Article
Clinical Neurology
David B. Burkholder, Christopher J. Boes
Summary: Robert Wartenberg had a successful career in medicine and played a crucial role in the establishment of the American Academy of Neurology. His strong personality and academic standing made him a valuable asset to the young leaders in neurology.
Article
Clinical Neurology
James A. Russell, John C. Hutchins, Leon G. Epstein
Summary: The Code of Professional Conduct developed by the American Academy of Neurology aims to formalize the standards of professional behavior for AAN members, guiding them in providing high-quality patient-centered neurologic care.
Article
Clinical Neurology
James A. Russell, John C. Hutchins, Leon G. Epstein
Summary: The AAN Code of Professional Conduct formalizes standards for behavior among members to ensure high-quality patient-centered neurologic care.
Article
Clinical Neurology
Adnan Qureshi, Carol Rheaume, Wei Huang, Iryna Lobanova, Raghav Govindarajan, Brandi R. French, Farhan Siddiq, Camilo R. Gomez, Pradeep K. Sahota
Summary: The survey revealed that 38% of respondents in neurology practice in the United States indicated exposure to COVID-19 at work, with tiredness (32%) and diarrhea (8%) as common symptoms. One out of 12 respondents who were tested for COVID-19 within the last 2 weeks tested positive.
Article
Clinical Neurology
Samuel W. Terman, Renate van Griethuysen, Carole E. Rheaume, Geertruida Slinger, Anisa S. Haque, Shawna N. Smith, Wesley T. Kerr, Charlotte van Asch, Willem M. Otte, Carolina Ferreira-Atuesta, Marian Galovic, James F. Burke, Kees P. J. Braun
Summary: This study evaluated the ability of neurologists to predict the risk of seizure recurrence after antiseizure medication withdrawal in well-controlled epilepsy. It also examined the barriers and influences of using risk calculation tools. The results showed a moderate correlation between clinician predictions and calculated predictions, but there was wide variation in clinician predictions. Calculated predictions had an impact on the clinicians' recommendations, particularly for cases without epileptiform abnormalities, leading to a more cautious approach. The main barrier to using risk calculation tools was doubting their accuracy.
Article
Critical Care Medicine
Krishanu Chatterjee, Mohamed Y. Rady, Joseph L. Verheijde, Richard J. Butterfield
Summary: The survey study reveals broad and stable support for the concept of brain death, but a tenuous belief exists regarding whether the AAN procedural criteria determine irreversible and complete loss of all brain function.
JOURNAL OF INTENSIVE CARE MEDICINE
(2021)
Article
Nutrition & Dietetics
Mandy L. Corrigan, Elizabeth Bobo, Christina Rollins, Kris M. Mogensen
Summary: Nutrition support is a therapy that aims to meet the nutritional needs of individuals who cannot meet them solely through oral intake, with registered dietitian nutritionists playing a crucial role in providing necessary information and determining the type of nutrition support therapy needed. The Standards of Practice and Standards of Professional Performance for RDNs working in nutrition support have been updated to ensure competent practice and professional development in various settings.
JOURNAL OF THE ACADEMY OF NUTRITION AND DIETETICS
(2021)
Article
Clinical Neurology
Rainer Surges
Summary: The aim of this guideline is to determine the frequency of sudden unexpected death in epilepsy (SUDEP) in different epilepsy populations and to answer whether risk factors for SUDEP can be identified. Through a systematic review of evidence and consensus-developed recommendations, it was found that the main risk factor for SUDEP is the occurrence of generalized tonic-clonic seizures, and recommendations were made for informing patients and actively continuing therapeutic efforts to reduce the risk of SUDEP.
ZEITSCHRIFT FUR EPILEPTOLOGIE
(2021)
Article
Nutrition & Dietetics
Mandy L. Corrigan, Elizabeth Bobo, Christina Rollins, Kris M. Mogensen
Summary: Nutrition support is a crucial therapy that aims to meet the nutrition requirements of individuals who cannot meet their needs through oral intake alone. Registered dietitian nutritionists play an integral role in providing information and setting professional standards to ensure competent practice in nutrition support. The Standards of Practice and Standards of Professional Performance help RDNs assess their practice and identify areas for improvement in various settings.
