Article
Multidisciplinary Sciences
Yee Ming Khaw, Abbey Tierney, Claire Cunningham, Katiria Soto-Diaz, Eunjoo Kang, Andrew J. Steelman, Makoto Inoue
Summary: Multiple sclerosis is a chronic neurological disease driven by immune cell infiltration and glial activation, leading to demyelination. Gray matter-infiltrated CD4(+) T cells play a key role in inducing neuronal damage. Inhibiting astrocyte chemokine production can prevent T cell migration into gray matter, reducing neuronal damage and motor dysfunction.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Review
Cell & Tissue Engineering
Foteini Tsouki, Anna Williams
Summary: The review highlights the significant role of microglia in gray matter changes in MS, particularly in neuronal loss and cortical atrophy. Microglia exhibit regional heterogeneity within the central nervous system, showing their ability to provide context-dependent responses tailored to the demands of their microenvironment.
Article
Clinical Neurology
Roberta Magliozzi, Giulia Fadda, Robert A. Brown, Amit Bar-Or, Owain W. Howell, Simon Hametner, Damiano Marastoni, Alberto Poli, Richard Nicholas, Massimiliano Calabrese, Salvatore Monaco, Richard Reynolds
Summary: Leptomeningeal and perivenular infiltrates play important roles in cortical grey matter damage and disease progression in multiple sclerosis (MS). This study investigated the potential gradient of damage in deep grey matter nuclei and found substantial subependymal-in gradient of neuro-axonal loss and microglia activation in active thalamic lesions of progressive MS cases. The presence of increased leptomeningeal and cerebrospinal fluid (CSF) inflammation was associated with the altered graded pathology and more severe disease progression.
ANNALS OF NEUROLOGY
(2022)
Review
Psychology, Clinical
Yuan Cao, Wei Diao, Fangfang Tian, Feifei Zhang, Laichang He, Xipeng Long, Fuqinq Zhou, Zhiyun Jia
Summary: Gray matter atrophy is associated with disability and cognitive impairment in multiple sclerosis, and differences in atrophy patterns between relapsing-remitting and primary progressive MS were identified. Specific gray matter regions were associated with disease characteristics in RRMS and PPMS, suggesting common and distinct pathogenesis between the two types of MS.
NEUROPSYCHOLOGY REVIEW
(2021)
Article
Neuroimaging
Charidimos Tsagkas, Emanuel Geiter, Laura Gaetano, Yvonne Naegelin, Michael Amann, Katrin Parmar, Athina Papadopoulou, Jens Wuerfel, Ludwig Kappos, Till Sprenger, Cristina Granziera, M. Mallar Chakravarty, Stefano Magon
Summary: This study investigates the longitudinal changes in deep gray matter (DGM) shape in relapse-onset multiple sclerosis (MS) and their relationship with clinical disability and white matter lesion-load. The study finds specific shape changes in DGM structures over time, but these changes are not associated with disease progression. However, there is a link between DGM shape and average disease severity as well as white matter lesion-load.
NEUROIMAGE-CLINICAL
(2022)
Article
Neurosciences
Emilie Lommers, Camille Guillemin, Gilles Reuter, Eve Fouarge, Gael Delrue, Fabienne Collette, Christian Degueldre, Evelyne Balteau, Pierre Maquet, Christophe Phillips
Summary: This study utilized a quantitative multiparametric voxel-based approach to reveal three different configurations of GM microstructural/volumetric alterations in MS patients, including GM atrophy with reduction in MT, R1, and/or R2* in primary cortices, microstructural modifications without significant GM loss in hippocampus and paralimbic cortices, and atrophy without significant change in microstructure in deep GM nuclei.
HUMAN BRAIN MAPPING
(2021)
Article
Behavioral Sciences
Juichi Fujimori, Kazuo Fujihara, Mike Wattjes, Ichiro Nakashima
Summary: The study found that cortical gray matter thickness reduction patterns in multiple sclerosis (MS) patients are mainly characterized by the degree of temporal lobe cortical atrophy, which may start in the relapsing-remitting phase. As the disease progresses, neurodegenerative changes in the temporal pole region may accelerate in the progressive phase.
BRAIN AND BEHAVIOR
(2021)
Article
Clinical Neurology
Mahmoud A. AbdelRazek, Subhash Tummala, Fariha Khalid, Shahamat Tauhid, Youmna Jalkh, Samar Khalil, Shelley Hurwitz, Jonathan Zurawski, Rohit Bakshi
Summary: This study compared gray matter atrophy in patients with multiple sclerosis (MS) treated with glatiramer acetate (GA) and patients with clinically benign MS (BMS). The results showed that there was no significant change in gray matter and whole brain atrophy in the GA group over 2 years, similar to the BMS group.
