacomo Evangelista, Fedele Dono, Stefano Consoli, Jacopo Lanzone, Clarissa Corniello, Mirella Russo, Francesca Anzellotti, Marco Onofrj, Catello Vollono, Stefano L. Sensi
Summary: HRV analysis is a valuable method for assessing cardiovascular risk and cardioautonomic impairment in SUDEP patients. The reduction of SDNN and RMSSD is common in SUDEP cases, while there are no significant differences in time and frequency domain parameters compared to controls. However, there is a trend towards increased LF/HF ratio in SUDEP patients.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Clinical Neurology
Maria Camila Gonzalez, Diego Alejandro Tovar-Rios, Guido Alves, Ingvild Dalen, Caroline H. Williams-Gray, Marta Camacho, Lars Forsgren, David Backstrom, Rachael A. Lawson, Angus D. Macleod, Carl E. Counsell, Claire Paquet, Carlo DeLena, Fabrizia D'Antonio, Andrea Pilotto, Alessandro Padovani, Frederic Blanc, Cristian Falup-Pecurariu, Simon J. G. Lewis, Konrad Rejdak, Ewa Papuc, Jakub Hort, Zuzana Nedelska, John O'Brien, Laura Bonanni, Marta Marquie, Merce Boada, Vanesa Pytel, Carla Abdelnour, Daniel Alcolea, Katrin Beyer, Ole-Bjorn Tysnes, Dag Aarsland, Jodi Maple-Grodem
Summary: This study compares the rate of cognitive and motor decline in patients with DLB and PDD, finding that both disorders show similar rates of decline. This has implications for future clinical trial designs.
MOVEMENT DISORDERS CLINICAL PRACTICE
(2023)
Article
Clinical Neurology
Winston Dzau, Sifat Sharmin, Francesco Patti, Guillermo Izquierdo, Sara Eichau, Alexandre Prat, Marc Girard, Pierre Duquette, Marco Onofrj, Alessandra Lugaresi, Serkan Ozakbas, Oliver Gerlach, Cavit Boz, Pierre Grammond, Murat Terzi, Maria Pia Amato, Daniele La Spitaleri, Cristina Ramo-Tello, Davide Maimone, Elisabetta Cartechini, Katherine Buzzard, Olga Skibina, Anneke van der Walt, Helmut Butzkueven, Gerardo Iuliano, Aysun Soysal, Tomas Kalincik
Summary: This study investigated the association between early progression independent of relapse activity (PIRA) and relapse-associated worsening (RAW) with the onset and disability accumulation of secondary progressive multiple sclerosis (SPMS). It found that early PIRA and RAW were associated with increased risk of SPMS, but not with the rate of disability progression during SPMS.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2023)
Article
Virology
Maria Elena Flacco, Cecilia Acuti Martellucci, Graziella Soldato, Giuseppe Di Martino, Annalisa Rosso, Roberto Carota, Marco De Benedictis, Graziano Di Marco, Rossano Di Luzio, Matteo Ricci, Antonio Caponetti, Davide Gori, Lamberto Manzoli
Summary: This cohort study in Italy found that females, older individuals, and those with diabetes, cardiovascular diseases, chronic obstructive pulmonary disease (COPD), kidney disease, and cancer were at a higher risk of SARS-CoV-2 infection. The likelihood of severe or lethal COVID-19 was significantly lower among younger individuals, while comorbidities were independently associated with a higher risk. Vaccination, especially with booster doses, significantly reduced the risk of severe or lethal disease.
Review
Medicine, General & Internal
Francesco D'Antonio, Nashwa Eltaweel, Smriti C. Prasad, Maria Elena C. Flacco, Lamberto C. Manzoli, Asma C. Khalil
Summary: This systematic review and meta-analysis aimed to evaluate the role of cervical cerclage in preventing preterm birth and adverse outcomes in twin pregnancies. The findings suggest that cervical cerclage in twin pregnancies with short cervical length or cervical dilatation is associated with a reduced risk of preterm birth and improved neonatal outcomes. However, confirmation of these findings in large and well-designed randomized controlled trials is needed for stronger evidence.
Article
Immunology
Annalisa Rosso, Maria Elena Flacco, Graziella Soldato, Giuseppe Di Martino, Cecilia Acuti Martellucci, Roberto Carota, Marco De Benedictis, Graziano Di Marco, Rossano Di Luzio, Matteo Fiore, Antonio Caponetti, Lamberto Manzoli
Summary: A cohort study was conducted in the province of Pescara, Italy, to assess the real-world effectiveness of SARS-CoV-2 vaccination. The study found that individuals who received at least one booster dose had an 85% lower risk of severe or lethal COVID-19. Moreover, during the Omicron predominance period, only the group who received at least a booster dose showed a reduced risk of COVID-19-related death.
Letter
Public, Environmental & Occupational Health
Lamberto Manzoli, Cecilia Acuti Martellucci
ENVIRONMENTAL HEALTH INSIGHTS
(2022)
Article
Public, Environmental & Occupational Health
Cecilia Acuti Martellucci, Maria Elena Flacco, Mose Martellucci, Francesco Saverio Violante, Lamberto Manzoli
Summary: This study evaluated the inhaled air carbon dioxide (CO2) concentration while wearing masks and found that both surgical masks and FFP2 respirators resulted in higher CO2 concentrations. After adjusting for age, gender, BMI, and smoking, it was found that increasing respiratory rate significantly increased the inhaled air CO2 concentration.
ENVIRONMENTAL HEALTH INSIGHTS
(2022)
Article
Geriatrics & Gerontology
Giovanni Zuliani, Massimo Gallerani, Cecilia Acuti Martellucci, Roberto Reverberi, Gloria Brombo, Carlo Cervellati, Marco Zuin, Chiara Pistolesi, Dario Pedrini, Maria Elena Flacco, Lamberto Manzoli
Summary: The study found that elderly patients with dementia have a higher in-hospital mortality rate, with dementia itself doubling the odds of death. Heart failure, pneumonia, and kidney disease were identified as high-risk diseases for in-hospital mortality among patients with dementia.
AGING CLINICAL AND EXPERIMENTAL RESEARCH
(2022)