NUTRITION IN CLINICAL PRACTICE
(2021)
Article
Psychology, Multidisciplinary
Panagiotis Kourtesis, Sarah E. MacPherson
Summary: Immersive virtual reality tools have advantages in cognitive neuroscience and neuropsychology, but face technical and methodological challenges. Key issues raised by professional organizations highlight the need for addressing safety, privacy, and reliability concerns in Computerized Neuropsychological Assessment Devices. The VR Everyday Assessment Lab (VR-EAL) is a promising tool with enhanced ecological validity, but improvements are needed in embodiment illusion and open access VR software library creation.
COMPUTERS IN HUMAN BEHAVIOR REPORTS
(2021)
Article
Clinical Neurology
Samuel W. Terman, Geertruida Slinger, Carol E. Rheaume, Anisa S. Haque, Shawna N. Smith, Renate van Griethuysen, Charlotte J. J. van Asch, Willem M. Otte, James F. Burke, Kees P. J. Braun
Summary: This study investigated the practice patterns, challenges, and decision support needs of neurologists regarding the withdrawal of antiseizure medications in patients with well-controlled epilepsy. Most respondents indicated that they might consider withdrawal, with seizure probability, consequences, and driving being the most important factors in decision-making. The study also found wide variation in the use of words or numbers in counseling methods. The findings will inform the development of decision support tools for optimizing withdrawal decisions.
NEUROLOGY-CLINICAL PRACTICE
(2023)
Review
Clinical Neurology
Brin E. Freund, Peter W. Kaplan
Summary: Prognosis after cardiorespiratory arrest depends on neurological examination supported by neuroimaging and neurophysiological testing. Acute posthypoxic myoclonus (PHM) is clinically significant and historically associated with poor outcome, but can have different forms with varying prognoses. Neurophysiological tests, especially electroencephalogram, and clinical phenotyping are crucial in distinguishing malignant and benign forms of acute PHM. This review discusses the neurophysiological and phenotypic markers of different forms of acute PHM, a clinical approach for evaluating prognosis following cardiorespiratory arrest, and areas that need further study.
JOURNAL OF CLINICAL NEUROPHYSIOLOGY
(2023)
Article
Clinical Neurology
Jacqueline French, Victor Biton, Hina Dave, Kamil Detyniecki, Michael A. Gelfand, Hui Gong, Kore Liow, Terence J. O'Brien, Ahmed Sadek, Bree DiVentura, Brittany Reich, Jouko Isojarvi
Summary: This study demonstrated that Staccato alprazolam administered via a breath-actuated device can rapidly terminate epileptic seizures in hospitalized patients. The next step is to conduct a Phase 3 confirmatory study to further evaluate the efficacy and safety of Staccato alprazolam for seizure termination in an outpatient setting.
Review
Clinical Neurology
Pia De Stefano, Peter W. Kaplan, Herve Quintard, Margitta Seeck, Raoul Sutter
Summary: Seizures and status epilepticus (SE) are common in comatose cardiac arrest survivors, but little is known about nonconvulsive SE (NCSE). This study aimed to compile evidence from the literature on the frequency and outcome of NCSE in adult patients remaining in coma after resuscitation. The results showed that NCSE occurred in a small percentage of patients, and the favorable outcome after NCSE was observed in approximately one-fourth of the patients. However, the limited quality of data calls for further investigation on the effects of NCSE on outcome.
JOURNAL OF NEUROLOGY
(2023)
Article
Public, Environmental & Occupational Health
Shuang Wang, Kimford J. Meador, Jayne Pawasauskas, Adam K. Lewkowitz, Kristina E. Ward, Todd N. Brothers, Abraham Hartzema, Brian J. Quilliam, Xuerong Wen
Summary: This study aimed to assess the effects of buprenorphine and methadone treatment during early and late pregnancy on perinatal and pregnancy outcomes. The results showed that there were varying risks associated with the two treatments, with buprenorphine potentially being the preferred choice.