JOURNAL OF THE NEUROLOGICAL SCIENCES
(2023)
Article
Clinical Neurology
Mikkel K. E. Nygaard, Martin Langeskov-Christensen, Ulrik Dalgas, Simon F. Eskildsen
Summary: The study found that cortical diffusion and thalamic volume are closely associated with walking and cognitive performance in patients with relapsing-remitting multiple sclerosis (RRMS), and are highly affected by the presence of white matter lesions.
JOURNAL OF NEUROLOGY
(2021)
Correction
Psychology, Clinical
Yuan Cao, Wei Diao, Fangfang Tian, Feifei Zhang, Laichang He, Xipeng Long, Fuqinq Zhou, Zhiyun Jia
Summary: A correction to this paper has been published and can be accessed from the provided link.
NEUROPSYCHOLOGY REVIEW
(2021)
Article
Clinical Neurology
Jie Sun, Yingying Xie, Qiuhui Wang, Junlin Shen, Wen Qin, Ningnannan Zhang, Chunshui Yu
Summary: The study identified 623 genes associated with grey matter volume reduction in multiple sclerosis, which are functionally related to ion channel, synaptic transmission, axon, and neuron projection. These genes show significant enrichment for MS-related genes identified by GWAS and are more significantly expressed in neurons than other cell types, indicating a potential role in the development of grey matter atrophy in MS.
JOURNAL OF NEUROLOGY
(2022)
Article
Biochemistry & Molecular Biology
Milagros Hidalgo de la Cruz, Paola Valsasina, Sarlota Mesaros, Alessandro Meani, Jovana Ivanovic, Vanja Martinovic, Jelena Drulovic, Massimo Filippi, Maria A. Rocca
Summary: In the study, it was found that abnormalities in sub-regional thalamic resting state functional connectivity in clinically isolated syndrome patients were associated with clinical disability and evolved over time. Some patients experienced multiple clinical relapses, but the median EDSS score remained stable.
MOLECULAR PSYCHIATRY
(2021)
Review
Clinical Neurology
Moein Amin, Daniel Ontaneda
Summary: Multiple sclerosis (MS) results in thalamic volume loss, which affects cognitive function such as processing speed and memory. Thalamic atrophy is a significant predictor of cognitive impairment (CI) in MS.
FRONTIERS IN NEUROLOGY
(2021)
Review
Clinical Neurology
E. E. Amelie Mock, Eveliina Honkonen, Laura Airas
Summary: Synaptic loss seems to be present throughout the central nervous system, but there are inconsistencies in the results, possibly due to variations in methodology. The dynamic nature of synaptic loss suggests that in vivo synaptic density measurements may provide a clearer understanding of this pathology.
FRONTIERS IN NEUROLOGY
(2021)
Article
Clinical Neurology
Dalit Cayam-Rand, Ting Guo, Anne Synnes, Vann Chau, Connor Mabbott, Isabel Benavente-Fernandez, Ruth E. Grunau, Steven P. Miller
Summary: In very preterm-born children, neonatal thalamic growth and WMI volume predict school-age thalamic volumes. An interaction between FA and WMI impacts school-age thalamic volume, affecting cognition and motor outcomes.
ANNALS OF NEUROLOGY
(2021)
Article
Clinical Neurology
Monica Margoni, Elisabetta Pagani, Paolo Preziosa, Marco Palombo, Mor Gueye, Matteo Azzimonti, Massimo Filippi, Maria Assunta Rocca
Summary: The SANDI model can be used to differentiate pathological abnormalities in multiple sclerosis, providing valuable insights into the neurodegenerative processes associated with the disease.
JOURNAL OF NEUROLOGY
(2023)
Article
Clinical Neurology
Paolo Preziosa, Elisabetta Pagani, Alessandro Meani, Olga Marchesi, Lorenzo Conti, Andrea Falini, Maria A. Rocca, Massimo Filippi
Summary: Using diffusion tensor and neurite orientation dispersion and density imaging (NODDI), this study found that neuro-axonal damage and loss of microarchitecture integrity in focal WM lesions, NAWM, and GM contribute to cognitive impairment in MS.
