Article
Clinical Neurology
Martje G. Pauly, Magdalena Barlage, Feline Hamami, Julia Steinhardt, Julianne Baarbe, Stephanie Tran, Henrike Hanssen, Rebecca Herzog, Vera Tadic, Norbert Brueggemann, Robert Chen, Alexander Muenchau, Tobias Baeumer, Anne Weissbach
Summary: This study investigated the effects of subthalamic nucleus and dorsal premotor cortex conditioning on corticospinal excitability and found that premotor-motor inhibition can be modulated by subthalamic nucleus conditioning, possibly through the monosynaptic hyperdirect pathway.
PARKINSONISM & RELATED DISORDERS
(2022)
Review
Chemistry, Medicinal
Thais Barreto Santos, Leonardo Gomes Cavalieri de Moraes, Paulo Anastacio Furtado Pacheco, Douglas Galdino dos Santos, Rafaella Machado de Assis Cabral Ribeiro, Caroline dos Santos Moreira, David Rodrigues da Rocha
Summary: This review provides an overview of neuroprotective naphthoquinones, such as shikonin, plumbagin, and vitamin K, which have been found to prevent oxidative stress and exhibit neuroprotective effects through various mechanisms. Synthetic naphthoquinones with inhibitory activity on the P2X7 receptor have also shown neuroprotective effects on Neuro-2a cells. Naphthazarin has been identified as an inhibitor of the MAO-B enzyme, and vitamin K and synthetic naphthoquinones derivatives have demonstrated inhibition of alpha-synuclein aggregation. Synthetic derivatives of juglone and naphthazarin have also been shown to protect Neuro-2a cells against neurodegenerative effects. The review also discusses routes for producing synthetic derivatives, highlighting the potential of 1,4-naphthoquinones as a promising class in the treatment of Parkinson's disease.
Article
Clinical Neurology
Julia E. Perkins, Annette Janzen, Felix P. Bernhard, Karen Wilhelm, Donald C. Brien, Jeff Huang, Brian C. Coe, David Vadasz, Geert Mayer, Douglas P. Munoz, Wolfgang H. Oertel
Summary: Patients with isolated REM Sleep Behavior Disorder (RBD) and Parkinson's disease (PD) show altered pupil and blink behavior compared to healthy controls. While RBD saccade parameters were similar to controls, suggesting that pupil and blink brain areas may be impacted before saccadic control areas, making them potential prodromal PD biomarkers.
MOVEMENT DISORDERS
(2021)
Article
Clinical Neurology
Cameron Miller-Patterson, Jesse Y. Hsu, Allison W. Willis, Ali G. Hamedani
Summary: This study aimed to evaluate whether functional limitations exist in individuals with Parkinson disease before diagnosis. Using Medicare-linked data from the National Health and Aging Trends Study (NHATS) in the US, researchers found that individuals with prodromal Parkinson disease may have greater impairment in mobility and strength up to 3 years prior to diagnosis compared with the general population.
Article
Public, Environmental & Occupational Health
Sarah Bauermeister, Joshua R. Bauermeister, Ruth Bridgman, Caterina Felici, Mark Newbury, Laura North, Christopher Orton, Emma Squires, Simon Thompson, Simon Young, John E. Gallacher
Summary: Research-ready data increase scientific opportunity and rigour by integrating the data environment. A standard data model (C-Surv) optimized for data discovery was developed using data from 5 cohort studies. The model uses a four-tier nested structure based on 18 data themes and standard variable naming conventions. The data model was used to develop a harmonized dataset for 11 cohorts, offering multiple benefits for data analysis.
EUROPEAN JOURNAL OF EPIDEMIOLOGY
(2023)
Article
Multidisciplinary Sciences
Joan Forns, J. Bradley Layton, Jennifer Bartsch, Mary Ellen Turner, Colleen Dempsey, Mary Anthony, Mary E. Ritchey, George Demos
Summary: The study evaluated the risk of falls and fractures in patients with Parkinson disease with psychosis (PDP) compared to those without psychosis at similar disease stages. The results showed that PDP patients had a slightly higher risk of falls and fractures, particularly in falls, compared to PD patients without psychosis.