Editorial Material
Clinical Neurology
Randi von Wrede, Juri-Alexander Witt, Stephane Auvin, Anita Devlin, Lieven Lagae, Anthony Marson, Kimford J. Meador, Terence J. O'Brien, Jun Park, Rainer Surges, Eugen Trinka, Samuel Wiebe, Christoph Helmstaedter
Article
Biochemistry & Molecular Biology
Bernard K. van der Veer, Lehua Chen, Colin Custers, Paraskevi Athanasouli, Mariana Schroiff, Riet Cornelis, Jonathan Sai-Hong Chui, Richard H. Finnell, Frederic Lluis, Kian Peng Koh
Summary: Gastrulation begins when the epiblast forms the primitive streak or becomes definitive ectoderm. During this process, TET1 plays a role in both transcriptional activation and repression, but the mechanisms are not well understood. By converting mouse embryonic stem cells into neuroprogenitors, researchers found that TET1 regulates the formation of mesoderm and endoderm by suppressing Wnt/beta-catenin and Nodal signalling. TET1 also affects chromatin accessibility and gene expression through DNA demethylation in a context-dependent manner. These findings highlight the versatile functions of TET1 during development.
NUCLEIC ACIDS RESEARCH
(2023)
Letter
Clinical Neurology
P. Emanuela Voinescu, Page B. Pennell, Kimford Meador
Article
Pharmacology & Pharmacy
R. L. Bromley, M. Bickle Graz, M. Bluett-Duncan, C. Chambers, P. Damkier, K. Dietrich, H. Dolk, K. Grant, S. Mattson, K. J. Meador, H. Nordeng, T. F. Oberlander, A. Ornoy, A. Revet, J. Richardson, J. Rovet, L. Schuler-Faccini, E. Smearman, V. Simms, C. Vorhees, K. Wide, A. Wood, L. Yates, E. Ystrom, T. A. Supraja, J. Adams
Summary: The study aims to achieve consensus on the core neurodevelopmental outcomes, optimize methodologies, and overcome barriers in conducting pregnancy pharmacovigilance studies with neurodevelopmental outcomes. The vision is to establish a comprehensive understanding of neurodevelopmental outcomes in pregnancy pharmacovigilance through a complementary set of studies.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Clinical Neurology
P. Emanuela Voinescu, McKenna Kelly, Jacqueline A. French, Cynthia Harden, Anne Davis, Connie Lau, Alexa Ehlert, Stephanie Allien, Emma Osterhaus, Sarah Barnard, Rishabh Jain, Page B. Pennell
Summary: This study examined the occurrence and distribution of catamenial epilepsy patterns in women with epilepsy not receiving hormonal therapies. The results showed that out of 89 women enrolled, 23 were eligible for analysis, with 12 meeting criteria for catamenial epilepsy. App-based tracking proved to be a useful tool in determining catamenial patterns.
Article
Clinical Neurology
Oluwadolapo D. Lawal, Kimford J. Meador, Anne L. Hume, Xuerong Wen
Summary: The study analyzed the pattern of antiseizure medication use in women of childbearing age with different indications, showing an increasing trend in the use of newer-generation ASMs and a decreasing trend in the use of older ASMs. The risk of teratogenicity associated with newer medications is largely unknown, emphasizing the importance of counseling and education in prescribing ASMs for women of childbearing age.
Meeting Abstract
Neurosciences
Rebecca Bromley, Miriam Bickle Graz, Matthew Bluett-Duncan, Christina Chambers, Per Damkier, Kim Dietrich, Helen Dolk, Kimberley Grant, Sarah Mattson, Kim Meador, Hedvig Nordeng, Tim Oberlander, Asher Ornoy, Alexis Revet, Jonathan Richardson, Joanne Rovet, Lavinia Schuler-Faccini, Erica Smearman, Victoria Simms, Charles Vorhees, Katrina Wide, Amanda Wood, Laura Yates, Evinid Ystrom, T. A. Supraja, Jane Adams
NEUROTOXICOLOGY AND TERATOLOGY
(2023)
Article
Clinical Neurology