JOURNAL OF NEUROLOGY
(2023)
Article
Clinical Neurology
Monica Margoni, Mor Gueye, Alessandro Meani, Elisabetta Pagani, Lucia Moiola, Paolo Preziosa, Massimo Filippi, Maria A. Rocca
Summary: This study found that there is enlargement of the choroid plexus (CP) in pediatric multiple sclerosis (MS) patients, suggesting its early involvement in the pathophysiology of the disease. The higher CP volume, especially in female patients, supports the hypothesis of sex-related differences in pediatric MS.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2023)
Article
Biochemistry & Molecular Biology
Alessia Fiore, Paolo Preziosa, Nicolo Tedone, Monica Margoni, Carmen Vizzino, Damiano Mistri, Mor Gueye, Maria A. Rocca, Massimo Filippi
Summary: Gray matter atrophy in multiple sclerosis (MS) progresses non-randomly and may be associated with specific neurotransmitter distributions in the central nervous system. This study investigated the correlations among regional GM atrophy, neurotransmitter maps, and clinical manifestations in a large group of MS patients.
MOLECULAR PSYCHIATRY
(2023)
Article
Clinical Neurology
Federico Montini, Agostino Nozzolillo, Paola M. V. Rancoita, Chiara Zanetta, Lucia Moiola, Federica Cugnata, Federica Esposito, Maria A. Rocca, Vittorio Martinelli, Massimo Filippi
Summary: This study assessed modifiable risk factors associated with COVID-19 in people with multiple sclerosis (PwMS). The results showed that higher vitamin D levels and active smoking status were associated with a lower risk of COVID-19, while external contact and working in the healthcare sector increased the risk. Therefore, vitamin D supplementation and teleworking may help prevent infection risk in PwMS.
JOURNAL OF NEUROLOGY
(2023)
Article
Clinical Neurology
R. Veldkamp, M. D'hooge, B. M. Sandroff, J. DeLuca, D. Kos, A. Salter, A. Feinstein, M. P. Amato, G. Brichetto, J. Chataway, R. Farrell, N. D. Chiaravalloti, U. Dalgas, M. Filippi, J. Freeman, R. W. Motl, C. Meza, M. Inglese, M. A. Rocca, G. Cutter, P. Feys
Summary: Performing cognitive-motor dual tasks can negatively affect walking performance and cognitive function in individuals with progressive multiple sclerosis and cognitive impairment. This study examined the dual task performance in different disability levels and found that it significantly affected walking performance, with similar effects across disability subgroups.
JOURNAL OF NEUROLOGY
(2023)
Review
Clinical Neurology
Susana Otero-Romero, Christine Lebrun-Frenay, Saul Reyes, Maria Pia Amato, Magda Campins, Mauricio Farez, Massimo Filippi, Yael Hacohen, Bernhard Hemmer, Rosa Juuti, Melinda Magyari, Celia Oreja-Guevara, Aksel Siva, Sandra Vukusic, Mar Tintore
Summary: This study aims to develop an evidence-based vaccination strategy for pwMS who are candidates for disease-modifying therapies. A multidisciplinary working group conducted a systematic literature search and formulated 53 recommendations based on the quality of evidence. The goal of this study is to homogenize immunization practices in pwMS.
MULTIPLE SCLEROSIS JOURNAL
(2023)
Article
Clinical Neurology
Laura Cacciaguerra, Vyanka Redenbaugh, John J. Chen, Pearse Morris, Elia Sechi, Stephanie B. Syc-Mazurek, A. Sebastian Lopez-Chiriboga, Jan-Mendelt Tillema, Maria A. Rocca, Massimo Filippi, Sean J. Pittock, Eoin P. Flanagan
Summary: The study investigated the timing and predictors of T2-lesion resolution in MOGAD, finding that small lesions resolved more frequently and faster than large lesions. Factors such as acute T1-hypointensity and acute steroids influenced the resolution of T2-lesions. Spontaneous resolution of T2-lesions without treatment was also observed.