Article
Environmental Sciences
Junxiang Wang, Yali Weng, Yinhan Li, Yu Zhang, Jinfu Zhou, Jianping Tang, Xinpei Lin, Zhenkun Guo, Fuli Zheng, Guangxia Yu, Wenya Shao, Hong Hu, Ping Cai, Siying Wu, Huangyuan Li
Summary: This study focused on the interaction between splicing factor 3 sub-unit 3 (SF3B3) and long non-coding RNA NR_030777 in PQ-induced Parkinson's disease. It was found that PQ exposure reduced SF3B3 protein expression in Neuro-2a cells, which was prevented by the ROS scavenger. Knockdown of SF3B3 reduced the increase in NR_030777 expression triggered by PQ, while overexpression of NR_030777 reduced the expression of Sf3b3. Additionally, SF3B3 knockdown exacerbated cell viability decrease and tyrosine hydroxylase (TH) protein reduction in PQ-induced damage.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Letter
Clinical Neurology
Aravind Ganesh, Steven Galetta
Summary: The study found lower total alpha-synuclein levels in the CSF of PD patients with high sensitivity but low specificity compared to HCs. Alpha-synuclein immunoreactivity in skin and submandibular gland was specific for PD but not sensitive. There are ongoing debates and uncertainties in methodology surrounding the detection of synuclein in tissue samples.
Article
Biochemistry & Molecular Biology
Milos Stanojlovic, Jean Pierre Pallais, Catherine M. Kotz
Summary: This study indicates that Parkinson's disease is associated with damage to orexin neurons and behavioral impairments. By using the A53T mouse model of Parkinson's, measuring various parameters, and evaluating neuronal disruptions, the researchers further confirmed this idea.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Melania Melis, Antje Haehner, Mariano Mastinu, Thomas Hummel, Iole Tomassini Barbarossa
Summary: Impairments in olfaction and taste are common non-motor symptoms in Parkinson's disease, often appearing before motor symptoms onset. The basis for these dysfunctions are likely multifactorial, potentially sharing determinants with other non-motor symptoms of PD. Associations with the microbiota may also represent risk factors associated with the disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Clinical Neurology
Anne Fink, Richard Dodel, Daniela Georges, Gabriele Doblhammer
Summary: The objective of this study was to analyze sex-specific patterns of Parkinson's disease dementia (PDD) incidence. The results showed that sex differences in survival after initial Parkinson's disease (PD) diagnosis influenced differences in PDD risk among PD patients, with men having a higher PDD risk than women. However, when accounting for death, there was no difference in PDD risk between men and women. Additionally, age and disease severity had significant effects on PDD risk in women but not in men.
MOVEMENT DISORDERS
(2023)
Article
Neurosciences
Liting Hang, Ziyin Wang, Aaron S. C. Foo, Geraldine W. Y. Goh, Huey Ching Choong, John Thundyil, Shengli Xu, Kong-Peng Lam, Kah-Leong Lim
Summary: Emerging studies suggest that energy dysregulation is a key factor in Parkinson's disease, and AMP kinase (AMPK) plays a crucial role in maintaining neuronal energy homeostasis. Loss of AMPK function can promote dopaminergic neurodegeneration and increase susceptibility to toxin-induced damage, making the AMPK pathway a promising therapeutic target for PD.
NEUROBIOLOGY OF DISEASE
(2021)
Article
Medicine, General & Internal
Jeong Won Lee, Yoo Sung Song, Hyeyun Kim, Bon D. Ku, Won Woo Lee
Summary: The rate of dopaminergic denervation in Parkinson's disease was estimated using imaging studies in a large prospective cohort, revealing a relatively weak association between dopaminergic denervation and age or symptom duration, as compared to previous knowledge. Different age onsets in patients did not show significant correlations between symptom durations and striatal specific binding ratios.
Article
Clinical Neurology
Ahro Kim, Han-Joon Kim, Aryun Kim, Yoon Kim, Mihee Jang, Sun Ha Paek, Beomseok Jeon
Summary: Bilateral subthalamic nucleus deep brain stimulation showed significant control over diphasic dyskinesia in patients with Parkinson's disease, with approximately 74% of patients experiencing remission after surgery. Patients with younger age of onset and longer disease duration at surgery were more likely to have persistent diphasic dyskinesia.
EUROPEAN JOURNAL OF NEUROLOGY
(2021)
Article
Clinical Neurology
J. Naisby, R. A. Lawson, B. Galna, L. Alcock, D. J. Burn, L. Rochester, A. J. Yarnall
Summary: Pain is a common non-motor symptom in Parkinson's disease, with unexplained pain being prevalent even in early stages. The frequency and type of pain fluctuates as symptoms progress, highlighting the importance of asking PD patients about their pain at clinical consultations and providing support in describing it.
JOURNAL OF NEUROLOGY
(2021)