Ignacio Valencia, Allyson L. Alexander, Danielle M. Andrade, Miguel Arevalo-Astrada, Clio Rubinos, Nancy Auer, Jacquelyn L. Bainbridge, Sallie A. Baxendale, Fabrice Bartolomei, Danielle A. Becker, Anne T. Berg, Andrea Bernasconi, Neda Bernasconi, Boris Bernhardt, Shivani Bhatnagar, Ingmar Bluemcke, Hal Blumenfeld, Gordon F. Buchanan, David E. Burdette, Jorge G. Burneo, Robyn M. Busch, Patrick Chauvel, Jeannie Chin, Lisa Clifford, Kelly R. Conner, Mark J. Cook, Jeannine Conway, Ramon Diaz-Arastia, Cornelia Drees, Jacqueline A. French, Taneeta Mindy Ganguly, Michael A. Gelfand, Tracy A. Glauser, Ezequiel Gleichgerrcht, Alica M. Goldman, Jorge Gonzalez-Martinez, Jean Gotman, Zachary Grinspan, Shanna Guilfoyle, Gita Gupta, Michael Hammer, Adam L. Hartman, Katie Hentges, R. Edward Hogan, Linda Huh, Ann Hyslop, Barbara Jobst, Colin B. Josephson, Sarah A. Kelley, Kelly Knupp, Matthias Koepp, Sanjeev Kothare, Esther Krook-Magnuson, Jasmine Kwasa, Maite La Vega-Talbott, Alice D. Lam, Jong Woo Lee, Daniel H. Lowenstein, Sarita Maturu, Luis Carlos Mayor, Carrie McDonald, Heather R. McKee, Guy M. McKhann, Kimford J. Meador, Heather C. Mefford, Elizabeth H. Michael, Mohamad A. Mikati, John J. Millichap, James W. Mitchell, Leah S. Myers, Dean Naritoku, Kerri L. Neville, Jeffrey Noebels, Terence J. O'Brien, Chima O. Oluigbo, Anup D. Patel, Milena K. Pavlova, Jeanne T. Paz, Page B. Pennell, M. Scott Perry, Piero Perucca, Asla Pitkaenen, Madona Plueger, Mary Jo Pugh, Mark Quigg, Shilpa B. Reddy, Christopher Ryan, Tamara S. Reynolds, Martha Sajatovic, Cesar Santana-Gomez, Linsday Schommer, Stephan Schuele, Renee A. Shellhaas, Daniel W. Shrey, Rani K. Singh, Michael R. Sperling, Saher Suleman, Jessica W. Templer, Maria Thom, Eugen Trinka, Sophia M. Varadkar, Naymee Velez-Ruiz, Jana Veliskova, Yuliya Voskobiynyk, Janelle L. Wagner, Jacy L. Wagnon, Claire Waller, Jill Waller, Zhong Irene Wang, Michelle W. Welborn, Elaine Wirrell, Barbara Jobst
Summary: The American Epilepsy Society Meeting 2022 in Nashville attracted over 6000 attendees and felt as busy as before the pandemic. The meeting provided a variety of symposia covering topics such as seizure generation, epilepsy pathophysiology, anti-seizure medications, and new treatment tools. It also included discussions on epilepsy comorbidities, practical issues in epilepsy care, and personal stories from patient advocates. Special lectures and smaller group sessions focused on specific areas of interest, and satellite symposia showcased the latest advancements in pharmaceutical and engineering fields.
Article
Clinical Neurology
Kimford J. Meador, Morris J. Cohen, David W. Loring, Abigail G. Matthews, Carrie Brown, Chelsea P. Robalino, Angela K. Birnbaum, Paula E. Voinescu, Laura A. Kalayjian, Elizabeth E. Gerard, Evan R. Gedzelman, Julie Hanna, Jennifer Cavitt, Maria Sam, Jacqueline A. French, Sean Hwang, Alison M. Pack, Page B. Pennell, MONEAD Invest Grp
Summary: This study aimed to investigate the neurodevelopmental effects of fetal exposure to commonly used antiseizure medications, and found no difference in neurodevelopmental outcomes between children with fetal exposure to newer antiseizure medications compared with unexposed children.
Review
Clinical Neurology
Brin E. Freund, Tara Brigham, Saif Salman, Peter W. Kaplan, William O. Tatum
Summary: Electroencephalogram (EEG) is essential for prognostication and diagnosis in critically ill patients. It can differentiate neurological disorders and indicate a potential for seizures. This study aimed to characterize zeta waves and found that they are often associated with focal cerebral lesions and a heightened risk for seizures.
JOURNAL OF CLINICAL NEUROPHYSIOLOGY
(2023)
Article
Clinical Neurology
Levente Hadady, Michael R. Sperling, Juan Luis Alcala-Zermeno, Jacqueline A. French, Patricia Dugan, Lara Jehi, Daniel Fabo, Peter Klivenyi, Guido Rubboli, Sandor Beniczky
Summary: This study conducted external validation of previously published epilepsy surgery prediction tools using a large independent multicenter dataset and found that these tools can effectively stratify patients for surgery and freedom from disabling seizures.