Article
Medicine, General & Internal
Cristiano Scandurra, Laura Rosa, Antonio Carotenuto, Marcello Moccia, Sebastiano Arena, Antonio Ianniello, Agostino Nozzolillo, Mariavittoria Turrini, Lidia Mislin Streito, Gianmarco Abbadessa, Elisabetta Ferraro, Manuela Mattioli, Alessandro Chiodi, Nelson Mauro Maldonato, Simona Bonavita, Marinella Clerico, Cinzia Cordioli, Lucia Moiola, Francesco Patti, Luigi Lavorgna, Massimo Filippi, Giovanna Borriello, Emanuele D'Amico, Carlo Pozzilli, Vincenzo Brescia Morra, Maria Petracca, Roberta Lanzillo
Summary: Despite being a common issue, sexual dysfunction in people with multiple sclerosis (pwMS) is underinvestigated. This study aimed to assess the potential determinants of sexual dysfunction in pwMS by considering its relationship with disease severity, illness perception, and depressive symptoms. The results showed that disease severity indirectly affects sexual dysfunction through illness perception and depressive symptoms. Illness perception plays a more crucial role in sexual dysfunction for pwMS with mild disability. Modulating the effect of illness perception might be a valid approach to mitigate sexual dysfunction symptoms in pwMS.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Cardiac & Cardiovascular Systems
Matteo Zavarella, Andrea Villatore, Maria Assunta Rocca, Giovanni Peretto, Massimo Filippi
Summary: Multiple sclerosis (MS) is a chronic neurological disorder characterized by CNS inflammation leading to neurodegeneration. The prevalence of MS is increasing globally, partly due to novel therapies. A multidisciplinary approach is essential for managing MS, considering its association with cardiovascular diseases and the higher prevalence of cardiovascular risk factors in MS patients. Rare complications such as Takotsubo syndrome and parallels with myocarditis are also observed. Cardiac toxicity is a common adverse reaction to MS drugs. This narrative review aims to provide an overview of cardiovascular complications in MS and their management, advocating for further research in this field.
JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE
(2023)
Article
Clinical Neurology
Teuta Domi, Paride Schito, Giacomo Sferruzza, Tommaso Russo, Laura Pozzi, Federica Agosta, Paola Carrera, Nilo Riva, Massimo Filippi, Angelo Quattrini, Yuri Matteo Falzone
Summary: This study aims to outline the clinical features of SOD1-ALS patients by comparing them to patients without ALS major gene variants and patients with variants in other major ALS genes. Defining the SOD1-ALS phenotype can assist clinicians in identifying patients who should be prioritized for genetic testing.
JOURNAL OF NEUROLOGY
(2023)
Article
Clinical Neurology
Massimo Filippi, Roberta Messina, Marta Bartezaghi, Ilaria Cetta, Bruno Colombo, Licia Grazzi, Daniele Martinelli, Raffaele Ornello, Anna Pichiecchio, Debora Raimondi, Antonio Russo, Simona Sacco, Alessandra Splendiani, Cristina Tassorelli, Renato Turrini, Paola Valsasina, Maria Assunta Rocca, RESET BRAIN Study Grp
Summary: This study aims to investigate the central effect of erenumab, a monoclonal antibody targeting the calcitonin gene-related peptide receptor, on brain network function in migraine patients, and to explore the persistence of this effect after treatment discontinuation. The findings show that erenumab modulates the brain network function involved in migraine and the effect tends to reverse when treatment is stopped.
JOURNAL OF NEUROLOGY
(2023)
Article
Clinical Neurology
Massimo Filippi, Luigi Grimaldi, Antonella Conte, Rocco Totaro, Maria Rosaria Valente, Simona Malucchi, Franco Granella, Cinzia Cordioli, Vincenzo Brescia Morra, Chiara Zanetta, Daria Perini, Laura Santoni, EASIER Study Working Grp
Summary: The EASIER study investigates the consumption of healthcare resources and associated costs of natalizumab administration. The study finds that adopting the subcutaneous route can significantly reduce patient and healthcare professional time and costs.
JOURNAL OF NEUROLOGY
(2023)
Article
Clinical Neurology
Loredana Storelli, Elisabetta Pagani, Patrizia Pantano, Antonio Gallo, Nicola De Stefano, Maria A. Rocca, Massimo Filippi
Summary: The use of FSL-MIST multimodal segmentation method improves the robustness of results and enables better detection of small variations in thalamic volumes.
AMERICAN JOURNAL OF NEURORADIOLOGY
(2023)
Article
Clinical Neurology
Damiano Mistri, Nicolo Tedone, Diana Biondi, Carmen Vizzino, Elisabetta Pagani, Maria A. Rocca, Massimo Filippi
Summary: This study identified five cognitive phenotypes with varying degrees of impairment in multiple sclerosis (MS) patients and described their characteristics. The findings suggest potential variations in the neural substrates of dysfunction throughout disease stages in MS.
JOURNAL OF NEUROLOGY
(2023)